The adrenal glands, which sit above the kidneys, are very important to your body as they secrete many important hormones. These hormones are required to regulate many functions within the body. The two most important hormones that these glands produce are  cortisol  and  aldosterone . When your body suffers from the condition of Addison s disease, the glands end up producing very little amounts of these hormones. This will result in many functions in the body being adversely affected.


How do you know your loved one is suffering from Addison s disease?
Addison s disease develops overtime and doesn t happen immediately. However, you would be able to notice some of the following symptoms:
Drop in blood pressure which may result in fainting as well
Development of darker skin due to hyperpigmentation
Development of hypoglycemia or low blood sugar
Unexpected weight loss and a decreased appetite in general 
Craving for salt
Extreme fatigue
Irritability and depression
Vomiting, nausea and diarrhea 
Muscle and joint pains
Abdominal pains
Of these, if you start seeing a combination of frequent hyperpigmentation, muscle and joint pains, nausea, vomiting, abdominal pain, extreme fatigue and unexplained weight loss, you should take your loved one to the doctor immediately as these are telltale signs of Addison s disease.


Diagnosis
There are no ways to self-diagnose this disease as it requires proper medical tests. Some of the medical tests that may be advised for this are:
Blood tests: These are done to measure the levels of sodium, potassium and cortisol in your blood.
ACTH tests: This is a test to determine the exact levels of  cortisol  in your blood and whether it is being produced normally or not.
Hypoglycemia test: This is a test to measure whether adrenal glands are producing enough hormones to regulate insulin. If blood sugar is low, it will indicate problems with the adrenal glands.
Imaging tests: Other tests, such as CT scans may also be prescribed to detect problems within your adrenal glands.


Steps to manage Addison s disease 
Pay regular visits to your doctor: This is very important along with regular tests and checkups as other dependent functions may be damaged and suddenly become life threatening. It may fall on you to take your loved one to a doctor regularly for this reason.
Carry bracelets which have your medical information: If your loved one has a tendency to faint due to the problems caused by Addison s disease, it is important that you ensure they always carry bracelets with medical information with them. This way, strangers will be able to recognize the problem and get help quickly in emergency situations. 
Always keep extra medications: This is a very important point as missing a couple of daily doses and medication can result in sudden deterioration of your loved one's  condition. Have all other forms of administering medications handy as well such as syringes among others.

Addison's disease - How to Support a Loved One Suffering from it?

Pregnancy is a time when women need to be in the best of their health. Yet, there are various kinds of conditions and ailments that a pregnant woman can suffer from. One of them is gestational diabetes mellitus. Gestational diabetes is a type of diabetes mellitus that usually afflicts pregnant women who are suffering from high glucose levels in their blood. Let us get to know more about this condition.

Timing: gestational diabetes strikes an expecting mother around the third trimester. This is usually the time when pregnant women exhibit levels that are higher than normal. This may be due to the fact that the placental lactogen can block the action of the insulin receptors, leading to a spike in blood sugar levels.&nbsp;

Past history of diabetes: women who have not previously witnessed a rise in their blood sugar levels or any previous diagnosis of diabetes can also end up contracting gestational diabetes during their pregnancy due to an ineffective insulin response of the body and its chemicals. Also, after suffering from gestational diabetes, women are at a higher risk of suffering from type 2 diabetes mellitus, thereafter.&nbsp;

Untreated gestational diabetes: the children born to mothers, who were not treated properly for gestational diabetes, are usually at risk of various other ailments. These children may be prone to complications during delivery. After birth, they are prone to various issues like low blood sugar levels as well as jaundice. These children may not be able to enjoy a normal delivery, and may have to be delivered via caesarean section, and even face premature delivery.&nbsp;

Food: it is important to monitor the blood sugar levels in gestational diabetes. One of the best ways to do this is to follow a proper diet plan. The food in the diet of these expecting mothers should include dietary fibres, carbohydrates and other nutrients like protein, calcium and iron. It is important to break the meals down into smaller portions or mini meals so that the insulin inhibitors can do their work more effectively, even as the body and the baby remain nourished.&nbsp;

Exercise: while most forms of exercise are discouraged during pregnancy, it is always a good idea to remain fit by doing your chores and walking. Pre-natal yoga can also help by introducing certain yogic poses that are good for expecting mothers. Gestational diabetes can also be tackled with the help of exercises like walking.&nbsp;
Gestational diabetes must be treated on time, and properly, so as to avoid complications for the baby and mother during and after birth.


Things To Know About Gestational Diabestes

Addison s disease is known as adrenal insufficiency or hypocortisolism. It is a hormonal disorder which occurs when adrenal glands which are located just above the kidneys do not produce enough of the hormone. The hormones produced by adrenal glands include cortisol and aldosterone, which are essential for a healthy life.

The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and darkening of the skin also sometimes. Most cases of Addison's disease are caused by autoimmune disorders.
It is quite a rare condition. Only 1 in 1 lakh suffer from this condition. this condition can affect a person of any age group irrespective of sex. To live a normal life people, with this condition, a patient will be required to take their medication regularly.

