Grading of brain cancer is entirely different as compared to the staging of other cancers in the body. Cancer in the breast, lung, colon etc. are staged depending on the possible spread, location of a tumor and lymph node involvement etc. However, brain tumors are graded based on the aggressiveness of the tumor cells under a microscope. The resect ability and the grade of the tumor cells guide a doctor on the treatment decisions. The decision of a brain surgery depends on factors such as the location, spread of a tumour and the general health of the patient.

Types of Brain Tumor Grading:

Grade 1 tumor- These sets of tumors are medically known as the juvenile pilocytic astrocytoma and subependymoma. They are slow growing and non-invasive. There is a likelihood of the patient getting cured with surgery.
Grade 2 tumor- These are brain tumors that do not possess dead cells as part of the tumour. But, they do portray a lot of abnormal cells. Tumors of this type can be categorized under oligodendroglioma, astrocytoma, and ependymoma.
Grade 3 tumor- Tumors of this type are graded based on the cell type of the cancer cells. For instance, an anaplastic astrocytoma is a grade 3 tumor that has no dead cells but possesses dividing cells. In contrast, anaplastic ependymoma and anaplastic oligodendroglioma are grade 3 tumor cells that have dead cells in them.
Grade 4 tumor- Tumors of this type are referred to as glioblastoma. The tumor cells are actively dividing, the growth of blood vessels is witnessed and areas of dead tissue keep expanding.

Treatment options:
Surgery- If the location of a brain tumor is such that it is accessible to a surgeon, the latter goes ahead and removes most of the tumor if not the whole. If, however, the brain tumor cells are placed very near to the surrounding very sensitive brain tissues, a doctor might remove a small portion of the tumor to curb its growth.
Radiation Therapy- This mode of treatment uses high energy X-ray beams to kill targeted cells of the brain. External beam radiation usually targets a small area of the brain. A whole brain radiation, on the other hand, is usually employed when a tumor has spread to most parts of the brain. Radiotherapy is now so evolved that it is highly targeted to tutor cells that kills cancer and spares normal brain .
Chemotherapy- Chemotherapy employs drugs to kill cancer cells. Chemotherapy can either be taken in the form of an IV or in the form of pills. The dosage of chemotherapy is decided based on the concentration of cancer cells, spread frequency, platelet count of the patient etc. The most common chemotherapy drug that is prescribed by doctors to fight cancer cells is temozolomide.

Brain Tumor - Stages and Treatment!

Epilepsy is a disorder in the central nervous system characterized by recurrent seizures. An unexpected rush of electrical activity inside the brain leads to a seizure. Brain activity becomes abnormal and leads to periods of unusual behaviour with loss of awareness at times.

Seizures do not always include unusual muscle movements or convulsions. Untreated seizures can seriously affect the lives of children having them. Epilepsy affects both men and women regardless of their ethnic background and age.

Signs of Epilepsy:

A staring spell
Momentary bewilderment
Loss of consciousness
Jerking movements of arms and legs.
Panic or anxiety
Kinds of Seizures:
Seizures are normally classified as focal or generalized depending on the commencement of abnormal brain activity.

Focal (partial) seizures result from abnormal activity in a particular area of the person's brain. Simple partial seizures may change emotions or the way things smell, appear, feel, sound or taste. It is characterized by tingling and dizziness.
Complex partial seizures or focal seizures with impaired awareness entail a modification of or loss of awareness and consciousness. Repetitive movements are performed during such seizures such as hand rubbing, walking in circles or swallowing.
Thorough testing is needed to differentiate epilepsy from other neurological disorders such as narcolepsy, migraine or mental illness.

Generalized seizures normally affect all areas of the brain and consist of:

Tonic seizures lead to muscle stiffness and normally affects muscles in the person's back, legs and arms.
Atonic seizures or drop seizures lead to a loss of muscle control which makes a person abruptly collapse or fall down.
Myoclonic seizures are visible as short jerks or twitches of a person's arms and legs.
Clonic seizures are characterized by repetitive or rhythmic jerking muscle movements.
Tonic-clonic seizures cause sudden loss of consciousness, quivering and body stiffening.
Absence seizures might take place in clusters and lead to momentary loss of awareness.
Symptoms of Epilepsy:
The main symptoms of epilepsy are seizures and it differs from one person to another.

