Ageing is inevitable, and as much as we want to escape, there is no way out. All organs, whether obvious or not, undergo gradual degeneration and deterioration. The brain is no exception, and memory being one of its main function also begins to decline with age. There are various factors which determine how quickly this ageing sets in and how rapidly it progresses. These are dictated by a person s lifestyle, activity levels, and overall body changes. Dementia also has a strong family history, and if you know someone who has a family history, there are some early signs that you could watch for. This will help in both empathizing with the person, as well as to help in arresting progression. Read on to know the signs that need to be watched out for.

Mood changes: Sudden changes in mood, especially going into short periods of depression without an obvious reason, is one of the first symptoms of dementia. If it is happening repeatedly, this can help identify dementia.
Personality changes: If a shy person suddenly becomes outgoing or vice versa, this could be an early indicator of dementia. They either develop or shed inhibitions, which is a new change for them.
Memory loss: Sudden short-term memory loss for a person who had a very strong memory is a definite indicator of dementia. They might clearly remember the distant events but forget small things like where to find their medicines, where things are in the kitchen or bathroom, etc. Because of this, you might see them repeating what they just did. This could be like washing a glass again, saying or asking the same thing again, etc.
The difficulty with regular tasks: Short-term memory loss causes difficulty with regular tasks like laying out the dinner table, finding regular medicines, paying utility bills, etc. There is also difficulty in learning new tasks, which further complicates things.
Feeling lost: Due to sudden memory loss and difficulty with regular tasks, they suddenly feel lost, which in turns adds to their depression.
Apathy: This also leads to a general lack of interest in things and people around them. They could have had hobbies, which no longer interest them.
Disoriented: They find it difficult to be aligned to time and space. Directions which they clearly know could seem difficult.
Not able to connect the dots: While the elderly people are generally good at telling stories and anecdotes, with dementia setting in, this becomes difficult.
These are some symptoms which can help identify if a near one is slowly developing dementia. Identifying in the early stages can help in arresting progress and extending support.

Dementia - How To Know If Someone Is Suffering From It?

With age, most body organs begin to deteriorate in their function. This happens to the brain also, thereby reducing the overall speed of functioning of most organs. While slowing of bodily movement is visible, the internal organs functioning also slows down, which is not that obvious. Memory loss or dementia is one of the main manifestations of this degeneration of the brain.

Alzheimer s is the most common form of dementia, and the associated symptoms includes reduced reasoning abilities and cognitive defects. Though it is seen only in the elderly, not all elderly people will have Alzheimer s. The overall quality of life of the affected person is reduced with difficulty remembering things that were recently learned. It is a progressive disease and as it gets more severe, a full-time caretaker may be required.

Causes: The brain cells are affected by protein masses known as plaques and tangles. These hamper the way communication between the brain cells happens as well as affect nutrition from reaching all parts of the brain. This leads to shrinking of the brain, eventually leading to memory loss and other problems. There is also a strong genetic linkage, as most people with Alzheimer s have the lipoprotein A gene.

Symptoms: Though memory loss is the most common symptom, there are other symptoms:

Being confused about places, people, and times
Inability to find the right words during conversations
Regular objects are misplaced
Becoming irritable, (in someone who was not so previously)
Mood swings
Personality changes
Inability to organise thoughts
Not able to make the right decisions
Repetitive talks and actions
Forgetfulness (not something the person always does)
Difficulty with numbers (again, not something calculations
Difficulty managing everyday tasks and minor problems
Suspicion of others (like immediate family members and friends)
Risk factors: While age is definitely a risk factor, the fact that not all aged people develop Alzheimer s is to be borne in mind. Other risk factors include the history of stroke, high cholesterol, high blood pressure, diabetes, smoking, obesity, and poor lifestyle choices.

Diagnosis: While there is no definitive way to diagnose Alzheimer s, symptoms along with brain scans and neuropsychological function testing are useful ways to confirm the diagnosis.

Treatment: This is aimed at two things reducing the rate of disease progression and treat (or reverse) symptoms if possible.

Cholinesterase inhibitors improve cellular communication in the brain and also manage depression and agitation. Memantine is used to slow the pace of disease progression.
In people with the disease, small changes are useful to help them with the symptoms. These include keeping essential things like keys and wallet in the same place, keep a daily diary to help them remember things, keep pictures of friends and family within visible distance.

Alzheimer's - An Overview!

