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Dear sir, I have been smoking since 7 years and till now I'm smoking. How to avoid smoking? After how many years do cancer occur in a body?
Aged 31 I suffered from disease name lymphoma since 2014 my treatment is completed abvd kimo and radiation tell me after treatment preconditions and protection about my life secure.
I am 49 years old, my problem is that I am suffering from Chronic Leukemia, and my question is how long can such patient live with medication of IMATINIB 400 mg?
Sildenafil (Viagra), whose function is to inhibit a substance called Phosphodiestarase-5 or PDE5 - was initially used only for the treatment of angina pectoris (a cardiovascular problem) and pulmonary hypertension. Incidentally, it was discovered that it could help the issue of erectile dysfunction too, and thus became hugely popular in the late 1990s. The little blue pill, as it was called, ruled more than 50% of the sexual dysfunction market for more than 15 years. However, as its popularity and usage increased, so did the scientific information about this drug, and now there is an increased speculation that it could be contributing to skin cancer, specifically melanoma. This is considered as one of the most dangerous forms of skin cancer and so the safety of Viagra sildenafil came into question.
Research has shown that users of Viagra sildenafil are at a higher risk for developing melanoma. There are reports stating that about 45 million men are at an increased risk of developing melanoma due to associated Viagra sildenafil use. The risk of developing melanoma was found to increase in men using ED drugs by 21%. Though there is no conclusive proof as yet that sildenafil is the cause, research is increasingly pointing out its role in melanoma. For example, PDE5 inhibitors (sildenafil, tadalafil, vardenafil) are known to promote melanin synthesis, which may exacerbate melanoma development.
The analysis of biochemical pathways of this correlation suggests that Viagra sildenafil triggers a special biochemical action involving the growth-stimulating cGMP (cyclic guanosine monophosphate (an intracellular signaling molecule) which in turn promotes the growth of malignant melanoma. In normal cases, the enzyme phosphodiesterase type 5 (PDE5) regulates the cGMP preventing any adverse cellular activity. Sildenafil inhibits the production of this enzyme, and potentiates a specific cGMP-related biochemical mechanism (called cGMP-cGKI pathway) , and thereby contributes to malignant melanoma. This has been proven to happen in mice and is yet to be proven in humans.
However, there are also reports which suggest that this does not happen due to Viagra sildenafil per se, but due to greater exposure to sun, which even otherwise increases the chances of skin cancer in general, and melanoma in particular. The countering theories also say that the population in which skin cancer was detected, comprised mostly of high income individuals who spent a significant amount of time holidaying on beaches and are not connected to the extensive use of Viagra per se.
Therefore, though there is a correlation that has been established, there is no definite proof that Viagra sildenafil causes skin cancer. It is however, advisable to use ED drugs after medical consultation. If a patient has a genetic predisposition to develop melanoma, it is advisable to seek medical advice before the use of ED drugs. Occasional use should not be harmful. Also, when going out in the sun, limiting exposure to direct sun and UV protection should be managed too. If you wish to discuss any specific problem, you can consult a sexologist.
Cancer, or the big C, is always in the news. Use any keyword related to cancer, and there is definitely information overload. Also, with more people surviving cancer, there are too many tales to tell. All this leads to misconceptions and myths, leaving people, who are looking for genuine information, completely confused. The following are some common misconceptions.
- Cancer is a new-age disease: There is reference to cancer in ancient Egyptian and Greek stories, so cancer is definitely not new. However, it is true that the incidence has increased tremendously with the modern lifestyle habits.
- Food items prevent cancer: There are claims that food items like kale, blueberries, green tea, broccoli, etc., can prevent cancer. It is not true. They do have antioxidant and anti-inflammatory properties, but are not helpful in preventing cancer.
- Acidic diet causes cancer: The body’s pH is not determined by the food products that we consume. Neither acidic nor alkaline environment is healthy, and further, the body has its own mechanism to regulate pH; so go ahead and eat what you like.
- Sugars cause cancer: Sugar, believed to be the main energy source, is required for growth. Since cancer is linked to uncontrolled growth, it is believed that more sugar leads to more cancer. This again is a false notion, as there is no connection between the two.
- Screening is only for breast cancer: Agreed, breast cancer is easy to screen for, but any person with predisposition can go for periodic screening to help in early identification and intervention.
- Cancer medicines kill more than they cure: Whether it is chemotherapy or radiation, they do not pick only the cancer cells. When directed at a body part, the radiation affects the entire area. Chemotherapy targets and controls growth of a lot of normal processes, thereby affecting normal life.
- There is no cure for cancer: It is not a simple process. Curing cancer involves multiple facets – some of which may not be known or unearthed. While there are some stories, which talk about how they conquered cancer completely, there are a greater number of failures. Do not conclude on either side. Each person and each type of cancer is treated differently.
- Tight undergarments are not connected to cancer: As popularly advertised, tight underwear and underwired bras do not cause testicular or breast cancer.
- Biopsies spread cancer: This is a misconception. Most people are scared to get a biopsy as they perceive that it may spread the cancerous cells to normal areas.
This is just a short list, and there are far too many false notions. Check with your doctor to validate the information before using it to take any decision. If you wish to discuss about any specific problem, you can consult an Oncologist.