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Bone Marrow Depression Tips

Bone Marrow Transplant - busting the myths!

European Society For Medical Oncology certification, DM - Oncology, MD - General Medicine, MBBS, Fellowship in Bone Marrow Transplant
Oncologist, Faridabad

The term bone marrow transplant is actually a misnomer in the present context as a vast majority of transplants are now conducted by harvesting stem cells from the blood of the donor. 

So the correct and logical term now is peripheral blood stem cell transplant. This is just like a blood donation for the donor and poses no risk at all to the donor. The term blood cancer is generally used for leukemias, these can be of two types - acute and chronic. 

For the chronic leukemias, especially chronic myeloid leukemia, stem cell transplant is now generally not required as drugs like imatinib, dasatinib and nilotinib are extremely effective. For chronic lymphocytic leukemia transplant is rarely done these days and is generally reserved for relatively younger patients. Even in the imatinib era transplant is an effective procedure and can cure patients with CML (chronic myeloid leukemia) who do not respond to imatinib and other tyrosine kinase inhibitors. 

For acute myeloid leukemias stem cell transplant is recommended for all cases except the low risk cases, after completion of chemotherapy. Risk is defined based on kind of genetic mutations in the leukemic cells for acute lymphoblastic leukemia transplant is generally done at relapse, but certain genetic mutations necessitate an earlier transplant, so does presence of or increase in minimal residual disease, which signifies cancer cells not visible to the human eye under the microscope.

Procedure of stem cell transplant HLA matching is done between patient and siblings. Best match is selected as a donor. Matched sibling is the most commonly used donor in blood cancers. In many cases a match is not available, for such cases matched unrelated donor, cord blood, or a partially matched donor (haploidentical donor) is sometimes selected. Donor is given growth factor injection subcutaneously to bring out the stem cells from the bone marrow to bloodstream, twice daily for 5 days. After that the stem cells are collected and stored. Patient is given high dose chemotherapy to kill cancer cells as well as his normal marrow. After chemotherapy, donor stem cells are injected into the body of patient from a vein. After approximately 11-14 days the donor cells get engrafted in the patient's marrow and start producing normal blood cells. The donor cells also kill the cancer cells and prevent cancer from coming back. 

Overall depending on whether the patients cancer is controlled or not before transplant the cure rate after transplant can vary from 60 % for patients who have a good control and less aggressive disease biology, to less then 20 % in patients with uncontrolled disease before transplant. Overall, approximately 40 % patients get cured with a transplant. Upto 40 % patients can develop complications, and half of these may be very severe and life threatening. This figure is more in mismatched transplants. Apart from complications, there is still a risk of relapse and these patients need close monitoring in the first few years after transplant.

1 person found this helpful

Bone Marrow Transplant- Busting the Myths Part 2!

European Society For Medical Oncology certification, DM - Oncology, MD - General Medicine, MBBS, Fellowship in Bone Marrow Transplant
Oncologist, Faridabad

Carrying on from my previous post, another important type of stem cell transplant is known as an autologous transplant, in which the patient's own stem cells are harvested in a manner similar to the harvest of donor cells.

After harvest, the patient is treated with high-dose chemotherapy. Autologous transplant is done mostly in multiple myeloma (standard of care), relapsed high-grade lymphomas (commonly diffuse large b cell) and Hodgkin lymphoma. After high-dose chemotherapy there is an intervening period of low blood counts when the patient is susceptible to infections and bleeding. Support is given in the form of blood, platelet transfusions and antimicrobial drugs. The stem cells start producing blood cells by around day 11 and recovery occurs. The outcome depends on the status of the disease before transplant. Patients in remission prior to transplant do much better in the long term than those with active disease.

Generally speaking, around 50 percent patients with relapsed lymphoma get cured with this approach. Multiple myeloma is a more complex disease and is known to relapse after varying intervals after transplant. Transplant in this scenario improves overall survival and provides freedom from disease for a few years.

1 person found this helpful

Bone and Joint Health - How To Take Care Of It?

