HIV: QUICK FACTSIntroductionThe human immunodeficiency virus (HIV) is a subgroup of retrovirus (lentivirus) that causes HIV infection. After a period of time, this infection leads to what is called acquired immunodeficiency syndrome (AIDS).

Epidemiology

According to the Centers for Disease Control and Prevention (CDC), from 2010-2015, the estimated rate of HIV infection in all 50 US states decreased from 14.2 per 100,000 population in 2010 to 12.3 per 100,000 population in 2015. In 2015, 39,513 individuals were diagnosed with HIV infection. From 2010 to 2014, the annual number of new HIV infections decreased by 9%.

Virology HIV-1 and HIV-2 are retroviruses in the Retroviridae family, Lentivirus genus. They are enveloped, diploid, single-stranded RNA viruses with a DNA intermediate.Upon entry into the target cell, the viral RNA genome is converted into double-stranded DNA by an enzyme, reverse transcriptase that is transported along with the viral genome in the virus particle. The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase. HIV contains three retroviral genes, namely gag, pol, and env.

Gag gene: Encodes group-specific antigen; the inner structural proteins
Pol gene: Encodes polymerase; it also contains integrase and protease
Env gene: Encodes the viral envelope, the outer structural proteins responsible for cell-type specificity. Glycoprotein 120, the viral envelope protein, binds to the host CD4+molecule
Pathophysiology

HIV infects vital cells in the human immune system, such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells and leads to cellular immune deficiency. This results in the development of opportunistic infections and neoplastic processes.

Mode of Transmission
Sexual intercourse: Unprotected sexual intercourse; especially receptive anal intercourse and different sexual partnersContact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids infected with the virus.Spread from an infected mother to her infant through breast milk. An HIV-positive mother can transmit HIV to her baby both during pregnancy and childbirth due to exposure to her blood or vaginal fluid.

Signs and Symptoms There are 3 categories of infection 

Category A: Asymptomatic HIV infection without a history of symptoms or AIDS-defining conditions
Category B: HIV infection with symptoms that are directly attributable to HIV infection
Category C: HIV infection with AIDS-defining opportunistic infections
Investigation

A high-sensitivity enzyme-linked immunosorbent assay (ELISA) should be used for screening.

Management

Start with antiretroviral therapy (ART) in all HIV-infected adults ready to start therapy. 
CD4 count is no longer a criterion for starting the therapy.
Use of nucleoside reverse transcriptase inhibitors and protease inhibitors.
For refractory cases, during the failing treatment regimen and before switching therapy, use rapid confirmation, perform resistance testing and reevaluate.

HIV - Quick Facts Need To Know!

HIV/AIDS is a type of sexually transmitted disease which is caused by the Human Immunodeficiency Virus (HIV). The HIV virus attacks the immune system and makes the body vulnerable to other diseases. AIDS is the last stage of the HIV infection; HIV takes about 10 to 12 years to fully culminate into AIDS. AIDS completely destroys the immune system and leads to fatal health conditions and diseases such as cancers and other infections because of AIDS.

Causes-

HIV is a retrovirus that infects the vital organs of the human immune system. The virus progresses in the absence of antiretroviral therapy. The rate of virus progression varies widely between individuals and depends on many factors (age of the patient, body s ability to defend against HIV, access to healthcare, existence of coexisting infections, the infected person s genetic inheritance, resistance to certain strains of HIV).

HIV can be transmitted through:

Sexual Transmission. It can happen when there is contact with infected sexual secretions. This can happen while having unprotected sex, including vaginal, oral and anal sex or sharing sex toys with someone infected with HIV.
Perinatal Transmission. The mother can pass the infection on to her child during childbirth, pregnancy, and also through breastfeeding.
Blood Transmission. The risk of transmitting HIV through blood transfusion is nowadays extremely low in developed countries, thanks to meticulous screening and precautions. Among drug users, sharing and reusing syringes contaminated with HIV-infected blood is extremely hazardous.
Contrary to popular belief, HIV can never spread by means of kissing as the virus cannot survive outside the body.

Symptoms-

The early symptoms of HIV appear within a few weeks of contamination by the virus. The early symptoms include headache, pain in the muscles and the joints, rashes and inflated lymph nodes. These symptoms tend to disappear within 2 to 3 weeks.
The next set of symptoms might appear after a few years and these are persistent. The symptoms include, but are not limited to fatigue, loss of body weight, inflated lymph nodes, fever, a sensation of numbness near the limbs, pain when you try to swallow, sores in the mouth and sweating at night.
If you are diagnosed with HIV, you should:

Try to maintain a daily diet containing vegetables, legumes, and fruits which provide you energy.
Try to include a little bit of fat, carbohydrates (at least 3 servings of vegetable per day), calcium (dairy products) and low-fat protein sources (generally 80-150 gram per day of fish, skinned chicken, low-fat cheese etc.) in your everyday meal.
Maintain a daily calorie intake of 17-25 calories per pound depending on whether the person is losing weight.
Vitamins and minerals are particularly necessary to repair the cells damaged by the HIV virus.
So, it is necessary to intake foods such as eggs, milk, peanuts, green vegetables, meat, beans and broccolis on a regular basis, if you have been diagnosed with HIV.

