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Embryo Freezing Health Feed

Egg Freezing - What Should You Know?

Dr.Anuj Sharma 92% (810ratings)
MBBS, MS - General Surgery, Fellowship of Indian Association of Gastrointestinal Endo Surgeons (FIAGES), Fellowship in Sexual Medicine
IVF Specialist, Meerut
Egg Freezing - What Should You Know?

As per the latest data released by the Human Fertilisation and Embryology Authority, the United Kingdom’s fertility industry regulator, there is an increasing number of women, who are freezing their eggs. There is also very little guidance for those women, who are considering to keep their eggs preserved.

Let us take a look at five things which women must consider and take into account before going for freezing their eggs:

  1. Women should look to freeze their eggs when they are young but not when they are too young. Women, who undergo the procedure of egg freezing before attaining the age of 30, usually tend to have the highest live birth rates from eggs which were frozen previously. Usually, women’s average age, when they go for freezing the eggs, is near about 37 years. In order to have the best chance of getting success for a live birth in the future, it is ideal to freeze the eggs before a woman attains the age of 36 years. By doing so, the stored eggs might still remain in sufficiently good quality for freezing and in all probability, can use them for future purposes. By getting them frozen at a relatively older age, for instance when you are in the 30s, there is a likelihood that one can make use of the frozen reserve and thus do not go through a procedure which is costly.
  2. Eggs Can Be Stored Only For Ten Years. In UK, there is a regulation which only permits women to freeze their eggs, once they have remained frozen for ten years. So, for that reason, women may not look to get their eggs freezed when they are in their 20s. Extension can be obtained until the period of storage, hence allowing the eggs to stay frozen till 55 years but only after meeting a condition. Women need to demonstrate that they have become infertile in a premature manner.
  3. There Is Possibility Of Losing Eggs Along The Way: The higher the number of eggs you freeze, there is a high possibility of having live birth in the future, till the time eggs are of good quality. Latest data shows that in order to have 75% chance of having one live birth, a woman of 34 years will need to freeze ten eggs, similarly at 37 years, she would require to freeze 20 eggs. In the process of egg freezing, eggs are lost. Some of the eggs may not freeze appropriately, may not even fertilise or not even reach blastocyst stage. 
  4. Women Might Require To Undergo This Procedure A Number of Times: The amount of eggs collected at the time of one cycle of stimulation and retrieval largely depends on the age of the woman at the time of going through the process, the remaining ovarian reserve of her and the way she responds to stimulation. So, some women can go on to produce 15 eggs for storage only after one round of treatment, while others may require to undergo several rounds of stimulation and retrieval to get hold of and freeze the similar number of eggs.



 

2320 people found this helpful

Embryo Implantation - What Contribute Its Results?

Dr.Anuj Sharma 92% (810ratings)
MBBS, MS - General Surgery, Fellowship of Indian Association of Gastrointestinal Endo Surgeons (FIAGES), Fellowship in Sexual Medicine
IVF Specialist, Meerut
Embryo Implantation - What Contribute Its Results?

The concept of egg quality of a woman is derived from the belief that the embryo implantation probability is powerfully related to the age and ovarian reserve of the woman. Thus, it is regarded that the quality of the egg is almost synonymous with the chances of embryo implantation. Its quality cannot be assessed merely by looking at the egg or measuring its ability to receive the fertilization by sperm or simply observing the initial embryo division.

There are a few important factors that contribute to the success or failure of the embryo implantation and some of them are:

  1. Diminished ovarian reserve: A woman with an increased FSH level on the third day of the menses is regarded as having diminished reserve of ovary. This implies that her ovary is not competent in sending feedback signals to the pituitary gland and the body responds by producing an increased amount of FSH for stimulating the ovary. For more than 10 years, it has been found that in over thousands of fertility treatment cycles, women with an increased FSH level have a lower egg quality.
  2. Advanced age of maternity: Even though the FSH level is normal, the age of the mother who provides the eggs plays an important role to determine the quality of the egg. Quite like women with increased FSH levels, eggs obtained from women aged more than 40 years can have some problems at a later stage of fertilization. Normal FSH levels are not considered a reassuring factor, owing to the lower implantation rate in females aged over 45 years.
  3. Diminished quality of egg: With an increase in age, the capacity of the mitochondria in producing energy slowly decreases. The egg is linked to the circulation before ovulation, and it is linked again after the embryo implantation. But during the one week time ranging from ovulation to implantation, the egg and the resulting embryo are contained in the zona pellucida and function on the basis of mitochondrial energy supply. The older age of the woman doesn’t cause any problem at the initial stage of ovulation. Its fertilization and embryonic development are also normal. But soon, it runs out of energy and stops dividing before reaching the stage of implantation.

