What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

To save life and the planet, it is important to follow an eco-friendly lifestyle. This will not only elongate your life span but also helps in sustainable development. Breathing in better air, living in a cleaner atmosphere, eating better food, drinking purer water - all ensure a healthier body. Moreover, the improved aesthetics of a clean environment has positive psychological effects on your brain! protecting your environment is of utmost importance in ensuring your good health. Following are the key health benefits of having an eco-friendly lifestyle,


	
	An eco-friendly human would automatically engage in more physical activity, as they d attempt to choose walking or cycling over driving or using public transports whenever possible. Increased physical activity is directly correlated to one s health and fitness.
	
	
	An eco-friendly lifestyle entails the consumption of more organic food which allows more nutrition and fewer pesticides or chemicals to enter your body. Hence, one becomes less exposed to carcinogenic compounds and other diseases causing or immunity hampering chemicals. Moreover, when one is producing their own vegetables, they end up consuming more seasonal items, which ensures a better diet.
	
	
	City air has multiple pollutants even in the absence of smog that can cause diseases. Fresh or pure air not only contains more oxygen but also lacks harmful pollutants and microparticles that adversely affect one s health. Hence, an environment-friendly lifestyle allows one to improve the quality of the air they breathe and thus, avoid life-threatening diseases. We can do this by replacing our regular vehicles with eco-friendly ones. Also, try carpooling to reduce the emission of pollutants.
	
	
	Cholera, diarrhea, typhoid are just a few waterborne diseases that are transmitted via unclean drinking water. Hence, an improved environment ensures the supply of cleaner water, allowing one to consume its minerals while avoiding its pollutants.
	


Protecting the environment by adopting eco-friendly habits not only improves our own health but also helps us ensure the healthy life for our future generation!

 

Ways To Make Your Lifestyle Eco-friendly

Blood donation is a procedure carried out for the noble cause of helping patients and saving lives. As the healthy donor's blood is transfused into the patient, it gives them a new life. That said, the donor has to fulfill a few criteria to be eligible to donate blood.

Eligibility

While any healthy adult of any gender can donate blood, it is advised for males to donate once every three months and for females to donate once every four months. Some of the other criteria are-


	
	Age
	


Any person in the age group of 18 to 65 years can donate blood depending on other factors.


	
	Weight
	


A donor should be at least weigh 45 kilograms in order to be eligible.


	
	Pulse
	


The temperature and pulse of the donor should be normal during the time of blood donation.


	
	Hemoglobin
	


Hemoglobin in the blood should be at least 12.5 grams otherwise the donor stands ineligible.


	
	Childbirth
	


A female donor should have delivered at least 1 year ago and stopped lactation.


	
	Blood pressure
	


Ensuring that the systolic and diastolic pressures are within normal limits is a must.


	
	Malaria
	


One should not have malarial symptoms and not have been treated for the same in the last 3 months.


	
	Tattoo
	


A person should not have had a tattoo in the past 12 months.


	
	Immunization and vaccination
	


A donor should not have had shots for cholera, typhoid, diphtheria, tetanus, or plague in the last 15 days.


	
	Cancer
	


A person should be checked for cancer and should not have any signs of cancer in the body.


	
	Infection
	


There should not be hepatitis b, c, tuberculosis, leprosy, or hiv infection in the body.


	
	Diseases
	


A person should not have epilepsy, bleeding disorders, sickle cell, or thalassemia.


	
	Drugs
	


One cannot donate blood if injected intravenously ever. It may cause risk to the recipient.


	
	Heart issues
	


A person willing to donate cannot have any heart disease.


	
	Diabetes
	


People on oral drugs or dieting to control diabetes can donate blood while patients with insulin injections cannot.

 

Strictly prohibited


	
	Ones who have been tested hiv positive.
	
	
	People suffering from cardiac problems, hypertension, cancer, epilepsy, or kidney ailments.
	
	
	Donors who have consumed alcohol in the past 24 hours.
	
	
	Ones with a major dental procedure done in the last one month.
	
	
	Women with miscarriages in the past 6 months.
	



 ;

Know Eligibility Rules For Donating Blood

High sugar levels can harm your body and impact the quality of life. However, you can manage your ;sugar levels by keeping a check on your nutritional intake.

Manage Your Diabetes By Keeping A Check On Your Nutritional Levels

If you have diabetes, many parts of your body are likely to get affected over time. You might observe that your digestion is not the same as it was before you had diabetes. In this case, you are likely to face stomach problems and bowel issues. This is due to the effect of diabetes on your vagus nerve.

