Chromosomal abnormality happens when a cell has too many or too few chromosomes. The most common form of chromosomal anomaly is Down s syndrome. If a parent has a chromosomal anomaly, she/he will pass it on to the child. PGD or Pre-implantation Genetic Testing aims to select only the embryos with normal chromosomal count and only these embryos are implanted to achieve a healthy pregnancy and bring down the number of children affected with a chromosomal anomaly.

The risk of Aneuploid pregnancy:

The older a woman is when she tries to conceive (aged 35 or more), the higher the risk of Aneuploid pregnancy (carrying a baby with genetic or chromosomal abnormality). Most of these pregnancies end in miscarriages and the few that come to term produce babies with chromosomal abnormalities.

Causes of Chromosomal Abnormality:

Usually, chromosomal abnormalities occur due to an error in the cell division. Meiosis refers to the cell division, which the sperm and the egg undergo during the development procedure. Normally, meiosis breaks the chromosomal material into two equal halves, so that each of the parents contributes 23 chromosomes to the pregnancy. However, when the number of chromosomes in the cell goes up or down than the normal, it results in genetic/chromosomal anomalies.

PGD Procedure for a Chromosomal Anomaly:

If a couple elects to go for Pre-implantation Genetic Diagnosis, they have to undergo ICSI Cycle. ICSI cycle initiates a fertilization cycle to produce embryos. When the embryos reach upto day 5 and blastocyst are formed, they are biopsied and further sent to genetic lab for detecting the chromosomal abnormalities. The embryos are incubated for the entire duration of the genetic screening. Only the embryos that the genetic test clears are implanted. PGD never reveals the gender of the embryo.

PGD can help detect the single genetic disorders that may lead to the following ailments:

  Cystic fibrosis
  Muscular dystrophy
  Tay-Sachs
  Sickle cell anaemia
  Thalassemia
  Turner syndrome

PGD is a revolutionary science that can help root out incurable disorders linked to genetics. It ensures that pregnancy is sustained until term and a healthy baby is born.

Suffering From Genetic & Chromosomal Anomalies - Know About PGD!

The brain contains numerous nerve cells which help in its normal functioning. Epilepsy or seizures occur when there is a disruption in the activity of the nerve cells in the brain. A neurological disorder of the CNS (Central Nervous System), epilepsy can affect all and sundry, irrespective of their age, sex and ethnicity. However, children and aged people (above 60 years) are more susceptible to the condition. A study suggests approximately 10 million people in India suffer from epilepsy.

Types of Epilepsy
Based on the activity of the brain that causes an epileptic attack, Epilepsy can be of two types - Focal or Generalized
Focal Epilepsy: An epileptic attack triggered by unusual activities restricted to a particular area of the brain.

In some cases, focal epilepsy may result in unconsciousness. A person may also lose awareness and become unresponsive (keeps staring into space), a condition termed as Focal Dyscognitive Seizures. A person with this condition may behave strange, such as walking in circles, chewing or rubbing their hands.
In another type of focal epilepsy known as Focal seizures without loss of consciousness, a person does not lose consciousness. In such cases, there may be sudden and involuntary jerking of the arms or the legs. There may also be dizziness or a tingling sensation.
Generalized Epilepsy: Here, the seizures or epilepsy result from unusual activities throughout the brain. Generalized epilepsy, may, in turn, be of the following subtypes

Tonic seizures: This affects the muscles of the legs, arms, or the back, causing them to stiffen and tighten up.
Atonic seizures: Here, a person may suddenly fall down due to loss of muscle control. The condition is also known as Drop Seizures.
Absence seizures: Mostly affecting children, the affected person may lose awareness (temporary) and behave strangely such as staring into spacing, smacking their lips, or blinking their eyes continuously.
Clonic seizures: They are characterized by sudden and continuous jerking movements of the arms, face, and neck muscles.
Tonic-clonic seizures: Here, a person may suddenly lose consciousness. There are violent shaking and stiffening of the body. Some people may even be seen biting their tongue.
Myoclonic seizures: In this arms, and legs of a person suddenly twitches and jerks.

