Cystic Fibrosis is a genetic disorder that is known to affect some of the vital organs of the body including the lungs, digestive system to name a few. For long it was believed that cystic fibrosis affects a person in their childhood. However, various research and studies suggest that adults are also susceptible to this inheritable disorder. In this article, we will discuss the cause and symptoms associated with cystic fibrosis.

Cause
The epithelial cells that line the stomach, nasal cavity and lungs, are responsible for the production of the digestive fluids, sweat, tears, mucus. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene codes for a protein called the CFTR protein. The CFTR protein, a membrane protein plays a pivotal role in transporting the chloride ions of the epithelial cells inside and out of the cell. This regulation of the chloride ions goes a long way in ensuring that the mucus produced is free-flowing and thin.

In the case of Cystic Fibrosis, the CFTR gene that codes for the protein undergoes a mutation. With the CFTR protein unable to perform its function, sticky and thick mucus builds up and clogs some of the major systems of the body including the digestive system, reproductive, and respiratory system. There is also a higher salt content in the sweat of the affected person.

For a person to be affected by cystic fibrosis, he/she must inherit a copy of the mutated CFTR gene from both the parents ( Autosomal Recessive Disorder) at birth.

Symptoms
The symptoms associated with cystic fibrosis depends on the organs and systems affected.

The thick mucus formed can clog the digestive tract resulting in incomplete absorption of the essential nutrients from the food. This may have an impact on the overall growth and development of the body.
- There may be stunted growth or no weight gain.
- The stool may appear greasy and foul smelling. Some may also suffer from constipation.
- Newborns and infants may suffer from an intestinal blockage.
Cystic fibrosis, left unattended can lead to diabetes, intestinal blockage or obstruction.
- The mucus can also block the bile duct triggering a host of problems including liver disorders.
- At times, the obstruction or blockage can occur at the junction where the large and the small intestine meets (Distal intestinal obstruction syndrome).
The thick mucus can also affect the lungs and the respiratory system by blocking the tubes that act as a passage carrying the air inside and out of the lungs. As a result,
- A person may suffer from lung infections frequently.
- There may be difficulty in breathing, stuffy and blocked nose, or wheezing.
- Some people may also suffer from a chronic cough with a thick sputum.
Left untreated the complications can worsen resulting in

Nasal polyps, Chronic infections, Hemoptysis (there is blood while coughing), and Pneumothorax (air fills up in the space bifurcates the chest wall from the lungs).

In severe cases, there may be a respiratory failure.

Cystic fibrosis can also trigger fertility problems (both in males and females).

Cystic Fibrosis- Causes and Symptoms!

The sense of hearing is a complex one. The ears are divided into three parts: the outer ear, the middle ear and the inner ear. While the outer ear sends the sound to the middle of the ear, the middle ear sends the same to the inner ear through the conductor. The inner ear in turn sends the auditory signal to the brain where the signal is processed and gives rise to a sense of hearing. 

Problems in hearings can arise if there is a problem in any of these parts. However, more often than not it is the middle or inner ear that is affected. However, there may also be situations when there are problems in both the middle and the inner ear. In that case, it is known as a mixed hearing loss. 

What is Mixed Hearing? 

Loss If there is damage to the middle ear, it may precipitate a conductive hearing loss. Now, in addition to that, if there is a sensorineural problem, then it gives rise to mixed hearing. So, in the case of a mixed hearing loss, all the parts of the ear and even the brain may be involved. There may be damage to the outer ear, middle ear, inner ear, as well as the auditory nerve. 

Causes of Hearing Loss 

Since mixed hearing loss may result from damage to any part of the ear, it is necessary that the causes be grouped into different categories. 

  Sensorineural Hearing Loss 

Sensorineural loss may result from drugs, different illnesses, head trauma, malformation of the inner ear etc. Genetic predisposition may also precipitate such problems. 

  Conductive Hearing Loss 

Such type of hearing loss may result from excessive deposition of earwax, ear infections, perforation in eardrums, malformation of the middle or outer ear, as well as problems with the fluid in the middle ear. 

Symptoms of Hearing Loss 

Reduced hearing in either or both ears is considered to be delineating symptoms of mixed hearing loss. 

Treatment 

Since mixed hearing loss can result from sensorineural failure as well as damage to outer or middle ear, treatment needs to be divided into different groups too.   To treat Conductive Hearing Loss, doctors can use surgical or medical options. 

  For sensorineural hearing loss, doctors usually prescribe hearing aids. This indicates that treatment for mixed hearing loss may include treatment for conductive hearing loss as well as that for sensorineural hearing loss. So, it is usually a combination of both medical and surgical options. Physicians may prescribe both medicines and hearing aids or resort to surgical interventions and also prescribe hearing aids. Sometimes, physicians use special hearing aids or implants to treat mixed hearing loss. 

