Hypopituitarism is defined as a condition in which the pituitary gland is unable to produce enough hormones. Under-secretion of pituitary hormones affects reproduction, body growth and blood pressure. It also results in pre-mature aging.

The pituitary gland is a small bean-shaped gland situated at the base of your brain, behind your nose and between your ears. Despite its size, this gland secretes hormones that influence nearly every part of your body.

In hypopituitarism, you have a short supply of one or more of these pituitary hormones. This deficiency can affect any number of your body's routine functions, such as growth, blood pressure and reproduction.

Few Causes:

Head injury

Tuberculosis

Radiation treatment

Stroke

Brain tumors

Brain surgery

Meningitis (brain infection)

Hypophysitis (autoimmune inflammatory disorder)

Sarcoidosis is an infiltrative (accumulation of cells and tissues in excess of the normal amount) disease which occurs in various organs.

Impaired hormone secretion by the pituitary gland is caused by genetic mutations.

Sheehan s syndrome: It is a condition in which the pituitary gland gets damaged due to severe blood loss during childbirth.

Hypothalamus (a part of the brain which is located above the pituitary gland) diseases wherein the pituitary activities are directly affected by the hypothalamus.

Symptoms:

Fatigue

Reduced sex drive

Decreased appetite

Anemia

Irregular menstruation, pubic hair loss, hot flashes (feverish heat), and inability to breast-feed properly because of low breast milk production).

Dwarfism in children

Weight loss

Increased sensitivity to cold temperature

Infertility

Facial puffiness

Reduction in body hair or facial hair

Treatment Options:

Hormone replacement drugs include:

Corticosteroids: Adrenocorticotropic hormone deficiency leads to low production of adrenal hormones (different kinds of hormones such as cortisol and adrenalin, produced in the endocrine glands). These drugs act as a replacement of adrenal hormones.

Growth hormone: Growth hormone, also known as somatropin, is injected beneath the skin. This treatment method promotes growth, which balances the height in children. Growth hormone deficiency in adults is also cured by these medications to some extent.

Surgery: Surgical procedure is needed if the condition of hypopituitarism is the result of a tumor. The doctor will remove the tumor through surgery, thus resulting in normal growth.

Radiation: Radiation therapy helps in reducing the size of the tumor which causes stunted growth or pre-mature aging.

Hypopituitarism: Causes, Symptoms and Treatment

Grading of brain cancer is entirely different as compared to the staging of other cancers in the body. Cancer in the breast, lung, colon etc. are staged depending on the possible spread, location of a tumor and lymph node involvement etc. However, brain tumors are graded based on the aggressiveness of the tumor cells under a microscope. The resect ability and the grade of the tumor cells guide a doctor on the treatment decisions. The decision of a brain surgery depends on factors such as the location, spread of a tumour and the general health of the patient.

Types of Brain Tumor Grading:

Grade 1 tumor- These sets of tumors are medically known as the juvenile pilocytic astrocytoma and subependymoma. They are slow growing and non-invasive. There is a likelihood of the patient getting cured with surgery.
Grade 2 tumor- These are brain tumors that do not possess dead cells as part of the tumour. But, they do portray a lot of abnormal cells. Tumors of this type can be categorized under oligodendroglioma, astrocytoma, and ependymoma.
Grade 3 tumor- Tumors of this type are graded based on the cell type of the cancer cells. For instance, an anaplastic astrocytoma is a grade 3 tumor that has no dead cells but possesses dividing cells. In contrast, anaplastic ependymoma and anaplastic oligodendroglioma are grade 3 tumor cells that have dead cells in them.
Grade 4 tumor- Tumors of this type are referred to as glioblastoma. The tumor cells are actively dividing, the growth of blood vessels is witnessed and areas of dead tissue keep expanding.

Treatment options:
Surgery- If the location of a brain tumor is such that it is accessible to a surgeon, the latter goes ahead and removes most of the tumor if not the whole. If, however, the brain tumor cells are placed very near to the surrounding very sensitive brain tissues, a doctor might remove a small portion of the tumor to curb its growth.
Radiation Therapy- This mode of treatment uses high energy X-ray beams to kill targeted cells of the brain. External beam radiation usually targets a small area of the brain. A whole brain radiation, on the other hand, is usually employed when a tumor has spread to most parts of the brain. Radiotherapy is now so evolved that it is highly targeted to tutor cells that kills cancer and spares normal brain .
Chemotherapy- Chemotherapy employs drugs to kill cancer cells. Chemotherapy can either be taken in the form of an IV or in the form of pills. The dosage of chemotherapy is decided based on the concentration of cancer cells, spread frequency, platelet count of the patient etc. The most common chemotherapy drug that is prescribed by doctors to fight cancer cells is temozolomide.

Brain Tumor - Stages and Treatment!

