Schnitzler s syndrome is a very rare condition described by a reddish rash that looks like hives (urticaria) and lifted levels of a particular protein in the blood (monoclonal IgM gammopathy). Symptoms connected with the Schnitzler disorder may include increased levels of fever, joint inflammation, joint pain (arthralgia), bone agony, and different discoveries, for example, swollen lymph nodes (lymphadenopathy). It also causes weight reduction, discomfort, exhaustion, and broadened spleen and liver. This condition should be treated in terms of taking care of the symptoms so that they do not become debilitating.

Some of the other symptoms include the following:

Urticaria (hives) depicts red raised patches of the skin. These are once in a while irritated. They may last for about 12 hours to 3 days. This may become severely painful if not treated in time.
80% of such patients suffer from painful or swollen. A few patients experience bone pain as well.
High fever might be there accompanied by chills and night sweating. This can give rise to further uneasiness and is usually caused when the immune system is attacked by the ailment.
One of the main symptoms of the Schnitzler disorder is monoclonal gammopathy. This mostly means a raised level of immunoglobulin M (IgM)
Reasons behind it

The main cause behind the Schnitzler syndrome is unknown. Specialists believe that particular parts of the immune system may not work appropriately in the end because of the Schnitzler syndrome. Individuals with the Schnitzler disorder additionally have monoclonal IgM gammopathy, in which abnormal production of immunoglobins result in elevated levels of immunoglobulin M (IgM) in the body. Immunoglobulins are proteins delivered by the white blood cells. A few analysts believe that IgM antibodies accumulate in the skin (epidermis), setting off a reaction that causes the rash. At the time of diagnosis, IgM levels may just be somewhat raised and may stay stable for quite a long time.

Diagnosis

The diagnosis of the Schnitzler disorder is based upon an intensive clinical assessment, patient history, rejection of different other disorders and proof of fever, joint pain or aggravation, bone pain, discernible lymph nodes, amplification of the liver or spleen, lifted quantities of white platelets (leukocytosis), raised red platelet (erythrocyte) or anomalies, which can uncover expanded bone thickness (osteosclerosis).

Treatment: 
Anakinra is a successful treatment for Schnitzler syndrome. It is also very commonly used to treat rheumatoid joint inflammation. The following medicines and therapies have been proven to be successful for treating the Schnitzler disorder over a period of time. These are as follows:

Antihistamines
Nonsteroidal calming specialists
Systemic steroids (prednisone)
Hydroxychloroquine
Colchicine
Dapsone
Pamidronate
Thalidomide
Pefloxacin
Phototherapy
Immunosuppressive specialists (ciclosporin, methotrexate, cycloposphamide)
Biologic specialists (tocilizumab, rituximab)
The Schnitzler disorder is a long-term infection, so stopping a promising treatment can tend to cause a relapse and may cause the disease to reappear. Also, the medicines mentioned above should not be taken without consulting a doctor as they can have sever side effects, if not administered under the guidance of a physician.

Schnitzler Syndrome - Things You Must Know About It!

Hives, also known as  urticuria  is a skin disorder that is characterized by formation of white or red welts on the surface of the skin. The sizes of the welts may vary and can last for up to six weeks or more. The disease is not life threatening but the general discomfort associated with it can interfere with your daily activities. The symptoms of hives are treated by taking anti-histamines and anti-itching medications.

Let s take a look at the symptoms:
1. Development of red or white welts, especially on torso, arms and the face
2. The welts may cause severe itching
3. Painful swelling on various parts of the body such as cheeks, lips and the insides of the throat
4. You may experience tightness in the chest and feel dizzy

What might be the causes?
Hives occur when certain cells are triggered into releasing histamine (an organic nitrogenous compound). The various factors that trigger this condition are:
1. Insects bites or parasite bites
2. Continuous scratching at the same spot
3. Various pain medications
4. Prolonged exposure to sunlight
5. High levels of stress
6. Excessive consumption of alcohol

This disease can lead to severe complications which have been listed below:
1. Severe allergic reaction: Anaphylaxis is an allergic reaction that causes the bronchial tubes to narrow down thus, obstructing normal breathing. It is a condition that may, in certain cases, lead to death as well. Hence, you need prompt medical attention if you suffer from this complication.