Fellow Adult Knee Reconstruction and Sports Injuries, Fellowship in Interventional Pain Practice, MS - Orthopaedics, MBBS
Orthopedist, Gurgaon
Bone and Joint Health - How To Take Care Of It?

Staying healthy involves a wholesome state of being where the mind and body are in perfect sync. A less than properly functioning body can leave you in a state of potential depression after a certain point of time, while a depressive mind can leave you feeling less than stellar where you end up imagining and experiencing pain. The health of your bones and joints is one such area that requires even more care as you start growing older. Wear and tear is just one of the reasons for degeneration while fractures and injuries can lead to a sudden halt of normal functioning of the bones and joints too. So how can you ensure bone and joint health in the long run? Follow our tips!

  1. Eating Right: Pick calcium rich food like dairy products that have a low fat content, including milk and yogurt. Also, have a daily dose of green, leafy vegetables and plenty of citrus fruit and juices for your fill of calcium. Further, food like eggs and soya beans which have lots of vitamin D can also help in retaining good bone and joint health. Vitamin C rich fruit like watermelon, oranges, squash and tomatoes also help in natural tissue and cartilage repair. And finally, get plenty of Vitamin K to retain good bone density for a prolonged period with ingredients like leafy green vegetables, eggs and cheese.
  2. Exercise: This is the key to good bone and joint health. Much like machinery and tools, the bones and joints of your body can also wither with disuse and prolonged inactivity. Make sure that you indulge in exercises like long walks and muscle strengthening exercises which will give your joints and bones good amount of strength as well. Remember to speak with your doctor before you start a new exercise regime so that you avoid anything that may be harmful in case you have any other ailment. Low impact exercises will strengthen the spine, while fat burning and weight loss exercises will ensure that there is less pressure on the knees and lumbar area. Swimming and resistance building exercises can also be practised for these purposes.
  3. Abstinence: A major factor in promoting better bone and joint health is abstinence from all those things that can create problems in the long run, like smoking, drinking excessively and even too much consumption of caffeine and fatty food. All these things can create depletion of the natural bone mass. Also, switching to a lower heel for everyday wear footwear and changing your position during your time at your work station are a few things that will go a long way.

Take care of your bones and joints the right way today, for a healthier tomorrow. If you wish to discuss about any specific problem, you can consult an Orthopedist.

2837 people found this helpful

Bone and Joint Health

M Ch. Ortho, MS - Orthopaedics, MBBS
Orthopedist, Delhi
Bone and Joint Health

Staying healthy involves a wholesome state of being where the mind and body are in perfect sync. A less than properly functioning body can leave you in a state of potential depression after a certain point of time, while a depressive mind can leave you feeling less than stellar where you end up imagining and experiencing pain. The health of your bones and joints is one such area that requires even more care as you start growing older. Wear and tear is just one of the reasons for degeneration while fractures and injuries can lead to a sudden halt of normal functioning of the bones and joints too.

So how can you ensure bone and joint health in the long run? Follow our tips!

  1. Eating Right: Pick calcium rich food like dairy products that have a low fat content, including milk and yogurt. Also, have a daily dose of green, leafy vegetables and plenty of citrus fruit and juices for your fill of calcium. Further, food like eggs and soybeans which have lots of vitamin D can also help in retaining good bone and joint health. Vitamin C rich fruit like watermelon, oranges, squash and tomatoes also help in natural tissue and cartilage repair. And finally, get plenty of vitamin K to retain good bone density for a prolonged period with ingredients like leafy green vegetables, eggs and cheese.
  2. Exercise: This is the key to good bone and joint health. Much like machinery and tools, the bones and joints of your body can also wither with disuse and prolonged inactivity. Make sure that you indulge in exercises like long walks and muscle strengthening exercises which will give your joints and bones good amount of strength as well. Remember to speak with your doctor before you start a new exercise regime so that you avoid anything that may be harmful in case you have any other ailment. Low impact exercises will strengthen the spine, while fat burning and weight loss exercises will ensure that there is less pressure on the knees and lumbar area. Swimming and resistance building exercises can also be practised for these purposes.
  3. Abstinence: A major factor in promoting better bone and joint health is abstinence from all those things that can create problems in the long run, like smoking, drinking excessively and even too much consumption of caffeine and fatty food. All these things can create depletion of the natural bone mass. Also, switching to a lower heel for everyday wear footwear and changing your position during your time at your workstation are a few things that will go a long way.

