Blood is one of the most crucial elements of human existence. It works as a commute for oxygen and various nutrients in reaching the cells. These functions make blood a vital source for the body to operate. That said, india needs 38, 000 blood donations every day, which adds up to 5 crore units required in a year. However, only 2.5 crore units are available against the huge unfulfilled numbers. Hence, it is essential to recognize the importance of blood donation.

 

Why is blood donation important?

While blood donations are essential to help people with surgeries, they are equally vital during cancer treatments, chronic diseases, and gruesome injuries. Moreover, they also benefit the donors in a significant way.

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Types of blood donations

Blood donations are of several types through which a single donor has the potential to help nearly three people.

 

Whole blood donation

It is the most common process of donating blood. One pint of blood collected supports numerous patients in the process. It is, then, divided into different components that aid the donation.

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Plasma donation

The process of plasma collection is carried out through a method called apheresis. It divides plasma from other blood components. Its blood clotting abilities help trauma patients and people undergoing cancer treatment.

 

Platelet donation

The collection of platelets is also done using apheresis. Once identified in the donor s blood, the rbcs and the donor gets other fluids back. Cancer patients are the chief beneficiaries of platelets as they play a prominent role during cancer treatments.

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Double red cell donation

Red blood cells are also collected through the apheresis process. It helps donors to donate twice the dose of a whole blood donation. One can help a patient suffering from blood loss using this method.

 

Advantages of blood donation

Blood donations have several advantages that people should know. They help fight many severe health conditions in the human body. Some of them include-


	
	Loss of blood due to internal or external injuries caused by accidents
	
	
	Sickle cell disease or other abnormalities that affect the blood
	
	
	In the treatment of cancer
	
	
	Cardiovascular or orthopedic surgeries
	
	
	Blood disorders
	
	
	Transplant processes
	
	
	Treatments involving plasma
	


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Covid-19

According to food and drug administration (fda) reports, patients who have recovered from covid-19 can help others by donating blood plasma. They contain antibodies that fight the infection, helping their body fight the virus.

 

Benefits for the donor

Even the donors receive many health and social benefits because of blood donation. Where donated blood saves lives, experts suggest that donors can also benefit from the same. Some of these advantages include:

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	Boosting cardiovascular health
	
	
	Maintaining blood pressure
	
	
	Contributing to the community
	
	
	Reducing the iron levels
	
	
	Improving overall health
	



 

Why Blood Donation Is Important?

Hepatitis is a condition that affects the liver by causing inflammation which is a common outcome resulting from a viral infection. While different types of hepatitis diseases are caused by different causes, there are some reasons like medications, toxins, alcohol, and drugs that are typically known.

 

Types

The five common types of viral hepatitis are hepatitis a, b, c, d, and e.

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	Hepatitis a
	


Hepatitis a is the result of an infection caused by the hepatitis a virus. This type of hepatitis is an acute disease.

 


	
	Hepatitis b
	


The hepatitis b virus causes hepatitis b. This is often a chronic disease that lasts longer.

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	Hepatitis c
	


Hepatitis c comes from the hepatitis c virus. It is one of the most common bloodborne infections in the world. It is a long-lasting condition.

 


	
	Hepatitis d
	


This is a not so commonly found form of hepatitis that only occurs in hepatitis b infected people. This virus not only causes liver inflammation but also cannot be contracted without an existing hbv infection.

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	Hepatitis e
	


Hepatitis e is waterborne. Hepatitis e virus infection is responsible for it. It is generally acute but can be severely chronic for pregnant women.


 

Causes of viral hepatitis

It is true that different types of viral hepatitis infections are caused by distinct modes of transmission. Here are the causes of a hepatitis infection:

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	Hepatitis a- when a person is exposed to the hepatitis a virus through food or water.
	


 


	
	Hepatitis b- when an individual comes in contact with hepatitis b virus through the transmission of bodily fluids like blood, semen, etc.
	


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	Hepatitis c- when someone gets infected with the hepatitis c virus through the contamination of bodily fluids.
	


 


	
	Hepatitis d- when a person is exposed to hepatitis d virus-infected blood, it causes this disease.
	


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	Hepatitis e- when a person comes in contact with the hepatitis e virus through water or food.
	


 

Causes of non-viral hepatitis

Although hepatitis is commonly caused due to an infection, other factors can also be reasons to cause hepatitis.

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Alcohol

Excessive alcohol can lead to liver damage, causing inflammation. It can also be called alcoholic hepatitis. The alcohol impacts the liver cells directly. Moreover, it can also cause cirrhosis or even permanent liver failure.

 

Autoimmune system response

In rare cases, the immune system of a person attacks the liver itself. It leads to inflammation that can be mild to severe according to the infection. Moreover, it s more common in females than in males.

How Is Hepatitis Caused And Some Common Types?

Your body needs some cholesterol to produce hormones and vitamins that help in digestion. Two types of lipoproteins   ldl cholesterol and hdl cholesterol   are responsible for carrying cholesterol to and from the cells in your body.

Hdl or high-density cholesterol is good cholesterol. It carries bad cholesterol away from the arteries and other body parts back to the liver to be processed by the liver.

Ldl or low-density cholesterol, also known as the bad cholesterol, contributes to fatty build-ups within the arteries. This results in narrowing of the arteries and increases your risk of cardiovascular diseases like pad, heart attack, or even stroke.

Although there are medications to bring down ldl cholesterol levels, your doctor may recommend using therapeutic lifestyle changes to see how well your cholesterol levels can be managed without medications.

