Nephropathy is also known as renal disease. It is any type of damage or disease relating to the kidneys. Though not everyone with diabetes has nephropathy, however, diabetic nephropathy can cause kidney failure.

How does diabetes affect the kidney?
Kidneys are responsible for taking waste out from your blood. They have a lot of tiny blood vessels to do this. High blood sugar may kill such blood vessels. Once these blood vessels are destroyed, the kidneys may not function as well or it may even lead to kidney failure.

What increases your risk of getting diabetic nephropathy?
There are several factors which increase your risk of getting diabetic nephropathy including: \
1. High blood pressure
2. High cholesterol
3. Smoking
4. Being native american, african american or of hispanic origin, for whom risk factors have proved to be magnified
5. If you have family history of diabetic nephropathy

Symptoms and diagnosis:
There are very few noticeable symptoms, which appear when you have diabetic nephropathy, except swelling in your arms and legs. The diagnosis is done by checking for a type of protein in your urine known as albumin, which is not supposed to be there. Getting the diagnosis done early is crucial.

Preventive measures
You can prevent kidney damage by doing the following:
1. Keeping your blood sugar levels under control - keep hba1c &lt; 6-7%
2. Keeping your blood pressure under control in the range of 130/80
3. Eating healthy food
4. Exercising regularly
5. Not eating too much protein
6. Not eating too much salt
7. Reducing smoke or excessive tobacco usage

Medicines for treatment
If you do get diabetic nephropathy, here are some medicines, which can help cure it
1. Ace inhibitors which are also called angiotensin-converting enzyme inhibitors
2. Angiotensin ii receptor blockers (arbs)

Possible complications
1. Blood pressure may rise
2. Triglyceride levels and cholesterol levels may rise.

All About Diabetic Nephropathy

Necrotizing enterocolitis is a disease that causes inflammation of the tissues present in the intestines and results in damaged tissues. It initially affects the inner lining which ultimately results in thickening of the intestine. It may also lead to a hole in the abdomen resulting in bacteria entering the intestine, thus resulting in infection.

Symptoms-
The symptoms of necrotizing enterocolitis are:

You may experience symptoms of bloating in the abdomen
The abdomen may be discolored
You may experience diarrhea and vomiting
You may not feel hungry
There may be presence of blood in your stool
You may have a fever and constantly feel lethargic
Causes-
Lack of blood and oxygen in the intestine causes it to become weak and increases the chances of necrotizing enterocolitis. It may result if oxygen levels drop during a difficult delivery. If the intestines are weak, then they are at a higher risk of getting infected by bacteria. If you have an excessive supply of blood cells in your body or other stomach condition, then it may lead to this disease.

Diagnosis-
Usually the doctor conducts a physical exam to detect the symptoms of this disease. If babies are born with this condition, then they may suffer from weak immune system and problems in blood circulation. The doctor may also recommend x-rays to get detailed images of the intestine in order to probe for symptoms of inflammation and damage.

Treatment-
The treatment of the disease depends on few factors such as:

The child's age
How far has the disease progressed?
Health of your child
It is recommended to stop breastfeeding. Feed the baby through intravenous methods. The doctor may also recommend antibiotics and oxygen support if the child has breathing problems. In severe cases, the child may require surgery to treat this disease.

If the treatment occurs early, then the child may recover. However, complications such as a narrow and damaged bowel may persist. This may cause problems in nutrient absorption in the intestine leading to other disorders.


All About Necrotizing Enterocolitis

HIV: QUICK FACTSIntroductionThe human immunodeficiency virus (HIV) is a subgroup of retrovirus (lentivirus) that causes HIV infection. After a period of time, this infection leads to what is called acquired immunodeficiency syndrome (AIDS).

Epidemiology

According to the Centers for Disease Control and Prevention (CDC), from 2010-2015, the estimated rate of HIV infection in all 50 US states decreased from 14.2 per 100,000 population in 2010 to 12.3 per 100,000 population in 2015. In 2015, 39,513 individuals were diagnosed with HIV infection. From 2010 to 2014, the annual number of new HIV infections decreased by 9%.

