Glomerulonephritis is a disease that is caused due to inflammation of the small filters that are present within the kidneys or glomeruli. Glomeruli eliminate the excess waste, electrolytes and fluids from the blood, discharged through urine. A glomerular disease can be either acute or chronic. If the condition arises without a combination of any other disease, it is termed as primary glomerulonephritis. Secondary glomerulonephritis is characterized by diabetes or lupus (an auto-immune disorder) being at the root of the disease. Prolonged or severe inflammation can take a toll on the kidneys.


Causes-


Nephrotic syndrome can be primary, being a disease specific to the kidneys, or it can be secondary, being a renal manifestation of a systemic general illness. In all cases, injury to glomeruli is an essential feature. Kidney diseases that affect tubules and interstitium, such as interstitial nephritis, will not cause nephrotic syndrome.


Primary causes of nephrotic syndrome include the following, in approximate order of frequency:
Minimal -change nephropathy
Focal glomerulosclerosis
Membranous nephropathy
Hereditary nephropathies


Secondary causes include the following, again in order of approximate frequency:
Diabetes mellitus
Lupus erythematosus
Viral infections (e.g., hepatitis B, hepatitis C, human immunodeficiency virus [HIV] )
Amyloidosis and paraproteinemias
Preeclampsia
Allo-antibodies from enzyme replacement therapy


Nephrotic- range proteinuria may occur in other kidney diseases, such as IgA nephropathy. In that common glomerular disease, one third of patients may have nephrotic- range proteinuria.


Nephrotic syndrome may occur in persons with sickle cell disease and evolve to renal failure. From a therapeutic perspective, nephrotic syndrome may be classified as steroid sensitive, steroid resistant, steroid dependent, or frequently relapsing.


Treatment-
Whether one is suffering from acute or chronic nephrotic glomerular , with symptoms moderate or severe, the treatment lies in treating high blood pressure and other underlying conditions of the disease.
Water pills help control sweating, thus increasing the fluid flushed from the kidneys.
Statins reduce cholesterol level.
Blood thinners such as anticoagulants lower the risk of blood clots.
Corticosteroids regulate the immune system and ease the inflammation that results from kidney disorders.
Incorporating certain lifestyle changes such as opting for lean proteins, cutting on the intake of fat in the diet and consuming lesser amounts of salt can treat inflammation and swelling.
For kidney failure, dialysis can come to the aid in eliminating excess fluids and regulating hypertension.


Nephrotic Syndrome: Causes and Treatment

Stone diseases are a part of health issues related to the urological system in our body. Depending on their position, they may be classified into kidney stones and ureteral stones. Stone diseases are extremely common in nature and if treated timely it does not cause much damage to the body.

Types of Stones in the Human Body:

There are four types of kidney stones and ureteral stones in the human body namely   calcium, uric acid, struvite and cystine. The main difference between kidney stones and ureteral stones is that of the location. Kidney stones are transformed into ureteral stones when they pass from the kidney into the ureter.

Warning Signs to detect Kidney and Ureteral Stones

Kidney stones may be present in your body but they do not cause any obstructions unless they move into the ureter. Symptoms to detect the presence of stones in your body include  

  Intense and shifting pain in the lower abdomen and groin
  Frequent and painful urination
  Presence of blood in urine
  Nausea and vomiting
  Frequent fever accompanied by chills

Modes of Diagnosis:

The following methods are used to diagnose kidney stones/ureteral stones in the body-

  Imaging Tests   X-rays and CT scans are used to detect the presence of bigger and smaller stones respectively.
  Urine Tests   They help to detect the presence of stone forming particles in urine thus helping to diagnose stones in the kidney.
  Blood Tests   They help display levels of calcium and uric acid in the blood and monitor the general health of kidneys.

Treatment of kidney/ureteral stones:

Treatment of stones depends on their size and severity. For smaller stones, doctors recommend drinking 2-3 litres of water per day that help in flushing out the stone through urine. Doctors also prescribe medicines which helps break down the stone and reduce pain.

If the stones are large in size and exhibit severe complications, then the urologist will resort to the following treatment procedures-

  Shock Wave Lithotripsy (SWL)   In this process, a machine called lithotripter is used which passes ultrasonic waves through the skin to break up the stone into smaller components. The shattered pieces then pass out of the body through the urinary tract.

