Addison s disease is known as adrenal insufficiency or hypocortisolism. It is a hormonal disorder which occurs when adrenal glands which are located just above the kidneys do not produce enough of the hormone. The hormones produced by adrenal glands include cortisol and aldosterone, which are essential for a healthy life.

The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and darkening of the skin also sometimes. Most cases of Addison's disease are caused by autoimmune disorders.
It is quite a rare condition. Only 1 in 1 lakh suffer from this condition. this condition can affect a person of any age group irrespective of sex. To live a normal life people, with this condition, a patient will be required to take their medication regularly.

Cortisol and Aldosterone - What do they do?
The most important function of the cortisol in the body is to respond to stress. It helps the body in using protein, carbohydrates, and fat. It maintains blood pressure, cardiovascular function; and controls inflammation. While as aldosterone helps kidneys in regulating the amount of salt and water in the body   which helps in regulating blood volume and keeping blood pressure under control.

Cause of Addison's Disease
Mostly Addison s disease occurs due to problems with adrenal glands themselves   which is known as primary adrenal insufficiency. While Autoimmune disease accounts for 70% of Addison s disease. In this condition, the body's immune system mistakenly attacks the adrenal glands. This attack destroys the outer layer of the glands.

Some long-term infections such as tuberculosis, HIV, and some fungal infections harm the adrenal glands. It is also caused by the cancer cells that spread from other parts of the body to the adrenal glands.
Less commonly, adrenal glands can also be affected by secondary adrenal insufficiency. It is caused by a problem with the pituitary gland or a problem with the hypothalamus, both located in the center of the brain.
These glands produce hormones that control the production of hormones in the rest of the body. A pituitary hormone called ACTH which turns on cortisol production in the adrenal gland. If ACTH levels are too low, the adrenal glands do not function.
One more cause of secondary adrenal insufficiency is also caused by the prolonged or abuse of steroid hormones such as prednisone.
Symptoms of Addison's disease
The symptoms of adrenal insufficiency grow gradually and the main characteristics are:

Chronic, worsening fatigue
Muscle weakness
Loss of appetite
Weight loss
About 50 percent of the time, one will notice:

Nausea
Vomiting
Diarrhea

A Quick Guide To Addison's Disease!

 Thyroid is a small gland situated in front of the neck and secretes hormones like thyroxine (T4) and tri-iodothyronine (T3). These hormones control various functions of our body like heart, blood pressure, digestion, metabolism, growth, blood formation, brain function etc. Any fluctuation in the functioning of the thyroid gland can have a great impact on health. The thyroid gland is primarily responsible for energy and metabolism. This gland triggers the genes that make all the cells in the body conduct their specific jobs. But over a period of time, the optimum functioning of the thyroid may reduce because of specific reasons. The gland may start to under-produce or overproduce the thyroid hormone, which may lead to conditions known as hypothyroidism or hyperthyroidism, respectively. 

Patients with hypothyroidism may feel extreme tiredness and fatigue even though they may be sleeping more than before. An unexplained gain in weight, constipation, inability to stand cold temperatures, and constant pain in muscles and joints are some of the other symptoms of hypothyroidism. 
Hyperthyroidism, or overactive thyroid, is an endocrine disorder. Patients with this disorder may experience excessive sweating, fatigue, and intolerance to heat. They may even experience restlessness, puffy or protruded eyes, hair loss, and muscle weakness. Such patients may lose weight and are unable to sleep properly at night. In some cases, palpitations or abnormal heart rhythm may also be experienced. 
Complications of Thyroid Disorder 

Hypothyroid and hyperthyroid can cause a number of complications if patients don t take medications. It is important for you to not to ignore any of the aforementioned symptoms and speak to your doctor as soon as possible. 