Virology HIV-1 and HIV-2 are retroviruses in the Retroviridae family, Lentivirus genus. They are enveloped, diploid, single-stranded RNA viruses with a DNA intermediate.Upon entry into the target cell, the viral RNA genome is converted into double-stranded DNA by an enzyme, reverse transcriptase that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase. HIV contains three retroviral genes, namely gag, pol, and env.

Gag gene: Encodes group-specific antigen; the inner structural proteins
Pol gene: Encodes polymerase; it also contains integrase and protease
Env gene: Encodes the viral envelope, the outer structural proteins responsible for cell-type specificity. Glycoprotein 120, the viral envelope protein, binds to the host CD4+molecule
Pathophysiology

HIV infects vital cells in the human immune system, such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells and leads to cellular immune deficiency. This results in the development of opportunistic infections and neoplastic processes.

Mode of Transmission
Sexual intercourse: Unprotected sexual intercourse; especially receptive anal intercourse and different sexual partnersContact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids infected with the virus.Spread from an infected mother to her infant through breast milk. An HIV-positive mother can transmit HIV to her baby both during pregnancy and childbirth due to exposure to her blood or vaginal fluid.

Signs and Symptoms There are 3 categories of infection 

Category A: Asymptomatic HIV infection without a history of symptoms or AIDS-defining conditions
Category B: HIV infection with symptoms that are directly attributable to HIV infection
Category C: HIV infection with AIDS-defining opportunistic infections
Investigation

A high-sensitivity enzyme-linked immunosorbent assay (ELISA) should be used for screening.

Management

Start with antiretroviral therapy (ART) in all HIV-infected adults ready to start therapy. 
CD4 count is no longer a criterion for starting the therapy.
Use of nucleoside reverse transcriptase inhibitors and protease inhibitors.
For refractory cases, during the failing treatment regimen and before switching therapy, use rapid confirmation, perform resistance testing and reevaluate.

HIV - Quick Facts Need To Know!

There are many different Ayurvedic medicines used in the treatment of ulcerative colitis, and one of the most common ways of treatment is to use a combination of the four best medicines, which work in unison to get rid of the disease.

Kutazghan vati: This medicine is derived from the tree Kutaz. Its scientific name is Halorrhreana anti dysentrica. The name itself suggests how effective the tree is in treating the disease. Diarrhea can occur due to many reasons, and one of the reasons is ulcerative colitis. If diarrhea is due to this, then it can get treated by taking Kutazghan Vati tablets, which are made from the bark of the tree.
Pitta balance with calcium compounds: When pitta or the gastric juices flow more inside the intestines, it leads to bleeding due to the ulcers inside, which needs to be balanced and controlled. The use of calcium compound rich Ayurvedic medicines serve the perfect remedy. Calcium is extracted from naturally occurring things like pearls and corals. When the tablets made from such calcium compounds are consumed, the inflammation within the colon goes down, bleeding reduces and gradually stops, and the internal irritation diminishes.
Vatsakadi churna: Tablets made from elements like fennel, coriander, Aegle Marmelos, Nutmeg, pomegranate, Green Cardamom, work like magic in treating ulcerative colitis. These are all ulcer healing items, proven beneficial for ages, and cure fast. The main function of a combination of these herbs is in restoring the metabolic imbalance carried on in the body. The ulcers are healed soon with their use, and the body balance is restored.
Arjuna capsules: One of the wound healing barks, really very famous in Ayurveda, is the bark of the Arjuna (Terminalia Arjuna) tree. This helps in many ways to heal wounds, and specially the endothelial layer inside the body arteries are healed from injuries related to free radicals, stress and other toxins. The same effects of the Arjuna tablets are seen inside the inner layers of the intestines. The ulcers are cleaned with time with the consumption of these tablets, while the bleeding also stops, and the diarrhea which was due to the inflamed colon gets cured. Moreover, the hemoglobin level is also normalized in the body, which was once affected due to bloody diarrhea.
Ulcerative colitis is a painful situation, but can be healed totally with proper administration of Ayurvedic medicines. These 4 essential medicines must be taken in combination without suddenly stopping them. They must be continued until the symptoms and irritation go away.

Ayurvedic Treatment For Ulcerative Colitis!

