Addison s disease is known as adrenal insufficiency or hypocortisolism. It is a hormonal disorder which occurs when adrenal glands which are located just above the kidneys do not produce enough of the hormone. The hormones produced by adrenal glands include cortisol and aldosterone, which are essential for a healthy life.

The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and darkening of the skin also sometimes. Most cases of Addison's disease are caused by autoimmune disorders.
It is quite a rare condition. Only 1 in 1 lakh suffer from this condition. this condition can affect a person of any age group irrespective of sex. To live a normal life people, with this condition, a patient will be required to take their medication regularly.

Cortisol and Aldosterone - What do they do?
The most important function of the cortisol in the body is to respond to stress. It helps the body in using protein, carbohydrates, and fat. It maintains blood pressure, cardiovascular function; and controls inflammation. While as aldosterone helps kidneys in regulating the amount of salt and water in the body   which helps in regulating blood volume and keeping blood pressure under control.

Cause of Addison's Disease
Mostly Addison s disease occurs due to problems with adrenal glands themselves   which is known as primary adrenal insufficiency. While Autoimmune disease accounts for 70% of Addison s disease. In this condition, the body's immune system mistakenly attacks the adrenal glands. This attack destroys the outer layer of the glands.

Some long-term infections such as tuberculosis, HIV, and some fungal infections harm the adrenal glands. It is also caused by the cancer cells that spread from other parts of the body to the adrenal glands.
Less commonly, adrenal glands can also be affected by secondary adrenal insufficiency. It is caused by a problem with the pituitary gland or a problem with the hypothalamus, both located in the center of the brain.
These glands produce hormones that control the production of hormones in the rest of the body. A pituitary hormone called ACTH which turns on cortisol production in the adrenal gland. If ACTH levels are too low, the adrenal glands do not function.
One more cause of secondary adrenal insufficiency is also caused by the prolonged or abuse of steroid hormones such as prednisone.
Symptoms of Addison's disease
The symptoms of adrenal insufficiency grow gradually and the main characteristics are:

Chronic, worsening fatigue
Muscle weakness
Loss of appetite
Weight loss
About 50 percent of the time, one will notice:

Nausea
Vomiting
Diarrhea

A Quick Guide To Addison's Disease!

If you are experiencing pain, irritation, or itchiness in your throat, the condition is referred to as a sore throat. It is likely for you to face difficulty in swallowing food and the pain worsens when you want to swallow. The primary symptom of a sore throat is throat pain. People of all ages can get affected by a sore throat.

Causes
There are several causes of a sore throat. The most common ones are as follows:

Viral infection
  Viral infections are the most common causes of sore throat.
  These are the infections that are caused by a virus, like the flu or cold.
  Measles, chicken pox, and croup are other viral infections that cause a sore throat.

Bacterial infection
  Several bacterial infections also lead to a sore throat.
  They may include strep throat, diphtheria, and whooping cough.

Environmental factors
  Several environmental factors also cause sore throat.
  Exposure to pollen, mold, pet dander, and several other irritants leads to postnasal drip.
  This causes throat pain and inflammation.
  Exposure to dry air, and smoking cigarettes are also common causes of a sore throat.

Diagnosis
  For the diagnosis of a sore throat, a physical examination of your throat is carried out, and your throat will be examined using a lighted instrument.
  Doctors usually look out for inflammations and white patches that indicate strep throat. Your breathing will also be checked.
  The back of your throat can be swabbed for examining samples in order to determine the virus.
  Certain blood tests may also be required to be undertaken.

Treatment
  The treatment of sore throat depends on the cause.
  In case your sore throat is caused by a bacterial infection, you will be prescribed antibiotics for killing the infectious bacteria.
  The medicines should be taken strictly according to a doctor s prescription.
  You should complete the course of 10 days to get effective results.
  If you stop the treatment at an early stage on noticing improvements, a sore throat can recur soon.

There are certain simple home remedies which are effective for curing the most common forms of sore throat. They include:
  Gargling with warm, salted water.
  Consuming warm fluids like soup, tea, and water.
  Having throat lozenges.
  Reducing the inflammation using ibuprofen and acetaminophen.
  Avoiding exposure to allergens and irritants.

In case your sore throat is caused by a viral infection, the virus should be left to run its course. During its course, you will be prescribed medicines like pain relievers and decongestants for relieving the symptoms. Antiviral drugs are also used in some cases for fighting the virus effectively.

Sore Throat - Factors That Can Put You At Risk!

Uterine fibroids, also known as leiomyomata, are non-cancerous growths which develop in and around the uterus or the womb and form benign tumors in course of time. Though there are several types of uterine fibroids, they are all consistently similar in their genetic makeup. They are generally classified depending on their specific locations:

Myometrial or intramural fibroids
Submucosal fibroids
Subserosal fibroids
Pedunculated fibroids
Signs and symptoms

In most cases, uterine fibroids display little or no symptoms at all. Therefore many women are caught unawares and do not realize whether they have leiomyomata or not. When symptoms do show, however, they may include any one of the following:

1. Prolonged menstrual periods, usually for seven days or even longer
2. Bloating belly or pelvis
3. Intensive bleeding during periods
4. Pain during sexual intercourse
5. Constipation

Treatment

Since uterine fibroids do not cause any significant complications, they normally do not require much treatment. The condition, however, can be treated through either one of the following approaches:

1. Non-surgical approach

(1) Alert and careful inspection as well as watchful anticipation of the growth and development of uterine fibroids
(2) Birth control pills or oral contraceptives which help reduce heavy periods caused by uterine fibroids
(3) Pain relievers to help numb the pain
(4) Intrauterine device along with levonorgestrel to help reduce heavy periods
(5) Iron tablets are helpful in substituting the blood loss caused by heavy menstruation

2.Surgical approach

i) Myomectomy

ii) Hysterectomy

These two procedures can be performed using several techniques like:

Laparoscopy
Open abdominal surgery
Robot-assisted laparoscopy
Vaginal approach
Hysteroscope approach
iii) Uterine artery embolization (UAE)

Uterine Fibroids - Surgical & Non Surgical Treatment!

