Abstract

Background: it is essential to have an understanding of life expectancy and risk factors among patients with sickle cell disease (sickle cell anemia, hemoglobin diseases, and thalassemias). These are required to counsel the patients, target treatment, and plan the right clinical trials.

 

Methods: a research followed 3764 people ranging from birth to 66 years of age and suffering from scd. The procedure was done to understand the life expectancy and calculate the average age at death. Moreover, the study understood the reasons for the death in all 209 adults. It used the proportional-hazards regression analysis to know the risks for an untimely death in adults with sickle cell anemia.

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Results: when the results for young kids and adults with sickle cell anemia were observed, it was found that the average age at death was 48 for women and 42 for men. Moreover, suffering from hemoglobin c disease had an average mortality age of 60 for men and 68 years for women.

 

In people with sickle cell disease, 18% of deaths took place in patients with mainly renal organ failures. 33% of the tested patients were medically free of organ failures but episodes of pain crisis took their life. Out of these patients, 78% experienced chronic pain, chest syndrome, or both, while 22% suffered a stroke that took their lives.

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Clinical modeling showed that people with sickle cell anemia faced acute chest syndrome, seizures, kidney failure, a white-cell count of over 15, 000 per cubic mm, and a low hemoglobin level were related to a risk of early death.

 

Conclusions: results suggested that 50% of patients with sickle cell anemia lived beyond the age of 50. A huge share of those who lost their lives suffered no noticeable chronic organ failure. However, most of them died due to acute episodes of pain or stroke. Early death was seen highest among patients who had symptomatic disease. High levels of fetal hemoglobin suggested improved chances of survival and are assumably a credible source to foresee the risks and other factors related to adult life expectancy.


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Life Expectancy And Risk Factors Involved In Sickle Cell Disease

Blood donation is a procedure carried out for the noble cause of helping patients and saving lives. As the healthy donor's blood is transfused into the patient, it gives them a new life. That said, the donor has to fulfill a few criteria to be eligible to donate blood.

Eligibility

While any healthy adult of any gender can donate blood, it is advised for males to donate once every three months and for females to donate once every four months. Some of the other criteria are-


	
	Age
	


Any person in the age group of 18 to 65 years can donate blood depending on other factors.


	
	Weight
	


A donor should be at least weigh 45 kilograms in order to be eligible.


	
	Pulse
	


The temperature and pulse of the donor should be normal during the time of blood donation.


	
	Hemoglobin
	


Hemoglobin in the blood should be at least 12.5 grams otherwise the donor stands ineligible.


	
	Childbirth
	


A female donor should have delivered at least 1 year ago and stopped lactation.


	
	Blood pressure
	


Ensuring that the systolic and diastolic pressures are within normal limits is a must.


	
	Malaria
	


One should not have malarial symptoms and not have been treated for the same in the last 3 months.


	
	Tattoo
	


A person should not have had a tattoo in the past 12 months.


	
	Immunization and vaccination
	


A donor should not have had shots for cholera, typhoid, diphtheria, tetanus, or plague in the last 15 days.


	
	Cancer
	


A person should be checked for cancer and should not have any signs of cancer in the body.


	
	Infection
	


There should not be hepatitis b, c, tuberculosis, leprosy, or hiv infection in the body.


	
	Diseases
	


A person should not have epilepsy, bleeding disorders, sickle cell, or thalassemia.


	
	Drugs
	


One cannot donate blood if injected intravenously ever. It may cause risk to the recipient.


	
	Heart issues
	


A person willing to donate cannot have any heart disease.


	
	Diabetes
	


People on oral drugs or dieting to control diabetes can donate blood while patients with insulin injections cannot.

 

Strictly prohibited


	
	Ones who have been tested hiv positive.
	
	
	People suffering from cardiac problems, hypertension, cancer, epilepsy, or kidney ailments.
	
	
	Donors who have consumed alcohol in the past 24 hours.
	
	
	Ones with a major dental procedure done in the last one month.
	
	
	Women with miscarriages in the past 6 months.
	



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Know Eligibility Rules For Donating Blood

A brain tumor is a common scenario these days. With around 40, 000 to 50, 000 cases per year, india has seen exponential growth in the numbers. However, understanding that brain tumors can be prevented or treated in various ways is important. Early detection of the tumor makes treatment and surgery easier and more effective. Signs usually include headaches, nausea, vomiting, facial paralysis, and sleep disturbance.

