Bladder cancer is characterized by irregular growth of abnormal tissue (tumor) on the lining of the bladder. This type of cancer may spread to the surrounding tissues or other body parts as well.

What are the causes?

Bladder cancer can be caused by environment-related factors and smoking. In fact, smoking tobacco is one of the major causes of bladder cancer around the world. The chemicals present in tobacco can irritate the bladder lining which ultimately leads to bladder cancer. It may also be caused by continuous exposure to chemicals such as dyes or leather dust and radiation. These chemicals tend to cause unusual changes in the cells of the bladder lining and causes cancer in the bladder.

It can also be caused by modifications in the dna in the cells of the bladder which may impair the functioning of the cells in the body. This can cause mutations in the bladder resulting in cancer.

What are the symptoms?

1. Presence of blood in the urine, often painless

2. Feeling of pain while passing urine

3. Back pain

4. Excessive urination

5. Infections in the urinary tract

6. Lower leg swelling

7. Pain in the bones, especially in the pelvic area

8. Weight loss

Treatment options

Treatments for bladder cancer depend on the stage of the cancer. The various treatment choices are:

Surgery - In some cases, these cancers are surgically removed by a surgeon. A type of surgery used is transurethral resection of bladder tumor (turbt) where the cancer cells are destroyed with laser by passing a thin fiber into the bladder.

Chemotherapy - In this method, medications are used to target and destroy cancer cells.

Radiation therapy - Radiation therapy uses rays such as x-ray or uv rays to destroy cancer cells in the body

Immunotherapy - This treatment boosts the immune system of the body so that it attacks the cancerous cells in the bladder.

Causes And Symptoms of Bladder Cancer

An overactive bladder is marked by problems with one s bladder storage system that results in sudden urge to urinate. Involuntary and leakage of urine is also a possibility in such a case.

The problem of an overactive bladder arises when the muscles of the bladder contract involuntarily. The conditions contributing to overactive bladder are:
1. Excessive production of urine due to diabetes, poor kidney function or excessive fluid intake
2. Medications that increase urine production by the bladder
3. Acute infections in the urinary tract
4. Abnormalities in the bladder, for instance, bladder stones or tumors
5. Factors hindering bladder outflow such as constipation, enlarged prostate or earlier treatments for incontinence (loss of bladder control)
6. Excessive intake of alcohol or caffeine
7. Decline in one s cognitive abilities due to factors such as ageing, thus making it hard for the bladder to comprehend the signals it gets from the brain
8. Incomplete emptying of the bladder, leaving only a little storage space for the urine
9. Constipation
10. Neurological disorders

How it can be treated?

Behavioral interventions help to manage overactive bladder effectively and without side-effects. They include-
Exercises to strengthen one s urinary sphincter and pelvic floor muscles
Maintaining a healthy weight
Regulating fluid consumption
Planning a schedule for trips to the toilet
Employing a catheter to empty the bladder entirely
Medications to alleviate the symptoms of incontinence and overactive bladder are-
Fesoterodine
Mirabegron
Darifenacin
Solifenacin
Trospium
Oxybutynin gel
Oxybutynin as a skin patch
Tolterodine
Injecting small doses of Botox (Botulinum toxin), protein-bacteria, directly into the bladder tissues to partially paralyze the bladder muscles, thus delaying urination.
Surgery to magnify bladder capacity
However, it is a must that you seek the guidance of a urologist on immediate basis. 

Overactive Bladder - Can Infection in Urinary Tract Lead To it?

Hunner's ulcers, simply put are painful ulcers in your urinary bladder. These ulcers are inextricably linked to another disorder called the painful bladder syndrome or intestinal cystitis. They occur in 10 to 15 percent of people with interstitia cystitis. These, in fact, are red patches or lesions on the bladder wall which can stiffen tissue and cause reduced bladder capacity. Hunner s ulcers bleed, ooze pus and can be of different sizes. The ulcers in the bladder can be extremely painful and uncomfortable.