Alzheimer's disease is a neurodegenerative disorder that causes a degradation and eventually death of the brain cells. People with Alzheimer's disease suffer from a memory loss. There is also a progressive decline in the cognitive capacity of the brain.Today, Alzheimer's disease and dementia have become almost synonymous with old age. It is a heartbreaking experience to see aged people with Alzheimer's disease. They have little or no memory of the present time, of their loved people or the things around them. 

The Alzheimer's disease starts off as a mild condition and then gradually progresses through stages. In this article, we will discuss the different stages associated with Alzheimer's disease.

The first stage: This stage shows no significant changes in the affected person. Thus, without any diagnostic tests (such as a PET scan), it will be difficult to detect the condition in the initial stage.
The second stage: This stage brings about some changes in the person. The person might misplace things or may even forget words (something that is often brushed aside as a small problem). However, this seldom interferes with their daily activities. Like the first stage, this stage, in most cases, goes unnoticed.
The third stage: This is the stage that brings about visible changes in the person concerned such as
The person experiences difficulties in trying to organize things.
They forget things they have read, or heard just a few seconds back.
In some cases, the person may not be able to recollect a person's name they have just met.
Some people may end up repeating the same question over and over again.
The fourth stage: This stage marks a further decline in the mental health. The person gets forgetful about himself or herself. They also start mixing up with the dates and months or makes major goof up while cooking (misses out on ingredients).
The fifth stage: The mental deterioration reaches a step further. The person slowly starts forgetting about the present, such as their address, the time of the day, their profession and even phone numbers.
The sixth stage: The problem is getting worse. Hallucination is slowly setting in. The person is starting to forget people and their faces, mixing one identity with another.
The seventh stage: The final and unfortunately, the worst stage. The person stops talking to people, eating, or even walking. They stay confined to their world, oblivious of their immediate surrounding.
Dealing with an Alzheimer patient

In addition to the treatment and medication, a person with Alzheimer's disease needs the love, care, and support of their close and dear ones. Isolating them will only worsen the situation.
It may not be easy to deal with an Alzheimer's patient as the disease progresses, but do not be rude to them. Give them the confidence.
Always keep a paper containing their name, address and emergency contact number in their wallet.
People after the age of 50 should undergo regular health check ups.

Alzheimer's - How The Disease Progresses?

Alzheimer's disease is a neurological problem that is characterised by a cognitive decline and memory loss. It is a type of neurodegenerative dementia. The symptoms of alzheimer's disease include not being able to absorb and retain new information, lack of reasoning and judging, not being able to take on complex tasks, impaired visuospatial abilities, problems in reading, writing and speech, among many others. If a person has at least two of these symptoms in a debilitating manner, then the diagnosis can be made in favour of alzheimer's disease. The main causes of alzheimer's are shrinkage of the brain size and death of the brain cells. The immune system is also said to trigger this neurodegenerative disease. Let us find out what medical science has found so far.

1. Connections: many a times, in alzheimer's disease, the memory and behaviour of the person changes because the brain is unable to make proper neural connections which can lead to memory loss of how a person behaved and the elements that formed the basis of the patient's cognition. Apparently, the immune system behaves in the same way within the brain and blocks the connection. This happens because there is constant communication between the brain and immune system along neurological lines, which is where the disease first emanates.

2. Inflammation: the brain is prone to inflammation or swelling that is not the normal kind. This inflammation happens as a result of the activation of the infection fighting neurotransmitters and the chemical changes that happen in the brain when an infection strikes. The inflammation usually happens in the plaques or clumps which the brain tries to protect. These clumps are made up of a protein called amyloid. The immune system is responsible for creating this inflammation in the brain of the patient.

3. Pattern recognition receptors: many of these receptors work in different manners and cooperate with each other to create a response in the brain. These prrs can be found in the brain plaques, and they develop the signs of danger which further fuels the inflammation in the brain as a matter of protection.

4. Activation of cells linked with the immune system: when the prrs begin to respond, it basically activates the immune system and the cells of the same. This is the basic reaction that causes the changes in brain which then leads to the attachment of the protein to the tissue that is diseased, in which case alzheimer's disease starts. The inflammation that we had spoken about earlier basically happens in the nervous tissue.

It is important to recognise and act on the initial signs of alzheimer's disease before it progresses beyond one's control.

