Addison s disease is considered to be a life threatening and serious illness. When one suffers from this disease, the amount of hormones like Aldosterone and Cortisol reduces rapidly due to the poor functioning of the Adrenal glands. The hormones that the Adrenal glands produce are necessary for the body to function normally. To better understand what Addison s disease is all about, below are some basic facts.

Fact 1: Addison s disease is often confused or linked with adrenal insufficiency. However, Addison s disease is more of an autoimmune disorder that later leads to adrenal insufficiency, which is a hormone-related imbalance.
Fact 2: Addison s disease can happen to anyone regardless of their gender or age. However, genetics may also have a role to play here, as those who have someone affected with Addison s in the family, face greater risks.
Fact 3: While for someone it may take years for totally disrupting the hormone production, for some it may grow worse very quickly. Though it is rare, it is possible.
Fact 4: The symptoms of Addison s disease often get unnoticed or misinterpreted, as the disease is very uncommon. This is a rare disease that occurs in one in a million.
Fact 5: When suspected of having Addison s disease, the screening process doesn t take much time. Generally, a normal blood test showing the amounts of ACTH and cortisol hormone will confirm the diagnosis.
Fact 6: Some very common symptoms of this disease are mild to severe pain in the bones and in the abdomen, weight loss, nausea, forgetfulness, low blood pressure and lack of energy. It is these common symptoms that can point to numerous other conditions that make its diagnosis a tricky one.
Fact-7: Sometimes, Addison's disease may cause the skin tone to become darker due to the hormonal changes. It is probably the only disease that can cause such darkening or skin discolorations of the otherwise normal skin.
Fact 8: People who have Addison s disease generally become dependent on the daily intake of cortisol medications or steroids. Without Cortisol, the stress hormone, the body may go into serious adrenal crisis.
Fact 9: When overlooked for a long time or not provided with the treatment and medication when needed, Addison's disease may lead to sudden organ failure. Therefore, understanding the symptoms and opting for a blood test is essential if this disease is suspected.
Fact 10: Lastly, Addison's disease can be easily cured and treated by introducing a few serious lifestyle changes and hormonal therapies. Sometimes when oral hormone supplements fail to get properly absorbed, injecting the supplements becomes necessary.
Studies have shown that around 140 people approximately suffers from Addison's disease out of every million. Therefore, knowing the above-mentioned facts becomes necessary for have a clear understanding of the disease which may help in dealing with it in the best way possible.

Addison's Disease - 10 Interesting Facts You Must Know!

While cold and cough are common, diseases like Addison s disease are rare. It is also known as chronic adrenal insufficiency or hypocortisolism as it is a result of insufficient production of hormones like cortisol and aldosterone by the adrenal glands. This disease can affect men and women of any age.

There are two types of Addison s disease. These are:

    Primary adrenal insufficiency: In this case, the adrenal glands themselves have a problem.
    Secondary adrenal insufficiency: If the hormone production in the adrenal glands is restricted by a problem that has started somewhere else like the pituitary gland, for example, it is known as secondary adrenal insufficiency.

Primary adrenal insufficiency is more common of the two. This could be triggered as a result of autoimmune diseases or a long lasting infection such as HIV, tuberculosis and some fungal infections. Cancer can also cause this type of Addison s disease.

Secondary adrenal insufficiency is usually caused by a problem with the pituitary gland or the hypothalamus as they are responsible for the production of hormones that stimulate the adrenal glands. Damage caused to the pituitary gland by tumors or radiation and surgery can also interfere with hormone production. Prolonged and improper use of steroid hormones can also trigger this condition.

Addison s disease has a very slow progression and its symptoms develop gradually over time. Some of these symptoms are:

    Weight loss and loss of appetite
    Extreme fatigue
    Hyperpigmentation
    Low blood pressure
    Craving for salt
    Nausea and diarrhea
    Pain in the abdomen and joint pains
    Irritability
    Depression
    Loss of body hair and sexual dysfunction in women

Treatment for Addison s disease involves hormone replacement therapy. This aims at correcting the hormone levels in the body. Hormone replacement therapy includes oral corticosteroids and corticosteroid injections. The dosage of these steroids could vary depending on the situation. For example, the doctor may suggest a temporary high dosage when the patient is in a stressful condition. Along with this, sodium is also recommended especially during the summer months and while exercising. This medication must be taken regularly as skipping a single dose can be dangerous.

In some cases this condition can become life threatening. An addisonian crisis causes a drop in blood pressure, sugar and a spike in potassium levels in the body. This requires immediate medical attention and can be treated with intravenous injections of hydrocortisone, saline solution and sugar.