2. Breathing complications: Swelling on the inner parts of the throat may obstruct normal breathing and cause you to pass out. It can also increase the risk of certain immune disorders such as rheumatoid arthritis and celiac disease (a disorder caused by eating gluten rich foods in excess).

Treatment
The treatment for this disorder includes taking anti-histamine medications that help in blocking histamine (organic compounds which help to regulate physiological functioning) in the body. You may also be administered anti-inflammation medications to reduce inflammation. Wear loose clothing and stop scratching away at the affected regions of the body to make sure you do not aggravate the condition.

Hives Rash or Urticuria - 6 Cause Behind Skin Disorder

Hives, or  Urticaria  in medical parlance, is a skin condition characterized by the appearance of itchy swellings on the skin surface. Hives may break out on any part of your body and can be of different sizes. It is not a prolonged condition and generally lasts for a few hours. Urticaria or hives usually occur due to the secretion of certain chemical substances such as  histamine  from underneath the skin surface.

Some of the possible causes of hives are mentioned below:

Overexposure to sunlight
As a side effect of medicines such as aspirin, painkillers or antibiotics.
Insect bites
Any food related allergy may also trigger hives
People allergic to certain chemicals or latex can also develop hives
Sensitivity to temperature or water can cause hives
Infections such as Hepatitis or chronic diseases such as thyroid may result in the occurrence of hives.
Alcohol or caffeine intake can cause chronic urticaria
The most common symptoms of Hives include:

Skin becomes swollen
Frequent itching sensation
Skin inflammation is also common
You may feel a burning sensation
Within a short span of time, it may disappear and then again reappear on different parts of the body
Red and white patches appear all over the skin surface known as  wheals 
Hives generally go untreated as the condition subsides within a few hours. But sometimes, hives can be chronic or acute in nature. If so, it would require treatment as it can give rise to further complications. Some of the treatment methods are given below:

Corticosteroids may be prescribed by the doctor to control the formation of hives and give relief from inflammation.
Antihistamines (drugs which hinder the impacts of histamines; mainly used for curing allergies) are advised to patients with chronic urticaria. It controls the effects caused due to the discharge of histamines.
Knowing and avoiding the trigger conditions may prove to be helpful.
Applying menthol creams can give comfort due to its cooling properties.

Hives - Causes, Symptoms & Treatments

Urticaria, also known as Hives and Nettle Rash. It is an allergic disorder. It is similar to the rashes that are caused due to touching a nettle plant. This allergic reaction can be caused due to a variety of reasons, thus increasing the difficulty in identifying the exact cause of the allergy. Homeopathic medication has proved to be very efficient in treating urticaria. Some of the best homeopathic remedies include:

1. Apis Mellifica: Described as one of the best solutions to urticaria, this medication is commonly prescribed with regard to treatment. The characterising symptoms of this medication is eruptions accompanied by inflammation and sting. It is similar to the sting of a bee where there is redness and swelling. Exposure to heat in any form is intolerable as the eruption are aggravated. The slightest of touch can cause burning or itching and the patient usually remains thirsty.

2. Dulcamara: This is a medication that is usually prescribed for Urticaria, caused due to cold air or wet weather or dampness. Consumption of sour food or indefinite diet can cause the eruptions. Even though the skin is often dry, there is redness and itching.

3. Natrum Mur: One of the frequently used medicines for urticaria, this medicine is prepared from common salt. It is used in cases where the eruptions are triggered by exposure to the sun, thereby resulting in intense itching. The skin has an oily or greasy feel. Most likely locations of occurrence include margins of hair or bends of joints.

4. Ledum Pal: This medication focuses on the eruptions that occur on the legs and feet. There is a possibility of the infection spreading from the lower to the upper regions at a later stage. Increase in itching can result from the warmth of bed or on scratching. Colder conditions provide a soothing sensation

5. Astacus Fluviatilis: This is an effective medication that be used to treat, both acute and chronic urticarial forms. Rashes are visible on the entire body and are at an increased sensitiveness to air. It is recommended for liver diseases and liver-related symptoms that are accompanied by urticaria.