A stroke, also called cerebrovascular accident (CVA), cerebrovascular insult(CVI), or brain attack, occurs when a part of the brain is deprived of blood flow. When the brain cells are deprived of oxygen they begin to die. When brain cells die, the functions controlled by that part of the brain also stops, which results in different types of disabilities among stroke survivors.

There are two types of strokes

Hemorrhagic
Ischemic stroke
The first is caused when a brain aneurysm or a weak blood vessel bursts. Most of the time, this type of stroke leads to death. The second one happens when a clot blocks the flow of blood to the brain. Patients suffering from stroke suffer from various side-effects, the most common ones being paralysis or loss of feeling in a certain part of the body, problem in understanding or talking and loss of vision in one side. The side-effects start showing up regularly after a person has had a stroke.

In certain conditions, blood flow to a certain part of the brain stops for only some time and hence the body suffers stroke like symptoms which only last a couple of hours before disappearing. This is known as a transient ischemic attack (TIA). Unfortunately, the effects of a stroke can be debilitating and also permanent. Hence its important to know the symptoms of a stroke and rush the patient to a doctor as soon as possible. Sometimes early treatment can save a lot of damage.

The primary symptoms of stroke are as follows:

Confusion and problems with talking and comprehension
Headache along with alteration of consciousness or vomiting
Numbness of the face, arms or legs, especially on one side of the body
Issue with seeing, in one or both eyes
Inability to walk with stability, including disrupted coordination
Problems with the bladder and bowel control
Acute depression
Body temperature fluctuates, and pain worsens with movement
Paralysis on one side of the body along with fatigue
Problem in expressing or controlling emotions
Risk Factors:

Hypertension
Diabetes
Increased Cholesterol
Smoking
Obesity
Sedentary Lifestyle
Diagnosis of stroke

Several tests are carried out to determine the type of stroke acquired. They are:

Physical examination, which involves observing the patient's overall condition.
Blood tests
CT scans
MRI scans
Cerebral angiogram
Echocardiograms
Stroke is a fatal brain disease and can cause permanent damage to your system so its best to check with your doctor to know how you can prevent it.

Brain Stroke - Factors That Can Lead To It!

A Brain Tumour can be defined as an abnormal growth of the tissues in the brain, which can disrupt the proper brain functions. Generally, the cells in the human body die and are replaced by new cells, while in the case of a tumour, the old cells do not die and form an accumulation and continues to grow to form a mass as more and more cells are added to it.

Symptoms of Brain Tumour:

Headache: Having headache on regular basis, without any history of having such frequent headaches in past, which becomes worse because of other pressure related activities, such as sneezing, coughing, exercising might be a possible symptom of brain tumour and issues related to such sudden and frequent headaches should be taken up with the doctor without any further delay.
Seizures: Seizures (fits) are amongst the most common symptoms of brain tumour, which might be limited to a particular body part or the whole body. Seizures might even continue after the treatment of brain tumour because of the left scar tissues in the brain.
Numbness in arms/legs: Numbness in any body part, especially arms and legs should also be get evaluated timely, so that, if the possible reason behind them is a brain tumour, then the same could be treated well on time.
Balancing problems: Poor coordination and balancing problems also arise as the most prominent symptom for the brain tumour and hence such small changes must be evaluated and the person suffering should be taken to a doctor immediately to get treated without any delay.
Memory problems: Lack of concentration, poor memory and short term memory loss are few of the possible symptoms that indicate the presence of tumour.
Nausea or vomiting: Nausea or vomiting might be the symptoms of many other possible health issues, but a headache supported by nausea and/or vomiting is one of the many symptoms of a brain tumour and hence should not be ignored.
Facial paralysis: The inability to keep the facial activities under control also indicates the presence of a possible brain tumour and the same should also be diagnosed as soon as one experiences it.
Change in vision: A person suffering from brain tumour might also experience changes in the vision, dizziness, blurry vision, among other sight related issues.
Change in speech: The inability to speak properly and changes in the speech of a person may also indicate a possible presence of a tumour.
Hearing problems: Sudden occurrence of hearing problems and other hearing related disorders might have the brain tumour as a possible reason.
Diagnosing a brain tumour may include one or more of many tests, including CT scan, Magnetic Resonance Imaging (MRI), Angiogram and biopsy. One should never ignore the symptoms of the brain tumour and should get himself/herself checked since the brain tumours might result into permanent damages to the brain; hence such issues should never be ignored.

Do You Think You are Suffering from Brain Tumor? 10 Signs You Must Take Seriously

Brain surgery involves several medical procedures, which incorporate fixing issues with the brain, including changes in the tissues of the brain, cerebrospinal fluid and brain blood flow. Brain surgery is quite a complicated method of surgery and the type of surgery to be conducted depends on the underlying conditions.