Symptoms of Focal (partial) seizures include:

Dizziness
Change or modification in the sense of smell, taste, hearing, sight or touch.
Twitching and tingling of limbs.
Symptoms of Complex partial seizures include:

Unresponsiveness
Staring blankly
Performing repetitive movements
Loss of awareness or consciousness
Genetics may provide a person with a natural seizure threshold as a person who is susceptible to seizure triggers is said to have inherited a low seizure threshold. A higher threshold conversely makes a person less liable to have seizures.

Epilepsy is a comparatively common neurological disorder that affects innumerable people worldwide and treatments range from medication to surgery.

Epilepsy - Signs and Symptoms You Must Know!

The primary aim of the treatment in patients suffering from seizure is leasing a seizure-free life without giving way to any adverse effects. This goal can be accomplished in over 60 percent people with the help of anticonvulsants. Some patients also experience adverse effects since they suffer from a seizure which is refractory to medical therapy. Here are some of the common treatment options for seizures:

Monotherapy: Sometimes, monotherapy is given as it reduces the chance of all sorts of adverse effects and even avoids drug interactions. Moreover, this type of treatment approach is much less expensive than polytherapy since many older generation of the anticonvulsant agent comprises of hepatic enzyme which is responsible for reducing the serum level of the concomitant drug which leads to an increase in the dosage level of such medicines.
Social And vocational rehabilitation: People suffering from problems in psychosocial adjustments after the diagnosis may also need social and vocational rehabilitation. Many physicians do not pay enough attention to the consequences that an epilepsy diagnosis may leave on the patient. For instance, people with epilepsy may have a fear of experiencing next attack of seizure and they may be unable to work at heights or drive.
Consulting an expert: It is important to refer patients with intractable spells to epileptologist or neurologist for subsequent workup. A neurosurgical consultation may also be needed when the patient has to be treated surgically.
Importance Of anticonvulsant therapy
Patients who have had already suffered from recurrent attacks of unprovoked seizure may need treatment with an anticonvulsant. This treatment is not recommended until the person has risk factors for suffering from the problem yet again. The primary means of treating seizure is anticonvulsant therapy where the most suitable drug is chosen based on accurate diagnosis of the syndrome as a response to specific anticonvulsants may vary from one patient to another. The difference in response may reflect the various pathophysiologic mechanisms in different types of seizures.

Types of anticonvulsant therapy
Some of the anticonvulsant therapy medication may have multiple action mechanism while some have an only single mechanism of action. Some of the most common variants of the therapy include:

Neuronal potassium channel referred to as KCNQ opener
Blockers of unique binding sites such as perampanel, gabapentin, and levetiracetam
H-current modulators such as lamotrigine and gabapentin
Carbonic anhydrase inhibitors such as zonisamide and topiramate
Alpha-amino 3-hydroxy 5-methyl 4-isoxazole propionic acid receptor blockers like topiramate and perampanel.
N and L-calcium channel blockers like zonisamide, valproate, topiramate, and lamotrigine
Even though there are so many types of drugs available, all of them cannot be used for the treatment of seizures. Doctors would evaluate the condition thoroughly before prescribing a medication that can be helpful in reducing the severity of the condition.

Seizures - 3 Ways It Can Be Treated!

Epilepsy is a condition that starts in the brain and causes seizures in which the patient loses consciousness and has convulsions. He also jerks his arms and legs along with trembling and frothing from the mouth.
The lesser known fact about epilepsy is that there are many types of epileptic conditions-over 40 - and similarly, there are numerous drugs available to treat your epileptic disorder and prevent seizures. Your doctor will diagnose your type of epileptic disorder and prepare a treatment plan for it.

Types of epileptic seizures
Epileptic seizures are generally categorized as either partial or primary, generalized depending on where they originate in the brain. Partial seizures are less intense and they start in one section rather than the entire brain. If you have this type of seizure, you will be aware of what s happening to you. The other type of seizure affects a larger part of the brain. Here you may have difficulty understanding what's happening to you. Since these spread to the entire brain, you lose consciousness and start convulsing.

Having a seizure can put you at risk for serious injuries including head injuries.
So, if you close to you suffers from epilepsy, it's critical to your health and well being to educate yourself about your condition and have an action plan in place to tackle the seizures which can happen anywhere, and sometimes with no one to assist you or him actively.