Therefore, it is important to have the eggs tested to find out any sort of chromosomal abnormality. In case the mother is deficient of producing high-quality eggs, the best option is to have donor eggs.

Mitochondrial Concept:

Mitochondrial replacement (MRT, sometimes called mitochondrial donation) is a special form of in vitro fertilisation in which the future baby's mitochondrial DNA comes from a third party. This technique is used in cases when mothers carry genes for mitochondrial diseases. The two most common techniques in mitochondrial donation are pronuclear transfer and maternal spindle transfer.

Cells are the tiniest part of any organism including the human body, but has various parts within, which have specific functions. The mitochondria, for instance, are the batteries of the cells and produce energy for all functions, including cellular movement and adequate cellular function.

The egg, being a single cell, also is highly dependent on the mitochondria for its optimal function. For an egg to be healthy, it should have optimal energy, and that comes only when the mitochondria is functioning at its best. This determines the overall quality of the egg too. Poor eggs, it is well established, is one of the major cause of infertility, as it cannot implant itself and sustain the entire term of pregnancy.
Studies have confirmed that eggs have more mitochondria than normal cells, as their energy requirements are higher.

The ovaries have cells called precursor cells, which eventually can become eggs and get fertilized. Studies have shown that when mitochondria from these precursor cells are infused into the fertilized egg, the overall quality of the egg improves and therefore improves chances of fertilization.

Mitochondrial transfer is the new technique which is being developed and has resulted in a baby but involves third party IVF and hence is in a ethical debate.

2414 people found this helpful

Frozen Embryo Transfer - How To Get Ready For It?

MBBS, MD - Obstetrtics & Gynaecology, DNB (Obstetrics and Gynecology)
IVF Specialist, Delhi
Frozen Embryo Transfer - How To Get Ready For It?

Infertility is becoming an increasingly common problem. With maternal ages advancing and lifestyle turning unhealthy, infertility is affecting many couples. The problem is that it is not just a physical issue but a hugely emotional one too. For many couples, failure to conceive is devastating news. With recent advances in medicine and technology, in-vitro fertilization or IVF is becoming a highly recommended procedure to treat infertility. Frozen Embryo Transfer or FET is the step where the retrieved frozen eggs are implanted in the uterus. This could be done as a part of regular IVF or when the previously transferred egg ends up with a miscarriage.

This requires some amount of preparation, though not as much as IVF, as there are not too many medications to take to boost egg production. However, preparing for FET about a couple of months ahead of the transfer can up your success rates to a great degree.

  1. Eat well and leave out junk, processed, oily, and packaged foods. Switch over to multiple grains, cereals, dairy products, omega-3 fatty acids, vitamins, and minerals so that your body turns healthy. Drink a lot of clear water and herbal drinks. Avoid alcohol and quit smoking. This will help it go through the rigours of IVF or FET.
  2. Fertility cleansing is aimed at cleaning up the toxins and ensure there is an adequate hormonal balance that is so essential for a healthy pregnancy. This takes about a month and so talk to your doctor about timing it. There are various natural options available for this, castor oil being an example.
  3. Taking about 500 mg of L-arginine is another way to create a healthy environment for the fetus. This also improves blood flow and creates a thick uterine lining.
  4. A fertility massage also helps to improve the uterine lining, so it is better prepared to receive and sustain the embryo throughout pregnancy. The massage improves circulation to the uterus and other reproductive organs and improves the ability of the uterus to hold the fetus. This should be done 2 to 3 months ahead of the FET and stopped after transfer.
  5. Surgically, the uterus could be scratched to clear it of debris and enhance its ability to receive and sustain a pregnancy.
  6. FET is an emotionally tense moment for a couple going through it. There is anxiety about the procedure per se and the results. So keep calm and be there for each other. Having a close family or friend also helps whom you can openly express your concerns to. Meet up with people who are also into IVF or FET so you don’t feel alone.
3041 people found this helpful

Egg Freezing - Know More About It!

