Alzheimer's disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of alzheimer's disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of alzheimer's disease. The main causes of alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: many a times, in alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: the brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern recognition receptors: many of these receptors work in different manners and cooperate with each other to create a response in the brain. These prrs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of cells linked with the immune system: when the prrs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case alzheimer's disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of alzheimer's disease before it progresses beyond one's control.

Can the Immune System Trigger Alzheimer's Disease

Depression is possibly regarded as the first sign of Alzheimer s disease. According to a research, the connection between Alzheimer s disease and depression is very interesting. It has been found that the life of people who are suffering from dementia is affected in 2 different ways. Individuals who have suffered from depression in their lives are at a greater risk of developing dementia. It has also been observed that people suffering from dementia also have depression. The health condition should be treated immediately because if it is ignored it can damage the quality of life and result in worst conditions like memory loss. Temperament, as well as behavioral changes, may precede memory problems in people with the disease.

Risk factor of dementia
The significant risk factor for dementia or common form of Alzheimer s is developing depression at a younger age. The other reasons for the link are not very clear, however, it has been speculated that the inflammation that occurs in depression is a contributing factor to the Alzheimer s disease. The risk of dementia also increases with certain proteins which spiral with depression. The common signs of Alzheimer s disease include lack of appetite, sadness, agitation, weight loss, and anxiety. People suffering from this condition are unable to tell if they are depressed, but their actions help in communicating a message. It is always better to seek the assistance of a physician as doctors can make use of tools to assess the neurological disorder.

Best way to treat patients with Alzheimer s
The best way to treat patients suffering from dementia and who are depressed is to engage them in activities. It is important that they step out and do some exercises. They should go out in the sunshine. It is necessary to engage them in activities and conversations and help them to lead a higher quality of life. Some of the symptoms of dementia and depression are alike but not all of them. The major symptoms of depression include feeling tired most of the times, feeling restless, irritable, feeling worthless/guilty, unplanned weight gain and trouble in focusing. These symptoms often occur for more than 2 weeks or longer.

Difficulties caused by Alzheimer s disease
In the case of Alzheimer s disease, it becomes very difficult for the individual to communicate, learn or remember mainly because the damage is caused to the brain. Due to the brain damage, there is a possibility of changes in the personality and moods of individuals suffering from this health condition. The quality of life is affected by depression as well as Alzheimer s disease. Hence, it is always better to treat the condition immediately. For that reason, it is very important to set up a pleasant environment around and help patients suffering from this condition by helping them do enjoyable tasks and make them feel positive about life.

Alzheimer's Disease & Depression - How They Are Related?

With age, most body organs begin to deteriorate in their function. This happens to the brain also, thereby reducing the overall speed of functioning of most organs. While slowing of bodily movement is visible, the internal organs functioning also slows down, which is not that obvious. Memory loss or dementia is one of the main manifestations of this degeneration of the brain.

Alzheimer s is the most common form of dementia, and the associated symptoms includes reduced reasoning abilities and cognitive defects. Though it is seen only in the elderly, not all elderly people will have Alzheimer s. The overall quality of life of the affected person is reduced with difficulty remembering things that were recently learned. It is a progressive disease and as it gets more severe, a full-time caretaker may be required.

Causes: The brain cells are affected by protein masses known as plaques and tangles. These hamper the way communication between the brain cells happens as well as affect nutrition from reaching all parts of the brain. This leads to shrinking of the brain, eventually leading to memory loss and other problems. There is also a strong genetic linkage, as most people with Alzheimer s have the lipoprotein A gene.

Symptoms: Though memory loss is the most common symptom, there are other symptoms:

Being confused about places, people, and times
Inability to find the right words during conversations
Regular objects are misplaced
Becoming irritable, (in someone who was not so previously)
Mood swings
Personality changes
Inability to organise thoughts
Not able to make the right decisions
Repetitive talks and actions
Forgetfulness (not something the person always does)
Difficulty with numbers (again, not something calculations
Difficulty managing everyday tasks and minor problems
Suspicion of others (like immediate family members and friends)
Risk factors: While age is definitely a risk factor, the fact that not all aged people develop Alzheimer s is to be borne in mind. Other risk factors include the history of stroke, high cholesterol, high blood pressure, diabetes, smoking, obesity, and poor lifestyle choices.

Diagnosis: While there is no definitive way to diagnose Alzheimer s, symptoms along with brain scans and neuropsychological function testing are useful ways to confirm the diagnosis.

Treatment: This is aimed at two things reducing the rate of disease progression and treat (or reverse) symptoms if possible.

Cholinesterase inhibitors improve cellular communication in the brain and also manage depression and agitation. Memantine is used to slow the pace of disease progression.
In people with the disease, small changes are useful to help them with the symptoms. These include keeping essential things like keys and wallet in the same place, keep a daily diary to help them remember things, keep pictures of friends and family within visible distance.

Alzheimer's - An Overview!

The skin is an elastic organ (yes, it is an organ!), but only to a certain extent. It has a limit to which it can accommodate the underlying tissues. With the increase in bulk, for example, puberty, pregnancy, muscle mass building or surgical implants, the skin is made to stretch beyond its limits. What happens is this stretch causes the skin to stretch too, and these stretch marks or striae become an unpleasant thing that needs to be hidden. 

Dressing needs to be changed so that they are not showing. Dermatologists see a big demand for getting rid of these marks too. There have been conventional, time-tested methods which help in getting rid of these. However, with newer advancements in dermatology, the platelet rich plasma is being widely used for getting rid of these stretch marks.

Why stretch marks? 