There are numerous myths and misconceptions among the general public about brain tumors. This leads to delays in seeking treatment. Some popular myths and facts about brain tumors are-

Myth: everyone has the same type of brain tumor

Fact: over 120 types of brain tumors are detected to date. They are differentiated based on the size, cell of origin, location, and grade of tumors.

Myth: everyone with a brain tumor has similar symptoms

Fact: not all persons show the same symptoms. They can have diverse signs depending on the condition. Some may even have seizures.

Myth: all tumors are cancerous in nature.

Fact: while not all tumors are cancerous in nature, brain tumors can be cancerous or benign depending on the condition.

Myth: only old people are susceptible to brain tumors

Fact: brain tumors can happen to people of any age. Moreover, some tumors are relatively more common in young adults. Brain tumors like medulloblastoma can also appear in children. Most lethal brain tumors like  glioblastoma mutiformae  can develop in adolescents and old people.

Myth: lifestyle modification can keep brain tumors away.

Fact: lifestyle changes have no role in preventing brain tumors. However, a workout, a nutrient-rich diet with high fiber content, and no smoking, no tobacco or alcohol consumption are good for overall health.

Myth: brain tumors are genetic.

Fact: it is not true that if no one in the family had a tumor, even you can t. Genetic mutations are too few to cause cancer. 90- 95% of cancer is by mutations that develop during an individual s life.

Myth: life gets back to normal as soon as the treatment is done in a patient.

Fact: benign tumors rarely recur. However, the cancerous tumors may recur posing a challenge to the doctor and the patient.

 

Myths And Facts Associated With Brain Tumour

Hepatitis is a medical condition that occurs when an infected person's liver gets inflamed. There are several reasons that can result in hepatitis, including viral infections, heavy alcohol abuse, and autoimmune conditions.

 

Mostly, hepatitis is a result of an infection caused by a virus. Such a condition is called viral hepatitis. Today, we will talk about the three most common types of viral hepatitis diseases:

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	Hepatitis a
	
	
	Hepatitis b
	
	
	Hepatitis c
	


 

Hepatitis a

Hepatitis a is a result of hepatitis a virus infection in a person and is relatively uncommon.

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Regions, where hepatitis a is more common, are:

 


	
	Africa
	
	
	Asia
	
	
	Central and south america
	
	
	Eastern europe
	


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How it is transmitted

Hepatitis a virus can be present in the fecal matter and blood of an infected person. Hence, it is transmitted via the oral route, involving ingestion of the virus into a person through the feces.

 

Different ways you can get hepatitis a infection are:

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	Having in-person contact with a hepatitis a-infected patient
	
	
	Sexual contact with a person who hosts the virus
	
	
	Consuming contaminated food or drink
	
	
	Eating undercooked shellfish
	
	
	Being near contaminated toilets and diaper changing areas
	


 

Hepatitis b

Hepatitis b is caused by the hepatitis b virus.

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Regions, where hepatitis b is more common, are:


	
	Western pacific region
	
	
	African region
	


 

How it is transmitted

You can contract hepatitis b virus through direct contact with blood or bodily fluids of hepatitis b infected person.

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Different ways you can get hepatitis b infection are:

 


	
	Sexual contact with someone with hepatitis b virus infection
	
	
	Sharing injections and other tools
	
	
	Born to hepatitis b infected parent
	
	
	Direct contact with blood of an infected individual
	
	
	Sharing personal belongings and toiletries like razors or nail clippers.
	


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Hepatitis c

Hepatitis c occurs by the infection caused by hepatitis c virus.

 

Regions, where hepatitis c is more common, are:


	
	Eastern mediterranean region
	
	
	European region
	


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How it is transmitted

Hepatitis c virus is spread through blood and other bodily fluids.

