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Chemotherapy Questions

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My grandmother has breast cancer. The biopsy result is'Invasive duct carcinoma grade 2' And her PET-CT scan result is'Hypermetabolic retroareolar right breast mass FDG avid regional lymph nodes. No FDG avid distant lesions. Her-2 result is negative. ER and PgR result is positive 90%? Strong. Doctor told that tumor is locally advanced. We have started her treatment and doctor suggested below plan - 1- 11 chemotherapy once in a week 5 chemo are already done. Doctor told that if she can't tolerate chemo then we can stop before 11. The reason doctor gave behind chemo treatment is to shrink a tumor and tumor is stick to skin so chemo will make it loose. 2- Surgery 3- 5 chemotherapy every 21 days of interval 4- Radiation 5- Hormonal treatment for 5 years My grandma is physically fit and she doesn't have BP and diabetics and any other health issues except acidity. Last week my grandma fell down and her x-ray report is'Diffuse osteopenia. Anterior wedging of L1, L2 & L3 vertebra, could represent osteoporosis collapse. She has severe pain in the back. Recently I have taken a 2nd opinion and the doctor suggested that she doesn't need chemotherapy as her ER test is positive. She told that only hormones tablet will help to shrink a tumor and she may not need surgery. She told if we give chemo to her at the age of 75, it may create health problems for her later. I'm in dilemma now. Shall we continue with chemo treatment or switch to hormone treatment? If yes then what about its side effects? If we switch to hormone treatment then the chemo which is given will create any problem? Will it be right to switch to hormone treatment after 5 chemo cycle? What are the chances of metastasis in hormone treatment? What if we have to switch to chemo again after hormone treatment? Will cancer cell become drug resistant because of first chemotherapy? Chemo drugs go in an entire body so if there are any cancer cells in initial stage then it will kill it so chances of metastasis will be less. Is it true? Does hormone treatment also help to prevent metastasis? Let me know if you need more details.

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UICC International Fellow in Oncollogy ,...read more

Oncologist•Jamnagar
Above the age of 65 ,role of chemotherapy is very limited.
Hormone receptor positive disease respond well to hormonal treatment, including shrinkage of tumour.
In advanced age, and advanced tumour, first goal is surgery, if at all it's possible, followed by Radiotherapy (if required) and hormonal treatment. I need to see PET CT report
Histopatho and ER PR Her 2 report. Please send me for further review.
Asked for female, 73 years old from Hassan
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MD - General Medicine

Internal Medicine Specialist•Noida
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The prognosis (chance of recovery) and treatment options depend on the following:
The stage of the cancer (whether the cancer has spread from the gallbladder to other places in the body).
Whether the cancer can be completely removed by surgery.
Treatment may also depend on the age and general health of the patient and whether the cancer is causing signs or symptoms.
Gallbladder cancer can be cured only if it is found before it has spread, when it can be removed by surgery. If the...more
Asked for Male, 40 years old from Noida
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Asked for male, 67 years old from Coimbatore
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MBBS, MD - Medicine, MD - Oncology, Fell...read more

Oncologist•Delhi
Dear lybrate-user,
the history you are giving, it means you had very early stage of cancer which was completely resected out. Also there was no abdominal lymph node involvement. In such no chemotherapy is required but timely suprvision is needed, you should consider that you are cured from this trouble after surgery.
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Membership of the Royal College of Surge...read more

General Surgeon•Mohali
Plenty of rest, high protein nutritious diet and she should stay positive. Avoid raw fruits and vegetables during chemotherapy and for 10 days after that. You can stew the apples for 15 sec in the microwave and give. If she has vomitting don't stop diet. Give Cerelac which is baby food hence easy to digest. Add black salt to all juices.
Asked for male, 24 years old from Visakhapatnam
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Membership of the Royal College of Surge...read more

General Surgeon•Mohali
She should do well. Do specific precautions. Good high protein diet, plenty of rest and staying positive.
178 people found this helpful
Asked for male, 64 years old from Bangalore
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MBBS, MD - Medicine, MD - Oncology, Fell...read more

Oncologist•Delhi
Dear lybrate-user,
if the liver was involved it becomes a stage 4 cancer. Since local disease has been removed by radical mastectomy you need some form of treatment for metastasis. We should know the other parameters of the biopsy like hormonal status. If positive you will need convenient chemo or hormone therapy.
Asked for Male, 40 years old from Varanasi
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MBBS, DNB ( Radiation Oncology)

Oncologist•Mumbai
Hi. Yes radiation has a very important role in your mother's treatment. You should consult a radiation oncologist for the appropriate plan of treatment.
Good Luck!
Asked for Male, 66 years old from Kolkata
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I am 65 years male from Kolkata suffering from DM type 2 from past 35 years, HTN, psychiatric problem from last 30 years, diagnosed with squamous cell carcinoma oral in 2011 undergone surgery, radiation, chemotherapy, at present carcinoma is in remission no abnormal uptake detected, having enlarged prostate from 2014 as per USG lower abdomen done it transpired as under: -urinary bladder normal in shape- walls are smooth and regular, lumen clear, pre void vol of urine- 330.2 ml post void vol of urine 295 approx of residual urine ,prostate gland measured 3.3×3.8×3.6 cm approx prostate wt 23.2 gms: -impression mildly enlarged prostate gland significant residual urine post void bladder (nearly same as pre void state) -PSA 1.3 ng/ml. On 17th instant repeated USG- whole abdomen: -all parameters normal, kidney right- 10. 9 cm left kidney 10.3.6 cm normal a cyst measure about 36 mm seen in left kidney (cyst was present before 2014 but those reports not found now unable to say the measurement of cyst) findings normal, post void residual urine vol 112 cc approx, prostate measures 35.8×30.9×32. 5 mm in size wt 20. 5mgm contour &ecotexer homogenous: -impression cortical seen in left kidney (present from long time, prostate gland size on higher side of the normal, post void residual urine 112 cc approx- PSA 6.16 ng/ml. Kindly give your opinion.

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MBBS, M S General Surgery ,

General Surgeon•Chandigarh
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Hi basically you are suffering from enlarged prostate if you have any symptoms relating to pass urine or increased in frequency or any other complaint let me know you have to visit a urologist for proper management plan.
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