Kizhi Questions

There is a 25% chance that your child may have Hemoglobin E disease. But relax. HbE disease patients are asymptomatic and can lead a healthy normal life off treatment.

In thalassemia you need first characterise that which phenotypic presentation you have major intermediate or minor and than accordingly one can manage. Till time avoid iron supplements and add folic acid.

No, it is not a life threatening disease.
Confirm the diagnosis with reliable labs, Hb-HPLC.
Precaution during the marriage age/period has to be taken.
He/she with Thalssemia minor should not marry a person with Thalassemia minor to avoid a offspring with Thalassemia major.
Thalassemia-'major' is a condition which requires life long blood transfusions, iron chelation or HLA matched Allogeneic stem cell transplantation.

Is it Thalassemia major or trait/minor.
If trait/minor no need of any treatment.
If it is major and family HLA match donor is available, Allogeneic stem cell transplant is the curative treatment. It is better to discuss Transplant treatment procedure with BMT/transplant physician working in good BMT/transplant center; it's not that simple to explain the procedures/indication/risk factors/outcome/expenditure here in this platform.
So, please, consultant Hematologist working in good tr...more

Its a genetic disease and you will not be symptomatic but during your marriage your husband should be thalassemia negative

Beta thalassemia trait is not a disease. You just are a carrier of the disease. You should just ensure that you marry somebody who is NOT a carrier of Beta thalassemia to ensure that your offspring has NO chance to have thalassemia. However in the scenario that you do eventually end up marrying somebody who is a carrier, you should first contact the local Thalassemia control center or a Hematologist to discuss what are tge steps and procedures do follow in your pregnancy to ensure that you do no...more

Ideally you can go for a hla matched sibling or unrelated transplant. However, transplant has its own problems. In that scenario regular blood transfusion and adequate iron chelation therapy should suffice to give a reasonable quality of life. However if you are adamant at cure a haplo transplant can also be done in thal major. But you must know that it is a costly procedure and can have many complications. However for that you need to consult a good centre with good expertise in haplo transplan...more

Following are the chances if you go ahead:-
50% chance of having a child with thalassaemia minor
50% chance of having a normal child
None of the couple’s children will get thalassaemia major

You need to consult an endocrinologist and he will prescribe the testosterone injection IF required. However, the cause of your stunted growth is a secondary iron overload from the monthly blood transfusion. You need to fix that by consulting a hematologist and taking medicines for your excess iron and have it under control. Feel free to discuss any other issues related to your condition over an​ online consult and I will be happy to help.

Kindly check whether your father is on any anti platelet agents like T. Ecosprin /Aspirin or clopidogrel. Which are routinely given in diabetic agents for prevention of blockages. Kindly check whether intermittently his blood pressure is going high because of stress or inadequate treatment. Kindly check whether your father is put on any heparin like agents to prevent deep vein thrombosis post hip surgery. Kindly check patients bleeding time / clotting time /platelet count /PTPI
You can start...more