What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

Kidney - prolonged periods of stress can indirectly hurt your kidneys. So you need to be stress free to keep your kidneys healthy.

Stress And Kidney Failure: Are They Connected?

Potassium is an essential mineral that helps in healthy functioning of your body   it helps in muscle contractions, fluid balance, and nerve signals. Your body receives the required amount of potassium from specific food sources and processes the same. The excess potassium is eliminated from the bloodstream by your kidneys.

Under normal circumstances, your blood levels should be between 3.5meq/l and 5.5meq/l for potassium to carry on these functions. Healthy kidneys play a vital role in keeping the potassium levels in check.

In case your kidneys are unable to remove excess potassium, it may get stored in your blood, leading to a condition known as hyperkalemia.

The link between your kidneys and potassium

The mineral potassium and your kidneys share an intricate relationship. If the levels of potassium in your blood are too high, it can pose a threat to your cardiac condition   leading to a ;heart attack or ;irregular heartbeat.

Hyperkalemia occurs when the kidneys fail to function properly. Your kidneys work to balance the amount of potassium consumed with that, which is eliminated through urine. Your body takes in potassium through the foods and drinks you consume. In the initial stages of your kidney disorder, they may be able to make up for high levels of potassium. However, as your condition worsens, they may be unable to eliminate enough of the mineral from the body.

How to find out if you have high potassium levels

The only way to figure out if your potassium levels are healthy or too elevated is to go for a blood test. The test measures the level of potassium in the bloodstream.

As long as your kidneys are healthy, your potassium levels will be under control. Therefore, if you have hyperkalemia, or if there are chances of you getting it, you may have to cut back on foods that are high in potassium content. Besides, you will have to rely on diuretics and potassium binders.

How Are Kidney And Potassium Connected?

Type 1 diabetes occurs when your pancreas is unable to produce enough insulin to keep the blood sugar ;levels under control. The condition, if not managed properly, can lead to related health disorders and complications, both long-term and short-term.

Health problems arising from type 1 diabetes

Type 1 diabetes can have severe effects on your eyes, kidney, nervous system, and heart health. The most common ailments associated with type 1 diabetes may include the following-

1. Diabetic retinopathy

Diabetic retinopathy is a disease of the eyes, which occurs when the blood vessels in the retina (tissue present at the back of your eyes) are damaged. The walls of the retina gradually weaken from increasing blood pressure and blood sugar levels, and this leads to leakage of blood or fluid into the nearby tissues.

Early symptoms of diabetic retinopathy include-


	
	Blurred vision
	
	
	Floaters
	
	
	Difficulty perceiving colors
	


2. ;Diabetic neuropathy

Diabetic neuropathy unfolds when the nerves are damaged due to type 1 diabetes. The condition mostly affects your feet and legs. Reduced blood circulation due to high blood glucose impedes normal wound healing in the extremities, hence, even a minor bruise ;can develop into a permanent injury.

Symptoms of diabetic neuropathy are-


	
	Numbness
	
	
	Reduced sensation
	
	
	Severe, debilitating pain in the extremities
	


3. Diabetic nephropathy

Also known as ;diabetic kidney disease, the condition is a slow deterioration of the kidney and its ability to function properly. In severe cases, where the levels of blood glucose are extremely high due to type 1 diabetes, diabetic nephropathy can ultimately result in kidney failure ;or end-stage renal disease (esrd).

The following are the symptoms of diabetic nephropathy-


	
	Dark urine
	
	
	Swollen ankles, feet, eyes, or hands
	
	
	Shortness of breath
	


4. Cardiovascular diseases

Cardiovascular diseases refer to a range of heart conditions including blood clots and diseased blood vessels. High blood glucose levels resulting from type 1 diabetes can contribute to the deposition of fat in the walls of the blood vessel. Over time, this may restrict the flow of blood and put you at risk of cardiovascular disorders such as coronary artery disease, stroke, or even ;heart attack.

Symptoms of cardiovascular diseases widely vary, ranging from palpitations ;to chest pain. Sometimes, such a condition may not exhibit any symptoms at all.

Type 1 diabetes complications are related to poor management of blood glucose. The best way to monitor the condition and control the symptoms is to get in touch with your doctor. A specialist in this field can prescribe the correct treatment and help prevent the onset the related health disorders.