Addison's Disease - What You Should Know About it

Thyroid disorders are associated with the thyroid gland. A thyroid gland is a butterfly-shaped gland situated right at the base of one s neck. The role of the thyroid gland is to carry out numerous metabolic processes within the body. The brain regulates the functioning of the thyroid gland through a feedback mechanism. There are a number of disorders, both severe and trivial, which could affect the thyroid gland.

Main symptoms of thyroid disorders:

Weight loss and weight gain

Changes in heart rate (arrhythmia)

Hair loss

Frequent mood swings

Swollen neck

Sudden bouts of moderate to high fever

Other symptoms include:

Numbness or a tingling sensation in the hands

Constipation

Abnormalities or irregularities in menstruation

Brittle nails and dry skin

Blurred vision

Weakened muscle tone and frequent tremors in the body

Treatment Options:

Intake of thyroid hormone pills may prove beneficial. Once you start with the treatment, you may notice significant improvement within the first two or three weeks. Generally, once affected by thyroid disorders, one might have to be on these medications his/her entire life. Over time, this treatment procedure should result in lowering of the cholesterol levels, increased energy; but in certain cases, might throw up side effects in the form of sudden and unexplained weight loss.



Anti-thyroid medications help reduce and regulate the secretion of the thyroid hormone, thus treating certain thyroid disorders (such as hyperthyroidism).

Beta blockers are drugs help in reducing high blood pressure, heart palpitations and controlling heart rate.

In severe cases, such as enlargement of the thyroid gland, surgery is advised by the doctor, in which the thyroid gland is removed. Tumors or thyroid nodules are also treated by this surgical process.

In cases of thyroid cancer, besides the surgical procedure, radioactive iodine therapy (radioiodine) is recommended. This therapy helps destroy the thyroid gland and other thyroid (malignant) cells which may be taking up iodine. However, the side effects of this technique are minimal. This procedure helps to destroy those tissues which may not have been removed by the surgery. If the thyroid cancer has spread to the lymph nodes or to other parts within the body, this particular mode of treatment can be very effective.

Types of Thyroid Disorders:

Hypothyroidism: This is a condition characterized by an underactive thyroid gland. In this case, sufficient thyroid hormone is not secreted in the body.

Hyperthyroidism: This is characterized by an overactive thyroid gland, that results in overproduction of the thyroid hormone.

Thyroid cancer: It is a type of cancer of the thyroid gland.

Goiter: This is a disorder wherein the thyroid gland gets abnormally enlarged.

Thyroid nodules: This is marked by swelling of the thyroid gland. If you wish to discuss about any specific problem, you can consult a endocrinologist and ask a free question.

Thyroid Disorders: Symptoms, Treatment and Types

Do you feel extremely tired many times in a day? Are you experiencing sudden weight gain, chills at night and hair loss? Is your neck a bit bloated up? If you are experiencing any of the mentioned symptoms, it might be that your body regulator- Thyroid- is unbalanced. Quick 3 tests can help you detect any abnormality - TSH, T3 and T4. Women were three times more likely to be affected by thyroid dysfunction than men. 1 in 10 adults in India suffers from hypothyroidism, with 50 per cent being women.

What is the thyroid gland?
The thyroid is a butterfly shaped gland in the front of the neck. It produces hormones that control the speed of your metabolism - the system that helps the body use energy. Thyroid disorders can slow down or rev up your metabolism by disrupting the production of thyroid hormones. When hormone levels become too low or too high, you may experience a wide range of symptoms.

What are the Symptoms?
Thyroid can be of 2 types - Hyper (Overactive) and Hypo (Underactive) Thyroid.
Low and Underactive Thyroid High and Overactive Thyroid
Fatigue Nervousness
Dry Skin & Hair Tremors - Hand Shaking
Brittle Hair Hair loss or thinning hair
Constipation Diarrhea
Low Pulse High Pulse
Weight Gain Weight loss without trying
Intolerance to cold temperature Intolerance to hot temperature
Depression Sweatiness
Swelling in lower part of neck Swelling in lower part of neck

The swelling in the neck is a major and most significant feature. Hence one should always do the Self Neck Test.

Who should be tested?
Women aged 35 and above or those with symptoms/risk factors/family history are the right candidates for screening. It has been estimated that 75% of the people suffering from thyroid are undiagnosed.

Diagnosing thyroid disorders - A simple blood test can provide an answer. TSH (Thyroid Stimulating Hormone) levels determine thyroid hypo and hyper function as it regulates the work of thyroid gland. Rarely an imaging study or biopsy is needed. Two additional tests may be required - T3 and T4.

