What are the latest advancements in male contraceptions?

The drawback of surgical approaches (such as vasectomy), especially patient compliance and the low success rates with condoms has spurred research on hormonal contraceptive dosage forms. There is a dearth of investigations in the development of pharmaceutical preparations. Evolving technology in the 21st century as well as improvement in living standards further underline the need for new male contraception approaches, especially those that entail new drug delivery methods.

Here are few areas where male contraception is being researched and used in some countries

Hormonal contraception for men is possible, and we are at the threshold of an important breakthrough. Combined testosterone plus progestin administration is more effective and safer than testosterone alone. Combination of testosterone plus an anti-androgenic progestin has several advantages over other formulations. In combined therapy, single injection formulation may have better compliance. 

Conventional male contraception 
Abstinence (doesn't work well)
Masturbation
Male condom
Vasectomy
There are other methods being developed but not sure they are there yet. But for guys? Their options are stuck in a time warp. If a man wants to take pregnancy prevention into his own hands, his choice basically comes down to condoms, a vasectomy, withdrawal, or abstinence. That s why it's so amazing that scientists are finally developing some real advancements when it comes to male contraception.

Researchers writing in the April issue of the Open Access Journal Contraception published a rundown of the top emerging options. A few hold real promise, particularly a daily or weekly pill that would deliver a dose of artificial hormones to a guy s bloodstream, which would then act on reproductive hormones to stop sperm from being produced. Like the female hormonal pill, the male hormonal pill would be reversible. But also like the female hormonal pill, there appear to be side effects, among them acne, weight gain, and even trickier to work around, changes in testosterone levels that trigger a plunge in libido.

Non-hormonal techniques are also being developed, particularly a vaccine that immunizes men with antibodies to halt sperm production. This so-called male birth-control shot is encouraging, because it targets sperm directly (rather than targeting other hormones in the body) and doesn t have the testosterone-lowering side effects of a hormonal pill. Each injection would last for long intervals (experts aren t yet sure how long), but the pregnancy-preventing effects would be reversible, if and when a guy decides he s ready to be a dad.

So when can you expect to see men rushing out to the pharmacy counter to pick up their new birth control Rx?  I think we may see a novel male contraceptive within 10-12 years, That may seem far off, but hey at least it s finally within sight.

Male Contraception - An Insight!

Many people suffer from a low libido problem. This can be a problem for their partners as well as for themselves. A low sex drive can also reduce one's self esteem and confidence. In severe cases it also leads to depression.

Factors which cause low sex drive:
1. Sexual problems: Many sexual problems also lead to a low sex drive. An inability to experience orgasm even after a lot of attempts can make one indifferent to sex. Some people also experience pain because of a tight vagina. In such cases their desire to have sex reduces greatly.

2. Medical diseases: Many medical conditions also affects your libido, such as cancer, arthritis, blood sugar (diabetes), artery diseases, high blood pressure and neurological diseases.

3. Medications: Some people suffer from depression and anxiety disorders. To get over these disorders most doctors prescribe them antidepressants and anti-anxiety pills, these medications create a very low libido.

4. Habits: Many lifestyle habits such as over-consumption of alcohol can make your sex drive reduce a lot. Smoking also decreases the blood flow in your body which may make your libido fall.

5. Surgery: Reconstructive surgeries such as breast reconstruction surgery and genital tract surgery can also affect sexual desire and give your body signals to not engage in an intercourse.

6. Fatigue: Tiredness because of physical activities or caring for your old parents or young children can also make you uninterested in sex. Your body and brain might not have the energy to engage in an intercourse due to fatigue.

7. Menopause: The levels of estrogen reduce greatly during menopause. Low estrogen levels make your vagina dry hence sex can be uncomfortable and painful. Women also go through hormonal changes which make them suffer from a low libido.

8. Pregnancy: After pregnancy, breastfeeding your baby becomes an everyday activity. This can reduce sexual desire because of the pressure of caring for a new born baby.

Regular exercising complemented with enough sleep is known to reduce stress thus giving you a high sex drive. Avoid consuming alcohol. Testosterone replacement therapy (a therapy used for treating erectile dysfunction) also treats low desire.

Worrying Factors That Lead to a Low Sex Drive

In medical terms, the pelvic floor refers to a group of muscles in the pelvic area. These muscles provide support to the organs in the pelvic region, including the bladder, uterus (women), prostate (men), and rectum.