The vagus nerve is responsible for managing the complex processes in your digestive system. When the nerve is not functioning properly, your digestion slows down. As a result, the contents of your stomach stay longer than they should. Such a condition is called diabetic ;gastroparesis, which is one of the most common diabetic problems.

What is diabetic gastroparesis?

In gastroparesis, your stomach takes too much time to clear the bowel due to disrupted digestion. Usually, after a meal, the vagus nerve helps to contract the stomach muscles to break down the food into smaller pieces and pass it to the small intestine.

However, if the nerve is damaged, the muscle contraction gets halted and the decomposition of the food is slowed down. This condition is common in patients suffering from type 1 and type 2 diabetes. This is because diabetes causes nerve damage, which in turn damages the vagus nerve.

Symptoms of gastroparesis

The most common symptoms of the condition are  


	
	Heartburn
	
	
	Nausea accompanied by ;vomiting
	
	
	Appetite loss
	
	
	Bloating in the abdomen
	
	
	Acid reflux
	
	
	Weight loss
	
	
	Fluctuations in the blood ;sugar level
	
	
	Feeling full even after consuming a little amount of food
	
	
	Spasms in the stomach
	


What are the treatment options?

The first step to treat diabetic gastroparesis is to manage the levels of blood sugar. In this case, your doctor might ask you to check your blood sugar regularly   that will help him to modify the treatment to cure this condition.

The treatment can include the following steps  


	
	Altering your insulin dosage and the number of times you take it
	
	
	Oral medication may be prescribed to improve the condition
	
	
	Gastric ;electrical stimulation   where a device called gastric neurostimulator is implanted in the lower abdominal region. It sends low energy electrical impulses to your stomach muscles to cure cases of severe vomiting and nausea.
	


The doctors will recommend some dietary changes   avoid fibre-rich foods and include low-fat foods instead. With proper treatment and lifestyle changes, diabetic patients may be able to avoid common digestive problems like gastroparesis.

What Is Gastroparesis- A Diabetes Induced Digestive Problem

World hepatitis day is observed on july 28th every year to raise awareness about hepatitis disease among people. It is organized on the occasion of the birthday of Dr. Baruch blumberg who found the hepatitis b virus in the year 1967 and also developed a vaccine for it. Moreover, this day educates everyone about hepatitis infections, the efforts to fight viral hepatitis, and methods people can use for its prevention.

What is viral hepatitis?

Viral hepatitis or hepatitis disease is a condition of inflammation in the liver that leads to severe liver disease and hepatocellular cancer. With deaths happening every 30 secs from a hepatitis-related infection, it is important to treat viral hepatitis at the earliest. Hepatitis is of different types depending on the infection. 

 ;

Types

Viral hepatitis impacts millions worldwide, resulting in both acute and chronic diseases. There are five major classifications of viral hepatitis-

 


	
	Hepatitis a- it is a liver infection that can be prevented by a vaccine. It is a result of the infection as a result of the hepatitis a virus.
	
	
	Hepatitis b- it is an infection that happens due to the hepatitis b virus. It is spread through the blood or other bodily fluids of a person.
	
	
	Hepatitis c- it is a liver infection caused by the hepatitis c virus. It transmits through the blood of a person who is infected.
	
	
	Hepatitis d- delta hepatitis is another name for this virus and the hepatitis d virus is responsible for this. It happens to only those who are already hepatitis b infected. ;
	
	
	Hepatitis e- it is a liver infection resulting from a hepatitis e infection. It is usually found in a person s stool.
	


 

Symptoms

Hepatitis is a condition where you don t show symptoms till it is chronic and starts affecting your liver health. However, people in the initial stages of hepatitis infection might start reflecting symptoms. Some common symptoms of viral hepatitis are:

 ;


	
	Flu-like signs
	
	
	Darker urine color
	
	
	Fatigue
	
	
	Abdominal cramps and pain
	
	
	Appetite loss
	
	
	Weight loss
	
	
	Yellow skin
	
	
	Pale eyes
	


 

People at risk

The risk of catching a hepatitis infection is high in individuals working around these environments-

 ;


	
	Direct contact with hepatitis a infected person
	
	
	Male in sexual relation with another male
	
	
	Drugs abuser
	
	
	Ones with clotting factor disorder
	
	
	Who work with primates
	


 

World Hepatitis Day: Know All About The Disease

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