MBBS, MD - Obstetrtics & Gynaecology, DNB (Obstetrics and Gynecology)
IVF Specialist, Delhi
Egg Freezing - Know More About It!

Egg Freezing, which is also known as mature oocyte cryopreservation, refers to the method through which reproductive potential is restored among women. Eggs get harvested from the ovaries, frozen and in an unfertilized manner and are stored for purpose of using them later on. The egg freezing procedure is recommended for those women, who would like to delay conceiving baby due to various kinds of reasons.

Before the freezing of eggs, it is important to first retrieve the eggs. Let us look at how the eggs are retrieved, followed by the procedure of egg freezing through two different ways.

Retrieval of Egg

Egg Retrieval takes place just like it is done in case of in vitro fertilization (IVF). Women would need to be put under medication for hormones or through injections, which shall lead to the stimulation of ovaries, leading to more eggs getting matured. After this women would receive the necessary medication to stimulate ovulation and then the extraction of eggs takes place through the use of a needle. Specialists perform this whole procedure by putting women under the effect of anesthesia and are also guided by ultrasounds. Once the extraction is completed, the freezing takes place.

There are two different techniques involved in the egg freezing process. They include:

Slow Egg Freezing Method

A substance called cryoprotectant is used in order to protect the biological tissues from getting damaged out of freezing. This slow freezing method of getting eggs freezed relies on low initial concentrations of crytoprotectant. The cryoprotectant in low concentration is introduced when the egg is at a relatively warm temperature and still continues to experience the usual functions of a living cell. Then the cryptoprotectant would spread all throughtout thus fill the egg, hence replacing most of the water inside the egg. The egg is then inserted into a small container made of plastic and ultimately get placed inside a cooling chamber. The lowering of temperature, to around -6 degree centigrade, takes place through injecting very tiny amounts of liquid nitrogen into the cooling chamber. The cooling process is controlled by a computer.

The main purpose of these techniques is to avoid ice crystals from getting formed in the egg. During the spreading of the cryoprotectant, if the ice crystals are still present, they can cause damage to the egg and hence the egg may not survive the process of thawing. Then the temperature is lowered further to around -32 degree centigrade. By this time, the egg’s metabolic rate become slow. The container where the egg was placed, is then dipped inside the liquid nitrogen, forming a solid.

Rapid Egg Freezing Method or Vitrification

At the time of rapid freezing method, there is high concentration of initial cryoprotectant whereas the cell remains at room temperature. The egg is unable to stay for long in this temperature and thus gets poured immediately onto the liquid nitrogen. Cryoprotectant spreads at a rapid rate so as to avoid ice-crystal from getting damaged. Vitrification is a very new method for freeing eggs. Recent research has shown that vitrification of eggs largely improves the possibility for survival after thawing and the rates of pregnancy.

3266 people found this helpful

Egg Freezing - Know How Is This Beneficial In Late Pregnancy!

Sneh Hospital 88% (12ratings)
IVF Specialist, Ahmedabad
Egg Freezing - Know How Is This Beneficial In Late Pregnancy!

The freezing of sperm and embryos has been recognized for long as way to pursue treatments for fertility later on in life. Nowadays, the new techniques for freezing of eggs have lead to greater success. Due to this reason, the American Society for Reproductive Medicine no longer takes egg freezing as a procedure for experimental purposes.

Ideal Candidates for Egg Freezing-

Now, we look into the candidates, who are ideal for going through the process of egg freezing. They include:

Women Who Intend To Put Off Childbearing: Generally fertility tends to decline with the advancement of age in women. Along with that, women who are in their twenties or thirties have less risk of miscarriage taking place and giving birth to babies with defects, in comparison to aged women. This happens mainly because of the increase in the percentage of embryos with abnormalities in the chromosome, which occurs with the advancement of age. Due to the problems that are associated with reproductive aging, a lot of women have preferred to use donor eggs, in order to increase their possibilities of bearing a child. Though this is an extremely effective method, yet the choice becomes hard to make as it involves the greatest amount of sacrifice.