Hypothyroid complications

Myxedema: This condition is characterized by slowed thinking, swelling of tissues, and accumulation of fluid around major organs like brain, lungs and/or heart. This condition may prove life-threatening if not treated on time. 
Enlarged goiter: This is characterized by enlargement of the thyroid gland because of a constant increase in the TSH levels. High cholesterol and triglycerides: This may eventually pave way for heart disease and stroke. 
Sleep apnea: Sleep apnea is a disorder that affects nighttime breathing where the brain that temporarily stops sending signals to the muscles that control breathing, or by an obstruction in the airway. This may prove fatal if left untreated. 
Low blood pressure: This means not enough blood is getting to capillaries and tissues, particularly in your hands, feet, and brain. You may have chronic nail fungal infections and cold hands and feet if so. 
Hyperthyroid complications 

Heart disorders (cardiac arrest): If left untreated, excess thyroid hormones can lead to congestive heart failure and heart rhythm disorders. 
Osteoporosis: Too much thyroid hormones interfere with the body s ability to use calcium to build bone. This may lead to brittle bones and osteoporosis. 
Thyrotoxic crisis: This is a rare yet life-threatening complication characterized by high fever, vomiting, irregular heartbeat, and agitation. 
Hypertension or high blood pressure: It is a condition in which a patient has high blood force striking the walls of the artery An early diagnosis can help make the treatment of this disorder easier. 
Depending on the condition of the thyroid condition, it requires different ways to manage it. The conventional TSH (thyroid-stimulating hormone) and T-4 (thyroxine) blood tests will be advised and the results should provide a reasonable confirmation of the condition. If doubts still persist an ultrasound or scan can also be ordered. In case you have a concern or query you can always consult an expert & get answers to your questions!

Is Your Thyroid Gland Working Against Your Body? 

Gestational diabetes is a condition characterized by higher than normal blood sugar levels during pregnancy. The symptoms of this disorder are mild and a blood test has to be conducted as a part of the diagnosis. In all cases, the women should be administered treatment to avoid medical complications associated with it and to be on the safer side. Proper diagnosis is absolutely essential in the case of women with prediabetes or those women who had diabetes prior to pregnancy.

When the insulin receptors fail to function normally, the blood sugar levels may rise. This is known to be one of the causes of gestational diabetes. Post pregnancy, the symptoms of gestations diabetes disappear on their own; however, such patients are an in increased risk of suffering from type 2 diabetes at a later stage. Moreover, children born to mothers with gestations diabetes are at an increased risk of suffering from conditions such as jaundice, diabetes, and certain other health issues. 

As a part of gestational diabetes treatment, the expecting mother is advised to consume a nutritious diet, practice a daily exercise regime, and monitor blood sugar levels on a regular basis. Nonetheless, if your blood sugar levels become extremely high, you may be advised to take specific medicines to control it and avoid complications. 

The following are some of the treatment methods used to manage gestational diabetes: 

Medical Treatment: Under modern medicine, the patients are prescribed antidiabetic drugs and insulin to keep blood sugar levels within the normal range.
Natural treatment: Some of the ways to naturally manage gestational diabetes include the following: 
Balanced Diet: According to several research studies, an erratic eating schedule can cause diabetes because the functioning of the body gets disrupted. For this reason, consuming a balanced diet becomes extremely important. In fact, eating small meals at an interval of two to three hours is recommended by the nutritional experts. Consequently, the body becomes accustomed to metabolizing the nutrients and blood sugar imbalances are avoided as well. 
Exercise Regime: If you are suffering from gestational diabetes, then maintaining a regular exercise regime is beneficial. At the start, you can exert the body for 30 minutes and gradually, increase the time limit. Only the low-impact exercises such as swimming and walking are advised. However, be sure to consult your doctor beforehand. 
Fiber-rich Diet: The intake of foods that are rich in fiber such as whole grains and flaxseeds is advised for women with gestational diabetes. This nutrient helps balance the insulin levels within the body by regulating the activity of the insulin receptors. During pregnancy, women are advised to increase their consumption of fiber-rich foods anyway to improve their cardiovascular and digestive health. However, the positive effect of fiber-rich foods on insulin receptors is crucial during the onset of gestational diabetes. 
Additional Dietary Recommendations: During the gestational diabetes recovery period, foods that are sources of vitamin D (such as tofu, salmon, and mushrooms) must be consumed as they foster the growth of healthy bacteria in the gut and helps to have a healthy pregnancy. Other foods that pregnant women with gestational diabetes can benefit from include foods rich in vitamin C and proteins. Also, foods that come under the category of complex carbohydrates must be consumed. Moreover, women with gestations diabetes should abstain from sugar-rich foods.
Conclusion: On a concluding note, you should note that the above treatments for gestational diabetes should be practiced only after a thorough discussion with the doctor. Keep in mind that during pregnancy you have to adopt a precarious approach; by doing so, you can prevent you and your baby from getting adversely affected.

