Abstract

Background: it is essential to have an understanding of life expectancy and risk factors among patients with sickle cell disease (sickle cell anemia, hemoglobin diseases, and thalassemias). These are required to counsel the patients, target treatment, and plan the right clinical trials.

 

Methods: a research followed 3764 people ranging from birth to 66 years of age and suffering from scd. The procedure was done to understand the life expectancy and calculate the average age at death. Moreover, the study understood the reasons for the death in all 209 adults. It used the proportional-hazards regression analysis to know the risks for an untimely death in adults with sickle cell anemia.

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Results: when the results for young kids and adults with sickle cell anemia were observed, it was found that the average age at death was 48 for women and 42 for men. Moreover, suffering from hemoglobin c disease had an average mortality age of 60 for men and 68 years for women.

 

In people with sickle cell disease, 18% of deaths took place in patients with mainly renal organ failures. 33% of the tested patients were medically free of organ failures but episodes of pain crisis took their life. Out of these patients, 78% experienced chronic pain, chest syndrome, or both, while 22% suffered a stroke that took their lives.

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Clinical modeling showed that people with sickle cell anemia faced acute chest syndrome, seizures, kidney failure, a white-cell count of over 15, 000 per cubic mm, and a low hemoglobin level were related to a risk of early death.

 

Conclusions: results suggested that 50% of patients with sickle cell anemia lived beyond the age of 50. A huge share of those who lost their lives suffered no noticeable chronic organ failure. However, most of them died due to acute episodes of pain or stroke. Early death was seen highest among patients who had symptomatic disease. High levels of fetal hemoglobin suggested improved chances of survival and are assumably a credible source to foresee the risks and other factors related to adult life expectancy.


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Life Expectancy And Risk Factors Involved In Sickle Cell Disease

A brain tumor is a common scenario these days. With around 40, 000 to 50, 000 cases per year, india has seen exponential growth in the numbers. However, understanding that brain tumors can be prevented or treated in various ways is important. Early detection of the tumor makes treatment and surgery easier and more effective. Signs usually include headaches, nausea, vomiting, facial paralysis, and sleep disturbance.

There are numerous myths and misconceptions among the general public about brain tumors. This leads to delays in seeking treatment. Some popular myths and facts about brain tumors are-

Myth: everyone has the same type of brain tumor

Fact: over 120 types of brain tumors are detected to date. They are differentiated based on the size, cell of origin, location, and grade of tumors.

Myth: everyone with a brain tumor has similar symptoms

Fact: not all persons show the same symptoms. They can have diverse signs depending on the condition. Some may even have seizures.

Myth: all tumors are cancerous in nature.

Fact: while not all tumors are cancerous in nature, brain tumors can be cancerous or benign depending on the condition.

Myth: only old people are susceptible to brain tumors

Fact: brain tumors can happen to people of any age. Moreover, some tumors are relatively more common in young adults. Brain tumors like medulloblastoma can also appear in children. Most lethal brain tumors like  glioblastoma mutiformae  can develop in adolescents and old people.

Myth: lifestyle modification can keep brain tumors away.

Fact: lifestyle changes have no role in preventing brain tumors. However, a workout, a nutrient-rich diet with high fiber content, and no smoking, no tobacco or alcohol consumption are good for overall health.

Myth: brain tumors are genetic.

Fact: it is not true that if no one in the family had a tumor, even you can t. Genetic mutations are too few to cause cancer. 90- 95% of cancer is by mutations that develop during an individual s life.

Myth: life gets back to normal as soon as the treatment is done in a patient.

Fact: benign tumors rarely recur. However, the cancerous tumors may recur posing a challenge to the doctor and the patient.

 

Myths And Facts Associated With Brain Tumour

While yoga is mainly considered to be a physical process that unites our spiritual conscience, there's more to it. Meditation, prayer, breathwork, and rituals are some self-disciplinary practices that make up the entirety of yoga.

 

Benefits

Apart from physical well-being, yoga also ensures that your overall health gets a boost and you feel rejuvenated. Some scientific benefits of yoga are-

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	Increases flexibility
	


Yoga offers many asanas and styles to choose from and almost all of them contribute to improving flexibility. Yoga acts as a catalyst to increase mobility in older people.


	
	Relieves stress
	


Studies suggest that the second most cited reason for people to practice yoga is that it releases stress. Science proves that yoga helps lower the stress and tension levels in individuals.


	
	Boosts mental health
	


Some studies have observed that yoga is an excellent practice to treat major depressive disorder (mdd). Both movement-based and breathing-based yoga therapies are helpful to improve mental health.


	
	Reduces inflammation
	


Reports suggest that yoga reduces inflammation in the body. As a result, it prevents any chronic disease.


	
	Increases strength
	


Some styles and asanas of yoga can also be strength building. Yoga s effectiveness at improving physical strength has been suggested by many reports.


	
	Reduces anxiety
	


There are numerous anxiety disorders that need care such as anxiety disorders, social anxiety, and phobias. Yoga in the form of meditation helps in reducing the symptoms of the same.


	
	Boosts immunity
	


Excessive stress affects your immune system directly. One is more susceptible to diseases if the immunity is weak. As yoga is a proven way to relieve stress and reduce inflammation, it helps the body develop stronger immunity with time.