Cortisol and Aldosterone - What do they do?
The most important function of the cortisol in the body is to respond to stress. It helps the body in using protein, carbohydrates, and fat. It maintains blood pressure, cardiovascular function; and controls inflammation. While as aldosterone helps kidneys in regulating the amount of salt and water in the body   which helps in regulating blood volume and keeping blood pressure under control.

Cause of Addison's Disease
Mostly Addison s disease occurs due to problems with adrenal glands themselves   which is known as primary adrenal insufficiency. While Autoimmune disease accounts for 70% of Addison s disease. In this condition, the body's immune system mistakenly attacks the adrenal glands. This attack destroys the outer layer of the glands.

Some long-term infections such as tuberculosis, HIV, and some fungal infections harm the adrenal glands. It is also caused by the cancer cells that spread from other parts of the body to the adrenal glands.
Less commonly, adrenal glands can also be affected by secondary adrenal insufficiency. It is caused by a problem with the pituitary gland or a problem with the hypothalamus, both located in the center of the brain.
These glands produce hormones that control the production of hormones in the rest of the body. A pituitary hormone called ACTH which turns on cortisol production in the adrenal gland. If ACTH levels are too low, the adrenal glands do not function.
One more cause of secondary adrenal insufficiency is also caused by the prolonged or abuse of steroid hormones such as prednisone.
Symptoms of Addison's disease
The symptoms of adrenal insufficiency grow gradually and the main characteristics are:

Chronic, worsening fatigue
Muscle weakness
Loss of appetite
Weight loss
About 50 percent of the time, one will notice:

Nausea
Vomiting
Diarrhea

A Quick Guide To Addison's Disease!

How many of us know that a deficiency of Vitamin B6, also known as pyridoxine can make you susceptible for heart disease, brain degenerative diseases like Alzheimer s as well as muscle pain, depression and dragging fatigue?

Vitamin B6 is one of the most crucial vitamins for health and it s a part of the vitamin B complex family. Now, all B vitamins, including vitamin B6, play an important role in a number of life-altering physical and psychological functions. All of them have a vital role to play in helping to maintain a healthy metabolism, nerve and liver function as well as skin and eye health, as well as good amount of energy levels.

Role of Vitamin B6
Vitamin B6 or pyridoxine has a number of derivatives, including pyridoxal, pyridoxal 5-phosphate and pyridoxamine. And all of these are involved in major body functions like movement, memory, energy use and blood flow. This is the primary reason why a vitamin B6 deficiency can show up in a range of symptoms from physical to psychological, temporary to chronic and serious.
Vitamin B6 also helps your body to

Maintain a healthy nervous system

To make more hemoglobin, blood cells that carry oxygen in blood
To provide energy from our food
To balance blood sugar levels
To act as a natural pain relief
To boost mood
To create antibodies for self-protection
Preventing a Vitamin B6 Deficiency
The recommended amount of vitamin B6 for an adult under the age of 50 is 1.3 milligrams. Normally, this amount is easy to get from your diet, assuming you are eating a balanced diet with enough calories. However, the amount the body s requirement for vitamin B6 jumps up as you age. Experts recommend that adults over 50 get up to 1.7 milligram daily of this vitamin.

As this requirement is not met, older people get more prone to a vitamin B6 deficiency and so do malnourished children and adults. Foods like poultry, pork, nuts and beans contain high levels of vitamin B6 and you can include more of these to get the recommended dose of vitamin B6. However, since vitamin B6 is a water-soluble vitamin, so you need to replenish your body with it daily as it doesn t get stored in the body.

Symptoms of Vitamin B6 deficiency:
Lack of energy and chronic fatigue: Vitamin B6 helps supply your body with energy by improving your metabolism. It has a vital role to play in protein metabolism   it helps your body break down the protein that you eat and produce energy quickly. So one very important pointer that you have a vitamin B6 deficiency is when you get fatigued quickly during exercise.
Brain function decline: Vitamin B6 vitamin helps your brain communicate with other parts of the body more efficiently. So, if you have a decline in muscle efficiency it could be a sign of vitamin B6 deficiency.
High Levels of amino acid Homocysteine: High levels of amino acid Homocysteine do not cause any symptoms that you can detect by yourself but tests can tell you if you have high levels of this amino acid in your body. And these high levels are directly linked to vitamin B6 deficiency. What high levels of homocysteine can do is cause heart attacks. But vitamin B6 helps keep a check on these levels to reduce your risk for a cardiovascular event.

Other symptoms of vitamin B6 deficiency are:

Changes in mood, such as depression, irritability, and anxiety
Confusion
Muscle pains
Fatigue
A worsening of PMS symptoms
And worsening of symptoms of anemia
As vitamin B6 is so important for nerve function, a deficiency is linked with neuro-psychiatric disorders like seizures, migraines, and chronic pain.
An increased risk of heart disease and rheumatoid arthritis
Higher risk for Alzheimer s disease and other forms of dementia.

Vitamin B6 Deficiency- Signs You Are Suffering From It!