Can the Immune System Trigger Alzheimer's Disease

In recent times, the advancement of medical science has substantially contributed in comprehending the Alzheimer s disease. Unfortunately, the number of individuals suffering from the disease is expected to rise in the next ten years which pose a threat to the allocation of health care resources and public health. Alzheimer s disease is thought to be a complex disease which influences a person s behavior as well as cognition through numerous mechanisms.

Can surgery be deemed as a treatment for Alzheimer s disease?
The surgery is a multicenter clinical trial which is making a new direction in clinical research. It is devised to halt or slow down the problems caused by the disease which gradually erases a lifetime of memories in elderly patients. Though there is no cure for Alzheimer s disease, it has been found that low-voltage electric charges delivered right at the brain. Only the symptomatic therapies for Alzheimer s disease are provided which do not have any effect on the evolution of the disease. The standard medical treatments for Alzheimer s disease include cholinesterase inhibitors along with a partial N-methyl D-aspartate antagonist. In most cases of mild to moderate symptoms of this disease, a combination of treatments is used according to the clinical history, age and condition of the patient.

Mental activity supporting cognition
Many patients having normal cognition or mild impairment have a fear that they may develop AD. Many experts are of the opinion that mentally challenging activities including brain teasers and crossword puzzles can be helpful in reducing the risks in such patients. Clinical trials are under the way for determining whether or not these types of activities have any substantial effect on halting the progression of AD.

Treating AD in its moderate to the severe stage
Numerous studies have shown that blockade of NMDA receptors by memantine can be used safely in combination with ChEls. This combination has been shown to delay the institutionalization in patients with Alzheimer s disease.

Treating secondary symptoms
A variety of behavioral as well as pharmacologic interventions can help in overcoming the clinical manifestations of the disease. These include anxiety, psychotic behavior, depression and agitation among others. The effectiveness of this disease can range from modest to excellent. No particular agent or dose of it can be unanimously accepted to be the sole treatment option for the wide range of clinical issues. Moreover, in the recent time, the FDA has not accepted any psychotropic agent for treating AD.

Along with these treatment options, there are behavioral interventions that can range from patient-centred approaches to caregiver training for helping manage the cognitive and behavioral manifestations of Alzheimer s disease. Last but not the least, it is very crucial to point out the significance of treatment in the early stages of AD in order to cure it better.

Alzheimer's Disease - Can Surgery Help You Treat It?

The skin is an elastic organ (yes, it is an organ!), but only to a certain extent. It has a limit to which it can accommodate the underlying tissues. With the increase in bulk, for example, puberty, pregnancy, muscle mass building or surgical implants, the skin is made to stretch beyond its limits. What happens is this stretch causes the skin to stretch too, and these stretch marks or striae become an unpleasant thing that needs to be hidden. 

Dressing needs to be changed so that they are not showing. Dermatologists see a big demand for getting rid of these marks too. There have been conventional, time-tested methods which help in getting rid of these. However, with newer advancements in dermatology, the platelet rich plasma is being widely used for getting rid of these stretch marks.

Why stretch marks? 

In any of the scenarios above, the stretch marks appear because there is a lack of underlying supportive tissue when it is stretched out. There is a lack of collagen and connective tissue, causing stretch marks. These are most evident in fat collecting areas like breasts, abdomen, thighs, upper arms, etc.

What is platelet-rich plasma or PRP? 

The blood is composed of a liquid portion known as plasma, which contains three main types of cells i.e. white blood cells, red blood cells, and platelets. The white blood cells are the ones responsible for fighting infections. The red cells give blood its color and also are responsible for carrying nutrients to the various organs. The platelets are tiny fragments of cells which help in blood clotting. Platelets are also rich in what are called totipotent cells, which can grow into any type of cells. When the body is affected, due to injury, infection, trauma, etc., these get concentrated in the affected area and are produced in large numbers to help in the recovery of the particular affected area.

Technique: 

The area to be treated is isolated and prepared. Blood is centrifuged to remove other cells and obtain platelet rich plasma. This RPR is injected into the underlying layers of the skin. This induces the release of growth factors into the connective tissue space. Collagen is produced over a period of time, which causes the skin to become taut and lose the stretch marks. The injection can be repeated if required on the topmost layer. It can also be mixed with thrombin to form a gel, which is then used similarly. Using it both in the underlying and superficial layers helps in completely getting rid of the marks.

Studies have shown a reduction in both the depth and size of the stretch marks and some might require two to three repeat injections.


Stretch Marks - How PRP Therapy Can Help You?

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