Gestational Diabetes Management Tips!

Your thyroid is a small, butterfly-shaped gland situated at the base of the front of your neck, just below your adam's apple. Hormones produced by the thyroid gland do everything from maintaining your heart rate to regulating your body temperature to controlling your body weight. 
Millions of people worldwide suffer from thyroid dysfunction and several don't know about it. This is primarily because people don't tend to link the common symptoms first with a thyroid disease. Some people suffer from mood swings, trouble with memory, weight gain or fatigue, all of which they look upon individually as a problem and hence not piecing together the puzzle of their real medical condition. Here are a few insights that'll help you cope:
How does the thyroid gland work?
About 85% of the hormone produced by our thyroid gland is t4, which is an inactive form of the hormone. After t4 is made, a small amount of is converted into t3, which is the active form of thyroid hormone. T3 is then converted to free t3 or reverse t3. It is the free t3 that forms the base of thyroid functions. 
What is hypothyroidism?
Hypothyroidism, or an underactive thyroid, accounts for 90% of all thyroid imbalances. The signs and symptoms of hypothyroidism develop slowly, often over a number of years, which is why it is often missed from regular treatment charts. For instance, fatigue and weight gain are often attributed to stress, lifestyle changes and natural ageing process. But as time goes by, some of the symptoms show a higher level of manifestation like muscle weakness, elevated blood cholesterol, thinning hair, puffy face, hoarse voice and slowed heart rate. 
If left untreated, hypothyroidism may lead to goiter (enlarged thyroid), increased memory problems, low blood pressure, decreased breathing and in extreme cases, unresponsiveness and coma. 
This disease may also occur in newborns, infants and children. Symptoms include excessive sleepiness, poor muscle tone and constipation. It is important to diagnose and treat it early, as in severe cases it may lead to mental and / or physical retardation. In children and teens, it can result in stunted growth, and delayed puberty.
What is hyperthyroidism?
It's the opposite of hypothyroidism, which means in this case the thyroid overproduces hormones. Common symptoms include lack of sleep, weakness, irregular heartbeat, elevated blood pressure and hand tremors. While genetics are partially responsible for it, it is also triggered by autoimmune disorder. Hyperthyroidism can be treated with medication, radioactive iodine (not the first or best choice as it harms white cells too) and surgery. Keeping a focus on your calcium and sodium intake is crucial to curb the disorder.
Treatments: 
Conventional treatments rely mainly on drugs and surgery. Alternative treatments involve diet and lifestyle changes. Taking multivitamins, going gluten free, getting a good night sleep, and reducing stress is all said to help heal your thyroid gradually.

Thyroid Dysfunction and Treatment

Blood sugar control is the core of the diabetes treatment plan as by losing control over your blood sugar, you risk serious complications related to health. Frequent or ongoing irregular blood sugar levels can damage your blood vessels, nerves and organs. Irregular Blood Sugar Level is a major concern and can affect diabetic as well as general people.

The most common causes of uncontrolled blood sugar level are:
1. Skipping Insulin or oral glucose medicines.
2. Eating too many carbohydrates in general.
3. Have an infection
4. Exercising less or not at all.

Symptoms of increased sugar level in body
1. Increased Thirst: If you feel unusually thirsty and feel the urge to drink more than usual, you should check your sugar levels.
2. Frequent Urination: Excessive urination occurs when glucose builds up in your blood, and your kidney begins to work harder to get rid of the extra glucose. The excess sugar is thrown away from the body through urine.
3. Fatigue: Extreme tiredness or fatigue is common symptoms of uncontrolled blood sugar. If you do not have sufficient amount of insulin in your body, or if the insulin is not processed properly, then it stays in our blood. Hence, it does not get used up for energy.
4. Blurry Vision: High blood sugar levels can lead to swollen lenses in your eyes due to fluid leaking in, according to Joslin Diabetes Center. This changes the shape of the lens and makes it unable to focus properly, resulting in blurry vision.