Working Women - Working women of corporate sector who wants to plan marraige at late age or planning child late after marraige are very good candidate for Egg freezing as it will ensure a healthy baby later in the life without sacrificing a flourishing career right now.

Egg Freezing for Cancer Patients: Egg Freezing can be an extremely useful proposition for those who are diagnosed with cancer. The health data from 2001 onwards in the United States shows that around 8% of women who have been diagnosed with cancer, were aged below 40 years. The year 2007, saw an estimated 180,000 women getting diagnosed with invasive breast cancer. Around 5% of all those women who were aged below 40 years during the time of diagnosis have never had the chance of becoming pregnant. Most of these women have stayed single. Women who have been diagnosed with breast cancer, 81% of those young women, who would go through treatments in the form of chemotherapy and radiation will remain alive and be free of ailments after a period of 5 years.

An unfortunate thing for all these women, who are in the childbearing age, chemotherapy and radiation would cause serious damage to the follicles which are in the process of getting matured in the ovaries.

Now, if a woman who has been diagnosed with cancer, looks to get involved with a male partner to conceive but still not ready to go for pregnancy, the ideal option would to create embryos through In Vitro Fertilization or IVF and go on to freeze the embryos. Embryo Cryopreservation has gone on for a year in a successful manner and is now known as the gold standard in preserving fertility.

Egg Freezing for Soldiers: Soldiers are also possible candidates, who could be ideal for egg freezing but unfortunately they tend to get overlooked. These people are often vulnerable towards getting pelvic injuries, which cause damage to their reproductive systems. Military records have shown that since the year 2003, well in excess of 1800 members, most of whom were Army troops, in Afghanistan and Iraq have gone on to suffer such injuries. There are cases when these injuries might well make a soldier incapable of bearing children.

3778 people found this helpful

Freezing & Storing Eggs - Know Benefits Of It!

Sneh Hospital 88% (12ratings)
IVF Specialist, Ahmedabad
Freezing & Storing Eggs - Know Benefits Of It!

Childbirth comes within an age bracket. Women feel this more so than men. Career demands or other personal choices can delay the time to get pregnant. Thus, freezing your eggs can prove to be beneficial, if you delay childbirth to focus on your career or education, or if you have certain medical conditions such as cancer.

  1. Egg Retrieval: Before the eggs are harvested, there is a lot you have to do. The first month is spent taking blood tests and ultrasounds. In the second month, you will have to take medicines before your procedure for egg retrieval. Ultrasounds and blood tests are also conducted at this stage to monitor the growth of the eggs. Around the time of your ovulation, the eggs will be harvested. You will be lightly sedated during the procedure. After the procedure, you might feel bloated and experience cramping. At least 15 eggs are retrieved for optimum chances. The medicines prescribed are all hormone injections which you can self-administer.
  2. Freezing and Storage: The largest human cell is the egg. It is comprised mainly of water. When the eggs are frozen, crystals can form which can destroy it. So an anti-freeze replaces the water after the eggs are dehydrated. This prevents crystal formation. Eggs are frozen using vitrification. In this process, the eggs are either slowly or flash frozen. Eggs can be frozen for as long as 10 years. This does not hamper the quality.
  3. Risks: There is no guarantee that freezing eggs will lead to having a baby. Sometimes, eggs do not survive the freezing or the thaw.
  4. Advantages: For women who are suffering from cancer, freezing their eggs might be the best option. They might want to preserve their fertility before their cancer treatment starts. This is useful since radiation and chemotherapy can harm your chances of getting pregnant.

The obvious advantage of freezing your eggs would be the fact that it gives you time. It lets you decide and keeps you one step ahead of your biological clock.

3493 people found this helpful

Frozen Embryo Transfer - What's The Success Rate Of It?

Dr.Ruchi Malhotra 89% (482ratings)
MBBS Bachelor of Medicine and Bachelor of Surgery, DNB - Obstetrics & Gynecology, DGO
IVF Specialist, Delhi
Frozen Embryo Transfer - What's The Success Rate Of It?

Women are not really sure about frozen embryos’ ability to result in pregnancy. Ironically, the success of Frozen Embryo Transfer has dramatically improved over the last few years. In the days gone by, the chance of women getting pregnant through the use of frozen embryos seemed to be on the lower side compared to that from the transfer of fresh embryos. Recent data related to this suggests that this is no longer the case.

