Autoimmune disorders are one of the least understood disorders in the whole of medical science. Systemic Sclerosis is also an autoimmune disorder in which the skin undergoes changes in texture and characteristics. 

However, the changes are not confined to the skin alone. It can affect blood vessels, muscles, digestive system, heart, kidneys, as well as the lungs. It typically affects people in the age group of 30 to 50 years, but the good thing is that doctors can diagnose this at any age. 

It has been observed that more women fall prey to this disorder than men. The severity of symptoms may also vary from person to person. Nevertheless, the real cause of worry is the progressive nature of the disease. Due to this, it is, in fact, sometimes referred to as Progressive Systemic Sclerosis. 

Causes of Systemic Sclerosis 

It is an autoimmune disorder in which the immune system attacks the skin and precipitates the problem. The attack by Immune System precipitates increased collagen production in the body, which accumulates in the skin tissue. This leads to changes in characteristics and the appearance of the skin. 

Symptoms of Systemic Sclerosis 

Systemic Sclerosis affects only the skin in the early stages. It may lead to thickening of skin and development of shiny areas around bony areas, such as nose, mouth, fingers etc. However, as the disease progresses, it may limit movement of these affected areas. So one may have a problem in opening the mouth, parting fingers etc. 

Other symptoms are: 

  Loss of hair 

  Deposit of lumps under the skin 

  Blood vessels under the skin getting dilated 

  Pain in the joints 

  Breathing difficulties 

  Dry cough 

  Constipation 

  Diarrhea 

  Swallowing difficulty 

  Reflux of food from esophagus 

  Feeling of bloating after taking meals 

In addition to the above, one may also sometimes experience spasms in the blood vessels of fingers and toes. Legs and hands may turn blue or white if a person is undergoing emotional stress or is in extreme cold. This is also known as Raynaud s phenomenon. 

Risk Factors

Though the causes of the disease are not yet known, there are some risk factors which can make a person susceptible to this disease: 

  If a person is undergoing chemotherapy with certain drugs like Bleomycin or are exposed to stuff like silica dust, organic solvents etc., one may become susceptible to this disease. 

  Women are more prone to acquiring this disease than men. 

  If a person is a Native American or an African-American then too he/she is more susceptible to this problem. 

Treatment of Systemic Sclerosis 

Systemic Sclerosis can t be cured, but its symptoms can certainly be reduced to some extent. So, treatment is specific to symptoms one is experiencing, and may include using the following: 

  corticosteroids 

  immunosuppressants 

  nonsteroidal anti-inflammatory drugs 

  blood pressure medication 

  aid to resolve breathing difficulty 

  physical therapy, light therapy etc. 

The fact that this disease really can t be fully cured makes this a pretty scare disease. Silver lining is that medication and other treatment options are able to suppress most of the symptoms.

Systemic Sclerosis - What Causes It?

Epilepsy is a neurological condition that leads to recurrent seizures. Seizures arise when electrical activity in the brain suddenly surges causing a temporary disturbance within the messaging systems located between the brain cells.

Epilepsy is more common in children below the age of two years and adults above the age of 65 years.

Seizure Types

Seizures are classified into two main categories depending on their area of impact. 

A focal seizure is one that affects only one part or area of the brain whereas a generalised seizure affects the whole brain. Further, both focal and generalised seizures have various sub-categories which are as follows-

Previous nomenclature- 

Partial Seizure

  Simple Partial Seizure
  Complex Partial Seizure
  Partial Seizure with Secondary Generalization

Generalized Seizure

  Absence Seizures
  Myoclonic Seizure
  Atonic Seizure
  Tonic Seizure
  Tonic-clonic Seizure
  Mixed Seizure
  Status Epilepticus

Latest nomenclature of seizure types:

Focal seizures-

  Focal aware seizures
  Focal impaired awareness seizures (previously called complex partial seizures)
. Bilateral tonic clonic seizures

Generalised onset seizures-

  Tonic clonic seizures.
  Atonic seizures (sometimes called drop attacks) and tonic seizure.
  Myoclonic seizures.
  Absence seizures.