	
	Improves balance
	


Balance is important for performing daily movements. Yoga has shown considerable progress in improving bodily balance. Being consistent with yoga makes sure that you get long-lasting benefits as well.


	
	Cardiovascular functioning
	


Pranayama or yogic breathing greatly helps numerous systems in the body. Controlled breathing lowers the chances of change in heart rate, stroke, and more.


	
	Improves quality of sleep
	


Yoga improves the quality of sleep. It is also because of the aftereffects of the exercise. However, yoga has some qualities like mental calming and stress relief that allow a sound sleep.


	
	Boosts bone health
	


Isometric contractions in yoga provide a holistic engagement of bones. They also reverse the bone loss related to osteoporosis and osteopenia.


	
	Improves brain functioning
	


Yoga stimulates the functioning of the brain and boosts energy levels. Studies suggest that it can improve executive functioning, mental flexibility, task switching capabilities, and memory.







 

Scientific Benefits Of Yoga

People suffering from sickle cell disease (scd) usually start showing symptoms very early. They can appear to show up even during the first year of life. Symptoms of a sickle cell vary from one person to another and can be mild to serious depending on the condition.

 

Sickle cell disease is a health condition that worsens with time. Despite the absence of any full-proof solution, some treatments prevent further complications. These treatments can help patients receive aid for a lifetime. Simply said, sickle cell diseases can be managed medically.

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Treatment

Treatment in a sickle cell patient depends on the severity of the symptoms. Preventing complications and relieving pain is the primary aim of the diagnosis. They can range from medications to blood transfusions.

 

Concerns

Some of the concerns that need to be taken care of during the treatment of scd are-

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	Prevent painful scenarios
	


A painful episode or sickle cell crisis can be avoided by consuming sufficient fluids, wearing warm clothing, and staying away from sudden temperature changes.

 


	
	Avoid infections
	


Children with sickle cell anemia are made safe from infections by using penicillin. Adults with anemia might need to take penicillin all their lives. Doctors should ensure that all vaccinations in children and adults are periodically done to avoid any infections. However, during the covid-19 pandemic sickle cell patients should take extra care.

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Medications

While there can be numerous ways to manage sickle cell treatment, medications help in a significant way. Some of the prescribed medicines are-


	
	Hydroxyurea- it reduces the frequency of sickle crises. Pregnant women should stay away from this according to experts.
	
	
	Crizanlizumab- this drug injected into the patient can help reduce the sickle crises in adults and children over the age of 16.
	
	
	Voxelotor- it is an oral drug used in children over 12. It lowers the risk of anemia by improving blood flow.
	
	
	Pain-relievers- narcotics to prevent excessive pain can also be used during the treatment.
	


 

Surgical procedures


	
	Blood transfusion
	


It is used to prevent stroke and other related complications in patients. This can increase the number of red blood cells in the body that can help reduce the symptoms.

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	Stem cell transplant
	


It is also called a bone marrow transplant and is used to replace affected bone marrow with a healthy one. This procedure is carried out between matched donor and recipient. Although it is a known cure for sickle cell disease, various risks involved make it a less used practice.

 

Can Sickle Cell Be Cured?

High sugar levels can harm your body and impact the quality of life. However, you can manage your ;sugar levels by keeping a check on your nutritional intake.

Manage Your Diabetes By Keeping A Check On Your Nutritional Levels

Cushing syndrome occurs due to prolonged exposure to high levels of cortisol hormone. The condition, often referred to as hypercortisolism, affects women   usually between ages 25 and 40   more than men. Nearly 80% of adults and about 47% of children are diagnosed with cushing syndrome.

The most common cause of cushing syndrome is an overproduction of the stress hormone   cortisol   by the adrenal glands. However, it can also result from overuse of steroid drugs.

If you have cushing syndrome, you are likely to notice symptoms like muscle weakness, weight gain, a buffalo lump, irregular periods, sleep disorders, high blood glucose and high blood pressure.

Recent research has claimed to establish a relation between cushing syndrome and high blood pressure   or what is called hypertension in medical terms.

The link between hypertension and cushing syndrome

Hypertension refers to high blood pressure that causes the force of blood to raise against the artery walls. A number of conditions can lead to hypertension, such as poor diet and lifestyle, an underlying health issue, stress, pregnancy and so on.

As your body encounters stress, the adrenal glands produce and release cortisol in the bloodstream. Studies show that producing excess stress hormone can create a host of pathological problems in the body, including hypertension.

Hypertension is a distinguishing feature of endogenous cushing syndrome. High blood pressure in cushing syndrome has a significant correlation with the duration of hypercortisolism and results from the interaction between various pathophysiological methods regulating peripheral vascular resistance, cardiac output, and plasma volume   all of which are elevated in this state.

How to treat the condition

Cushing syndrome is usually treatable and curable. You will be prescribed to stop using steroid drugs that are likely to increase cortisol levels. If the condition does not improve after treatment, you will have to look for ways to manage the symptoms, especially by monitoring your blood pressure. Team up with your doctor and ask for ways to de-stress yourself.

Relation Between Cushing Syndrome And Hypertension: Know More

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