The pancreas is a gland located in the abdominal region that performs two main functions for the body: produces digestive juices and the hormone insulin which regulates the blood sugar levels. The part which produces the digestive juices is exocrine and the insulin-producing part is the endocrine portion. Pancreatic cancer, which is an uncontrolled growth of the pancreas cells, often starts in the exocrine portion and is known as the pancreatic adenocarcinoma. The one which develops in the endocrine portion is known as neuroendocrine cancer or islet cell tumors.

Risk factors
Though not clearly established, the following factors are believed to up the risk of pancreatic cancer.

Smoking
Family history
Prolonged uncontrolled diabetes
Pancreatic conditions like inherited pancreatitis
Chronic inflammation of the pancreas
Symptoms
A pancreatic condition is of insidious onset, and the exact period of onset cannot be determined. The symptoms also are nonspecific abdominal symptoms, which do not pinpoint the pancreas per se.

Jaundice, which includes yellowing of the skin and whites of the white. This is because the growth of the pancreas puts pressure on the liver and bile ducts, and so hampers bile flow.
Weight loss, which was unintended. This is due to a bloated feeling plus inability to digest the foods.
Severe pain, which can be difficult and may even require regular injections to control.
Fluctuating sugar levels, which is unexplained.
Onset of diabetes, which is associated with weight loss and jaundice.
Increased tendency for blood clots.
Loss of appetite.
Bowel obstruction due to blockage of the growing pancreas.
Diagnosis
The above symptoms could lead to a further investigation that includes a few important tests, like the following.

Blood tests
Insulin levels
CT scan
Ultrasound
MRI
Laparoscopy, both to look for the extent of the disease and to do a biopsy, which can be used for confirming the type of cancer
Percutaneous transhepatic cholangiography: A dye is injected into the pancreas to study the spread of the dye, which will also help identify the diseased portion.
Treatment
Pancreatic cancer is very aggressive, usually not detected early, and has a very poor prognosis. So, if there is a family history or one has a prolonged pancreatic condition, it is advisable to go for annual screening to help with early detection and intervention. Once identified, treatment would include a combination of the three modalities   surgery, radiation, and chemotherapy. Surgery often may be followed by chemotherapy and/or radiation.

Prognosis
The prognosis for pancreatic cancer is very poor. Only about 25% of patients diagnosed with pancreatic cancer live past the first year. Early detection of risk factor remains the best way to improve prognosis. In case you have a concern or query you can always consult an expert & get answers to your questions!

Pancreatic Cancer - 8 Common Signs You Must Be Aware Of!

Problems of the large intestine are very common and patients should usually consult gastroenterologists for the proper diagnosis and treatment

1. Bleeding per rectum: Bleeding through the anal canal or rectum is usually the most common problem of the patients. It can be due to following reasons: 

A. Piles also known as Hemorrhoids: Hemorrhoids are dilated venous channels of the anal canal. They occur due to long term constipation or chronic cough or due to less fibre intake in the diet. Sigmoidoscopy or proctoscopy is required for diagnosis. Treatment options include medicines and high fibre intake, Injection therapy(Sclerotherapy) for stopping bleeding from piles and Stapler hemorrhoidectomy if the piles are large.

B.  Polyps: Polyps are soft tissue growths seen in the large intestine. They are usually silent but can present with bleeding or anaemia. Polyps usually grow slowly in size and large polyps can turn into cancer of large intestine also known as colorectal carcinoma. Colonoscopy is required for the diagnosis. The gastroenterologists can diagnose the presence of polyps by colonoscopy. Smaller polyps can be removed by polypectomy by gastroenterologists without the need for open surgery. However large polyps or those polyps with suspicion of cancer require surgery.

C. Large intestine Ulcer: They can occur due to early cancer, SRUS, Infections or drugs. They require colonoscopy for the diagnosis. The gastroenterologists usually take Biopsy from the ulcer to know the cause of the ulcer. The mere taking of biopsy does not mean cancer and biopsy samples are seen in the microscope for better diagnosis.

D. Ulcerative Colitis and Crohn s disease: Ulcerative colitis is one form of Inflammatory bowel disease (IBD). The other IBD is known as Crohn s disease. Whereas ulcerative colitis involves only large intestine, Crohn s disease can involve any part of the gastrointestinal tract including small intestine. Ulcerative colitis and Crohn s disease present with Loose stools(diarrhea), bleeding , abdominal pain, weight loss, Anemia and Perianal fissures and  fistula. The diagnosis of IBD is challenging and involves blood tests, CT Scan abdomen, Colonoscopy with biopsy and clinical history. Management includes Medicines which control the inflammation such as Pentasa, Rowasa, Mesacol etc. Severe disease requires additional drugs such as Azathioprine and Anti TNF sich as Infliximab and Adalimumab. Occasional cases require surgery such as those with tight stricture of the intestine, severe dilatation of Large intestine (also known as Toxic megacolon), excessive bleeding, the disease not responding to medical management, or presence of cancer with IBD.

