World sickle cell day is observed annually on the 19th of june to raise awareness of sickle cell-related diseases. It is observed to increase people's knowledge and the understanding required to face the challenges posed by the disease.


 

What is sickle cell disorder (scd)?

Sickle cell disorders or sickle cell diseases are genetic blood disorders that cause an abnormality in the red blood cells. The rbcs turn into sickle-shaped cells that stick together and block the blood flow in the body.


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Types

There are four major classifications of sickle cell diseases-


	
	Hemoglobin ss disease
	
	
	Hemoglobin sc disease
	
	
	Hemoglobin sb+ thalassemia
	
	
	Hemoglobin sb 0 thalassemia
	



 

Symptoms

One can start noticing symptoms of sickle cell in a patient at around 6 years of age. However, they can differ from person to person. Some of the most typical symptoms are-

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	Anemia
	


A shortage of red blood cells occurs due to the excessive early dying in 10-20 days. It leads to an oxygen shortage in the body.


	
	Excessive pain
	


Blockage of blood flow due to the change in shape leads to periodic cycles of pain in the body.


	
	Swelling in the body
	


As the blood circulation becomes irregular, swelling becomes a regular phenomenon.


	
	Infections
	


Sickle cell can be damaging to the spleen. It increases the risk of ailments in the body that can be prevented only by antibiotics.


	
	Delayed puberty
	


Oxygen and nutrients carried by the blood are required for growth. As a reason, irregular blood flow can lead to slow growth or delay in puberty.


	
	Vision issues
	


Infected blood vessels carrying blood to the eyes can cause damage to the retina. It can lead to visual problems.


 

Traits and treatment

As sickle cell is genetic, it is suggested to take a test that can detect any trait of the disease. It can prevent any life-threatening risks to the newborn. However, we don't have a complete cure for sickle cell disorders. There are preventive measures that reduce the adversity of the disease to an extent. Procedures like blood transfusions help greatly in minimizing the effects of the disorder.

World Sickle Cell Day: Know All About Sickle Cell Disease

Hepatitis- related to an inflammatory condition of the liver. It occurs mainly due to infection caused by viruses but there are other possible causes as well. Hepatitis can be temporary or viral. Temporary hepatitis, which is acute in nature, gets resolved on its own. Viral hepatitis can be of five types, a, b, c, d, and e.

Symptoms of hepatitis

Hepatitis, in its initial phase, is called the acute phase. The following symptoms along with mild flu are visible:

Loss of appetite
Fatigue
Joint pains
Pain in the abdomen
Nausea
Weight loss
Jaundice
Though this phase is not really dangerous for some patients, it can result in liver failure leading to death.

How is hepatitis diagnosed?

Physical examination
Laboratory tests
Imaging tests


Treatment for hepatitis

Treatment options for different types of hepatitis are:

Hepatitis a: this doesn t require treatment as it is short-term in nature. In case the symptoms cause a lot of discomforts, then bed rest is recommended. The vaccine is available to prevent this infection.

Hepatitis b: acute hepatitis b doesn t require treatment either. Its chronic form can be treated with antiviral medications. This can be prevented with vaccination.

Hepatitis c: this type of hepatitis, both in its acute and chronic forms, is treated through antiviral medications.

Hepatitis d: according to a study in 2013, a drug known as alpha interferon is used to treat this type of hepatitis. Unfortunately, this only comes to the rescue of 25-30% of people.

Hepatitis e: this acute form of hepatitis gets resolved on its own. Adequate rest, drinking a sufficient amount of water, and taking enough nutrients in their food are some of the ways to get healed from this disease.


 

Hepatitis: Signs, Diagnosis, And Treatment

While yoga is mainly considered to be a physical process that unites our spiritual conscience, there's more to it. Meditation, prayer, breathwork, and rituals are some self-disciplinary practices that make up the entirety of yoga.

 

Benefits

Apart from physical well-being, yoga also ensures that your overall health gets a boost and you feel rejuvenated. Some scientific benefits of yoga are-

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	Increases flexibility
	


Yoga offers many asanas and styles to choose from and almost all of them contribute to improving flexibility. Yoga acts as a catalyst to increase mobility in older people.