Symptoms

The well know symptom of epilepsy is a convulsion/ fit, a few other symptoms include-

  Intermittent spells of fainting. When this happens the patient is likely to lose control of his/her bladder or bowel movements. Following this, the person is likely to suffer from extreme tiredness.
  Spells of a blackout with difficulty in remembering
  Becoming unresponsive to any instructions or questions asked during brief periods of time
  Bouts of continuous blinking without any known reason
  Inappropriate movements that keep on occurring
  Changes in sensory perceptions
  Sudden stiffness in the body

Reasons for Epilepsy

Messaging systems within the brain are responsible for every function that goes about in your body. A disruption to this system caused by defective electrical activity leads to epilepsy in a person. Many people inherit epilepsy while others may develop this condition as a result of-

  Head trauma sustained during an accident
  A stroke or a tumour that has affected the brain impairing its normal capabilities
  An injury to the brain before or during birth
  Associated with developmental issues
  Infections of the brain

Treatment for Epilepsy

Epilepsy in childhood can be treated by using medications and by adopting dietary changes in some cases. Medications for epilepsy mainly include-

  Anticonvulsants - Helps control seizures and manages the symptoms of epilepsy
  Medications for nerve pain - Reduce pain that is caused by the damaged nerves

These medications should be consumed as and when prescribed by the doctor. You must consult a paediatrician for this, as he/she will take your child s physical and mental in consideration before starting the treatment.

Seizures that occur in childhood may be benign. This means that it will not continue into one s adult life. Further, those children who have suffered from epilepsy in their childhood have been seen to have normal mental and intellectual development in their adulthood. However, some epilepsy syndromes in children can have a devastating effect on the child.

Seizure threshold is a term that is used to refer to the conditions that are important for the production of seizures. The threshold is lower for people who are more prone to having seizures whereas the threshold is higher for those who do not have a tendency to suffer from seizures.

A Complete Guide To Childhood Epilepsy!

It's International Women s Day yet again. A time to celebrate women s accomplishments- both those of legendary creators including Mother Teresa, Kiran Bedi, Anuradha Koirala   the anti-sex-trafficking activist & Mary Kom to name a few and the women in our lives who mentor and inspire us every day. It s a day to celebrate our journey towards gender equality and women empowerment.

This year s International Women s Day theme is  Time is Now: Rural and urban activists transforming women's lives.  It comes on the heels of unprecedented global movement for women s rights, equality, and justice. The theme has taken the global campaigns and marches on issues ranging from sexual harassment and femicide to equal pay and women s political representation.

Women still have a long way to go to attain equality and non-discrimination from her male counterparts. 2018 International Women s day is an 'iron in the fire opportunity' to bring a call to action to entrust women with what they actually deserve, not only in a particular sector but to every woman who resides in urban as well as rural areas. It is a step to respect and appreciate the women who step out every day for the livelihood of their families and kids - a step to stop casual sexism faced by urban women in the workplace.

Women, experiencing sexual harassment in the workplace, not only bear strained relationships with their counterparts but also are at risk of numerous health problems. Let us know about the health effects of sexual harassment:

Depression: Self-doubt and criticism can lead to depression and loss of interest in work or other activities. Women also experience loss of self-confidence and feelings of failure & powerlessness.
Anxiety: Many women feel anxious about going to work, communicating with co-workers or being involved in social situations.
Insomnia: Sexual harassment trauma can cause nightmares and may lessen the woman's ability to sleep properly.
Post-traumatic stress disorder (PTSD): Studies say that sexual harassment meets the Criteria A1 and A2 of PTSD. The stress of sexual harassment may cause a woman to relive the trauma even when it is not happening, or avoid things or people that remind her of the sexual harassment.
The International Women s Day echoes a word for transforming the lives of women with a bold determination not just on papers but in reality to support the women all around the globe. Many working women have sad tales to tell as they are exploited at a very high level, and they actually lead a stressful life in comparison to their male counterparts.