Conclusion 

In case a person is sensing reduced hearing in one or both ears, he/she needs to seek medical advice. It may be a symptom of mixed hearing loss. Getting in touch with an experienced physician is the first step towards that.

Mixed Hearing Loss - How To Treat It?

Valvar aortic stenosis, commonly called aortic stenosis, is a disorder which occurs when the aortic valve of the heart becomes narrow. The narrowing of the valve prevents its full opening, and hence, blood flow from the heart to the aorta is restricted. When the aortic valve gets obstructed, the heart has to exert much more effort to pump the blood. The heart muscles get weakened as a result. This condition is more common in children.

Diagnosis of valvar aortic stenosis-
Before diagnosis, we should know about the symptoms of valvar aortic stenosis in children. They include:

 Feeling breathless
 Angina or chest pain with a feeling of pressure or tightness
 Syncope of fainting
 Palpitations and enhanced heartbeats
 A steady decline in regular activities and energy levels
 Fatigue due to little exertion
 Not gaining weight
 Poor eating patterns
 Problems in breathing

The wall of the left ventricle also thickens muscularly, and the thick wall occupies more space in the lower chamber of the heart and hence, the room for adequate blood supply is reduced. This may lead to heart failure.

Echocardiogram-
The initial test that is recommended for patients with symptoms of valvar aortic stenosis is doppler echocardiography. This test enables the doctor to estimate the aortic valve region, peak or mean transvalvular gradients and the maximum aortic velocity. These primary measures are required to assess the severity of the disease. Echocardiography provides important information on the valve function, left ventricular filling pressure and disruptions in other valves.

Other major tests which help in the diagnosis of valvar aortic stenosis include:
 Mri or magnetic resonance imaging, which provides images of internal body structures with great detail.
 Ct scan or computed tomography where three-dimensional images are extracted.
 Chest x ray
 Cardiac catheterization where a dye is used to highlight blockages, if any, in the heart.

Treatment-
Usually, there are no medicines for fixing valvar aortic stenosis as the disease is not reversible. Medicines can be used to treat the problems, which are caused by the condition.

Replacement of the damaged valve by surgery is the best treatment for valvar aortic stenosis. The surgery performed is called valvuloplasty. This is a cardioscopic surgery where a tube with a small balloon is inserted into a vein. The tube is guided into the heart, and the balloon is inflated. The balloon and tube are removed after the valve is opened. The damaged valve is replaced by mechanical valve or the valve of a cow or pig by an open-heart surgery.

Valvar aortic stenosis is a severe heart condition in children, and the only permanent remedy for this disease is a valve replacement surgery.

Diagnosis and Treatment of Valvar Aortic Stenosis in Children

What causes cervical Cancer?
Genital Human papilloma virus (HPV) is a very common virus in both men and women that can lead to the development of genital warts, abnormal cervical cells or cervical cancer.
This virus can cause normal cells on your cervix to turn abnormal. Over many years, abnormal cells can turn into cancer if they are not found and treated by your doctor. It can take 10 to 15 years (or more) for cells to change from normal to abnormal, and then into cancer. Abnormal cells are sometimes called 'pre cancer ' because they are not normal, but they are not yet cancer.
You cannot see or feel HPV or these cell changes on your cervix. Screening tests help us to look for these changes or for abnormal cells
How is HPV spread?
HPV is transmitted during genital skin to-skin sexual contact. This includes vaginal or anal sex and possibly oral sex.A person can get HPV even if years have passed since he or she had sex. They will never know it because HPV usually has no signs and symptoms.
In most cases, HPV goes away within two years, without causing any health problems. It is thought that the immune system  fights off HPV infection naturally
What screening tests exist for HPV- related diseases?
Cervical Cancer: Cervical cancer can be detected with routine Cervical cancer screening (Pap test) and follow-up of abnormal results. The Pap test can find abnormal cells on the cervix so that they can be removed before cancer develops.    Abnormal cells often become normal over time, but can sometimes turn into cancer. These cells can usually be treated, depending on their severity and on the woman's age, past medical history, and other test results.
An HPV DNA test, which can find certain HPV types on a woman's cervix, may also be used with a Pap test in certain cases (called co-testing). The HPV-DNA test is done to determine if you are infected with one of the high-risk types or if your doctor finds certain type of abnormal Pap test result.
Even women who were vaccinated when they were younger need regular cervical cancer screening because the vaccines do not protect against all cervical cancer strains.
Is there a treatment for HPV or related problems?
HPV vaccination could prevent most cancers and other diseases caused by HPV. There is no treatment for the virus itself, but there are treatments for the problems that HPV can cause:
Visible genital warts may remain the same, grow more in number, or go away on their own. The warts can be treated when they appear.
Abnormal cervical cells (found on a Pap test) often become normal over time, but they can sometimes turn into cancer. If they remain abnormal, these cells can usually be treated to prevent cervical cancer from developing. This may depend on the severity of the cell changes, the woman's age , past medical history, and other test results. It is critical to follow up with testing and treatment, as recommended by a doctor.
Post detection of ovarian cancer the doctors , depending on your cancer stage can recommend the treatment more- surgery, medical treatment, radiation therapy or chemotherapy.