How to reduce  bad  cholesterol naturally

You can lower ldl cholesterol levels naturally with the following measures  

Diet and weight loss

Being obese or overweight not only increases the odds of developing high ldl levels but also contributes to cardiac diseases and chronic conditions. Studies suggest that losing even a little weight may help reduce ldl levels.

Your diet plays an important role in losing excess fat and maintaining ideal body weight. Eating the right kind of food   such as those that contain a good amount of monosaturated fats, phytosterols and soluble fibre   can help lower harmful ldl cholesterol and increase the levels of hdl cholesterol in the blood. Focus on eating whole grains, fruits and leafy vegetables, legumes, nuts and seeds, and fatty fish.

Exercise more often

Exercising regularly, in moderate amounts, can bring down your cholesterol levels and promote weight loss. Any form of cardiovascular activity, such as cycling, running, swimming and jogging benefits your heart health. You may also turn to other forms of exercise   weight training or yoga   as they also work to decrease the levels of bad cholesterol.

Quit smoking

Smoking causes a number of chemical changes in your body. Cigarette smoke increases bad cholesterol (ldl) and triglycerides levels. This leads to the accumulation of waxy plaque, which clogs the arteries. At the same time, smoking reduces the level of good cholesterol   the one that prevents the formation of plaque in your blood. Quit smoking and turn to a healthier lifestyle to see a difference in the levels of your ldl cholesterol.

Limit alcohol consumption

According to studies, heavy alcohol consumption or drinking more than what is considered moderate significantly increases bad cholesterol, which again raises triglyceride levels and ldl cholesterol.

Lifestyle changes are the natural and first line of treatment for people with high cholesterol levels. However, if your doctor suspects these levels could put you at risk of other medical conditions, he/she might recommend medications to manage bad cholesterol.

Reduce LDL Cholesterol With These Easy Steps

People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

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Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

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	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

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Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

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	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

Cushing syndrome occurs due to prolonged exposure to high levels of cortisol hormone. The condition, often referred to as hypercortisolism, affects women   usually between ages 25 and 40   more than men. Nearly 80% of adults and about 47% of children are diagnosed with cushing syndrome.

The most common cause of cushing syndrome is an overproduction of the stress hormone   cortisol   by the adrenal glands. However, it can also result from overuse of steroid drugs.

If you have cushing syndrome, you are likely to notice symptoms like muscle weakness, weight gain, a buffalo lump, irregular periods, sleep disorders, high blood glucose and high blood pressure.

Recent research has claimed to establish a relation between cushing syndrome and high blood pressure   or what is called hypertension in medical terms.

The link between hypertension and cushing syndrome

Hypertension refers to high blood pressure that causes the force of blood to raise against the artery walls. A number of conditions can lead to hypertension, such as poor diet and lifestyle, an underlying health issue, stress, pregnancy and so on.

As your body encounters stress, the adrenal glands produce and release cortisol in the bloodstream. Studies show that producing excess stress hormone can create a host of pathological problems in the body, including hypertension.

Hypertension is a distinguishing feature of endogenous cushing syndrome. High blood pressure in cushing syndrome has a significant correlation with the duration of hypercortisolism and results from the interaction between various pathophysiological methods regulating peripheral vascular resistance, cardiac output, and plasma volume   all of which are elevated in this state.

How to treat the condition

Cushing syndrome is usually treatable and curable. You will be prescribed to stop using steroid drugs that are likely to increase cortisol levels. If the condition does not improve after treatment, you will have to look for ways to manage the symptoms, especially by monitoring your blood pressure. Team up with your doctor and ask for ways to de-stress yourself.

Relation Between Cushing Syndrome And Hypertension: Know More

Abstract

Background: it is essential to have an understanding of life expectancy and risk factors among patients with sickle cell disease (sickle cell anemia, hemoglobin diseases, and thalassemias). These are required to counsel the patients, target treatment, and plan the right clinical trials.

 

Methods: a research followed 3764 people ranging from birth to 66 years of age and suffering from scd. The procedure was done to understand the life expectancy and calculate the average age at death. Moreover, the study understood the reasons for the death in all 209 adults. It used the proportional-hazards regression analysis to know the risks for an untimely death in adults with sickle cell anemia.

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Results: when the results for young kids and adults with sickle cell anemia were observed, it was found that the average age at death was 48 for women and 42 for men. Moreover, suffering from hemoglobin c disease had an average mortality age of 60 for men and 68 years for women.

 

In people with sickle cell disease, 18% of deaths took place in patients with mainly renal organ failures. 33% of the tested patients were medically free of organ failures but episodes of pain crisis took their life. Out of these patients, 78% experienced chronic pain, chest syndrome, or both, while 22% suffered a stroke that took their lives.

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Clinical modeling showed that people with sickle cell anemia faced acute chest syndrome, seizures, kidney failure, a white-cell count of over 15, 000 per cubic mm, and a low hemoglobin level were related to a risk of early death.

 

Conclusions: results suggested that 50% of patients with sickle cell anemia lived beyond the age of 50. A huge share of those who lost their lives suffered no noticeable chronic organ failure. However, most of them died due to acute episodes of pain or stroke. Early death was seen highest among patients who had symptomatic disease. High levels of fetal hemoglobin suggested improved chances of survival and are assumably a credible source to foresee the risks and other factors related to adult life expectancy.


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Life Expectancy And Risk Factors Involved In Sickle Cell Disease

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