So, the spotlight this year is to fight against the injustice that most women face every day and to bring about a change that will be remembered for years and will outshine the lives of such women who devote themselves for the livelihood of their families.

Join a campaign, embrace your inner activist and empower the women in your life...

The #TimeisNow To-

Raise your voice
Support each other
Share the workload
Get involved
Educate the next generation
Know your rights

#TimeIsNow - This International Women's Day, Empower The Woman In Your Life! 

One of the most debilitating conditions that anyone can experience is migraine. They can severely limit you by affecting your personal and professional life as you are in constant pain. Migraine can manifest in a type of headache with intense pain, an acute sensitivity to light, vomiting and nausea. Often described as a severe throbbing pain in the head, it may stop you from completing regular daily tasks and may delay or postpone your work.

How can migraines be treated?
The exact cause for these debilitating migraine pain hasn't been pointed out yet, but certain triggers such as stress, hormonal changes in the menstrual cycle, sun exposure, bright or flashing lights, among many others have been identified. The first line of defense for you would be to understand and identify what your triggers are. Once that is done, you can try and avoid them. If these still trigger a migraine or are about to trigger one, you can immediately take medications or steps to control it or at least lessen the pain to go through your day. Some of the options you can employ to this effect are mentioned below.

Medications to prevent a migraine attack: The medications mentioned here are specialized treatments and can only be taken after a consultation with a doctor. If you are deemed as a candidate for preventative medication for migraines, then either one or a combination of drugs from the following may be prescribed to you.
Valproate and Topiramate are anti-seizure medications which can be used to prevent migraines.
Propranolol, a type of beta blocker and used for cardio vascular problems, has proven to be very effective in preventing migraines.
Onabotulinumtoxin A or a type of Botox, has shown a lot of promise in preventing migraines and is being slowly rolled out as a proper drug as a treatment option.
Certain antidepressants have also shown to be quite effective in reducing the symptoms of migraines as well.
Medications to relieve pain: Some of the go to medications that help relieve your pain from migraine are mentioned below. Although some of them are OTC (over the counter) drugs, it is best advised that you consult with your doctor for medications which suit you better. The side effects of these medications can be bad and thus, it is not advised to continue them in the long run and to find other means to control pain from migraines. Some of the medications to relieve pain temporarily are:
Triptan is a drug used to treat severe migraines
Caffeine along with Ergotamine can also help dull the pain and deal with it.
Ibuprofen and aspirin and Acetaminophen are common pain killers that you can use
Codeine, which contains opioids are also used to treat this problem.
Metoclopramide and chlorpromazine are two examples of anti-nausea medications as vomiting along with nausea may frequently accompany your migraine.
Always remember that these medications can have strong side effects if not taken properly, therefore do not just pop a pill, consult your physician first and know which one should you take and how frequently. 

Severe Headache - Can it Be Migraine?

One of the worst neurological disorders to have is dementia. It is a general term used to describe cognitive decline of the brain. It s not specific disease but denotes several brain disorders and mental illnesses. A person suffering from dementia can have severe impairment in judgment, loss of memory and thinking. Dementia is a very difficult disease not only for the patient but also for their families and caregivers. 