E. Anal fissures: Cut in the anal skin (fissure) causes severe pain in the anal area during passing motions. It is usually due to constipation or straining. It is usually treated by Gastroenterologists initially by medicines and ointments. If the pain continues Surgery is required named as Lateral internal sphincterotomy (LIS).

2. Loose motions or Diarrhea: Excessive passing of liquid motions is known as diarrhea or commonly lose motions. It is usually due to Infections caused by contaminated food and water. It is usually self-limiting. Severe cases with dehydration require admission for IV fluids and antibiotics for the infection. Loose motions for more than 6 to 8 weeks is known as chronic diarrhea. It is evaluated by blood tests and colonoscopy. Usual causes include tuberculosis, celiac disease, ulcerative colitis, microscopic colitis, Malabsorption such as chronic pancreatitis and small bowel bacterial overgrowth.

3. Irritable bowel syndrome (IBS): IBS is very common and at least 20 to 30 percent of Indian patients suffer from it. Symptoms include altered bowel habits such as diarrhoea or constipation, abdominal pain which is usually relieved or increased by defecation. Weight loss or bleeding is not the feature of IBS. Few simple blood tests are required and good medicines are now available for IBS. Few cases may require colonoscopy to rule out alternative causes of the symptoms.

Understanding colonoscopy: Colonoscope is a flexible tube with a camera at its tip to see the inside of the large and small intestine. Bowel preparation is required at least 8 hours before the procedure so that the inside of the large intestine can be seen clearly without the interference of stools.colonoscopy is an OPD based procedure where the patients are discharged the same day. A colonoscopy helps in evaluation symptoms of the large intestine such as loose stools, bleeding and abdominal pain.

In Detail About Colorectal Disorders!

Diarrhea is a disorder that affects people of all age groups. Medically speaking, Diarrhea is a mechanism that the body uses to eliminate germs from the body. Usually this disorder lasts for a few days to a week. It is usually accompanied by nausea, fever and dehydration.

Children can be affected by diarrhea in a number of ways, some of them are:
1. Infections: Various infections, such as the ones caused by rotavirus and salmonella bacteria can lead to diarrhea. Usually diarrhea in children is caused by viruses; if it is viral in nature, then it can also cause stomach cramps, headache and vomiting. It also leads to loss of fluid from the body. Hence, the child's fluid intake should be compensated accordingly. Usually oral rehydration solution that contains nutrient such as potassium and sodium are preferred.

2. Medications: Intake of certain medications, such as antibiotics and laxatives can cause diarrhea in children. If the cause is due to antibiotic intake, then you should consult a doctor. The doctor may alter the dosage or ask to increase the child's water intake. Yoghurt may also help ease the symptoms of diarrhea if it is caused by antibiotics.

3. Food poisoning: Diarrhea may also result from food poisoning; symptoms of this type usually disappear quickly. Along with loose and watery stools, the child may vomit frequently.
The major complication that results from diarrhea is dehydration. Severe dehydration may lead to severe brain damage and seizures. It may also cause symptoms of dry mouth, fatigue, dizziness and dark yellow urine.

Certain preventive measures are:
1. Use your good judgment while eating outside. Do not consume food from places which use unhygienic modes of preparation.

2. Make sure your child does not drink contaminated water and there is access to clean and filtered water all the time.

3. Your child should be eating a balanced diet that primarily consists of vegetable and fruits. They also help in adding fiber to the diet that keeps your bowels healthy.

All About Diarrhea in Children

Fatty liver is a condition where excess fat is deposited on this organ. Also called as steatosis, this condition happens when more than 5- 10 percent of the weight of the liver is made up of fat.

Fatty liver is a common condition among people. A study from coastal regions of India found ~ 25% of healthy persons had patients had fatty liver on ultrasound.

It can occur at all ages including childhood, highest prevalence is in 40 50 year age group. Prevalence more in patient who are obese and in diabetic patients.

Types of Fatty Liver

1 Alcoholic fatty liver: This condition occurs when there is a heavy consumption of alcohol. Gastroenterologists recommend abstention from alcohol for this condition to subside. If the patient continues to consume alcohol, then liver cirrhosis may develop.

2 Non alcoholic fatty liver (NAFL): One may develop a fatty liver even if one is not an alcoholic. The liver in some cases is unable to process the fat in cells causing them to build-up on the organ.

When more than 10% of the liver is made of fat then this condition is called Non Alcoholic Fatty Liver (NAFL).