If you are suffering from hypothyroidism, it is important for you to deal with the condition so that your daily life and activities do not get affected. Hypothyroidism occurs when your thyroid gland becomes under active and does not produces sufficient amount of hormones. This affects the metabolism rate of your body. Hypothyroidism has several symptoms which include fatigue, constipation, dry skin, muscle cramping, hoarse voice, depression, sudden gain of weight and brittle hair and fingernails.

Here are some important tips which you should follow in order to deal with hypothyroidism and for its treatment:

Go Gluten and A1 Casein free: Common allergies and food intolerance, which occur today are because of wheat and dairy products because of the hybridized proteins of A1 casein and gluten. These may lead to a leaky gut, as a result of which inflammation of the thyroid gland takes place. This affects the thyroid s functioning. You should avoid grain and gluten in your diet. Try to consume dairy products coming from A2 cow s milk.
Avoid BPA: Bisphenol A or BPA is present in plastic bottles. These are capable of disrupting the endocrine system and also affect the thyroid gland. You should avoid drinking from plastic bottles and drink water from glass, stainless steel and plastic bottles which are BPA free.
Check your iodine levels: In case your iodine levels are low, you should use an organic liquid supplement. Kelp is ideal for this purpose.
Heavy metal detox: You need to detoxify your body and eliminate traces of harmful metals from your organs and cells. For this, you may use a combination of milk, turmeric, chlorella, cilantro and thistle, which are ideal for a metal detox.
Increase your selenium intake: It is important for you to consume sufficient amounts of selenium in your everyday diet, but you should not consume them in excess. You should eat food items containing selenium in good amount such as salmon, sunflower seeds, Brazil nuts, mushrooms, onions and beef.
Take adaptogen supplements: You should lower your cortisol levels and improve thyroid functioning by taking supplements such as tulsi and ashwaganda.
Remove silver fillings: If you have amalgam fillings, you should consult a dentist and get the fillings removed.
Lower your carbohydrate intake: You also need to reduce the amount of sugar and grains in your regular diet. Instead, take healthy fats. Consuming too much carbohydrates leads to increased estrogen, which affects thyroid negatively. Choose healthy fats like coconut oils, avocado, wild salmon, hemp seeds and flax seeds. These will help in balancing your hormone levels.
Hypothyroidism usually occurs from common causes such as toxicity due to radiation and metal exposure, deficiency of iodine and selenium, food intolerance and hormonal imbalance due to stress and excess carbohydrates.

Hypothyroidism - 8 Tips To Help You Deal With It!

The body has multiple chemicals called hormones, which regulate many of its functions. Increased or decreased levels of these hormones affect various functions including metabolism, growth and sexual functions. Thyroxin produced by the thyroid (situated in the front of the neck) is one such hormone, which has a significant role to play in metabolism.

Graves  disease is one of the main causes of hyperthyroidism, where there is excessive production of thyroid hormones. Graves  disease is an autoimmune disorder, wherein the body reacts against its own tissues. It is very common in women than men, especially after 20 years of age. Family history also has a strong correlation in developing Graves  disease. The high levels of thyroid hormone increase the rate of metabolism, thereby altering weight, mental energy levels, physical stamina, and also mood.

Thyroid hormone is related to metabolism and more amount of it lead to higher metabolism. This causes the following symptoms.

    Intolerance to heat
    Excessive sweating
    Nervousness and anxiety
    Inability sleep, as the mind is always excited
    Increased appetite (sometimes despite weight loss) due to higher metabolism
    Irregular menstrual cycles
    Palpitations (rapid, loud heartbeat)
    Irregular heartbeats (tachyarrhythmia)
    Fine tremors of the extended arms
    Breast enlargement in men, known as gynecomastia
    Extreme moodiness, causing irritability and anger
    Inability to focus and concentrate
    General fatigue and shortness of breath with any exertion
    Increased frequency of bowel movements

In addition, the eye symptoms are quite diagnostic including:

    Protrusion of the eyes (exophthalmos), giving an impression that they are going to fall out
    Double vision
    Excessive tearing
    Increased irritation in the eyes

Diagnosis: The first symptom would be the presence of an enlarged thyroid gland (front of the neck above the collarbone), and the some of the above symptoms would be present.
In addition, tests to check for thyroid gland functioning including T3 and T4 levels would reveal increased amounts of hormone in the blood stream.
As a confirmatory test, the radioactive iodine uptake test also is done, which will indicate increased uptake by the thyroid gland. This indicates that the gland is functioning at an increased pace and requires additional iodine for the production of thyroid hormones.

Treatment: There are two approaches to it, one to control the symptoms and the other to control the thyroid gland per se.

    Beta blockers are very useful in controlling rapid heart rate and anxiety.
    Prednisone may be used to control eye irritation and swelling
    Antithyroid drugs are used to control the production of thyroid
    Radioactive iodine is given orally to control excessive thyroid production
    In severe cases, thyroid gland may be surgically removed partially or completely

Graves  disease is not life-threatening and once symptoms are controlled, the patient s quality of life improves drastically.

Graves' Disease - Things You Should Know About It

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