Some facts about dementia are as follows:

It s not a mental disorder occurring in old age but it does degenerates with age.
An estimation of 47.5 million people worldwide suffers from dementia and 60% of these people live in low and middle-income countries and according to WHO this figure is likely to increase.
Every 4 seconds a new case of dementia is reported
Dementia is a collective term to describe the many types of in people, such as 

Alzheimer s Disease: It is one of the most common type of dementia accounting for 60-80% of dementia case. People suffering from Alzheimer s have fewer nerve cells and the size of the brain shrinks.
Vascular Dementia: Another most common form of dementia occurring after a stroke.
Lewy Body Dementia: It is neurodegenerative condition that involves a protein called alpha-synuclein which changes the brain. Symptoms may be similar to Parkinson s disease.
Symptoms of dementia can range from mild to moderate to severe that includes:

Memory Loss
Disorientation meaning inability to focus or pay attention
Changes in visual perception
Impairment in reasoning and judgment
Dementia can be caused by damage to brain cells or progressive brain cell death. As a result communication between brain cells become difficult. Other symptoms include:

Stroke
Brain Tumor
Head Injury
Prion Disease
HIV Infection
Reversible Factors

There are no definite tests for dementia. Doctors and neurologists have to medical history, blood tests and CT scans to find out whether a person has dementia or not. However, the most potent evaluation comes from a set of questions that are asked to a patient suspected of having dementia. The ability to answer those questions correctly is one of the best diagnoses for dementia.
There is no specific treatment for dementia as it is not a curable disease and degenerates with time. However, medicines or drugs given for Alzheimer s can be given to people suffering from dementia.
Although results vary depending upon a person s lifestyle s and habits, doctors suggest eating healthy, exercising regularly, and stopping smoking and drinking may prevent some types of dementia.
The best treatment for dementia is to treat the person with care and love so that they don t feel neglected.
Dementia is often associated with old age but that is not always true. It is important to gain knowledge and educate others also.

Dementia - Quick Facts You Must Know About It!

One of the common ailments in the elderly people is the Parkinson s. A progressive disorder, when left untreated, results in worsening of the symptoms. Hence, it is essential to understand the treatment options available to manage the condition effectively. You may be suggested surgical therapies if medication is not effective enough to treat the symptoms.

Surgical treatment options can be beneficial for patients who are suffering from symptoms, but they do not help with treating the disease. In the past, surgical methods like Thalamotomy and Pallidotomy were used to destroy brain cells that contributed to the symptoms. While these methods are still used, they are very rare and situational.

Deep Brain Stimulation (DBS), an FDA-approved procedure, has become much more popular as it is much safer and does not involve invasive surgery. Instead of destroying brain cells like traditional methods, DBS involves sending electric pulses to the affected brain cells to reduce the symptoms. It is not a treatment procedure, but a means of bringing down the severity of Parkinson s to allow better and more comfortable treatment.

Deep Brain Simulation   Who are the right candidates?
Deep Brain Simulation is commonly used for Parkinson  s disease, but it is not recommended for everyone. It is a preferred method of treatment for people who have had Parkinson s for at least four years but have complications which include long periods of time where medications do not work, or symptoms return, uncontrolled and involuntary movements or the freezing/stiffness in the body.

Deep Brain Simulation is not recommended for those who have Dementia as it can lead to memory problems. The general rule of thumb that neurosurgeons follow is that Deep Brain Simulation can help with symptoms that do not get better with medication. DBS can help reduce medication requirements for patients as well as reduce the side effects that may occur due to medication.

Disorder specialists and neurosurgeons can conduct tests to determine if DBS is going to be effective for a patient before going ahead with such a procedure. An extensive assessment is necessary to understand the symptoms, the effect of Parkinson's drugs and also brain imaging is done. All of the expected benefits are then evaluated for the patients, and if the procedure can help alleviate the symptoms, DBS is given a green signal by neurosurgeons and patients can undergo the procedure.

How Does Deep Brain Simulation Work?
Deep Brain Simulation is a very complex procedure. Brain cells communicate with the rest of the body through electric signal, and these become irregular and do not work properly when affected by Parkinson's. DBS smoothens the functioning of these brain cells and reduces symptoms through electric pulses through the implantation of a medical device known as neurostimulator which is also referred as brain pacemaker.

But, as with any treatment procedure, DBS has potential risks and side effects, hence discuss with neurosurgeon thoroughly to access the suitability.

Adopting Deep Brain Stimulation For Parkinson's disease

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