Reasons for Brain Surgery:
Brain surgery is performed for the correction of physical brain abnormalities. These abnormalities could occur because of diseases, birth defects and injuries. A brain surgery is required when the following conditions arise in the brain:

Abnormal blood vessels
Aneurysm
Bleeding
Blood clots in the brain
When the protective tissue or dura is damaged
Epilepsy
Due to nerve damage
Parkinson's disease
Any kind of pressure after an injury
Abscesses
Skull fractures
In case of stroke and tumors
A surgery may not be required for all the above mentioned conditions, but in case of many, a brain surgery is very important as the conditions may worsen health problems.

Types of brain surgeries:

Craniotomy: During this open brain surgery, an incision is made in the scalp, and a hole is created in the skull, near the area, which is being treated. After this process is complete, the hole or bone flap is secured in its place using plates or wires.
Biopsy: This form of brain surgery helps in the removal of a small amount of brain tissues or tumors. After removal, the tissues or tumors are examined under a microscope. The creation of a small incision and a hole in the skull is indicated as a part of this process.
Minimally invasive endonasal endoscopic surgery: This form of brain surgery enables the removal or lesions and tumors via the nose and sinuses. Private parts of the brain can be accessed without creating an incision. An endoscope is utilized in the process which is used to examine tumors all across the brain.
Minimally Invasive neuroendoscopy: This process is similar to the minimally invasive endonasal endoscopic surgery. This method also involves the use of an endoscope for removal of brain tumors. Small, dime sized holes may be made in the skull to access some brain parts.
Risks:
Brain surgeries may be associated with several risks. They may be:

Allergic reactions to anesthesia
Bleeding
Blood clot formations
Swelling of the brain
A state of coma
Impairment in speech, coordination and vision.
Problems in memory
Strokes and seizures
Infections in the brain
A brain surgery is a serious and very complex surgery. There are different kinds of brain surgeries, which are conducted depending on the condition and severity of the disease.

Brain Surgery - When It Is Required?

A tumor is an uncontrolled and abnormal growth of cells. A brain tumor is thus an abnormal growth and multiplication of cells in the brain. The cell growth can also be in areas adjacent to the brain. The brain tumor may

Have its origin in the brain (Primary brain tumor), or
Its origin may be in some other parts or organs of the body, which gradually spreads to the brain (Secondary/metastatic brain tumor).
Not all brain tumors are harmful and life threatening.

Brain tumors that exist as noncancerous cell growths are known as Benign brain tumors. Benign brain tumors seldom pose any threat to life.

Brain tumors that are cancerous and, thus, harmful, are known as Malignant brain tumors.

Do not neglect any brain tumors (malignant or not). It is better to be safe than to be sorry.

Types of Primary brain tumors:

Based on its cell of origin, primary brain tumors (benign as well as malignant) may be of the following types:

Meningiomas: Brain tumors that originate from the meninges (the membranes that cover the brain and the spinal cord). Meningiomas are seldom malignant.
Acoustic Neuromas: A noncancerous cell growth that has its origin in the vestibulocochlear nerve (the eighth cranial nerve). This nerve connects the brain with the inner ear.
Gliomas: Here, the tumor has its origin in the brain and the spinal cord (glial cells). This type of brain tumors, in most cases (~80%), are malignant.
Primitive Neuroectodermal Tumors (PNETs): Extremely rare, PNETs are malignant tumors that develop in the embryonic cells in the brain.
Medulloblastomas: Medulloblastomas is a malignant brain tumor that mostly affects children. It originates in the cerebellum (lower part of the brain).
Craniopharyngiomas: A benign brain tumor that has its origin near the pituitary gland (base of the brain). Craniopharyngiomas are common in children.
Probability of a secondary brain tumor are more in people who have had;

Kidney cancer
Breast cancer
Lung cancer
Colon cancer
Melanoma
Symptoms:

The symptoms of brain tumor include:

Chronic and regular headaches.
A change in the headache pattern.
Seizures.
A person may experience vision problems (Peripheral vision may be affected, double or blurred vision).
There may be difficulty in hearing.
Nausea and vomiting.
Behavioral and speech problems.
An arm or a leg may lose sensation.
A person has difficulty with balance.
Diagnosis and Treatment:
Though brain tumor can affect anyone and everyone, its chances are higher in

People who are more exposed to ionizing radiation. People having undergone a radiation therapy are equally vulnerable.
Children as well as older people.
People having a family history of brain tumors.
The diagnosis includes;

An imaging test like the MRI, CT scan and PET (Positron Emission Tomography).
Biopsy, whereby samples of the abnormal tissue is collected and examined.
Neurological examination.
Treatment:

Surgery is an effective treatment for brain tumors.
One can also opt for:

Radiations, whereby the abnormal tumor cells are destroyed using protons and x-rays (high-energy beams).
Chemotherapy: In this treatment, the tumor cells are destroyed using strong drugs (taken orally or intravenously).
Radiosurgery.
Targeted drug therapy: This treatment blocks the abnormalities that are characteristically present only in the cancer cells.

Brain Tumors: Types, Symptoms, Diagnosis, and Treatment

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