 

Different ways you can get hepatitis c infection are:

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	Sharing injections
	
	
	Born to hepatitis c mother
	
	
	Sexual contact with an infected person
	
	
	Piercing or tattooing with unsterilized equipment
	
	
	Injuries with needles pr blades
	
	
	Sharing razors, or toothbrushes
	


The A, B and C of Hepatitis

Hepatitis- related to an inflammatory condition of the liver. It occurs mainly due to infection caused by viruses but there are other possible causes as well. Hepatitis can be temporary or viral. Temporary hepatitis, which is acute in nature, gets resolved on its own. Viral hepatitis can be of five types, a, b, c, d, and e.

Symptoms of hepatitis

Hepatitis, in its initial phase, is called the acute phase. The following symptoms along with mild flu are visible:

Loss of appetite
Fatigue
Joint pains
Pain in the abdomen
Nausea
Weight loss
Jaundice
Though this phase is not really dangerous for some patients, it can result in liver failure leading to death.

How is hepatitis diagnosed?

Physical examination
Laboratory tests
Imaging tests


Treatment for hepatitis

Treatment options for different types of hepatitis are:

Hepatitis a: this doesn t require treatment as it is short-term in nature. In case the symptoms cause a lot of discomforts, then bed rest is recommended. The vaccine is available to prevent this infection.

Hepatitis b: acute hepatitis b doesn t require treatment either. Its chronic form can be treated with antiviral medications. This can be prevented with vaccination.

Hepatitis c: this type of hepatitis, both in its acute and chronic forms, is treated through antiviral medications.

Hepatitis d: according to a study in 2013, a drug known as alpha interferon is used to treat this type of hepatitis. Unfortunately, this only comes to the rescue of 25-30% of people.

Hepatitis e: this acute form of hepatitis gets resolved on its own. Adequate rest, drinking a sufficient amount of water, and taking enough nutrients in their food are some of the ways to get healed from this disease.


 

Hepatitis: Signs, Diagnosis, And Treatment

Type 1 diabetes occurs when your pancreas is unable to produce enough insulin to keep the blood sugar ;levels under control. The condition, if not managed properly, can lead to related health disorders and complications, both long-term and short-term.

Health problems arising from type 1 diabetes

Type 1 diabetes can have severe effects on your eyes, kidney, nervous system, and heart health. The most common ailments associated with type 1 diabetes may include the following-

1. Diabetic retinopathy

Diabetic retinopathy is a disease of the eyes, which occurs when the blood vessels in the retina (tissue present at the back of your eyes) are damaged. The walls of the retina gradually weaken from increasing blood pressure and blood sugar levels, and this leads to leakage of blood or fluid into the nearby tissues.

Early symptoms of diabetic retinopathy include-


	
	Blurred vision
	
	
	Floaters
	
	
	Difficulty perceiving colors
	


2. ;Diabetic neuropathy

Diabetic neuropathy unfolds when the nerves are damaged due to type 1 diabetes. The condition mostly affects your feet and legs. Reduced blood circulation due to high blood glucose impedes normal wound healing in the extremities, hence, even a minor bruise ;can develop into a permanent injury.

Symptoms of diabetic neuropathy are-


	
	Numbness
	
	
	Reduced sensation
	
	
	Severe, debilitating pain in the extremities
	


3. Diabetic nephropathy

Also known as ;diabetic kidney disease, the condition is a slow deterioration of the kidney and its ability to function properly. In severe cases, where the levels of blood glucose are extremely high due to type 1 diabetes, diabetic nephropathy can ultimately result in kidney failure ;or end-stage renal disease (esrd).

The following are the symptoms of diabetic nephropathy-


	
	Dark urine
	
	
	Swollen ankles, feet, eyes, or hands
	
	
	Shortness of breath
	


4. Cardiovascular diseases

Cardiovascular diseases refer to a range of heart conditions including blood clots and diseased blood vessels. High blood glucose levels resulting from type 1 diabetes can contribute to the deposition of fat in the walls of the blood vessel. Over time, this may restrict the flow of blood and put you at risk of cardiovascular disorders such as coronary artery disease, stroke, or even ;heart attack.

Symptoms of cardiovascular diseases widely vary, ranging from palpitations ;to chest pain. Sometimes, such a condition may not exhibit any symptoms at all.

Type 1 diabetes complications are related to poor management of blood glucose. The best way to monitor the condition and control the symptoms is to get in touch with your doctor. A specialist in this field can prescribe the correct treatment and help prevent the onset the related health disorders.

Complications Associated With Type 1 Diabetes

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