Complications Associated With Type 1 Diabetes

A brain tumor is a common scenario these days. With around 40, 000 to 50, 000 cases per year, india has seen exponential growth in the numbers. However, understanding that brain tumors can be prevented or treated in various ways is important. Early detection of the tumor makes treatment and surgery easier and more effective. Signs usually include headaches, nausea, vomiting, facial paralysis, and sleep disturbance.

There are numerous myths and misconceptions among the general public about brain tumors. This leads to delays in seeking treatment. Some popular myths and facts about brain tumors are-

Myth: everyone has the same type of brain tumor

Fact: over 120 types of brain tumors are detected to date. They are differentiated based on the size, cell of origin, location, and grade of tumors.

Myth: everyone with a brain tumor has similar symptoms

Fact: not all persons show the same symptoms. They can have diverse signs depending on the condition. Some may even have seizures.

Myth: all tumors are cancerous in nature.

Fact: while not all tumors are cancerous in nature, brain tumors can be cancerous or benign depending on the condition.

Myth: only old people are susceptible to brain tumors

Fact: brain tumors can happen to people of any age. Moreover, some tumors are relatively more common in young adults. Brain tumors like medulloblastoma can also appear in children. Most lethal brain tumors like  glioblastoma mutiformae  can develop in adolescents and old people.

Myth: lifestyle modification can keep brain tumors away.

Fact: lifestyle changes have no role in preventing brain tumors. However, a workout, a nutrient-rich diet with high fiber content, and no smoking, no tobacco or alcohol consumption are good for overall health.

Myth: brain tumors are genetic.

Fact: it is not true that if no one in the family had a tumor, even you can t. Genetic mutations are too few to cause cancer. 90- 95% of cancer is by mutations that develop during an individual s life.

Myth: life gets back to normal as soon as the treatment is done in a patient.

Fact: benign tumors rarely recur. However, the cancerous tumors may recur posing a challenge to the doctor and the patient.

 

Myths And Facts Associated With Brain Tumour

Yoga is the answer for a lot of aspects which everyone desires, such as a peaceful mind, a strong and flexible body and healthy, glowing skin. Yoga is not simply a set of exercises but a lifestyle. Yoga is a complete workout for the body and mind and is a combination of stretching along with deep breathing and meditation. It is a way of keeping yourself fit without doing strenuous workouts and lifting heavyweights. When practising yoga, asanas and nutrition go hand in hand to improve your quality of life. Your digestive system, immunity and energy levels are directly linked to the food you intake. If there is a problem with any of these, yoga asanas can help resolve it.

 

Yoga helps in maintaining overall fitness

 ;

Yoga ensures that you are healthy in the true sense. Health is like a dynamic expression of life based on how happy, loving and enthusiastic you are in life. The various postures of yoga help in maintaining overall fitness, and balance both your mind and body in an ideal way.

 

Yoga boosts immunity

 ;

A combination of asanas and yogic breathing techniques can help boost your immunity. Some asanas to try include viparita karani, bhujangasana, matsyasana and adho mukha svanasana. These poses help lower stress and boost immunity by pumping rich oxygenated blood to all the parts of the body.

 

Yoga always keeps you energetic

 ;

Yoga asanas help increase blood flow and increase the heart's capacity to pump blood through the body. A few yoga poses that can boost energy are the camel pose, tree pose and warrior asana.

 

Yoga relieves stress

 ;

Doing yoga every day is a good way of eliminating the stress that you experience in daily life. It refers to both physical and mental stress. Certain yoga postures, meditation, and pranayama are ideal practices for getting rid of stress.

 

Yoga keeps you calm

 ;

Yoga is very essential for calming your disturbed and troubled mind.

Moreover, yoga poses massage your organs and help in strengthening your muscles. The various breathing exercises and meditation forms associated with yoga are great for releasing unwanted, undesirable stress from your system. 

 ;

Yoga keeps the digestive system strong

 

Yogic asanas such as the spinal twist, apanasana and paschimottanasana can help smoothen the digestive process.

Why Yoga Is Important For Everyone?

Book a consultation online and get access to the best Bariatric Surgeon in India at Lybrate now.

Consult with a Bariatric Surgeon - Online and Easy!

FilterClear All

COMMON SPECIALITIES

COMMON ISSUES