A couple of decades ago, medical professionals believed that a lot of females could not climax at all. There are a number of reasons for this. It is easy for the male to know when he has achieved an orgasm, which usually happens with ejaculation, which is quite evident. For the females, on the other hand, it is not so evident. It is a perceived feeling and while the media showcase it in a particular way, reality is far moved from it.
There are various reasons why it is very difficult to pin this down. Orgasms are not just an elusive feeling for the woman, it is an elusive topic for the medical professionals too. Read on to know some of the common causes (more beliefs or notions) about this and some simple but effective ways of managing this.
- Private topic: Girls are very shy compared to boys and both their exposure to sex education and discussion about this is limited compared to boys. We might tend to think of it as common in India alone, but this is true across a vast number of countries. We are not alone! This shyness continues into their later years too, and unless transformed by the partner, it may continue to be a topic that is shunned.
- Purpose: Sex is more deemed as a form of procreation rather than for sex. Therefore, while sex is necessary for conception, orgasm is not. This is one more reason (strange but true) that orgasm is very elusive for a woman.
- Psychological factors: It could be guilt from past relationships or fear of past abuse. It could be fear of losing control or fear of coming across as vulnerable. For any of these reasons, women can have difficulties climaxing during the act.
In men, the causes are more defined and physical in nature and include erectile dysfunction, premature ejaculation, retrograde ejaculation, and delayed ejaculation.
Whatever the cause of the problem, the first step in coping up with the issue is to acknowledge the issue. Being a private topic, this is not something that is going to draw the person towards medical help. However, this needs to be discussed frankly with the partner or with the doctor. Getting the partner involved removes a lot of psychological barriers (guilt, fear, anxiety, etc.) This would result in natural ironing out of issues, improving the performance of both the people involved.
If that does not happen, seeking professional help, be it medical help to correct physical issues or counselling, is the next suggestion. A frank discussion will do wonders, and what was once elusive can be well within your reach.

The Elusive Orgasm - Causes and Coping!

A problem pertaining to the storage function of the bladder that results in bouts of sudden, often uncontrollable urge to urinate is referred to as an overactive bladder. This condition which is marked by unconditioned or involuntary loss of urine can sometimes be quite difficult to stop. People who experience such a condition often feel humiliated and as such tend to limit their social and work life. Despite such, only a few are conscious that a brief evaluation can help them manage and overcome an overactive bladder.

Mechanism of urination

During urination, the urine proceeds from the bladder and flows into the urethra which is located at the tip of the penis in men and above the vagina in women. As the bladder fills, the nerve signals in the brain prompts urination by coordinating the relaxation and contraction of the urinary sphincter muscles.

Causes and symptoms of an overactive bladder

Primarily caused due to involuntary contraction and relaxation of sphincter muscles, several conditions can lead to overactive bladder. 

Some of them are: 
1. Parkinson's disease, alzheimer's and other neurological disorders
2. Poor kidney function due to diabetes
3. Medications that lead to increased production of urine
4. Bladder abnormalities like tumors or stones
5. Constipation
6. Excessive consumption of caffeine or alcohol

Some of the common signs of an overactive bladder are:
1. Bouts of sudden, uncontrollable urge to urinate
2. Awakening at night frequently to urinate
3. Urinating more than eight times a day

Risks
The risk of an overactive bladder gradually increases with age. Conditions, such as diabetes and an enlarged prostate results in the increased likelihood of an overactive bladder. People who have previously faced strokes and heart attacks experience cognitive decline, which often times lead to the development of an overactive bladder.

Urinary incontinence as well as a host of associated factors can be detrimental to your life. Emotional distress, interrupted sleep cycles and depression are some of the observed complications of this condition.

Thus if you experience or entertain suspicion of an overactive bladder, you should consider visiting a general physician who might refer you to a specialist, if need be.

All about Overactive Bladder

When is Your Throat Pain, a Serious One?

Throat pain mainly occurs due to two conditions-'sore throat' or 'strep throat'. Often the terms 'sore throat' and 'strep throat' are used interchangeably, but they don't indicate the same thing. While a sore throat is a condition mostly followed by common cold, runny nose or congestion; strep throat is a bacteria-induced infection. The bacterium called Streptococcus is responsible for strep throat.

The most common reason behind a sore throat is a viral infection like flu or cold. So, if you've a sore throat that is caused by virus, there is no reason to worry as it can be treated easily. But if you are suffering from strep throat or streptococcal infection, then antibiotic drugs for additional treatment will be required to avoid complications.

Signs and symptoms of a strep throat (which indicates that your throat pain is serious and needs attention) include:

Pain while swallowing food
Sore throat which usually persists for more than 48 hours
Small red spots at the roof top of your mouth
Swollen and red tonsils at times with streaks of pus or white patches
Fever
Swollen, benign lymph nodes in your neck
Headache
Rash
Body aches
Vomiting or feeling of nausea, especially amongst younger children

When these signs and symptoms become noticeable, you need to promptly visit your doctor for test and treatment. And, if the reports indicate strep throat, then your doctor will prescribe you some oral antibiotics to reduce the complications and severity of symptoms so that it doesn't spread to others. You are advised to follow your prescription properly and stay indoors for at least a day after starting your medication.



When is Your Throat Pain, a Serious One?

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