People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

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Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

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	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

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Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

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	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

Type 1 diabetes occurs when your pancreas is unable to produce enough insulin to keep the blood sugar ;levels under control. The condition, if not managed properly, can lead to related health disorders and complications, both long-term and short-term.

Health problems arising from type 1 diabetes

Type 1 diabetes can have severe effects on your eyes, kidney, nervous system, and heart health. The most common ailments associated with type 1 diabetes may include the following-

1. Diabetic retinopathy

Diabetic retinopathy is a disease of the eyes, which occurs when the blood vessels in the retina (tissue present at the back of your eyes) are damaged. The walls of the retina gradually weaken from increasing blood pressure and blood sugar levels, and this leads to leakage of blood or fluid into the nearby tissues.

Early symptoms of diabetic retinopathy include-


	
	Blurred vision
	
	
	Floaters
	
	
	Difficulty perceiving colors
	


2. ;Diabetic neuropathy

Diabetic neuropathy unfolds when the nerves are damaged due to type 1 diabetes. The condition mostly affects your feet and legs. Reduced blood circulation due to high blood glucose impedes normal wound healing in the extremities, hence, even a minor bruise ;can develop into a permanent injury.

Symptoms of diabetic neuropathy are-


	
	Numbness
	
	
	Reduced sensation
	
	
	Severe, debilitating pain in the extremities
	


3. Diabetic nephropathy

Also known as ;diabetic kidney disease, the condition is a slow deterioration of the kidney and its ability to function properly. In severe cases, where the levels of blood glucose are extremely high due to type 1 diabetes, diabetic nephropathy can ultimately result in kidney failure ;or end-stage renal disease (esrd).

The following are the symptoms of diabetic nephropathy-


	
	Dark urine
	
	
	Swollen ankles, feet, eyes, or hands
	
	
	Shortness of breath
	


4. Cardiovascular diseases

Cardiovascular diseases refer to a range of heart conditions including blood clots and diseased blood vessels. High blood glucose levels resulting from type 1 diabetes can contribute to the deposition of fat in the walls of the blood vessel. Over time, this may restrict the flow of blood and put you at risk of cardiovascular disorders such as coronary artery disease, stroke, or even ;heart attack.

Symptoms of cardiovascular diseases widely vary, ranging from palpitations ;to chest pain. Sometimes, such a condition may not exhibit any symptoms at all.

Type 1 diabetes complications are related to poor management of blood glucose. The best way to monitor the condition and control the symptoms is to get in touch with your doctor. A specialist in this field can prescribe the correct treatment and help prevent the onset the related health disorders.

Complications Associated With Type 1 Diabetes

When abnormal cells grow inside the brain and are in the form of a mass the condition is called a brain tumour. However, on the other hand, brain cancer is a disease of the brain in which cancer cells (malignant cells) arise in the brain tissue. Cancer cells grow to form a mass of cancer tissue (tumour) that interferes with brain functions such as muscle control, sensation, memory, and other normal body functions. 

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Some brain tumours are cancerous while others fall under the category of non-cancerous ones.

Brain cancer is actually the abnormal growth and uncontrolled growth of the cancer cells in the brain, that forms a tumour in the brain. Tumours can be either benign or malignant.

Benign brain tumours are abnormal collections of cells that reproduce slowly and usually remain separate from the surrounding normal brain.

Malignant tumours reproduce and grow quickly. Their borders are hard to distinguish from the normal brain around them.

 

The underlying cause of primary brain cancer, cancer that begins in the brain, is not known. Secondary brain cancer is caused by a cancer of another organ in the body, such as the breast, prostate, kidney, skin, or bone, that has spread to the brain.

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The brain tumours originate in the brain itself. Tumours start to develop if there are mutations in the dna. It is because of these mutations that cells of the brain increasingly grow and divide. Usually, in adults, the primary brain tumours are uncommon in comparison to the secondary brain tumours.


 

There are few early symptoms of brain cancer, but as the tumour grows within the confines of the skull, it causes increased intracranial pressure and exerts pressure on the brain, causing signs to develop.


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Brain cancer occurs when there is an uncontrolled growth of cancer cells in the brain that form a malignant brain tumour. The underlying cause of primary brain cancer, cancer that begins in the brain, is not known. Secondary brain cancer is caused by a cancer of another organ in the body, such as the breast, prostate, kidney, skin, or bone, that has spread to the brain.


 

What Is The Significant Difference Between Brain Tumour And Brain Cancer?