Here is what you can do to manage epilepsy-

Educate yourself: You must know as much as possible about your condition. Know your symptoms and learn to recognize the symptoms preceding a seizure. Also, educate your friends and family about epilepsy so that they can support you during a seizure. Educate your family to do the right things when you have a seizure.
Make a seizure response plan: This plan should list the names and numbers of your doctors and two emergency contacts.
Other things you can do as an epileptic:
Antiepileptic drugs are quite successful in preventing seizures but they should be taken as prescribed. Don t change your dosage before talking to your doctor.
Sleep properly as lack of sleep can trigger seizures.
Exercising regularly can help keep you physically healthy and reduce depression and also help in managing seizures.
Manage your stress levels, limit alcohol and cigarettes.
On the other hand, if your family member or friend has epilepsy, this is what you can do:

Roll the person onto one side during a seizure.
Place something soft under the person s head.
Loosen tie and top buttons.
Don t put an object in an epileptic s mouth. It can hurt his/her teeth.
Don't try to restrain him during a seizure.
Clear away stones and other dangerous objects if the patient is thrashing around.
Time the seizures and be calm during them.
Don t leave the patient alone.

Epileptic Conditions - How To Deal With Them?

Pain related sleep disruption has affected a large number of people around the globe. Statistics has it that, in India, about 25% of the population suffers from pain-related sleep deprivation. Studies call it  the vicious cycle of pain and sleep  as pain affects your ability to sleep and lack of sleep makes the pain even worse.

Back pain and arthritis are examples of some common pain-related medical disorders. People with these types of chronic pains have reported persistent sleeplessness or have had immense trouble falling asleep.

The following are the primary sleep disorders associated with chronic pain:

Insomnia: It is a medical condition that is characterized by an inability to fall asleep no matter how physically exhausted you are. Insomnia can be acute (lasting for one night to a week) or chronic (that lasts for more than 3 weeks).
Hypersomnia: It is a condition wherein you tend to sleep excessively; in this condition, you will have trouble being awake throughout the day or can fall asleep at any point of time.
Sleep Apnoea: This is a sleep disorder wherein breathing pauses and resumes repeatedly. Risk factors include obesity, age and gender; it is more commonly observed in men. This condition can be chronic with symptoms such as snoring loudly or feeling very tired even after one has had a night s sleep.
Restless leg syndrome: It is a sleep disorder wherein you continuously move your legs while sleeping. However, this condition can also cause you to move your legs even if you aren t sleeping.
Some of the causes of sleep disorders due to chronic pain are:

Pain
Worry and anxiety
Sweating at night
Depression and other mental disorders
Treatment

A pain and sleep disorder should be simultaneous as both the components of it, pain and sleep, are interrelated. Some of the ways people with chronic pain can still have a good night s sleep are:

Limiting caffeine intake
Abstaining from alcohol and smoking, as these disrupt the sleep cycles, thus aggravating the existing pain.
Practicing meditation and other relaxation techniques
Pain killers or sleeping pills can be administered, but only with the doctor s advice.
Hot water fomentation over painful area during night, for better sleep.

Back Pain and Bad Sleep

The most powerful and amazing organ in our body is the brain. It differs from many other organs of our body not only by its shape, but also by its special type of cell called neurons. When these cells gets affected or dead it can never be reverted or regenerated which is the most exclusive nature found only in brain cells. The cells in other parts of our body has the capacity to regenerate (can be replaced or new one can be grown or produced), but brain cells are exception. Hence any damage to the brain, injury or trauma is really a crucial thing to be considered with utmost care.

Brain surgeries really need skill, proper training, confidence and intelligence to perform this highly complicated and risky surgery.

Purpose:
Brain surgeries are performed to:

Remove the brain tissues that are grown abnormally
Aneurysm is clipped to prevent flow of blood cliff off an aneurysm
Biopsy purpose or to remove the tumour
Make a nerve free
Drain the abnormal blood or clot collection or to drain any excessive fluid collection caused by infection.
To implant artificial electronic device as a treatment for conditions like Parkinson's disease
Types:

Biopsy: A part of brain tissue is removed for the brain or whole tumour is removed.
Craniotomy: The skull bone is opened to remove tumour, an aneurysm and drain fluid or blood from infection.
Minimally invasive endonasal endoscopic surgery: Endoscopic devices are inserted through the nose to remove the lesions or tumour.
Minimally invasive neuroendoscopy: Similar to endonasal surgery but small incision is made.
Risks:

Anaesthesia risks like breathing difficulty, allergic reaction to medications, excessive bleeding or clots and infection.
Risk related to the brain surgeries are seizures, coma, swelling of brain, infection to brain or meanings, surgical wound infection that intrudes to the brain structures, abnormal clot formation and bleeding.
General risks include muscle weakness, disturbances in memory, speech, vision, coordination, balance and other functions that are controlled by the brain.

Brain Surgery - Know The Purpose Behind It!

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