These are called Hunner s ulcers because they were first described by Dr. Guy LeRoy Hunner, a Johns Hopkins gynecologist, in 1915. Since Hunner s ulcers are seen only in people with intestinal cystitis, it s important to know more about this painful life-altering bladder disorder before we can even understand how to deal with them.

Interstitial cystitis (IC)
IC is also called painful bladder syndrome. Another important thing to know about IC is that it strikes more women than men. IC is a chronic disorder and there s no cure for it. It causes recurring bouts of pain and pressure in the urinary bladder and the pelvic area. This is often accompanied by an urgent and frequent need to urinate. Sufferers may have to rush to the  loo  as much as 40, 50, or 60 times a day.

Diagnosis
Hunner's ulcers can only be accurately diagnosed by doing a cytoscopy which involves inserting a fibre-optic tube through the urethra to look at the bladder wall closely. During this procedure, a tissue sample from the bladder wall is usually also taken to rule out bladder cancer. Cytoscopy is usually done with hydrodistention under local anesthesia. This involves filling the bladder with a liquid for stretching it to provide a closer view of the bladder wall. Usually, a urologist performs this surgery along with a gynaecologist. IC and also Hunner s ulcers are both a diagnosis of exclusion. This means that they re diagnosed only after a number of other conditions have been ruled out.

Hence, the urologist will first take your thorough medical history, followed by a physical exam and a pelvic exam for women patients and perform tests for ruling out infection, and other disorders like bladder stones and cancer, kidney disease, multiple sclerosis, endometriosis, sexually transmitted diseases amongst others. Only after these tests are inconclusive or uncertain and if there is blood in urine, will the urologist go for cystoscopy.

Treatment
There's no cure for IC, but Hunner s ulcers can be cured by burning them off the bladder wall. Called fulguration, the process uses electricity or laser to burn the ulcers on the bladder wall. Resection is also used in which skin from around the Hunner s ulcer is cut for removing both the ulcer and the inflamed tissue around it. The problem is that ulcers may recur in the same location.
So, managing IC becomes critical. Your doctor can try to treat the patient with one treatment or with a combination of treatment depending on the condition of the patient.

Pain medicines are the first line of treatment to manage Hunner s ulcers and IC both, and many patients do go in for this. Patients also find relief by modifying their diet to remove foods and drinks like caffeinated beverages- tea, coffee, colas etc. Sodas, artificial sugars and fruit juices, especially Cranberry juice can trigger intense pain and discomfort, so these are usually contraindicated. Another important aspect is patient education about normal bladder function and tips on self-care and behavioural modifications like stress control to manage Hunner s ulcers.

Hunner's Ulcer In Urinary Bladder - How They Can Be Treated?

Causes of bladder control problems in women

Urinary incontinence is the term used to describe bladder control problems that affect several people. Many think it only occurs among older, menopausal women but it actually isn't uncommon amid young and active women.

Inability to control the bladder accompanied by pain can be symptomatic of various disorders ranging from a minor infection to cancer. Fortunately, bladder cancer is rare, and bladder pain is usually not serious.

The varied causes of urinary incontinence in women are as follows:

1) Urinary Tract Infection - This is the most common cause of urinary incontinence and it affects women more than men due to anatomical factors. It can also happen at any age.

2) Medicinal Side Effect: The inability to control one's bladder may be a result of the administration of certain medicinal substances such as alpha-blockers, antidepressants, sleeping pills and various narcotics.

3) Changes in the Reproductive System - Pregnancy and fluctuations in hormone levels can cause bladder irritation, which leads to urinary incontinence.

4) Impacted Stool - When stool gets tightly packed in the lower end of the digestive system and rectum, bladder control is affected. Chronic constipation and constraint strain on the lower intestines leads to the weakening of bladder muscles and hampers the bladder control.

5) Surgical Side Effects - Temporary loss of control of the bladder is often a result of prior surgery and radiation therapy in the pelvic region.

6) Nerve Damage and Neurological Disorders - Strokes and spinal cord injuries have a heavy impact on bladder control and amount to urinary incontinence. Diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis also lead to the same.