Take care of your bones and joints the right way today, for a healthier tomorrow.

5033 people found this helpful

How Can You Ensure Bone And Joint Health?

MBBS, MS - Orthopaedics
Orthopedist, Nashik
How Can You Ensure Bone And Joint Health?

Staying healthy involves a wholesome state of being where the mind and body are in perfect sync. A less than properly functioning body can leave you in a state of potential depression after a certain point of time, while a depressive mind can leave you feeling less than stellar where you end up imagining and experiencing pain. The health of your bones and joints is one such area that requires even more care as you start growing older. Wear and tear is just one of the reasons for degeneration while fractures and injuries can lead to a sudden halt of normal functioning of the bones and joints too. So how can you ensure bone and joint health in the long run? Follow our tips!

  1. Eating Right: Pick calcium rich food like dairy products that have a low fat content, including milk and yogurt. Also, have a daily dose of green, leafy vegetables and plenty of citrus fruit and juices for your fill of calcium. Further, food like eggs and soya beans which have lots of vitamin D can also help in retaining good bone and joint health. Vitamin C rich fruit like watermelon, oranges, squash and tomatoes also help in natural tissue and cartilage repair. And finally, get plenty of Vitamin K to retain good bone density for a prolonged period with ingredients like leafy green vegetables, eggs and cheese.
  2. Exercise: This is the key to good bone and joint health. Much like machinery and tools, the bones and joints of your body can also wither with disuse and prolonged inactivity. Make sure that you indulge in exercises like long walks and muscle strengthening exercises which will give your joints and bones good amount of strength as well. Remember to speak with your doctor before you start a new exercise regime so that you avoid anything that may be harmful in case you have any other ailment. Low impact exercises will strengthen the spine, while fat burning and weight loss exercises will ensure that there is less pressure on the knees and lumbar area. Swimming and resistance building exercises can also be practised for these purposes.
  3. Abstinence: A major factor in promoting better bone and joint health is abstinence from all those things that can create problems in the long run, like smoking, drinking excessively and even too much consumption of caffeine and fatty food. All these things can create depletion of the natural bone mass. Also, switching to a lower heel for everyday wear footwear and changing your position during your time at your work station are a few things that will go a long way.

Take care of your bones and joints the right way today, for a healthier tomorrow.

Know How To Manage Your Osteoporosis (Bone Loss) Naturally!

Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Dietitian/Nutritionist, Delhi
Know How To Manage Your Osteoporosis (Bone Loss) Naturally!

Osteoporosis (meaning porous bones) refers to a medical condition in which the bones of an individual become thin and weak. The previous stage is called osteopenia (a precursor to osteoporosis). The bones become fragile and therefore start losing its strength. The medical researchers have reported that women are more prone to getting osteoporosis as compared to that of men, but that does not mean that men are completely immune to this disease. Where there are almost 50% women suffer from osteoporosis by the age of 60, there are about 30% of men who face the problem of osteoporosis.

Well, it has always been said that sooner you start taking care of your health especially bones, the better it is. Osteoporosis is a very common medical condition nowadays and major factors that are responsible for the increased prevalence of this disease is the lifestyle changes which include the living patterns and the diet changes.

What Causes Osteoporosis?

Osteoporosis happens when there is an imbalance between new bone formation and old bone resorption. The body may fail to produce enough new bone, or too much old bone may be reabsorbed, or both. If calcium intake is not sufficient or if the body does not absorb enough calcium from the diet, bone production and bone tissue may suffer. Thus, the bones may become porous, resulting in spongy and brittle, prone to fractures.