Environmental factors play a quintessential role in affecting our health. Fresh air, fresh food and fresh water, not only strengthen our body and mind but also make our life worth living. Contrary to this bad environment hampers the quality of life. This is the main reason why people from hill stations or the countryside seem to be healthier than those living in polluted urban cities. Following are the environmental factors that affect your health:

Polluted air

The health effects of polluted air are several. Not many people know that one-third of the deaths are caused because of strokes, lung cancer and heart failure. Air pollution is the chief reason behind these chronic ailments. The other life-threatening diseases caused by polluted air is- asthma or bronchitis. Smoke from machines, vehicles outside, and stoves, the burning of fuels inside can cause breathing problems and wheezing. 

Dirty environment

A dirty environment often leads to the breeding of insects and bacteria that become carriers of life-threatening diseases such as dengue, typhoid, diphtheria, malaria, and so on. Most of the diseases mentioned here are caused by mosquitoes that thrive on stagnant water.

Toxic food ;

The environmental quality of a region has a direct impact on the food produced in that area. Both vegetarian and non-vegetarian food faces the danger of becoming toxic if the environment it is being grown in is polluted. For eg- chemical wastes that are often dumped in water bodies cause the seafood in that area to become highly toxic.

Chemical pollutants

Cancer nowadays is becoming a household disease. The major reason behind this is that technological development has brought new categories of pollutants. Many of these contain chemicals and compounds that are carcinogenic in nature. This ultimately leads to the development of cancer in most people. 

Climate change and natural calamities

Change in climate disrupts the functioning of nature in many ways that further impact the health of humans. These changes include- the natural temperature of the planet, heavy rainfalls and sandstorms. The numerous impacts of climate may result in a high risk of nervous and respiratory diseases. ;

Hence protecting the environment is extremely important for the life of a human being. The change will come after taking small steps. Numerous small steps can really make a difference. 

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Environmental Factors That Affect Health

What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

Your body needs some cholesterol to produce hormones and vitamins that help in digestion. Two types of lipoproteins   ldl cholesterol and hdl cholesterol   are responsible for carrying cholesterol to and from the cells in your body.

Hdl or high-density cholesterol is good cholesterol. It carries bad cholesterol away from the arteries and other body parts back to the liver to be processed by the liver.

Ldl or low-density cholesterol, also known as the bad cholesterol, contributes to fatty build-ups within the arteries. This results in narrowing of the arteries and increases your risk of cardiovascular diseases like pad, heart attack, or even stroke.

Although there are medications to bring down ldl cholesterol levels, your doctor may recommend using therapeutic lifestyle changes to see how well your cholesterol levels can be managed without medications.

How to reduce  bad  cholesterol naturally

You can lower ldl cholesterol levels naturally with the following measures  

Diet and weight loss

Being obese or overweight not only increases the odds of developing high ldl levels but also contributes to cardiac diseases and chronic conditions. Studies suggest that losing even a little weight may help reduce ldl levels.

Your diet plays an important role in losing excess fat and maintaining ideal body weight. Eating the right kind of food   such as those that contain a good amount of monosaturated fats, phytosterols and soluble fibre   can help lower harmful ldl cholesterol and increase the levels of hdl cholesterol in the blood. Focus on eating whole grains, fruits and leafy vegetables, legumes, nuts and seeds, and fatty fish.

Exercise more often

Exercising regularly, in moderate amounts, can bring down your cholesterol levels and promote weight loss. Any form of cardiovascular activity, such as cycling, running, swimming and jogging benefits your heart health. You may also turn to other forms of exercise   weight training or yoga   as they also work to decrease the levels of bad cholesterol.

Quit smoking

Smoking causes a number of chemical changes in your body. Cigarette smoke increases bad cholesterol (ldl) and triglycerides levels. This leads to the accumulation of waxy plaque, which clogs the arteries. At the same time, smoking reduces the level of good cholesterol   the one that prevents the formation of plaque in your blood. Quit smoking and turn to a healthier lifestyle to see a difference in the levels of your ldl cholesterol.

Limit alcohol consumption

According to studies, heavy alcohol consumption or drinking more than what is considered moderate significantly increases bad cholesterol, which again raises triglyceride levels and ldl cholesterol.

Lifestyle changes are the natural and first line of treatment for people with high cholesterol levels. However, if your doctor suspects these levels could put you at risk of other medical conditions, he/she might recommend medications to manage bad cholesterol.

Reduce LDL Cholesterol With These Easy Steps

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