How you can control the level of sugar in your body

Diet: Eat right. Consult a diabetes educator or dietician to help you figure out a healthy diet that works for you. Do share all your sugar levels, your preference with them. This would enable them to make a proper and more suitable diet plan for you, which will help you in keeping your blood sugar under control.
Exercise: To keep your blood sugar control, do exercise regularly. Exercise will increase your insulin activity, after which you don t need to as much insulin to help your body in processing carbohydrates.
Medication: Insulin is a hormone that is normally produced in the body. But for people with abnormal blood sugar level, it is either not working as it should or the body has stopped producing it. People with abnormal Blood sugar level may need to take insulin in order to keep their blood glucose levels in a healthy range. Insulin helps your body to use glucose properly.
Blood Glucose Monitoring: Monitor your blood glucose levels regularly in order to know how much insulin you require, especially before you take a meal. Keeping a check on your blood glucose levels will help you in adjusting your insulin medication as well as your meals, so that your blood sugar remains stable.

High Blood Sugar Level in Body - How Can You Control It?

Female infertility is considered as the inability of conceiving. As per WHO it is described as the inability to be pregnant, maintain and carry forward a pregnancy to its full term. It is often of two types:

    Primary Infertility: This is the inability to give birth to a baby either due to the inability to become pregnant or maintain a pregnancy, which includes stillborn and miscarriage.
    Secondary Infertility: This refers to the inability to give birth when there is already a live birth or the woman was pregnant.

The causes of infertility can vary from being acquired or genetic. However, following factors are largely responsible for infertility:

    Genetic: Some genes can lead to mutation leading to infertility like, in case of BMP15 gene there is a hypergonadotrophic ovarian failure which causes infertility.
    Acquired: This is caused by factors like age, smoking, sexually transmitted diseases, obesity, body weight, eating disorders, diseases like diabetes, thrombophilia and also radiation and chemotherapy.

The treatment for infertility usually depends on the cause, age, duration of time for which a person has been infertile and preference of the patient. Infertility is believed to be a complex disorder and the treatment involves a huge amount of physical, financial and psychological commitments. All this also requires a lot of time. Some women might need just a minimum of two therapies to attain fertility while others might require different treatment before they can conceive.

Treatment is largely aimed to restore the fertility either by means of medication and surgery or help in reproduction with the help of some procedures.

Fertility Restoration through medication

This is the main treatment for women who are infertile because of ovulation disorders. These drugs include:

    Gonadotropins: These are injected to stimulate the ovaries. Drugs like Menopur, Repronex, Follistim AQ, Gonal-F, Bravelle restore the production of eggs, while Ovidrel and Pregnyl are used for maturing the eggs and for their release.
    Clomiphene citrate: This is taken orally and stimulates ovulation by releasing more Follicle Stimulating Hormone and Luteinizing Hormone from the pituitary gland.
    Metformin: This is used in females who have PCOS and also when insulin resistance plays a major role in infertility.
    Bromocriptine: Used when the infertility is caused due to excess prolactin production.
    Letrozole: This also induces ovulation

Fertility Restoration through surgery

Surgical procedures can amend the problem of infertility. However, these treatments are very rare these days owing to the success of other fertility treatments. These include:

    Tubal ligation reversal surgery: In case a tubal ligation has been performed it can be reversed by reconnecting the tubes again through surgery.
    Hysteroscopic surgery: This corrects or removes the abnormalities that cause infertility. This surgery can correct the shape of the uterus, remove endometrial polyps and improve chance of getting pregnant.
    Tubal surgeries: In case of blocked fallopian tubes laproscopic surgery can be performed to dilate the tubes, removed blockages or create a new opening.

Assistance in Reproduction through techniques

The most common used techniques for reproduction assistance are:

    Intrauterine insemination or IUI: In this about million healthy sperms are put in the uterus at the time of ovulation.
    Assisted reproductive technology: In this mature eggs are retrieved from a woman and this is then fertilized with sperms in a dish in the lab. Once the fertilization is done the embryo is placed in the uterus for further development. IVF is the most common and effective assisted reproductive technology. This procedure takes place over weeks with several blood tests and hormone injections.

Dealing with infertility is not easy and can be emotionally and physically draining. To cope with the various tests and treatments of infertility one should be fully prepared, eat a healthy diet, exercise reach out for help and support of family and friends and look for other options like a donor egg, adoption or no children.

Treatments of Infertility

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