  Percutaneous Nephrolithotomy (PNL)   This is an endoscopic method used to remove large stones, which are not possible to eliminate through SWL. This is an invasive procedure and general anaesthesia is done prior to surgery.

  Ureteroscopy   In this process, a ureteroscope is inserted into the urethra to locate the stone and a tool is used to break it into smaller pieces or is taken out as a whole.

Prevention of Kidney and Ureteral Stones

Certain lifestyle changes can go a long way in preventing stones in the body. Some of them include drinking lots of healthy fluids, reducing consumption of oxalate-rich foods and animal protein, reducing sodium intake and controlling one s body weight.

Maintaining a healthy lifestyle and taking prompt medical action in case of detection of stone lessens the harmful effect of kidney and ureteral stones in the body.

Stone Disease - All You Should Know About It!

What are kidney stones?
The primary function of the kidney is to filter the blood and eliminate the waste products through urine. The waste deposition is sometimes in the form of excessive calcium, uric acid and other undesirable contents. It may cause the urine to get highly saturated. This is when stone like formations take place inside the kidneys. Kidney stones are also termed renal lithiasis or calculi. There are different kinds of kidney stones, which are differentiated based on its varied constituents. Kidney stones cause excruciating pain and uneasiness. Frequent urination, extreme discomfort during urinating and presence of blood in the urine are some of the major signs of kidney stones. The symptoms are not evident if the stones are very small in size.

Causes of kidney stones:

Incorrect calcium intake: High amounts of calcium can lead to high calcium depositions in the kidneys. It is important to keep the calcium intake moderate. Calcium supplements must be checked if you have already included dairy products in your diet.
Abnormal rates of sodium in the body: Sodium, just like calcium, gets deposited in the kidneys.
Excessive animal protein intake: Too much of animal protein intake can make the urine turn acidic, leading to uric acid depositions in the kidneys.
Sugary, aerated drinks: These lead to undesirable waste deposition in the blood stream and eventually in the kidneys.
Inadequate water intake: Not keeping the body well hydrated can cause the urine to turn acidic and increase waste deposition.
Potential risks and complications of kidney stones:

Kidney stones may cause an infection in the kidneys which may eventually spread to the other internal organs and surrounding tissues.
Kidney stones block the ureter and cause severe pain and discomfort that make sitting, standing or any other posture difficult.
Kidney stones rarely cause kidney failures but the severe blockage and infection may cause such detrimental results in the human body.

Kidney Stones - 5 Causes Behind It!

5 reasons you will see blood in urine

The condition in which blood appears in the urine is known as hematuria. The loss of blood in this condition could be gross or microscopic depending on the cause of the condition. There are several causes why blood may appear in the urine. Whatever the cause may be, hematuria is mostly indicative of a serious medical condition.

Here are 5 reasons that cause blood to appear in the urine.

1. Infection

Infections like urethritis, pyelonephritis, cystitis or infection in any other body organ along the urinary tract is one of the most common causes of hematuria. Such bacterial infection in the urethra can also infect the kidneys and the urinary bladder. It results in the urge to urinate frequently and also causes blood to appear in the urine.

2. Kidney stones and bladder stones

Another reason that can cause blood to appear in the urine is the presence of stones in the kidney or bladder. These stones are crystallized minerals that are formed in the kidney or the bladder but fail to pass through the urinary tract. They cause blockage and pain and result in hematuria.

3. An enlarged prostate

An enlarged prostate is a common cause of the appearance of blood in the urine in men who are in their middle ages or older. Enlargement of the prostate gland causes the urethra to be compressed. This prevents the urethra from getting fully emptied while urination.

4. Polycystic kidney disease

PKD is a kidney disorder in which cysts filled with fluid form in the kidneys and impair the kidneys, causing them to fail entirely at times. It is an inherited disease and causes blood to appear in the urine.

In children who are between 6-10 years of age, kidney disorder after streptococcal glomerulonephritis can be a possible cause of hematuria.

5. Cancer

A cancerous kidney, bladder or prostate gland can also cause blood to appear in the urine. It is another major cause of hematuria but usually occurs in older patients.