Best Homeopathic Remedies for Urticaria

Hives are a common allergic reaction that appears in the form of swollen, red bumps or patches on the skin. These usually appear suddenly and cause itchiness. In some cases, it may also sting or burn. Hives can affect any part of the body including the face, ears, tongue, lips and throat. Hives are usually small in size but may grow as large as the size of a dinner plate. In some cases, hives may also join together to form plaques.

Hives are caused as a result of the production of histamines in the body that make plasma leak out of blood vessels in the skin. These histamines are released as a result of an allergic reaction, exposure to chemicals, insect bites, sunlight or adverse reactions to certain medicines. There are four main types of hives:

Acute Urticaria: These hives usually last for less than 6 weeks. They are triggered by insect bites, allergic reactions to food, latex, medicines or by exposure to infections. The most common food items that trigger this type of hives are chocolates, nuts, fish, tomatoes, eggs, soy, wheat and milk. Aspirin and other medicines like ibuprofen, ACE inhibitors and codeine can also trigger these hives.

Chronic Urticaria: Hives that last for longer than 6 weeks fall into the category of chronic urticaria. IT is harder to find what triggers a case of chronic urticaria than it is for acute urticaria. Along with the triggers mentioned above, hormonal disorders, tumours, chronic infections and immune system disorders can also trigger these hives.

Physical Urticaria: Hives caused as a result of physically stimulating skin are called physical urticaria. This includes sudden exposure to heat or cold, sunlight, vibrations, pressure, exercise etc. These hives usually resolve themselves within an hour and only affect the part of the skin that has been stimulated.

Dermatographism: Hives caused by scratching or firmly stroking the skin fall under this fourth category.

Hives can also be genetic in nature. Some people suffer from hereditary angioedema which is a painful swelling under the skin.

Hives caused by an allergic reaction can recur and hence if you suffer from hives you should try and identify the allergen. This can be done by taking an allergen test in a hospital or by changing aspects of your diet and studying the results. Hives are usually treated with antihistamines but in some cases, steroids may also be needed. However, it is usually nothing to worry about.

What Are Hives? What Causes Hives?

If stressed, consuming certain food and medications can trigger skin rashes. This kind of rash is called hives. It is also known as urticaria. Anyone can be affected by hives, at least 20% of people are affected by hives at some time or the other in their lives. The itching could be severe or mild. It starts as a patch of scaly white skin that develops into red welts over time. To make sure the itching does not worsen, scratching, emotional stress, alcoholic drinks and exercise should be avoided.

Symptoms
1. Itchy bumps that are raised and are either red or flesh coloured
2. If the hive is pressed in the middle, the skin whitens this symptom is called blanching.
3. The hive formation can appear anywhere, disappear and then reappear somewhere else.

Common Triggers
1. Certain food like shellfish, eggs, peanuts and other nuts
2. Certain medicines like antibiotics, ibuprofen and aspirin
3. Insect bites or stings
4. Physical causes like pressure, sun exposure, cold, exercise and heat
5. Latex
6. Blood transfusions
7. Bacterial infections
8. Pet allergens
9. Viral infections like the common cold, hepatitis and infectious mononucleosis
10. Certain plants like poison ivy and poison oak
11. Pollen

Treatment
There is no distinct cure for hives. But you can control its symptoms in the following ways:
1. Antihistamines help in blocking histamines, which cause the allergy symptoms. Non sedating or low sedating Antihistamines will be mostly recommended by your doctor.
2. If episodes of hives are several, it may require limited treatment with prednisone. Prednisone will be able to lessen the symptoms.
3. If the symptoms get severe enough so much so that it swells up your tongue and you have problem breathing, then the doctor might prescribe an epinephrine. However, these symptoms can mean another thing, an anaphylaxis shock. Epinephrine is the only treatment for an anaphylaxis shock.

Prevention
If what caused hives to break out is figured out, then measures should be taken to avoid or eliminate the triggers.
1. Avoid eating food items that triggered the symptoms in the first place
2. If harsh soaps, frequent bathing cause hives, they should be avoided
3. Tight clothing should be avoided
4. If cold triggers hives, then wear warm clothing, wrap a scarf and do not swim in cold water.
5. Avoid sun exposure and wear sunblock
6. If a specific medication is causing the hives, inform your doctor.

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