What are the different types of sickle cell disease?

Sickle cell disease or sickle cell disorder is a term often used to talk about a group of diseases affecting hemoglobin. It is the oxygen-carrying element of blood that makes up 2 alpha globins and 2 beta globins. Sickle cell disease happens due to beta-globin mutation and depending on the abnormality in mutation.

Types-
Sickle cell diseases can be of many types depending on the gene mutation in the blood. Some of the common types are-

Sickle hemoglobin s disease (ss)
Hemoglobin ss disease or sickle cell anemia is the most popular type of scd. It takes place when hemoglobin s gene mutation is inherited from both mother and father. In simple words, it happens when the child inherits one substitution beta-globin gene from each parent. In this type, the body only produces hemoglobin s. It is mostly found in people of african and indian origin.

Sickle hemoglobin- c disease (sc):
Patients with sickle hemoglobin sc disease have a moderately dissimilar swapping in their genes of beta-globin. Here, both hemoglobin c and hemoglobin s are inherited from each parent. It may cause similar symptoms like anemia but remains relatively l. People of west african and mediterranean origin are more prone to this.

Hbs beta-thalassemia
People with this type of scd inherit one sickle cell gene s and one gene for beta-thalassemia from each parent. Zero and plus are the two common types of beta-thalassemia. While beta 0 thalassemia usually takes a severe form, beta + thalassemia is a milder form of the disease.

Sickle beta-zero thalassemia
Beta-zero thalassemia takes form when the child inherits the beta s gene from one parent and beta 0 thalassemia gene mutation from the other. With similar symptoms to anemia, it is a slightly severe form of beta-thalassemia.

Sickle beta-plus thalassemia
Substitutions in both beta-globin genes take place in patients with sickle beta thalassemia (sb) disease. This may even lead to the requirement of blood transfusion if no normal beta globin is produced. Mediterranean and caribbean people are more likely to have this disorder.

Hemoglobin sd, hemoglobin se, and hemoglobin so
These are the few rare and not less common types of sickle cell diseases. They are also less severe. People with these forms of scd inherit one sickle cell gene s and one gene from uncommon hemoglobin (d, e, or o) from each parent.

Sickle cell trait
Hbas
People with sct have one sickle cell gene s and one normal gene a from both mother and father. Ones with this disorder show few to no signs of the disease and usually spend a normal life. However, the risk to their future generations still exists.
 

What Are The Different Types Of Sickle Cell Disease?

The world celebrates world blood donor day on the 14th of june to raise awareness of the need for safe blood and blood products and to thank voluntary and unpaid blood donors for their life-saving gift of blood. 

Importance of blood donation

The importance of donating blood is not only to save the lives of thousands of people who are deprived of life but also to save the lives of many more who are affected by the various diseases. ;

 

It has also been seen that when people; e have donated their blood, they have gained many health benefits as it helps in weight loss, helps maintain healthy liver and iron levels, it helps reduce the risk of heart attack and cancer. ;

 

A blood donation can save a life of- ;


	
	Victims of natural disasters, including earthquakes
	
	
	Patients with hemophilia, sickle cell disease, or cancer
	
	
	People who suffer traumatic injuries from being in a car accident
	
	
	Surgery patients
	
	
	Shooting or stabbing victims
	
	
	Women who suffer complications during childbirth
	


 

Blood types that are needed most

It s good to donate if you re healthy. However, there s always a need for specific blood and plasma which are universal and can be used when a patient blood type is unknown. For newborn infants or if a patient's particular blood type is unavailable.

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	Type o negative blood is always needed because it can be used in patients regardless of their blood type.
	
	
	Type ab positive plasma can also be transfused to patients with other blood types. 
	


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Donations are constantly needed

Because of their short shelf life of 5 days after being collected, platelet donations are constantly by the blood blank. Red blood cells also have a short shelf life and needed to be used within 42 days after the collection. Cryoprecipitate and plasma can be frozen and stored for up to a year after donation.


 

Some misconceptions about blood donations


	
	The donor will not experience any kind of pain while donating. ;
	
	
	There will be no scarcity of blood in the body after donating the blood as even after the donation the body will have a surplus quantity of blood. 
	
	
	The common misconception everyone has is that they will faint after donating their blood. ;
	
	
	You will be able to resume your everyday activity immediately after donating the blood. 
	