	
	Relieves stress
	


Studies suggest that the second most cited reason for people to practice yoga is that it releases stress. Science proves that yoga helps lower the stress and tension levels in individuals.


	
	Boosts mental health
	


Some studies have observed that yoga is an excellent practice to treat major depressive disorder (mdd). Both movement-based and breathing-based yoga therapies are helpful to improve mental health.


	
	Reduces inflammation
	


Reports suggest that yoga reduces inflammation in the body. As a result, it prevents any chronic disease.


	
	Increases strength
	


Some styles and asanas of yoga can also be strength building. Yoga s effectiveness at improving physical strength has been suggested by many reports.


	
	Reduces anxiety
	


There are numerous anxiety disorders that need care such as anxiety disorders, social anxiety, and phobias. Yoga in the form of meditation helps in reducing the symptoms of the same.


	
	Boosts immunity
	


Excessive stress affects your immune system directly. One is more susceptible to diseases if the immunity is weak. As yoga is a proven way to relieve stress and reduce inflammation, it helps the body develop stronger immunity with time.


	
	Improves balance
	


Balance is important for performing daily movements. Yoga has shown considerable progress in improving bodily balance. Being consistent with yoga makes sure that you get long-lasting benefits as well.


	
	Cardiovascular functioning
	


Pranayama or yogic breathing greatly helps numerous systems in the body. Controlled breathing lowers the chances of change in heart rate, stroke, and more.


	
	Improves quality of sleep
	


Yoga improves the quality of sleep. It is also because of the aftereffects of the exercise. However, yoga has some qualities like mental calming and stress relief that allow a sound sleep.


	
	Boosts bone health
	


Isometric contractions in yoga provide a holistic engagement of bones. They also reverse the bone loss related to osteoporosis and osteopenia.


	
	Improves brain functioning
	


Yoga stimulates the functioning of the brain and boosts energy levels. Studies suggest that it can improve executive functioning, mental flexibility, task switching capabilities, and memory.







 

Scientific Benefits Of Yoga

Hepatitis is a medical condition that occurs when an infected person's liver gets inflamed. There are several reasons that can result in hepatitis, including viral infections, heavy alcohol abuse, and autoimmune conditions.

 

Mostly, hepatitis is a result of an infection caused by a virus. Such a condition is called viral hepatitis. Today, we will talk about the three most common types of viral hepatitis diseases:

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	Hepatitis a
	
	
	Hepatitis b
	
	
	Hepatitis c
	


 

Hepatitis a

Hepatitis a is a result of hepatitis a virus infection in a person and is relatively uncommon.

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Regions, where hepatitis a is more common, are:

 


	
	Africa
	
	
	Asia
	
	
	Central and south america
	
	
	Eastern europe
	


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How it is transmitted

Hepatitis a virus can be present in the fecal matter and blood of an infected person. Hence, it is transmitted via the oral route, involving ingestion of the virus into a person through the feces.

 

Different ways you can get hepatitis a infection are:

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	Having in-person contact with a hepatitis a-infected patient
	
	
	Sexual contact with a person who hosts the virus
	
	
	Consuming contaminated food or drink
	
	
	Eating undercooked shellfish
	
	
	Being near contaminated toilets and diaper changing areas
	


 

Hepatitis b

Hepatitis b is caused by the hepatitis b virus.

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Regions, where hepatitis b is more common, are:


	
	Western pacific region
	
	
	African region
	


 

How it is transmitted

You can contract hepatitis b virus through direct contact with blood or bodily fluids of hepatitis b infected person.

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Different ways you can get hepatitis b infection are:

 


	
	Sexual contact with someone with hepatitis b virus infection
	
	
	Sharing injections and other tools
	
	
	Born to hepatitis b infected parent
	
	
	Direct contact with blood of an infected individual
	
	
	Sharing personal belongings and toiletries like razors or nail clippers.
	


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Hepatitis c

Hepatitis c occurs by the infection caused by hepatitis c virus.

 

Regions, where hepatitis c is more common, are:


	
	Eastern mediterranean region
	
	
	European region
	


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How it is transmitted

Hepatitis c virus is spread through blood and other bodily fluids.