If you are suffering from HIV, you must maintain the following food safety measures:

You should try to restrict the intake of fat
Restrict your alcohol intake
You should try to avoid fast foods
You should also limit your regular sugar intake and should avoid foods with extra sugar

HIV/AIDS - Diet, Nutrition & Food Safety You Must Follow!

There is a contrast between intimacy satisfaction and intimacy happiness. Happiness tends to be a byproduct of the relationship. Therefore, while it just takes one partner to be sexually satisfied, it takes two to make the conditions for sexual happiness. A key indication of sexual bliss in a relationship is a couple's capacity to endlessly rejuvenate the sexual energy between them. Consequently, the term sexual happiness depicts couples who can revive, reestablish and extend their sexual desire with each other for a very long time or even forever. Here are a few ways through which one can integrate happiness and sexuality:

Since sexual happiness is a result of the relationship, both the partners need to be happy with each other in general to achieve happiness rather than satisfaction.
Staying in shape can be very beneficial. Being sound and fit promotes better sex. Not just are fit individuals perform better sexually, but also it is proven that healthier and fit individuals have a more noteworthy longing for sex. There are numerous reasons behind this. Healthy, fit individuals are not only more joyful, but also physiologically, they are capable of producing more sex hormones due to a number of other health factors.
Enthusiasm is not found in sex; it is found in individuals. To completely grasp sexual enthusiasm, you should be completely present in the moment. As such, you should bring your psyche, body, and soul to your partner. This implies being conscious, aware, and present mentally as well as emotionally.
Decreasing or managing sex levels can also help one integrate happiness and sexuality. Life is clearly unpleasant many times, and our reaction to all the anxiety can be devastating when it comes to sexual experiences. Not only does a lot of stress or anxiety decrease the yearning for sex, it also additionally hinders sexual performance. Hence, one should vent out to their partners or try therapy or yoga for stress release.
Routine tend to repel romance and consistency cools the flames of sexual excitement and energy. To neutralize these twin constrains, you should deliberately plan and design different rituals of sexual pleasure. Indulge in customs of joy and particular actions, thoughts, activities, and exercises like back rub, animate, and stimulation of the sexual and emotional pleasures.
Being happy in general is very important. Being cheerful and idealistic is the establishment of numerous parts of a successful life. Inquiring about actions that make your partner happy are more advantageous, beneficial, and have better connections, including better and more continuous sex.
Sex is very important in a relationship for knowing and feeling that your partner still fancies you, yet having sex once a week is a practical and an achievable objective for people who tend to be very busy. A study demonstrates that regular sex additionally makes individuals more joyful than a high income.

Sexual Happiness and Satisfaction - How You Can Integrate Them?

Tuberculosis is an opportunistic infection caused by the bacteria Mycobacterium tuberculosis. The infections occurring in people with weak immunity as compared to the people with a healthy immune system are called as opportunistic infections. As, HIV enters the human body, it replicates and weakens the immune system which in turn increases the risk of contracting Tuberculosis in people already suffering from HIV infection.

An HIV and Tuberculosis co-infection occurs when an individual has both, the HIV infection and an either latent or active TB disease simultaneously.  Each disease acts in speeding up the progress of the other, when HIV and TB infection is present together in the body. HIV infection speeds up the progression from latent to active Tuberculosis, Mycobacterium tuberculosis also accelerates the progression of replication and spread of the HIV infection.

HIV infection and Tuberculosis are totally different type of infectious diseases. HIV is a viral infection and TB is a bacterial one. An HIV infected person will not contract TB unless a contact happens with a TB infected person. TB spreads via droplet infection and is communicable. If a person lives in a country with a high prevalence rate of TB, an HIV patient is highly susceptible to contracting the infection. In the similar manner, a person suffering from TB gets infected with the HIV infection only through the blood and bodily fluids borne route, with unprotected sexual intercourse with an HIV infected individual being the most important cause.

Amongst all the other opportunistic infections, TB occurs at an earlier stage in the course of an HIV infection than most other opportunistic infections. Mortality rate in the co-infected patients is more than twice that of HIV infected individuals without a TB infection. Even if a patient is undergoing anti-retroviral therapy, the death rates remain high in co-infected individuals.The natural history and course of TB gets altered in people with an infected immune system. The damage to immunity due to HIV infection causes a drastic reduction in the pathogen killing capacity of the body. In such patients if there is no anti-retroviral treatment prescribed, then the latency period between the infection and progression of disease gets eliminated. 