	
	You will not get infected with aids if you donate your blood. ;
	


 

Donating blood is a great way to give back to your community and potentially save a life by only giving up an hour of your time.

World Blood Donor Day: How Can We Save Life By Donating Blood?

Abstract

Background: it is essential to have an understanding of life expectancy and risk factors among patients with sickle cell disease (sickle cell anemia, hemoglobin diseases, and thalassemias). These are required to counsel the patients, target treatment, and plan the right clinical trials.

 

Methods: a research followed 3764 people ranging from birth to 66 years of age and suffering from scd. The procedure was done to understand the life expectancy and calculate the average age at death. Moreover, the study understood the reasons for the death in all 209 adults. It used the proportional-hazards regression analysis to know the risks for an untimely death in adults with sickle cell anemia.

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Results: when the results for young kids and adults with sickle cell anemia were observed, it was found that the average age at death was 48 for women and 42 for men. Moreover, suffering from hemoglobin c disease had an average mortality age of 60 for men and 68 years for women.

 

In people with sickle cell disease, 18% of deaths took place in patients with mainly renal organ failures. 33% of the tested patients were medically free of organ failures but episodes of pain crisis took their life. Out of these patients, 78% experienced chronic pain, chest syndrome, or both, while 22% suffered a stroke that took their lives.

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Clinical modeling showed that people with sickle cell anemia faced acute chest syndrome, seizures, kidney failure, a white-cell count of over 15, 000 per cubic mm, and a low hemoglobin level were related to a risk of early death.

 

Conclusions: results suggested that 50% of patients with sickle cell anemia lived beyond the age of 50. A huge share of those who lost their lives suffered no noticeable chronic organ failure. However, most of them died due to acute episodes of pain or stroke. Early death was seen highest among patients who had symptomatic disease. High levels of fetal hemoglobin suggested improved chances of survival and are assumably a credible source to foresee the risks and other factors related to adult life expectancy.


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Life Expectancy And Risk Factors Involved In Sickle Cell Disease

Hepatitis is a medical condition that occurs when an infected person's liver gets inflamed. There are several reasons that can result in hepatitis, including viral infections, heavy alcohol abuse, and autoimmune conditions.

 

Mostly, hepatitis is a result of an infection caused by a virus. Such a condition is called viral hepatitis. Today, we will talk about the three most common types of viral hepatitis diseases:

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	Hepatitis a
	
	
	Hepatitis b
	
	
	Hepatitis c
	


 

Hepatitis a

Hepatitis a is a result of hepatitis a virus infection in a person and is relatively uncommon.

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Regions, where hepatitis a is more common, are:

 


	
	Africa
	
	
	Asia
	
	
	Central and south america
	
	
	Eastern europe
	


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How it is transmitted

Hepatitis a virus can be present in the fecal matter and blood of an infected person. Hence, it is transmitted via the oral route, involving ingestion of the virus into a person through the feces.

 

Different ways you can get hepatitis a infection are:

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	Having in-person contact with a hepatitis a-infected patient
	
	
	Sexual contact with a person who hosts the virus
	
	
	Consuming contaminated food or drink
	
	
	Eating undercooked shellfish
	
	
	Being near contaminated toilets and diaper changing areas
	


 

Hepatitis b

Hepatitis b is caused by the hepatitis b virus.

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Regions, where hepatitis b is more common, are:


	
	Western pacific region
	
	
	African region
	


 

How it is transmitted

You can contract hepatitis b virus through direct contact with blood or bodily fluids of hepatitis b infected person.

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Different ways you can get hepatitis b infection are:

 


	
	Sexual contact with someone with hepatitis b virus infection
	
	
	Sharing injections and other tools
	
	
	Born to hepatitis b infected parent
	
	
	Direct contact with blood of an infected individual
	
	
	Sharing personal belongings and toiletries like razors or nail clippers.
	


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Hepatitis c

Hepatitis c occurs by the infection caused by hepatitis c virus.

 

Regions, where hepatitis c is more common, are:


	
	Eastern mediterranean region
	
	
	European region
	


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How it is transmitted

Hepatitis c virus is spread through blood and other bodily fluids.