What happens if Thyroid remains undetected?
As Thyroid disorders are hormonal imbalances, undetection can lead to a number of secondary complications:
Obesity
High Cholesterol and Hypertension
Hair Fall
Heart Disease
Complications in pregnancy

Understanding Thyroid Problems in Women: Did You Get the Test Done?

Addison s disease is known as adrenal insufficiency or hypocortisolism. It is a hormonal disorder which occurs when adrenal glands which are located just above the kidneys do not produce enough of the hormone. The hormones produced by adrenal glands include cortisol and aldosterone, which are essential for a healthy life.

The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and darkening of the skin also sometimes. Most cases of Addison's disease are caused by autoimmune disorders.
It is quite a rare condition. Only 1 in 1 lakh suffer from this condition. this condition can affect a person of any age group irrespective of sex. To live a normal life people, with this condition, a patient will be required to take their medication regularly.

Cortisol and Aldosterone - What do they do?
The most important function of the cortisol in the body is to respond to stress. It helps the body in using protein, carbohydrates, and fat. It maintains blood pressure, cardiovascular function; and controls inflammation. While as aldosterone helps kidneys in regulating the amount of salt and water in the body   which helps in regulating blood volume and keeping blood pressure under control.

Cause of Addison's Disease
Mostly Addison s disease occurs due to problems with adrenal glands themselves   which is known as primary adrenal insufficiency. While Autoimmune disease accounts for 70% of Addison s disease. In this condition, the body's immune system mistakenly attacks the adrenal glands. This attack destroys the outer layer of the glands.

Some long-term infections such as tuberculosis, HIV, and some fungal infections harm the adrenal glands. It is also caused by the cancer cells that spread from other parts of the body to the adrenal glands.
Less commonly, adrenal glands can also be affected by secondary adrenal insufficiency. It is caused by a problem with the pituitary gland or a problem with the hypothalamus, both located in the center of the brain.
These glands produce hormones that control the production of hormones in the rest of the body. A pituitary hormone called ACTH which turns on cortisol production in the adrenal gland. If ACTH levels are too low, the adrenal glands do not function.
One more cause of secondary adrenal insufficiency is also caused by the prolonged or abuse of steroid hormones such as prednisone.
Symptoms of Addison's disease
The symptoms of adrenal insufficiency grow gradually and the main characteristics are:

Chronic, worsening fatigue
Muscle weakness
Loss of appetite
Weight loss
About 50 percent of the time, one will notice:

Nausea
Vomiting
Diarrhea

A Quick Guide To Addison's Disease!

Infertility is a very common problem among both men and women and it refers to the inability to conceive even after regular unprotected sex. The causes of this can be varied and some of the most prominent ones are:

Causes in Women:

1. Polycystic ovarian syndrome

PCOS is a medical condition in women in which they do not ovulate. It is a major cause of infertility in most women. It can often result in irregular menstruation and an increase in the release of male hormones in the female body. This causes male symptoms like the growth of a beard, hoarse voice etc. in females. The probable causes of this condition comprise being over or under weight, thyroid imbalance etc. It is possible to treat this condition with medical aid and weight management can also prove to be helpful.

2. Lack of sufficient healthy eggs

As you grow in age, the number and health of your eggs decline significantly. This could be a possible reason for your infertility. In this condition, optimizing egg health by maintaining a healthy weight and quitting alcohol and cigarettes can help you get rid of your infertility.

3. Blockage of the fallopian tubes

Blockage of or damage to the fallopian tubes causes the tubal factor that is responsible for infertility in women. The tubal factor can also be a result of endometriosis or any sexually transmitted disease like Chlamydia etc.

Causes in Men:

1. Ejaculatory disorders

Retrograde ejaculation, premature ejaculation, and other issues associated with ejaculation may cause infertility in men. In retrograde ejaculation, the semen enters the bladder instead of emerging out of the penis during orgasm. In premature ejaculation, the ejaculation occurs before the vagina is prepared to receive the semen.

2. Chromosome defects

Disorders like Klinefelter's syndrome can cause abnormal growth of the male reproductive organs resulting in infertility. Other such syndromes include Kallmann's syndrome, Karatagener's syndrome, cystic fibrosis etc. These conditions are mostly genetic.

3. Hormonal imbalance

Male infertility can also be a result of hormonal imbalances like hypogonadism (low testosterone levels), disorders of the testicles, abnormal functioning of the pituitary, thyroid, adrenal and the other glands as well.

6 Common Causes of Infertility That are also Curable

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