What is pelvic floor dysfunction?
This is a medical condition that is used to refer to a situation when you are unable to control the functioning of the pelvic floor. It means you fail to control the bowel movement. People suffering from pelvic floor dysfunction use these muscles to contract rather than to relax. It is for this reason that they cannot have a bowel movement. They often have an incomplete one.

What causes pelvic floor dysfunction?
In most of the cases, the exact reason behind this dysfunction is unknown. It is often believed that this condition is caused due to traumatic injuries to the pelvic area. This can happen after an accident and due to complications aroused after vaginal childbirth.

What are the symptoms?
There are several symptoms that are linked to this medical condition. You must visit your doctor if you come across the following signs:

The feel of having several bowel movements within a short period of time.
If you feel that you cannot complete a bowel movement.
When there is constipation pain linked with bowel movements.
A frequent urge to urinate.
Painful urination.
Pain in lower back.
Continuous pain in pelvic region, genitals, or rectum.
Pain during intercourse in women
How is pelvic floor dysfunction diagnosed?
It may be diagnosed through a physical examination by the doctor. You will ask several questions to know the case history and find out the cause. You may also be asked to take pelvic muscle control test by placing surface electrodes on the perineum or sacrum. A small device called a perineometer is also used for the same.

What are the best ways for treating pelvic floor dysfunction?
It can be treated without surgery. There are several techniques. Some of these are as follows:

Biofeedback: It is done with the help of a physical therapist.He uses special sensors to watch and monitor the muscles.
Medication: A low-dose muscle relaxant is prescribed to treat the same.
Relaxation techniques: Your therapist may ask you to take up techniques for relaxation such as warm baths, yoga, and exercises.
Surgery: If your physician finds out that the dysfunction is caused by a rectal prolapse or rectocele, he or she will take up surgery.
Pelvic Floor Dysfunction results in Urinary Dysfunction. Urinary incontinence is the unintentional passing of urine. It's a common problem thought to affect millions of people. There are several types of urinary incontinence, including:

Stress Incontinence   when urine leaks out at times when your bladder is under pressure; for example, when you cough or laugh
Urge Incontinence   when urine leaks as you feel a sudden, intense urge to pass urine, or soon afterwards
Overflow Incontinence (chronic urinary retention)   when you're unable to fully empty your bladder, which causes frequent leaking
Total Incontinence   when your bladder can't store any urine at all, which causes you to pass urine constantly or have frequent leaking
It's also possible to have a mixture of both stress and urge urinary incontinence.

Pelvic Organ Prolapse

Pelvic organ prolapse is a condition in which structures such as the uterus, rectum, bladder, urethra, small bowel, or the vagina itself may begin to prolapse, or fall, out of their normal positions. Without medical treatment or surgery, these structures may eventually fall farther into the vagina or even through the vaginal opening if their supports weaken enough.


Pelvic Floor Dysfunction - What is the Best Way to Treat it?

Intracytoplasmic Sperm Injection i.e. ICSI is different from conventional IVF i.e. In Vitro Fertilization because a single sperm is selected by the embryologist to be injected by a needle into the egg rather than a dish with many sperms placed near the egg so that the fastest swimming sperm enters it. Once the sperm is injected directly into the egg, it fertilizes, after which the embryo is transferred into the womb or uterus. 

Your doctor might recommend ICSI treatment for you if you have an extremely low sperm count resulting in infertility or other medical sperm conditions such as poor motility or poor morphology. It may also be suggested if prior attempts at IVF procedures have failed in fertilizing the egg or the fertilization rate is extremely low. You must also consider ICSI treatment if you resort to embryo testing or if the sperm needs to be collected from the epididymis or testicles surgically. 

However, you must keep in mind that if your partner has a genetic problem resulting in low sperm count, it could be passed on to your child, if you decide to use your husband's sperm for this process.

Success Rates of ICSI:
The success rate of ICSI treatment depends on your age and your fertility problem. Your eggs are healthier when you are young and as you age, chances are that they will become less healthy.
1. 35 per cent if you are under 35 years of age
2. 29 per cent if you are between 35 to 37 years of age
3. 21 per cent if you are between 38 to 39 years of age
4. 14 per cent if you are between 40 to 42 years of age
5. 6 per cent if you are between 43 to 44 years of age
6. 5 per cent if you are above 44 years of age

Advantages of ICSI Treatment:
Intracytoplasmic Sperm Injection gives you a chance to conceive a child genetically when most other options are exhausted. Males may be unable to ejaculate on the day the eggs are collected due to anxiety. ICSI proves to be advantageous because sperm may also be surgically extracted for this process. It is extremely helpful for those couples who suffer from unexplained infertility. However, one of the most important factors is that ICSI treatment does not affect your child's physical or mental health.