Other conditions that may lead to osteoporosis include overuse of corticosteroids (Cushing syndrome), thyroid problems, lack of muscle use, bone cancer, certain genetic disorders, use of certain medications, and dietary deficiency of calcium.

Risk factors for osteoporosis:

  • Women above 60 years of age.

  • Early menopause natural or surgical.

  • Poor diet & lifestyle  i.e. Cigarette smoking, eating disorders such as anorexia nervosa or bulimia, low amounts of calcium in the diet, heavy alcohol consumption, inactive lifestyle.

  • Rheumatoid arthritis itself is a risk factor for osteoporosis

  • Family History of osteoporosis.

  • Overuse of corticosteroids

  • Hypothyroidism

  • Chronic Emotional stress

Foods That Cause Osteoporosis

  • Alcohol – Increases inflammation that can lead to more calcium being leached from bones.

  • Sweetened / Aerated drinks beverages – The sugary drinks like canned juices and aerated drinks like cola are the most dreadful drinks for your health especially bones, as these drinks extract the calcium from the bones. Carbonated drinks contain a lot of phosphates which is responsible for leaching of calcium from bones. It has been proven in a Harvard Study that the women just 16-20 years young had already started loss of bones as they were consuming a lot of carbonated drinks. Sugar is also responsible for inflammations.

  • Processed, red meat – A high intake of sodium and red meat may result in bone loss.

  • Caffeine/Tea – Excessive caffeine intake can result in bone loss as it causes hindrance in iron and calcium absorption from food.

Natural Treatments for Osteoporosis:

1. Osteoporosis Diet

To help you get all the vitamins and minerals you need to build and maintain strong bones, it’s important to eat a varied diet with adequate calories to fuel all your body’s processes. Mainly calcium and vitamin D are important. Other Nutrients needed to prevent bone disorders include iron, vitamin C and magnesium. Iron deficiency (anaemia) is a risk factor for osteopenia and osteoporosis because iron is essential for collagen synthesis and vitamin D metabolism. Vitamin C plays a role in collagen formation. It also helps stimulate the cells that build bones, enhances calcium absorption, and helps vitamin D to work properly.

Foods that provide Calcium include: dairy products like yogurt, milk or paneer. salmon or sardines; dark leafy green vegetables; and other veggies like broccoli, Makhanas (puffed lotus seeds), sesame seeds, calcium.

Magnesium rich foods include: leafy greens like spinach, pumpkin seeds, yogurt, black beans, figs, banana, cranberries, sunflower seeds, dark chocolates and Almonds & Avocados.

Sources of vitamin C include: citrus fruits, papaya or guava, berries, peppers, kiwi, broccoli and Amla(Indian gooseberry), star fruit, phalsa ,tomato.

Collagen protein: collagen is one component of bone that helps to build its framework and provide a flexible structure that can withstand pressure. Collagen is found naturally in things like bone broth or can be taken in protein powder form or supplement form.

Foods that supply Iron (which can help to prevent anaemia) include: chicken, fish, eggs, nuts, seeds, spinach, kala chana , garden cress seeds, dates and raisins etc.

Alkaline diet that helps protect bones. This means eating lots of veggies, fruit, sea vegetables and plant foods. Wheat grass is highly alkaline food.

It’s also best to lower the amount of sodium in your diet by eating more unprocessed/whole foods. It also helps to avoid things like: processed meats, fast foods, fried foods, canned goods, salty condiments or sauces, frozen meals, ready to eat meals etc. In addition, try to limit your intake of sugary products, sweetened drinks, alcohol and caffeine.

2. Practice Exercises:

To help maintain skeletal strength, it’s important to stay active. Osteoporosis has greater risk of fractures, so be careful while Exercising. Avoid strenuous and jerky movements. Exercise helps your body reduce the decline in bone mass associated with aging. It has many others benefits, too, such as contributing to hormone balance and a healthy body weight. Exercise is needed to keep muscles strong. It also helps with coordination and balance.

Weight-bearing exercises are the most beneficial for your bones, although this term often confuses people. Weight-bearing exercises include any type that “forces you to work against gravity” and that you practice with an upright posture. This way your bones and muscles must support your body weight.