5 Reasons You Will See Blood in Urine

Blood in urine, medically known as Hematuria is not usually a cause of concern, but it can translate into an adverse condition if left unevaluated. The kidneys and other structures in the urinary tracts such as urethra (tube connecting the bladder to the outer part of the body); bladder (that stores the urine) and ureters (tube joining the bladder to the kidney) are the sources of blood flow to the urine. Hematuria can be accompanied by symptoms such as discharge of tea-colored, brownish-red or pink colored urine due to the presence of red blood cells, traces of which can only be detected under the microscope.

Underlying causes behind this disorder might be

Urinary tract infection is where the bacteria enter the body through the urethra and begin to proliferate in the bladder.
Kidney infections (pyelonephritis) is when bacteria infiltrate into the kidneys from the bloodstream or travel up from the uterus to the kidneys.
A kidney or a bladder stone is marked by the minerals in the concentrated urine precipitating out and molding into crystals that deposit on the bladder or kidney walls.
Enlarged prostate is a condition in which the prostate gland, that is situated just below the bladder surrounding the upper part of the urethra, starts growing as males head towards their middle age.
Kidney disease such as glomerulonephritis causes swelling of the kidneys, thus disrupting the filtering system.
Bladder, kidney and prostate cancer are also possible causes.
Hereditary disorders such as sickle cell anemia (a hereditary disease of the red blood cells in the hemoglobin) can also pose as a cause behind this disorder.
Kidney injury as a result of heavy blows, accidents or injuries sustained while playing a spot can also contribute to this condition.
Medications such as penicillin or the anti-cancer drug  cyclophosphamide 
Strenuous physical exercises like intense workout or running may also result in Hematuria.
Treatments
There is no fixed cure for Hematuria; instead the doctor would work on treating the repressed conditions behind the symptoms, such as prescribing antibiotics to heal the urinary tract infection or a medicine to shrink and normalize the enlarged prostate or administer a shock wave therapy to destroy the kidney or bladder stones. 

Blood in Urine - 10 Reasons Behind It!

The presence of red blood cells in the urine is called hematuria. If there are sufficient red cells, the urine turns to a bright red, pink or cola shade. Frequently, the urine looks totally ordinary because there is insufficient blood to change the colour. In this situation, the condition is called 'microscopic' hematuria.

The most common causes of hematuria are given below:

    Urinary tract infection (UTI)
    Kidney stones
    Tumours in the kidney or bladder
    Exercise: In this case, the blood is produced in the urine after strenuous activity. It is more commonly experienced by male patients.
    Injury: Traumatic damage to any part of the urinary tract, from the kidneys to the urethral opening, can cause hematuria.

The symptoms of hematuria vary depending upon the condition. These are as follows:

    Glomerulonephritis: If the glomerulonephritis is not serious, it may not show any signs. If the symptoms do show up, they can cause swelling, particularly in the lower furthest points(the thighs, legs, feet, and toes), decreased urine, and hypertension.
    Kidney or bladder infection: Symptoms rely on the site of the diseaseand can even cause extreme pain on one side of the lower back, fever, chills, nausea with vomiting, and pain in the bladder.
    Prostate infection: There can be pain in the lower back or in the region between the scrotum and rearend. Pain with discharge, blood in the semen, andfever and chills can also occuronce in a while.
    Tumour in the kidney or bladder: Most kidney and bladder problems develop without bringing about any pain or uneasiness. At the point when side effects build up, abdomen pain may be persistent.
    Kidney stones: When a kidney stone gets attached to the ureters, it can bring about extreme pain in the back, side or crotch, with nausea and difficulties in urination.

Based upon the suspected cause of hematuria, some of the treatments may include the following:

    Urine culture: In this test, a urine sample is extracted and examined to check whether bacteria has developed. This test is used to find a case of a kidney or bladder disease.
    Computed tomography (CT) of the kidneys, ureters and bladder: For most cases,a CT scan is conducted. This helps in viewing the internal organs and finding the areas that may have been affected by the condition. It also shows the extent of the damage and the spread of the disease so that a proper treatment plan may be laid out.
    Ultrasound: This test uses sound waves to create images that can show whether or not a kidney mass is a non cancerous. This method can also be used to find out whether or not there are any kidney stones, which may be causing hematuria.
    Cystoscopy: In this test, the specialist embeds an adaptable telescope into the urethra and passes it into the bladder to investigate the bladder lining for tumours or different issues.

Can Hematuria Be Treated?

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