Reasons behind the low success rate of frozen embryo transfer in the past
Previously during the frozen embryo transfer process, the embryos which had to get frozen were the ones that did not get chosen for the fresh embryo transfer initially. The reason being that the embryologist had gone ahead to choose the best possible embryos for getting them transferred initially. As far as the fresh embryo transfer is concerned, the quality of embryo has got a major effect on the chance of a woman getting pregnant. On the other hand, if the quality of embryos frozen is not good, the rate of survival after it gets thawed along with the rate of pregnancy would be on the lower side.

The second important reason is the number of embryos that got transferred. Let us consider a couple who produce four very good quality embryos. Two of them are transferred during fresh In Vitro Fertilization Process and the remaining two are frozen. This leads to pregnancy and the woman gives birth to a baby. Later on, the couple once again decides to go for pregnancy by using the frozen embryos. Though only one embryo survives after getting thawed. The frozen embryo transfer is that of a single embryo. The success rate of a frozen embryo transfer through a single embryo is always going to be on the lower side than what it will be when multiple embryo transfers are involved.

Finally, the method of freezing embryos has seen a sea change quite a number of years ago. Nowadays the freezing of embryos takes place by a fast method, known as vitrification. This process has got a much better survival rate when embryos get thawed along with good rates of pregnancy when those particular embryos are transferred in a much better manner.

Studies about the high success rate of frozen embryo transfer
There have been studies performed in women, who have had quite a vigorous stimulation of their ovaries and were considered to be at high risk for Ovarian Hyperstimulation Syndrome. The physicians took the decision of skipping the process of embryo transfer and instead go ahead to freeze all the embryos for use at a later stage.

This tends to significantly decrease the risk of having serious Ovarian Hyperstimulation Syndrome along with the decrease in complications. Other cases involved, physicians deciding to move on with a fresh embryo transfer despite the risk of Ovarian Hyperstimulation Syndrome. In both the scenarios the couples have quite a large number of embryos and the embryos selected for transfer were the best embryos.

The studies have shown no difference in the rates of pregnancy between fresh or frozen embryos or for that matter higher rate of pregnancy with frozen embryos.

4068 people found this helpful

Egg Freezing - Who Stands Eligible?

Dr.Ruchi Malhotra 89% (482ratings)
MBBS Bachelor of Medicine and Bachelor of Surgery, DNB - Obstetrics & Gynecology, DGO
IVF Specialist, Delhi
Egg Freezing - Who Stands Eligible?

The freezing of sperm and embryos has been recognized for long as a way to pursue treatments for fertility later on in life. Nowadays, the new techniques for the freezing of eggs have lead to greater success. Due to this reason, the American Society for Reproductive Medicine no longer takes egg freezing as a procedure for experimental purposes.

Ideal Candidates for Egg Freezing

Now, we look into the candidates, who are ideal for going through the process of egg freezing. They include:

Women Who Intend To Put Off Childbearing: 

Generally, fertility tends to decline with the advancement of age in women. Along with that, women who are in their twenties or thirties have less risk of miscarriage taking place and giving birth to babies with defects, in comparison to aged women. This happens mainly because of the increase in the percentage of embryos with abnormalities in chromosome, which occurs with advancement of age. Due to the problems that are associated with reproductive aging, a lot of women have preferred to use donor eggs, in order to increase their possibilities of bearing a child. Though this is an extremely effective method, yet the choice becomes hard to make as it involves the greatest amount of sacrifice.

Egg Freezing for Cancer Patients: 

Egg Freezing can be an extremely useful proposition for those who are diagnosed with cancer. The health data from 2001 onwards in the United States shows that around 8% of women who have been diagnosed with cancer, were aged below 40 years. The year 2007, saw an estimated 180,000 women getting diagnosed with invasive breast cancer. Around 5% of all those women who were aged below 40 years during the time of diagnosis have never had the chance of becoming pregnant. Most of these women have stayed single. Women who have been diagnosed with breast cancer, 81% of those young women, who would go through treatments in the form of chemotherapy and radiation will remain alive and be free of ailments after a period of 5 years.