In any of the scenarios above, the stretch marks appear because there is a lack of underlying supportive tissue when it is stretched out. There is a lack of collagen and connective tissue, causing stretch marks. These are most evident in fat collecting areas like breasts, abdomen, thighs, upper arms, etc.

What is platelet-rich plasma or PRP? 

The blood is composed of a liquid portion known as plasma, which contains three main types of cells i.e. white blood cells, red blood cells, and platelets. The white blood cells are the ones responsible for fighting infections. The red cells give blood its color and also are responsible for carrying nutrients to the various organs. The platelets are tiny fragments of cells which help in blood clotting. Platelets are also rich in what are called totipotent cells, which can grow into any type of cells. When the body is affected, due to injury, infection, trauma, etc., these get concentrated in the affected area and are produced in large numbers to help in the recovery of the particular affected area.

Technique: 

The area to be treated is isolated and prepared. Blood is centrifuged to remove other cells and obtain platelet rich plasma. This RPR is injected into the underlying layers of the skin. This induces the release of growth factors into the connective tissue space. Collagen is produced over a period of time, which causes the skin to become taut and lose the stretch marks. The injection can be repeated if required on the topmost layer. It can also be mixed with thrombin to form a gel, which is then used similarly. Using it both in the underlying and superficial layers helps in completely getting rid of the marks.

Studies have shown a reduction in both the depth and size of the stretch marks and some might require two to three repeat injections.


Stretch Marks - How PRP Therapy Can Help You?

Dementia is a general classification of a brain disease that causes a long haul and frequently steady abatement in the capacity to think and recall that is sufficiently incredible to influence a man's everyday  functioning. Other normal manifestations incorporate passionate issues, issues with dialect, and a lessening in motivation. An individual's awareness is not influenced. The most common example of dementia is the Alzheimer's disease.

Physiotherapy for Dementia:
A patient with dementia can benefit from physiotherapy regardless of the possibility that the patient can't perceive their own family. Physiotherapy, notwithstanding, can be of good advantage to the individual who has dementia and also their family and parental figures at different stages. The principle explanation behind this is that recovery administrations can help the dementia patient to be as utilitarian as would be prudent for whatever length of time that is conceivable. Here are 5 ways physiotherapy benefits an Alzheimer's patient:

Physiotherapy can keep up the Alzheimer's patient's freedom and mobility as much as one could expect reasonably. A physiotherapist can outline a home activity program and work intimately with relatives to administer to the Alzheimer's patient.
Physiotherapists, as independent experts, embrace much detailed, separately custom-made appraisals of the disorders, action confinements and restrictions imposed upon individuals with dementia.
The caretakers of individuals with dementia regularly show weakness when contrasted with their same aged companions. Physiotherapy helps with diminishing the weight of consideration by instructing caregivers to provide encouragement and upliftment to individuals with dementia.
Patients with dementia are always at a risk of falling down and hurting themselves. Poor balance accounts for the danger of falls. This can be worked upon and improved by physiotherapy driven exercises. Exercise can have a huge and positive effect on behavioral and mental indications of dementia, enhancing psychological capacity and mindset, which can decrease the doses of strong medicines. Special exercise routines are assigned to the patients which help improve their body balance while walking.    
Physiotherapy has crucial influence in advancing and keeping up portability of individuals with dementia. It assumes a basic part in the end of life consideration by overseeing situations, seating and complicated muscle contracture. Individuals with dementia regularly experience issues in communicating pain. Pain influences cognizance, inspiration and reaction to any intervention. Physiotherapists are specialists in recognizing and treating pain in dementia patients and give training to care home staff and caregivers of the patients.
Physiotherapy is very important for dementia patients. Regular physiotherapy sessions are beneficial for patients for improvement in condition.

5 Ways Physiotherapy Helps in Dementia

Ageing is inevitable, and as much as we want to escape, there is no way out. All organs, whether obvious or not, undergo gradual degeneration and deterioration. The brain is no exception, and memory being one of its main function also begins to decline with age. There are various factors which determine how quickly this ageing sets in and how rapidly it progresses. These are dictated by a person s lifestyle, activity levels, and overall body changes. Dementia also has a strong family history, and if you know someone who has a family history, there are some early signs that you could watch for. This will help in both empathizing with the person, as well as to help in arresting progression. Read on to know the signs that need to be watched out for.

Mood changes: Sudden changes in mood, especially going into short periods of depression without an obvious reason, is one of the first symptoms of dementia. If it is happening repeatedly, this can help identify dementia.
Personality changes: If a shy person suddenly becomes outgoing or vice versa, this could be an early indicator of dementia. They either develop or shed inhibitions, which is a new change for them.
Memory loss: Sudden short-term memory loss for a person who had a very strong memory is a definite indicator of dementia. They might clearly remember the distant events but forget small things like where to find their medicines, where things are in the kitchen or bathroom, etc. Because of this, you might see them repeating what they just did. This could be like washing a glass again, saying or asking the same thing again, etc.
The difficulty with regular tasks: Short-term memory loss causes difficulty with regular tasks like laying out the dinner table, finding regular medicines, paying utility bills, etc. There is also difficulty in learning new tasks, which further complicates things.
Feeling lost: Due to sudden memory loss and difficulty with regular tasks, they suddenly feel lost, which in turns adds to their depression.
Apathy: This also leads to a general lack of interest in things and people around them. They could have had hobbies, which no longer interest them.
Disoriented: They find it difficult to be aligned to time and space. Directions which they clearly know could seem difficult.
Not able to connect the dots: While the elderly people are generally good at telling stories and anecdotes, with dementia setting in, this becomes difficult.
These are some symptoms which can help identify if a near one is slowly developing dementia. Identifying in the early stages can help in arresting progress and extending support.

Dementia - How To Know If Someone Is Suffering From It?

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