To prevent and cure osteoporosis, yoga and Pranayama will be a great addition in your lifestyle. It will fix up your hormonal balance which is the root cause of problem. Oxygenation by breathing techniques will make your body alkaline and will help you in reducing bone sponginess. Cool, Calm and Clean environment and yoga practice – a wows combination for your health.

3. Take Supplements That Can Help Protect Bones

  • Calcium: It’s best to obtain calcium from foods in your diet. However, you can take a supplement for boost. Most adults need about 1,000 milligrams daily. Choose calcium citrate, take it before meals for better absorption in a divided dose of 500mg everyday.
  • Vitamin D: Experts recommend that people who have a history of deficiency, elderly adults,take a vitamin D supplement daily. Dosage recommendations vary person to person.
  • Magnesium: Magnesium is a mineral; your body requires for proper calcium metabolism. Aim to get between 300–500 milligrams daily. Epsom salt bath is super source to get it through skin.

Ayurveda perspective of osteoporosis is, when vata (air) element is vitiated in our body and affects our bones is called Asthi Majja Kashaya. Traditionally used medicines for Asthi-majja kashaya (osteoporosis):Asthi shrinkhala ghrita, Shatavari, Ashwagandha churna, Shuddha guggulu, Mukta pisti, Praval pisti, Shankhabhama. Oil enemas (basti) particularly work on Asthi Dhatu (bones) and Majja Dhatu (bone marrow) along with Abhyangam therapy.

4. Maintain A Healthy Weight: Obesity can increase inflammation and contribute to hormonal changes that damage bones. Maintaining a healthy weight makes it easier to exercise and stay active into older age.

5. Get Enough Sunlight: Vitamin D helps improve calcium absorption. It’s best to obtain it via natural sunlight. To allow your body to make enough vitamin D to protect your bones, aim to get 15–20 minutes of sunshine on your bare skin daily.

6 Get Enough sleep: A sound sleep of at least 7-8 hours per day helps in better assimilation and absorption of nutrients. Lack of sleep may lead to adrenal fatigue and associated symptoms.

Final Thoughts on Osteoporosis:

Osteopenia is a condition characterized by lower-than-normal bone density. It precedes osteoporosis and causes brittle, weaker than normal bones that are more likely to fracture on minor jerk.

Risk factors for osteopenia include: being a woman following menopause; dieting or calorie restriction; eating disorders; taking medications that interfere with mineral absorption; anaemia; smoking cigarettes; too little exercise; obesity and a family history.

Natural treatments and prevention include: balanced diet with enough calcium and vitamin D; getting regular & safe exercise; maintaining a healthy weight; not smoking; and preventing vitamin D deficiency by getting adequate sunlight exposure and sound sleep, maintaining alkalinity in body. In case you have a concern or query you can always consult an expert & get answers to your questions!

4412 people found this helpful

Ways To Ensure Bone And Joint Health!

MBBS, MS - Orthopaedics
Orthopedist, Chennai
Ways To Ensure Bone And Joint Health!

Staying healthy involves a wholesome state of being where the mind and body are in perfect sync. A less than properly functioning body can leave you in a state of potential depression after a certain point of time, while a depressive mind can leave you feeling less than stellar where you end up imagining and experiencing pain. The health of your bones and joints is one such area that requires even more care as you start growing older. Wear and tear is just one of the reasons for degeneration while fractures and injuries can lead to a sudden halt of normal functioning of the bones and joints too.

So how can you ensure bone and joint health in the long run? Follow our tips!

