Question

My wife is suffering from ITP Immune thrombocytopenia  .please tell me for best treatment.

Dr.Surbhi Agrawal · Accepted Answer

In ITP, the body's immune system, for unknown reasons, destroys healthy blood platelets. It also impairs the body's ability to produce platelets. Slowing the destruction of platelets is one approach to ITP treatment. Most treatments for ITP interfere with the immune system to help reduce platelet destruction. Some of these treatments are FDA approved for ITP and some are not. Many of these treatments are immunosuppressants.
Corticosteroids: Often the first treatment a patient receives, corticosteroids raise platelet counts by slowing the immune system's ability to clear platelets from the bloodstream. 5 In fact, a positive response to corticosteroids can be used to confirm the diagnosis of ITP. A panel of ITP experts recently suggested that patients should only be on corticosteroids for 4 weeks as patients often experience complications because of their corticosteroids medicines over time. 4
Anti-D and IVIG: These blood products include antibodies that are made from human plasma. They slow the clearance of platelets from the bloodstream tend to be used when platelet counts are dangerously low, and have an effect that is usually temporary.
Anti-CD20: Treatment with antibodies that bind to the CD20 antigen on malignant human B cells marks these cells for destruction by the immune system.
Several other medications are used to treat ITP, including other immunosuppressants, hormone therapies, chemotherapeutics, and biologics.
Medical treatments that increase platelet production
In recent years, it has become clearer that there is an additional process involved in ITP: The body doesn’t produce enough platelets to make up for the healthy platelets that are destroyed. An alternative approach works to increase platelet production supporting a normal process in the body.
Platelet boosters. These are medicines that do not work on the immune system, but instead imitate thrombopoietin, or TPO. TPO is the protein that tells special cells in the bone marrow called megakaryocytes to produce platelets. By doing this, platelet boosters help increase platelet production.
Hope this helps.

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