 

Different ways you can get hepatitis c infection are:

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	Sharing injections
	
	
	Born to hepatitis c mother
	
	
	Sexual contact with an infected person
	
	
	Piercing or tattooing with unsterilized equipment
	
	
	Injuries with needles pr blades
	
	
	Sharing razors, or toothbrushes
	


The A, B and C of Hepatitis

World hepatitis day is observed on july 28th every year to raise awareness about hepatitis disease among people. It is organized on the occasion of the birthday of Dr. Baruch blumberg who found the hepatitis b virus in the year 1967 and also developed a vaccine for it. Moreover, this day educates everyone about hepatitis infections, the efforts to fight viral hepatitis, and methods people can use for its prevention.

What is viral hepatitis?

Viral hepatitis or hepatitis disease is a condition of inflammation in the liver that leads to severe liver disease and hepatocellular cancer. With deaths happening every 30 secs from a hepatitis-related infection, it is important to treat viral hepatitis at the earliest. Hepatitis is of different types depending on the infection. 

 ;

Types

Viral hepatitis impacts millions worldwide, resulting in both acute and chronic diseases. There are five major classifications of viral hepatitis-

 


	
	Hepatitis a- it is a liver infection that can be prevented by a vaccine. It is a result of the infection as a result of the hepatitis a virus.
	
	
	Hepatitis b- it is an infection that happens due to the hepatitis b virus. It is spread through the blood or other bodily fluids of a person.
	
	
	Hepatitis c- it is a liver infection caused by the hepatitis c virus. It transmits through the blood of a person who is infected.
	
	
	Hepatitis d- delta hepatitis is another name for this virus and the hepatitis d virus is responsible for this. It happens to only those who are already hepatitis b infected. ;
	
	
	Hepatitis e- it is a liver infection resulting from a hepatitis e infection. It is usually found in a person s stool.
	


 

Symptoms

Hepatitis is a condition where you don t show symptoms till it is chronic and starts affecting your liver health. However, people in the initial stages of hepatitis infection might start reflecting symptoms. Some common symptoms of viral hepatitis are:

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	Flu-like signs
	
	
	Darker urine color
	
	
	Fatigue
	
	
	Abdominal cramps and pain
	
	
	Appetite loss
	
	
	Weight loss
	
	
	Yellow skin
	
	
	Pale eyes
	


 

People at risk

The risk of catching a hepatitis infection is high in individuals working around these environments-

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	Direct contact with hepatitis a infected person
	
	
	Male in sexual relation with another male
	
	
	Drugs abuser
	
	
	Ones with clotting factor disorder
	
	
	Who work with primates
	


 

World Hepatitis Day: Know All About The Disease

Yoga is the answer for a lot of aspects which everyone desires, such as a peaceful mind, a strong and flexible body and healthy, glowing skin. Yoga is not simply a set of exercises but a lifestyle. Yoga is a complete workout for the body and mind and is a combination of stretching along with deep breathing and meditation. It is a way of keeping yourself fit without doing strenuous workouts and lifting heavyweights. When practising yoga, asanas and nutrition go hand in hand to improve your quality of life. Your digestive system, immunity and energy levels are directly linked to the food you intake. If there is a problem with any of these, yoga asanas can help resolve it.

 

Yoga helps in maintaining overall fitness

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Yoga ensures that you are healthy in the true sense. Health is like a dynamic expression of life based on how happy, loving and enthusiastic you are in life. The various postures of yoga help in maintaining overall fitness, and balance both your mind and body in an ideal way.

 

Yoga boosts immunity

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A combination of asanas and yogic breathing techniques can help boost your immunity. Some asanas to try include viparita karani, bhujangasana, matsyasana and adho mukha svanasana. These poses help lower stress and boost immunity by pumping rich oxygenated blood to all the parts of the body.

 

Yoga always keeps you energetic

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Yoga asanas help increase blood flow and increase the heart's capacity to pump blood through the body. A few yoga poses that can boost energy are the camel pose, tree pose and warrior asana.

 

Yoga relieves stress

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Doing yoga every day is a good way of eliminating the stress that you experience in daily life. It refers to both physical and mental stress. Certain yoga postures, meditation, and pranayama are ideal practices for getting rid of stress.

 

Yoga keeps you calm

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Yoga is very essential for calming your disturbed and troubled mind.

Moreover, yoga poses massage your organs and help in strengthening your muscles. The various breathing exercises and meditation forms associated with yoga are great for releasing unwanted, undesirable stress from your system. 

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Yoga keeps the digestive system strong

 

Yogic asanas such as the spinal twist, apanasana and paschimottanasana can help smoothen the digestive process.

Why Yoga Is Important For Everyone?

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