Common Specialities
{{speciality.keyWord}}
Common Issues
{{issue.keyWord}}
Common Treatments
{{treatment.keyWord}}

Chronic Myeloid Leukemia Health Feed

Hi Sir/Madam, I'm diagnosed as cml I'm on treatment with tab imatinib 400 mg. Now my WBC count is normal, how many years can I live, can I marry a girl & lead a happy life. Please suggest to me.

Dr.Sushil Kumar Sompur 94% (2748ratings)
MB BS, MD - Psychiatry, MBA - Healthcare
Psychiatrist, Davanagere
Hi Sir/Madam, I'm diagnosed as cml I'm on treatment with tab imatinib 400 mg. Now my WBC count is normal, how many ye...
It seems like you are an otherwise healthy person, a man who is 6 ft tall and 75 kgs. Your current wbc count is normal and you are on treatment for imatinib. With regards to your prognosis of cml your oncologist should have told you about how things might turn out for you. Most blood cancers are curable, however it is best to speak with your oncologist regarding your condition or get a second opinion. Look forward to hearing from you. If you need help with booking an appointment online with me on this website either text, an appointment for a confidential and private consultation you may do so by contacting the help desk of Lybrate.
Submit FeedbackFeedback

Chronic Myeloid Leukemia - Know The Facts About It!

Dr.Mukul Gharote 92% (35ratings)
MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Chronic Myeloid Leukemia - Know The Facts About It!

CML refers to Chronic Myeloid Leukemia. This type of cancer originates in the bone marrow. It occurs when a genetic change takes place in immature myeloid cells. These cells are responsible for the production of platelets, red blood cells and many types of white blood cells. As a result of these changes an abnormal gene known as BCR-ABL is formed. In turn, this gene converts the myeloid cells into CML cells.

As cancer progresses, the cells spill out of the bone marrow and enter the circulatory system. The cells are transported through the blood to other organs and can settle in various other parts of the body. CML is a slow growing cancer but in some cases, it can turn into fast-growing cancer that is hard to treat. It is more common amongst adult and is rarely seen among children.

Studies on CML are directed towards both the understanding of how cancer develops and how it can be treated. Scientists are making steady progress towards understanding how a person’s DNA can change and in turn cause a mutating of bone marrow cells into CML cells. For this, researchers are studying what changes can make a cell grow fast, live longer than usual etc.

There are a few drugs that have proven to be effective in the treatment of CML. These drugs target proteins like BCR-ABL. However, not all patients benefit from it. Hence, studies are now underway to evaluate how it could be combined with other forms of treatment such as cancer vaccines, interferon or chemotherapy to be more effective. It is also being combined with other medicines to study the effects.

New drugs have also been developed to target and treat CML. In cases where CML cells create a mutation known as T315I by changing the BCR-ABL cells, the cancer is resistant to many different types of therapy. This includes targeted therapies like nilotinib, imatinib, and dasatinib. Thus, drugs are being created that can treat this mutation. Another type of drug that is being developed is known as farnesyl transferase inhibitors. In some tests, these are also being combined with imatinib.

Vaccinations that can protect a person from CML are also being studied. For this several vaccines have been developed and are currently being tested for effectiveness. CMLVAX100 is one such vaccine. Some studies have shown that when this vaccine is combined with imatinib, it is more effective.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3458 people found this helpful

Chronic Myeloid Leukemia - Why Does It Happen?

Dr.Ankur Mittal 92% (164ratings)
MBBS, MD, FICH
Hematologist, Ludhiana
Chronic Myeloid Leukemia - Why Does It Happen?

Chronic myeloid leukemia (CML) is a cancer of the white blood cells. It is characterized by an increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.

Epidemiology, Incidence, Prevalence
In Western countries, CML accounts for 15–25% of all adult leukemias and 14% of leukemias overall (including the pediatric population, where CML is less common).

Why Does It Happen?
Neither you get it from your parents or infections, nor your smoking habits and diet seem to raise any chance of getting it. The only risk is if you've been in contact with high levels of radiation. Higher incidence of CML was seen in Hiroshima and Nagasaki nuclear bombing survivors. The rate of CML in these individuals seems to peak about 10 years after the exposure.

How would you know about it?

  • CML has three phases: Chronic, Accelerated, and Blastic
  • Chronic- It is the earliest stage. You might not even have symptoms.
  • Accelerated- The number of blood cells that don't work right increases Symptoms are as follows
  • Night sweats due to hypermetabolism
  • Dyspnea
  • Decreased appetite
  • Left upper quadrant abdominal pain from spleen infarction
  • Pain in your bones
  • Stroke
  • Changes in your vision
  • Ringing in your ear
  • Fatigue, weight loss
  • Loss of energy
  • Decreased exercise tolerance
  • Bruise

Blastic- The cells multiply and take over the healthy blood cells and platelets.

Symptoms-

  1. Thrombocytopenia
  2. Basophilia
  3. Anemia
  4. Rapidly enlarging spleen in blast crisis
  5. Skin changes including bumps, tumors
  6. Swollen gland
  7. Infections
  8. Bleeding, petechiae, and ecchymosis
  9. Bone pain
  10. Fever
  11. Investigations

Complete blood count- To see how many white blood cells, red blood cells, and platelets you have.

  1. FISH test (fluorescence in situ hybridization)- It is a detailed lab test of your genes to see for Philadelphia (Ph) chromosome in bone marrow cells.
  2. Polymerase chain reaction test- It is a lab test that looks for the BCR-ABL gene, which is involved in the process that tells your body to make too many of the wrong kind of white blood cells.

Ultrasonography- to see for splenomegaly.
Bone marrow test. It helps you figure out how advanced your cancer is. The doctor uses a needle to take a sample, usually from your hip bone.

Treatment

  1. The goal of your treatment is to destroy the leukemia blood cells in your body and restore healthy ones to a normal level. It's usually not possible to get rid of all the bad cells.
  2. If you get treatment during the early, chronic phase of CML, it can help prevent the disease from moving to a more serious level.
  3. Doctors usually give drugs known as tyrosine kinase inhibitors (TKIs) first. They slow down the rate at which your body makes leukemia cells.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2605 people found this helpful
Icon

Book appointment with top doctors for Chronic Myeloid Leukemia treatment

View fees, clinic timings and reviews