Cervical Cancer - Causes and Testing for Diagnosis

Breastfeeding is best for the baby and its benefits extend well beyond the paradigm of basic nutrition. Breast milk contains all the vital vitamins and nutrients, which a baby needs in the first six months of life. It is fully loaded with disease fighting substances, which protect baby from illness. Many international paediatric organisation recommend exclusive breastfeeding for the first six months and recent research reports have proven that breastfeeding is good for both mother and the baby.

Breastfeeding protects the baby from a long list of illnesses, such as ear infections, lower respiratory illnesses, stomach disorder and meningitis and are less severe when they do happen. Breast milk adapts as the baby grows to meet the changing needs. Breastfeeding builds a strong emotional bond between the mother and the baby and it has long term benefits lasting right into adulthood.

The first milk of the mother contains high concentrations of secretory immunoglobulin A (IgA), which guards against invading germs by forming a protective layer on the mucous membranes in baby's intestines, nose, and throat. Mother's body responds to pathogens (virus and bacteria) that are in her body and makes secretory IgA, which is specific to those pathogens, creating protection for the baby based on to whatever mother is exposed. 

The antibodies in breast milk gives a baby's immune system a boost and also helps children avoid type 1 and type 2 diabetes, high cholesterol and inflammatory bowel disease that strike later in life. Babies who were not breastfed run the risk of developing Crohn's disease and ulcerative colitis.

Breastfeeding boosts child's intelligence. Surveys have shown that premature infants with extremely low birth weight who receive breast milk shortly after birth improved their scores of mental development at eighteen months when compared with premature infants who weren't given breast milk. The emotional bonding happening during breastfeeding contributes to some of the brainpower benefits. Breastfeeding lowers the risk of sudden infant death syndrome (SIDS). It reduces a child's risk of becoming obese as a teen or adult as the breast milk contains less insulin, which stimulates creation of fat. The high content of leptin in the milk regulates appetite and fat.

Breastfeeding triggers the release of the hormone oxytocin that promotes relaxation and nurturing. Oxytocin released while nursing also helps your uterus contract after birth, resulting in less postpartum bleeding. It reduces stress level and the risk of postpartum depression. Research studies show that breastfeeding results in changes in breast tissue and lactation reduces the production of oestrogen, which reduces the risk of breast and ovarian cancer. It also reduces the risk of osteoporosis and cardiovascular disease.

Benefits of Breastfeeding for Baby & Mother

Stomach aches or abdominal pains are one of the most frequently reported health complaints faced by children. Children below the age of twelve are known to suffer from recurrent stomach pain. While pains such as these lead to momentary discomfiture, they also lay the path for graver worries if neglected for too long. Your child may feel sick and bunk school for two days; rest and home care can restore his or her health, but that in no way, is the best suited way of dealing with the situation. If tummy aches resurface over a certain period of time, parents should be cautious enough to look for the root cause and should try to eliminate it accordingly.

Widely noticed causes of stomach aches in children:

Unhygienic food can affect the child s digestive system.
Intolerance to a certain food item should not be overlooked.
Perpetual anxiety can make the tummy twist and turn.
Urinary Tract Infections can also lead to acute abdominal pain.
Serious factors such as gallstones or appendicitis could also be present. Immediate expert consultation is advised in such a case.
Caffeine and packaged soft drinks can be harmful.
Butter, ghee and other greasy products can trigger tummy aches.
Ways to treat tummy aches in children:

Keep children away from gas producing food items: Food that is hard to digest should be avoided. Lentil soup or dal should only be consumed in limited amounts to prevent the formation of gas. Don t let your child have too many nuts regularly.
Keep them hydrated: Fluid intake should be monitored. A child should drink at least six to seven glasses of water per day. Fruit juices or soups can also be given to them alongside main meals. This helps digestion.
Do not stack up food in one go: Eating a lot in one meal is a bad way of satisfying hunger. Have smaller meals in more numbers. Six to eight meals will keep your child full and will also eliminate chances of acid reflux which happens either due to an empty stomach or too much piling up of greasy food.
Timely check - up with the doctor: If tummy aches refuse to go away, take your child to a doctor for a thorough check- up. Administer medicines as prescribed by the physician.

Stomach Ache in Kids - 7 Causes Behind It!

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