An active phase of TB is observed in such individuals progressing within a short span of time, ranging from weeks to months, rather than years as it normally should be spanning. Risk of progression from a latent stage to an active stage of TB is around 10-15 times greater in an HIV infected individual as compared to the non-infected person. Such individuals also communicate the disease more rapidly to others.Pulmonary tuberculosis in an HIV infected person can present similar symptoms like that of a classic TB disease. However, a co-infection can sometimes show less presenting TB symptoms, where even the chest X-ray scans can be observed to be normal. A  subclinical  phase of Tb in co-infected patients can cause delay in the diagnosis of the symptoms and subsequently affect the prognosis due to lack of timely treatment.

Social stigma and discrimination has caused an obstacle in provision of adequate treatment for people with HIV. Proper counseling  and initiatives taken to provide indiscriminate care can aid in identification of co-infection and earlier stages. Anti-retroviral treatment teamed up with anti-tubercular drug regimen is prescribed and a successful treatment for drug sensitive cases of TB can be provided with medications for 6-8 months.

How HIV & TB  Are Related?

According to the tenets of Ayurveda, HIV is primarily a disease involving low immunity which is considered the most vital sap of the body. Immunity is in charge of providing both mental and physical strengths required to cope up with the foreign bodies that cause unwanted changes in the human body. When the immune system gets disrupted, the individual becomes susceptible to a host of infections and disorders. There are incessant numbers of bacteria and viruses in the environment, and some of them are highly contagious which can easily cause an infection.

Ayurveda has numerous highly effective therapies to combat HIV exposure. There is a sector of Ayurveda specifically dedicated to boosting immunity and vitality in the body with the help of herbs, minerals, and practice of Ayurvedic techniques. The treatment first aims to detoxify the body and strengthen the immune system which improves the immune system with the help of certain "rasayanic" techniques.

How is HIV exposure treated through Ayurveda?
The first step of HIV exposure treatment through Ayurveda is having nourishing food and leading a positive life supported by well-meaning friends and relatives. The patient can also take part in some physical exercises which don't cause any strain to the fragile health condition. Engaging in comfortable yet fruitful activities can help in strengthening good tendencies and stimulating appetite as well.

Then the patient will have to take some Ayurvedic tonics along with rejuvenators that can boost immunity levels and eliminate the toxins from the body. This is particularly done through emesis, purgation, and enemas. The medications which are given at this stage are neither drastic nor very harsh for the body so that they can be digested without any difficulty.

In the third stage of treatment, appropriate medications will help in purifying the blood, and this is where the role of liver corrective measures come to the fore. The patient has to take preparations with medicated ghee and soups that can alleviate the signs and symptoms of HIV exposure. There is no scope of consuming spicy and oily junk foods as they can take a toll on the patient s liver. Medicated alcohol may have to be used to aid in the digestive procedure and removal of blockages in the flow of energy.

Participating in physical activities on a daily basis is important. In case the patient is too weak to exercise or even run, then steaming can be helpful. This is very crucial since it is believed in Ayurveda that heated blood can weaken and sometimes destroy the virus involved in HIV.

There are some herbal cum mineral compounds which are helpful for subsiding the conditions of HIV exposure. It is important to consult with an expert who can evaluate your condition and help in healing the signs and symptoms that you are suffering from.

HIV Exposure - How Ayurveda Can Help You Manage It?

Any kind of dysfunction points to the issues experienced during any stage of the cycle of physical issue that prevents the participants from experiencing any kind of satisfaction from the intimate activities. Though the researches imply that sexual problems are common all across the globe; 43% of women along with 31% of men are affected by some sort of dysfunction; however, it is something that most people are hesitant to talk about. But thankfully enough, most cases of sexual problems can be effectively treated, and can be prevented from occurring again, by sharing your concerns with a qualified doctor. You should consider visiting the doctor along with your partner.

What leads to sexual problems?
Sexual problems can be caused either due to physical or psychological reasons. Many medications and clinical conditions can cause a variety of sexual dysfunctions, and these physical conditions include heart and vascular disease, high levels of blood sugar and blood pressure, any kind of neurological disorder, chronic diseases of the kidneys, liver and lungs, and hormonal imbalances. In addition to this, the side effects stemming from any medicine, including antidepressant drugs, can cast a harmful impact on the sexual desire and its normal functioning. On the other hand, psychological causes refer to the stress caused due to work pressures, anxiety, depression, excessive concern about sexual performance, feelings of guilt, and relationship problems.

What are the common sexual problems?
What leads to sexual problems can cause a wide variety of issues in both men and women. While erectile dysfunction is most commonly found in men, vaginal dryness is the most common issue in women. Sexual dysfunction can take a variety of forms, and it is not plainly confined to the dysfunction or simple disinterest in sex, which is commonly termed as lack of sex drive. It can also involve pain while having sex or an inability to maintain the erection or experiencing pain while getting an orgasm. There are some people who experience excruciating pain during intercourse, which is often accompanied with a burning sensation.

All couples have the right to enjoy a happy and healthy sex life, which can be considered a crucial aspect of any relationship. So, if you are having any kind of difficulty that is interrupting your lovemaking, it is imperative to speak with your doctor to get the right diagnosis, and discuss openly with your partner to find out the ideal solution of your sexual problems.

Sexual Problems - Things That Can Lead to It

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