An unfortunate thing for all these women, who are in the childbearing age, chemotherapy and radiation would cause serious damage to the follicles which are in the process of getting matured in the ovaries.

Now, if a woman who has been diagnosed with cancer, looks to get involved with a male partner to conceive but still not ready to go for pregnancy, the ideal option would to create embryos through In Vitro Fertilization or IVF and go on to freeze the embryos. Embryo Cryptopreservation has gone on for year in a successful manner and is now known as the gold standard in preserving fertility.

Egg Freezing for Soldiers: 

Soldiers are also possible candidates, who could be ideal for egg freezing but unfortunately, they tend to get overlooked. These people are often vulnerable towards getting pelvic injuries, which cause damage to their reproductive systems. Military records have shown that since the year 2003, well in excess of 1800 members, most of whom were Army troops, in Afghanistan and Iraq have gone on to suffer such injuries. There are cases when these injuries might well make a soldier incapable of bearing children.

3655 people found this helpful

Embryo Freezing - Understanding The Benefits Of It!

IVF Specialist, Mumbai
Embryo Freezing - Understanding The Benefits Of It!

In the process of in vitro fertilization, the stimulation of the ovaries of a female is done so as to produce multiple eggs. This technique is performed in laboratories by creating the special environment and using freezing equipment so that the embryos can be stored in liquid nitrogen for the longer period of time.

What is Embryo Freezing?

Embryo freezing is also known as cryopreservation. This technique refers to a procedural method in which the viable embryos are preserved by keeping them at the cool place at very low temperatures, at -196 degree Celsius. After the process of fertilization is done and acculturation of embryo is performed, then the best embryos out of the group are selected for transfer of embryos. In 50 percent of cases, there are ample amount of embryos to fulfill the requirement of embryo transfer. And hence, these embryos can be frozen for use in future purposes.

Advantages of Embryo Freezing:

One of the best advantages of embryo freezing is that thawing of frozen embryos can be done and then these can be transferred in the uterus of women without stimulating ovaries. The cycle of transferring frozen embryos is quite simple. The assessment of the menstrual cycle is done to estimate the uterus lining development in females and at the time of ovulation, the embryo is transferred. In certain cases, the women’s medical history is taken before and the hormonally controlled cycle is warranted. However, one should always consult the clinician before going for any treatment procedure.

Disadvantages of embryo freezing:

As per the research history, almost 70% of the frozen embryos are able to survive the thawing purpose. But the success rate varies from individual to individual. It may be possible that even after saving many embryos, none of the embryos survive the thawing process.

Embryo Freezing - Know Its Benefits!

Dr.Ruchi Malhotra 89% (482ratings)
MBBS Bachelor of Medicine and Bachelor of Surgery, DNB - Obstetrics & Gynecology, DGO
IVF Specialist, Delhi
Embryo Freezing - Know Its Benefits!

In the process of in vitro fertilization, the stimulation of the ovaries of a female is done so as to produce multiple eggs. This technique is performed in laboratories by creating the special environment and using freezing equipment so that the embryos can be stored in liquid nitrogen for the longer period of time.

What is Embryo Freezing?
Embryo freezing is also known as cryopreservation. This technique refers to a procedural method in which the viable embryos are preserved by keeping them at the cool place at very low temperatures, at -196 degree Celsius. After the process of fertilization is done and acculturation of embryo is performed, then the best embryos out of the group are selected for transfer of embryos. In 50 percent of cases, there are ample amount of embryos to fulfill the requirement of embryo transfer. And hence, these embryos can be frozen for use in future purposes.

Advantages of Embryo Freezing
One of the best advantages of embryo freezing is that thawing of frozen embryos can be done and then these can be transferred in the uterus of women without stimulating ovaries. The cycle of transferring frozen embryos is quite simple. The assessment of the menstrual cycle is done to estimate the uterus lining development in females and at the time of ovulation, the embryo is transferred. In certain cases, the women’s medical history is taken before and the hormonally controlled cycle is warranted. However, one should always consult the clinician before going for any treatment procedure.

Disadvantages of embryo freezing
As per the research history, almost 70% of the frozen embryos are able to survive the thawing purpose. But the success rate varies from individual to individual. It may be possible that even after saving many embryos, none of the embryos survive the thawing process.

3401 people found this helpful
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