What triggers an Epilepsy?
Epilepsy may be an outcome of the following factors

Medical conditions such as stroke or even brain tumors may affect the normal activities of the brain, thereby resulting in epilepsy. Diseases such as Viral Encephalitis, AIDS or Meningitis act also act as a trigger, accelerating the chances of epilepsy.
Developmental disorders such as Neurofibromatosis or Autism can also trigger epilepsy.
In some cases, epilepsy may be a genetic predisposition. Thus, a person with a family history of epilepsy may suffer from the condition.
Epilepsy may also be an outcome of a prenatal brain injury due to oxygen deficiency or an infection to the mother.
People with dementia may also suffer from an epileptic attack.

Epilepsy - Know The Most Common Types!

Alzheimer s disease is a neurological, irreversible, progressive brain disorder. It is a chronic neurodegenerative dementia that causes the death of brain cells, causing memory loss and cognitive decline. It affects a person s thinking and behavior. The symptoms develop slowly and get worse as time passes.

Causes:
As it is a kind of dementia, Alzheimer s is caused by the death of brain cells. Over a course of time, brain cells die progressively and at the end, the tissue is left with fewer nerve cells and connections. As a result, the total brain size shrinks. Tiny inclusions called plaques and tangles can be seen in the postmortem. These cannot be seen or tested in a living Alzheimer s affected brain. These plaques are given the name  amyloid plaques  because they are found among the dying cells of the brain when a protein called beta-amyloid builds. The tangles stay in the neurons; they are formed from a protein called tau.

There are several reasons behind all this, some of which are listed below-

Anti-anxiety medications
Hitting on the head too many times
Regularly sleep-deprived
Loneliness
Diabetes in the brain
Old age
Genetic line
Down s syndrome
Cardiovascular diseases
Symptoms:
Alzheimer s disease damages the brain, so the clinical signs and symptoms begin to show very early. The symptoms are-

Memory loss
Agitation and mood swings
Poor judgment
The trouble with money calculations
Difficulty doing familiar tasks
Trouble in planning or solving a problem
Confusion with time and place
Difficulty in communicating
Loss of motivation
Inappropriate behavior
Aggressive personality
Childlike behavior
Preventing Alzheimer s disease:
Alzheimer s disease ultimately results in death. Even if there are treatments, they cannot fully cure it. So it s better to try to prevent it before it happens. Ways to prevent Alzheimer s disease are-

Eating more fruits and vegetables.
Eating berries every day.
Increasing omega-3 fatty acids.
Taking folic acid supplements.
Drinking grape juice or red wine with evening meal.
Doing the Mediterranean style diet.
Controlling the blood pressure.
Having strong social support.
Treatment of Alzheimer s disease:

Treatment of Alzheimer s disease is a long time process.
First of all, doctors perform a physical exam to check the overall neurological health. By this, they check muscle strength, reflexes, walking ability, sense of sight and hearing, coordination and balance.
Then comes the blood test to find the cause of confusion and memory loss by checking the thyroid disorder and vitamin deficiency.
Then they perform the neuropsychological test and check the mental status.
Then there are other tests, like MRI, CT, and PET.
After all this, drugs are given and a safe and supportive environment is created with proper exercise and nutrition.
Alzheimer s disease is undoubtedly the worst kind of disease. Hence, it is highly recommended to contact a doctor as soon as any symptom is noticed.

All About Alzheimer's Disease!

Memory lapses aren t exclusive to old-age which is why it is necessary to keep your mind sharp across all ages. The cognitive skill, memory, can be affected by various factors such as lack of sleep, hypertension, substance abuse etc. Here are a few tips which will help you keep your mind sharp:

Take Frequent Breaks: If you work for long hours at a stretch without taking a break, you run a risk of putting excessive strain on your brain which slows down its reflexes. Giving the brain a break once a while is a good idea and during a  brain break , you could engage in mentally stimulating activities such as playing Sudoku or puzzles.

Repeat To Learn Better: If you want to remember a crucial piece of information, it is advisable that you repeat that particular piece of information more than twice for a more comprehensive understanding. This tip would be even more effective if you read out aloud the information which needs to be remembered for uninterrupted concentration and comprehension.

Learn To Play An Instrument: Learn to play a musical instrument and regularly practice it as music stimulates the cells in your brain. Studies have shown a strong connection between relaxing forms of music such as instrumental or Celtic music and the motor areas of the brain which are linked to the learning and cognitive spaces. This happens because music triggers the  feel good  neurotransmitter in your brain.