7) Health Complications - Disorders such as diabetes and obesity directly affect the bladder and the ability to exercise control over it.

8) Disability and Impaired Mobility - For women who are physically impaired and suffer from problems of arthritis, urinary incontinence is a major problem as they are unable to reach the toilet easily.

9) Bladder Cancer - Even though it is extremely rare, bladder cancer affects a number of women every year and is treated through surgery and chemotherapy.



What Causes Bladder Control Problems in Women?

Urinary Tract Infections are a group of diseases that affect one s urinary system such as the urethra, bladder, ureters or kidneys. Women are more prone to contracting UTIs than men. They may be accompanied by symptoms such as a constant urge to urinate frequently along with a burning sensation in the concerned parts and pelvic pain. The urine may have traces of blood in it. These infections are usually treated with antibiotics.

Causes behind Urinary Tract Infection:

Urinary Tract infection generally occurs when the bacteria enter the urinary tract via the urethra and begin to proliferate in the bladder. Although the urinary system is structured to ward off such invaders, at times, the defense mechanism fails. In that case, the bacteria may evolve into a full-blown infection in the urinary tract.

Few risk factors are:

Female anatomy: A woman s urethra is shorter as compared to a man s, thus lessening the distance the bacteria need to travel to the bladder. This increases the chances of UTIs in women.

Using diaphragms and spermicidal agents for birth controls

A dip in the levels of estrogen post menopause

Abnormalities in the urinary tract that hinder the discharge of urine or cause the urine to travel back into the urethra.

Enlarged prostate or kidney stones that cause the urine to be trapped in the bladder.

An impaired immune system because of diabetes and other ailments

Using catheters (tube) to urinate is one of the common risk factors because of the chances of infections.

Urinary Tract Infection - Reasons behind It

The bladder is a muscular sac that is seated just above the pubic bone. The organ stores urine produced by the kidneys allows us the control the frequency of urination by the expansion and contraction of its muscles. Pain in the bladder is usually caused due to one of three reasons:

Interstitial cystitis: This is a chronic condition which affects more women than men. It makes the bladder inflamed and irritated. The bladder walls turn stiff because of this which makes it difficult for the bladder to expand. Interstitial cystitis may be caused by a defect in the lining of the bladder.

Urinary tract infection: Urinary tract infections can affect a person at any age and may develop in the ureter, urethra, bladder or kidneys. However, it is most commonly seen in the bladder. This infection is caused by bacteria that enter the body through the urinary tract.

Bladder cancer: Cancer that develops in the bladder is known as bladder cancer. Transitional cell carcinoma is the most common type of bladder cancer cell. This begins in the innermost layer of the bladder lining. Pain during urination and discomfort in the lower pelvic region are common symptoms of this disease. Once the cause is diagnosed, antibiotic medication can help treat bladder pain. Along with that, there are a few things you could do at home as well.

Drink plenty of fluids: Ideally, we should drink 8-10 glasses of water a day. Water keeps the body hydrated and helps flush toxins from the body. It also helps dilute the urine. This can make urination less painful as concentrated urine may be acidic and difficult to pass. Water also helps prevent the formation of kidney stones and thus helps the kidneys function optimally.
Urinate frequently: Do not try to control your urine. Holding urine in for extended periods of time allows bacteria to multiply within the body. It is also important to urinate after intercourse as sexual activities can push the bacteria present on the skin deeper into your body. This is important for both men and women.
Dress comfortably: Avoid synthetic, tight fitting underwear and clothes. Instead wear, loose, comfortable clothes that are preferably made out of cotton. These clothes will help keep your skin dry and not allow bacteria to breed.
Pain relievers and heating pads: Sometimes, antibiotics can take a day or two before addressing bladder pain. In such cases, pain relievers can help deal with the discomfort and cramps. Heating pads can also help soothe abdominal and lower back pain that results from bladder infections.

Painful Bladder - What Should You Know About It?

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