Benign prostatic hyperplasia or BPH is a condition where the prostate gland gets enlarged. This is mostly common in men who are ageing. When the prostate gland gets enlarged, the flow of urine through the urethra gets blocked, and hence, several problems related to urination may occur. BPH occurs as a result of hormonal imbalance. If untreated, BPH can lead to severe bladder and urinary health conditions.
There are several symptoms and signs of benign prostatic hyperplasia. Here are 7 common symptoms:

1. A frequent need for urination: Men affected by BPH feel an increased need to urinate frequently. This gets enhanced during the night and is called nocturia. The patient may even need to urinate more than eight times a day. Due to the enlarged prostate gland, more pressure is put on the urethra, which leads to uncontrollable urination.
2. Urinating difficulties: The act of urination becomes difficult. Because of enhanced pressure on the urethra, the flow of urine to the penis from the bladder gets blocked. This makes a urine stream hard to start. The urine stream gets weak and interrupted, and more difficulty may be experienced during the end of urination.
3. Pain during urination and ejaculation: Due to pressure on the urinary tract and reproductive system, pain can accompany urination and ejaculation. Some patients tend to push urine out, which results in pain. The pain may also occur because of infection during BPH.
4. Blood in urine and an unusual color/smell: Urine may take a dark color and have an unusual smell due to urinary retention. Unpleasant urine smell signifies urinary tract infection. Blood in the urine may also result because of dilated veins present on the surface of the enlarged prostate.
5. Urinary retention: When a patient is unable to pass any urine, it is called urinary retention. Such a condition requires immediate treatment, and you need to consult a doctor immediately.
6. Urinary tract infections: Bacteria may start growing in the bladder when the bladder is not fully emptied of urine. This bacterial infection causes darkening of the urine, and emission of a foul odor.
7. Bladder stones: Bladder stones may develop because of the inability of the bladder to empty itself completely. This is a major symptom of BPH. Hard lumps of minerals or bladder stones are formed when the urine present in the bladder gets highly concentrated, which causes the crystallization of minerals. Bladder stones may cause infections, result in blood in urine, cause bladder irritation and may also block urine flow.

So you see that benign prostatic hyperplasia involves the enlargement of the prostate gland, and results in several problems related to urination and different symptoms. Hence, immediate treatment is advisable.

7 Symptoms of Benign Prostatic Hyperplasia

6 Symptoms of Low Testosterone

Testosterone is an important hormone for men and is responsible for male sexual and reproductive health. It begins to spike during the years of puberty, helping in development of primary and secondary sexual characters. In boys, it helps to build muscles, deepens his voice, and boosts the size of their penis and testes. It plays an important role during later years as well, by maintaining mood, libido, emotional and physical health. That’s why low testosterone can cause a variety of problems in men. 

Here is a list of symptoms that will help you understand if you may have lower testosterone levels.

1. Drop in Energy: Sometimes, we all feel full of energy, but sometimes those energy levels are quite low. And then, there are occasions when we feel low on energy, you may feel that you are getting tired easily and frequently. Fatigue is one of the common effects of low testosterone. If this happens with you regularly, if you are tired all the time despite sleeping for 6-8 hours, consider getting yourself checked by a consultant.

2. Changes in Sex Life: A sudden drop in your sex drive or facing problems in erection (erectile dysfunction) can be another  common symptom of low testosterone. But you should get yourself tested for other conditions as well, including heart disease or diabetes, especially if you are over 35 years of age. Ask for online consultation if you want everything to be private and discreet.
 
 3. Fuzzy Thinking: Do you sometimes think that your thoughts are a blur? Low testosterone can also impact your memory. It can make you feel stressed, sad and even depressed, resulting in concentration problems. These  can be a result of low testosterone

4. Mood Changes: Testosterone directly impacts your mood, even leading to extreme sadness or psychological depression. If nothing seems to make you happy, if you are not what you used to be, then visit a doctor.

5. Muscle Changes: Muscle mass and strength reduces over the years. As testosterone helps build muscle, low levels may be the cause if you witness sudden drop in muscle mass. In such a case you should consult a doctor. It can be because of low hormone function.

6. More Body Fat: If you have been enjoying a more fit or healthier weight most of your life but suddenly start gaining weight, it might point towards low testosterone in the body. Also, if you are unable to lose weight even on a healthy diet, consider consulting a doctor.



6 Symptoms of Lower Testosterone - Most Important Male Sex Hormone

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