Dietary Changes: Incorporate more nutritious items to your diet such as fresh fruits and vegetables as they are rich in fibre and vitamins which keep the brain and body healthy. Adding fish oil or fatty fishes such as salmon and trout is a must because they are rich in Omega-3 acids which help your brain retain information for a longer period.

Over-indulging in junk food can cause your brain to slow down while extreme crash-diets can cause lethargy in the cognitive areas of your brain. Hence, you should aim to balance your meals.

Forgetting Things - Keep Your Mind Sharp With These Tips

In India, crimes against women have been on the rise; they might have always happened at the same rate but today's media have become more attentive towards these crimes by bringing them to the forefront. Recently, the devastating news of an Assamese higher secondary student being raped and killed has surfaced. Her floating decomposed body was not discovered until 4th of May when the incident itself occurred on 28th of April. If a rape victim dies, it is the most unfortunate consequence that the parents and the loved ones have to live with but there are numerous victims who survive and they can lead a normal life with guidance and care. Any occurrence of sexual assault not only leaves scars on the outside but also have deeper psychological and emotional effects. The emotional scars can manifest in the form of post-traumatic disorder, depression and suicidal tendencies. If you know anyone who has undergone such an experience, then read on to find out how you can help her get back to her life.

Medical Examination: Physical effects of rape can be adverse on the victim. Forced sexual assault causes bruising, wounds and vaginal bleeding and immediate medical attention is required to ensure safety. Subsequent medical tests should also be carried out to check for Urinary Tract infection, Sexually transmitted diseases (STDs) and uterine fibroids.

Therapy: Wounds of the flesh heal, but it takes a lot of time to recover from emotional damage and in some cases the survivors bear the burden of psychological scars all through their lives. They may see the incident as an assault to their souls and develop depression, post-traumatic disorder, borderline personality disorder, sleeping and eating disorder. The loved ones have to be understanding and be patient with them. One-on-one therapy or group therapy sessions can be very helpful. Talking about their emotions and resolving issues of anger, regret, pain, fear, guilt in a friendly, supported and understanding environment can help them reconstruct their self-image.

Counseling: Guilt and shame are two most common stigmas that most survivors have to deal with. They somehow blame themselves for the incident and regret any step they think that might have led to the incident. They become so consumed by the incident that they think the experience defines them, instead of their persona which is called dissociative identity disorder. In such cases counseling sessions can prove to be very beneficial. They need guidance to understand the situation and separate themselves from the incident. The survivors may feel weak and victimized, overpowered and violated; they may also think that they have lost control of their bodies. Counseling can assist to resolve such issues and help them empower themselves with time.
It is important to make the survivors realize that it is not the end of their lives. With a positive attitude, proper rehabilitation and counseling rape survivors can lead a normal, happy life.

Overcoming Sexual Harassment: You Are Stronger Than You Think

Paranoid personality disorder (ppd) is a mental disorder which makes you feel fearful, nervous and suspicious about people or situations around. This disease usually starts to show its signs from early adulthood and is more common in men than women. People suffering from this disorder are unable to maintain close and long lasting relationships with people as they have the habit of blaming and not trusting other people. The most common symptoms of this disorder are:


	Doubting the loyalty of others
	Fear of revealing their own personal information
	A tendency of holding long lasting grudges
	Inability to handle criticisms
	Abrupt instances of anger and instant reaction
	Showing traits of coldness in a relationship
	Having a feeling of always being right
	Having problems in relaxing
	Being stubborn, argumentative and hostile



	Causes: the exact cause behind pdd is still unknown, but according to some medical researchers it happens due to a combination of biological and psychological conditions. Additionally, bad emotional experiences during childhood and having gone through a physical or mental trauma also leads to the development of the disease.
	Diagnosis:&nbsp;this condition cannot be diagnosed at home and is usually diagnosed by a specialist. The first step taken by a doctor in order to diagnose the disorder is an examination of the medical and psychiatric history of the person. Additionally, if the health records of a person do not indicate anything, then the doctors usually go for some expert opinions by a psychiatrist.
	Treatment:&nbsp;most of the people suffering from this disease are not even aware about it, until someone brings it to their notice. Doctors usually believe that psychotherapy, which is a form of counseling, is the best way to treat pdd.



All About Paranoid Personality Disorder

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