Non alcoholic steatohepatitis (NASH): When fatty liver is associated with inflammation in liver patient is said to be having Non alcoholic steatohepatitis. NASH is a more advanced stage of NAFLD, and has a higher risk of progressing to liver cirrhosis or hepatocellular carcinoma (HCC). These condition display symptoms like jaundice, vomiting, nausea, loss of appetite and abdominal pain. Blood test (LFT) shows raised enzymes level. Approx 5-8% of the Indian population has NASH. Consult a doctor if you are experiencing any of these symptoms.

3 Fatty liver during pregnancy: Occurring mainly in the third trimester, the symptoms of this condition are vomiting, nausea, pain the right part of the abdomen and jaundice.

Symptoms

During the early stages (fatty liver) of the disease, patients usually have no symptoms directly related to liver disease. However, people may experience a vague abdominal discomfort. If their liver is inflamed (NASH) then they may display symptoms of poor appetite, weight loss, pain in the abdomen and disorientation.

What causes fatty liver?

The most common cause of fatty liver is alcoholism. When the human liver is unable to metabolize fat fast enough or when there is an excess accumulation of fat on the liver cells then the liver becomes fatty. However, intake of high-fat foods may not result in a fatty liver.

Predisposing factor:

1 Diabetes mellitus

2 Obesity or being overweight

3 Hyperlipidemia or the condition where there are high levels of fat in the blood

4 Genetic reasons

5 Rapid loss of weight

6 Drugs: Aspirin, steroids, tamoxifen, tetracycline etc. cause side effects which also leads to fatty liver

7 Nutritional status (eg, overnutrition, severe malnutrition, total parenteral nutrition [TPN], or starvation diet)

8 Other health problems (eg, Hepatitis C infection, celiac sprue and Wilson disease)

Know More About Fatty Liver!

Colitis is characterized by an inflammation of the large intestine (colon). It is generally caused due to reduced blood supply, autoimmune reactions (wherein the immune system erroneously starts attacking the body s healthy tissues) and infections in the large intestine.

Symptoms of colitis
1. Presence of blood traces in the stool.
2. Acute colitis can itself be a symptom of hemorrhoids (inflamed and swollen veins in the anus or the rectum)
3. Tenesmus (constant urge to empty the bowels) is also quite common
4. Occurrence of abdominal pain in regular intervals, thus resulting in diarrhea
5. Constant abdominal pain
6. Fever and sudden chills throughout the day

Types of colitis
1. Inflammatory bowel disease: This condition is characterized by inflammation of the intestines or all the parts of one s digestive tract
2. Microscopic colitis: This involves inflammation of the large intestine (colon), resulting in a cramping sensation that can be painful
3. Chemical colitis: This condition is caused due to prolonged exposure to certain harsh chemicals which results in intestinal swelling and inflammation
4. Ischemic colitis: The most common form of colitis, this occurs mainly due to an insufficient blood supply to the large intestine
5. Infectious colitis: Caused due to certain bacterial or parasitic infections

Treatment for colitis
1. Medications such as acetaminophen and ibuprofen can be recommended to ease the pain
2. The drug  Loperamide  can control the diarrhea. However, this should not be consumed if there is presence of blood in the stool
3. Colitis reduces your appetite. Thus, it is important to maintain a healthy diet in this regard. Avoid consuming dairy products or high fiber foods because they further inflame the large intestine.
4. Colectomy (surgically removing a part of the whole of the colon) is recommended in the most severe of cases.

Colitis - 5 Common Types!

Stomach problems are one of the most common issues you face. Irrespective of what your age is, it is highly likely that you have an upset stomach once in while. A stomach upset has a distinguishable characteristic -  that stomach linings as well as the small and large intestines tend to swell. This is called inflammation. The following are the most common causes of an upset stomach.

1. Viruses
Viruses are the most common causes of an upset stomach. It is highly likely that your stomach upset is because of a virus since there are so many types of them.

2. Parasites or bacteria like Salmonella and Escherichia coli
This is also a very common cause of stomach upset. Salmonella infections are usually caused by eating raw eggs, meat and meat products whereas Escherichia coli infections come from raw vegetables as well as milk and dairy products.

3. Allergic reactions
These happen very specifically to people who have a reaction to a certain type of food.

4. Excess alcohol
Most people think that alcohol will only make you pass out or get liver cirrhosis. Many people do not know that alcohol can actually adversely affect your stomach as well.

5. Excess caffeine
Caffeine is also dangerous to your stomach as taking too much of it can cause a stomach upset.

6. Fatty foods
Fatty foods such as cheese, dark chocolates, whole eggs, fatty fish, etc. are dangerous because they are harder to digest than many other types of food. This means that eating even a small amount of fatty foods are enough to cause a stomach upset sometimes.

7. Eating too much
This is also a major cause of stomach upset simply because your stomach can only digest a certain amount of food.

You must also be able to distinguish when you have a stomach infection and when you have Chron's disease as it is basically a chronic stomach upset. Chron's disease causes the whole digestive tract to be inflamed.

Common Causes Of Stomach Problems

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