Intracytoplasmic Sperm Injection (ICSI)

In vitro fertilisation, commonly known as IVF, is the process of fertilising single or multiple eggs outside the body. This treatment can be performed by either using your own egg and sperm or using donated egg or sperm or sometimes both. The resulting sperms and eggs are evaluated for quality and then one or more of them are positioned properly in the uterus through the cervix. IVF is regarded as one of the most commonly opted treatment plans, and it accounts for more than 99% of assisted reproductive technology processes.

Who are suitable for IVF?
IVF can be helpful for you in case you have some issues with the egg quality or ovulation, fallopian tubes that are blocked in some way or endometriosis. It can also help you to get pregnant if your partner has problems with mortality and sperm count and when you have opted for donor eggs. About 1.5% of babies in the United States are conceived through the IVF process.

How does IVF work?
There are several steps through which IVF process works and the timeline follows the following steps:

    Stimulation for ovary: You will have to take a special kind of fertility drug for 8 to 14 days near the start of your menstruation cycle. This drug aids in the stimulation of your ovaries for developing multiple mature eggs to fertilise instead of a single one. You may also need to take an artificial hormone-like cetrofelix and leuprolide for keeping your body from releasing eggs very early.
    Development of follicle: When you are under all these medications, you will have to visit your doctor s office often for checking the hormone levels as well as ultrasound measurements for the ovaries.
    Getting the trigger shot: Once the follicles are ready, you are likely to receive a trigger shot, which is an injection causing the eggs for maturing fully and becoming capable of being fertilised. Your eggs are ready for being retrieved after about 36 hours of receiving this shot.
    Gathering the eggs: At this stage, you are likely to receive an aesthetic or ultrasound probe that is inserted through the vagina for checking the ovaries and identifying the follicles. Normally, about 8 to 15 eggs are retrieved through the insertion of a thin needle.
    Fertlisation: This is the most vital step, where an embryologist is going to examine the eggs before they are combined with the sperm and incubated overnight. Fertilisation happens at this particular time, but abnormal eggs are not fertilised.

Then the embryos slowly develop and are planted on the basis of your age and clinical condition. When the treatment is working, an embryo is implanted in the uterine walls and starts developing. 

IVF - How Does it Work?

Pregnancy can be a tricky time for most women, although it is not a pathological condition. One must be prepared for pregnancy with the best of health in the pre-pregnancy period. This also includes women who are suffering from diabetes. The complications during pregnancy and delivery increase manifold if one has not controlled the glucose and blood sugar levels before getting pregnant. So read on to know more about coping with the pregnancy if you happen to have diabetes.

Complications: Pregnancy with diabetes can cause severe complications if blood sugar levels are not controlled properly before pregnancy. This can cause diabetes to become even worse in the long run, with the onset of various other related ailments like kidney disease, heart disease, eye problems and more. It can also increase the risk of premature delivery, and too much birth weight of the baby as well as low glucose levels right after the baby s birth. Further, one can also lose the baby to a miscarriage due to excessively high blood sugar levels. This can also affect the glucose and blood sugar level of the baby as the glucose passes through the body.

Related conditions: If you happen to have high blood sugar levels, then you and your baby can get affected in an adverse way. To begin with, you may come down with severe depression regarding how you will be able to manage your diabetes and pregnancy together, and also due to the implications of the condition after the birth of the baby. It can also cause a condition called Preeclampsia in which the pregnant woman s blood pressure becomes high and too much protein starts to pass from the urine, which can also result in frequent urination and life-threatening defects and problems for you and the baby. In such cases, you will have to be hospitalised and the baby will need to be delivered via a C section or a Caesarean Section.



Planning ahead: If you know that you are trying to conceive, the best way is to be fully prepared well in advance. This includes planning ahead for managing the blood sugar levels and keeping the risk of other ailments at bay. You can start by losing excessive weight and seek treatment to bring down the blood sugar levels. Exercising and watching your diet are also some good ways to ensure that your Type 1 or Type 2 diabetes is in control.

Medical Team: It is pertinent to be in touch with your medical team on a constant basis. This team should include the obstetrician and gynaecologist as well as your regular doctor to whom you can report any changes.
Keep health close to your heart when you are pregnant by taking care of all existing ailments.

If you wish to discuss about any specific problem, you can consult a doctor and ask a free question.

Diabetes in Pregnancy - How to Tackle it?

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