 

Different ways you can get hepatitis c infection are:

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	Sharing injections
	
	
	Born to hepatitis c mother
	
	
	Sexual contact with an infected person
	
	
	Piercing or tattooing with unsterilized equipment
	
	
	Injuries with needles pr blades
	
	
	Sharing razors, or toothbrushes
	


The A, B and C of Hepatitis

Environmental factors play a quintessential role in affecting our health. Fresh air, fresh food and fresh water, not only strengthen our body and mind but also make our life worth living. Contrary to this bad environment hampers the quality of life. This is the main reason why people from hill stations or the countryside seem to be healthier than those living in polluted urban cities. Following are the environmental factors that affect your health:

Polluted air

The health effects of polluted air are several. Not many people know that one-third of the deaths are caused because of strokes, lung cancer and heart failure. Air pollution is the chief reason behind these chronic ailments. The other life-threatening diseases caused by polluted air is- asthma or bronchitis. Smoke from machines, vehicles outside, and stoves, the burning of fuels inside can cause breathing problems and wheezing. 

Dirty environment

A dirty environment often leads to the breeding of insects and bacteria that become carriers of life-threatening diseases such as dengue, typhoid, diphtheria, malaria, and so on. Most of the diseases mentioned here are caused by mosquitoes that thrive on stagnant water.

Toxic food ;

The environmental quality of a region has a direct impact on the food produced in that area. Both vegetarian and non-vegetarian food faces the danger of becoming toxic if the environment it is being grown in is polluted. For eg- chemical wastes that are often dumped in water bodies cause the seafood in that area to become highly toxic.

Chemical pollutants

Cancer nowadays is becoming a household disease. The major reason behind this is that technological development has brought new categories of pollutants. Many of these contain chemicals and compounds that are carcinogenic in nature. This ultimately leads to the development of cancer in most people. 

Climate change and natural calamities

Change in climate disrupts the functioning of nature in many ways that further impact the health of humans. These changes include- the natural temperature of the planet, heavy rainfalls and sandstorms. The numerous impacts of climate may result in a high risk of nervous and respiratory diseases. ;

Hence protecting the environment is extremely important for the life of a human being. The change will come after taking small steps. Numerous small steps can really make a difference. 

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Environmental Factors That Affect Health

Abstract

Background: it is essential to have an understanding of life expectancy and risk factors among patients with sickle cell disease (sickle cell anemia, hemoglobin diseases, and thalassemias). These are required to counsel the patients, target treatment, and plan the right clinical trials.

 

Methods: a research followed 3764 people ranging from birth to 66 years of age and suffering from scd. The procedure was done to understand the life expectancy and calculate the average age at death. Moreover, the study understood the reasons for the death in all 209 adults. It used the proportional-hazards regression analysis to know the risks for an untimely death in adults with sickle cell anemia.

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Results: when the results for young kids and adults with sickle cell anemia were observed, it was found that the average age at death was 48 for women and 42 for men. Moreover, suffering from hemoglobin c disease had an average mortality age of 60 for men and 68 years for women.

 

In people with sickle cell disease, 18% of deaths took place in patients with mainly renal organ failures. 33% of the tested patients were medically free of organ failures but episodes of pain crisis took their life. Out of these patients, 78% experienced chronic pain, chest syndrome, or both, while 22% suffered a stroke that took their lives.

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Clinical modeling showed that people with sickle cell anemia faced acute chest syndrome, seizures, kidney failure, a white-cell count of over 15, 000 per cubic mm, and a low hemoglobin level were related to a risk of early death.

 

Conclusions: results suggested that 50% of patients with sickle cell anemia lived beyond the age of 50. A huge share of those who lost their lives suffered no noticeable chronic organ failure. However, most of them died due to acute episodes of pain or stroke. Early death was seen highest among patients who had symptomatic disease. High levels of fetal hemoglobin suggested improved chances of survival and are assumably a credible source to foresee the risks and other factors related to adult life expectancy.


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Life Expectancy And Risk Factors Involved In Sickle Cell Disease

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