  1. Eating Right: Pick calcium rich food like dairy products that have a low fat content, including milk and yogurt. Also, have a daily dose of green, leafy vegetables and plenty of citrus fruit and juices for your fill of calcium. Further, food like eggs and soybeans which have lots of vitamin D can also help in retaining good bone and joint health. Vitamin C rich fruit like watermelon, oranges, squash and tomatoes also help in natural tissue and cartilage repair. And finally, get plenty of vitamin K to retain good bone density for a prolonged period with ingredients like leafy green vegetables, eggs and cheese.
  2. Exercise: This is the key to good bone and joint health. Much like machinery and tools, the bones and joints of your body can also wither with disuse and prolonged inactivity. Make sure that you indulge in exercises like long walks and muscle strengthening exercises which will give your joints and bones good amount of strength as well. Remember to speak with your doctor before you start a new exercise regime so that you avoid anything that may be harmful in case you have any other ailment. Low impact exercises will strengthen the spine, while fat burning and weight loss exercises will ensure that there is less pressure on the knees and lumbar area. Swimming and resistance building exercises can also be practised for these purposes.
  3. Abstinence: A major factor in promoting better bone and joint health is abstinence from all those things that can create problems in the long run, like smoking, drinking excessively and even too much consumption of caffeine and fatty food. All these things can create depletion of the natural bone mass. Also, switching to a lower heel for everyday wear footwear and changing your position during your time at your workstation are a few things that will go a long way.

Take care of your bones and joints the right way today, for a healthier tomorrow. If you wish to discuss about any specific problem, you can consult an Orthopedist.

5022 people found this helpful

How Exercise Can Help Manage Bone And Joint Health?

M.S in Orthopedic, Fellowship in arthroplasty & reconstructive surgery , D.N.B in Orthopedic, Fellowship in Joint Replacement
Orthopedist, Ahmedabad
How Exercise Can Help Manage Bone And Joint Health?

Staying healthy involves a wholesome state of being where the mind and body are in perfect sync. A less than properly functioning body can leave you in a state of potential depression after a certain point of time, while a depressive mind can leave you feeling less than stellar where you end up imagining and experiencing pain. The health of your bones and joints is one such area that requires even more care as you start growing older. Wear and tear is just one of the reasons for degeneration while fractures and injuries can lead to a sudden halt of normal functioning of the bones and joints too.

So how can you ensure bone and joint health in the long run? Follow our tips!

  1. Eating Right: Pick calcium rich food like dairy products that have a low fat content, including milk and yogurt. Also, have a daily dose of green, leafy vegetables and plenty of citrus fruit and juices for your fill of calcium. Further, food like eggs and soybeans which have lots of vitamin D can also help in retaining good bone and joint health. Vitamin C rich fruit like watermelon, oranges, squash and tomatoes also help in natural tissue and cartilage repair. And finally, get plenty of vitamin K to retain good bone density for a prolonged period with ingredients like leafy green vegetables, eggs and cheese.
  2. Exercise: This is the key to good bone and joint health. Much like machinery and tools, the bones and joints of your body can also wither with disuse and prolonged inactivity. Make sure that you indulge in exercises like long walks and muscle strengthening exercises which will give your joints and bones good amount of strength as well. Remember to speak with your doctor before you start a new exercise regime so that you avoid anything that may be harmful in case you have any other ailment. Low impact exercises will strengthen the spine, while fat burning and weight loss exercises will ensure that there is less pressure on the knees and lumbar area. Swimming and resistance building exercises can also be practised for these purposes.
  3. Abstinence: A major factor in promoting better bone and joint health is abstinence from all those things that can create problems in the long run, like smoking, drinking excessively and even too much consumption of caffeine and fatty food. All these things can create depletion of the natural bone mass. Also, switching to a lower heel for everyday wear footwear and changing your position during your time at your workstation are a few things that will go a long way.

Take care of your bones and joints the right way today, for a healthier tomorrow.

5 people found this helpful

Joint And Bone Fitness - How To Maintain It?

MBBS, MS - Orthopaedics
Orthopedist, Raipur
Joint And Bone Fitness - How To Maintain It?

Staying healthy involves a wholesome state of being where the mind and body are in perfect sync. A less than properly functioning body can leave you in a state of potential depression after a certain point of time, while a depressive mind can leave you feeling less than stellar where you end up imagining and experiencing pain. The health of your bones and joints is one such area that requires even more care as you start growing older. Wear and tear is just one of the reasons for degeneration while fractures and injuries can lead to a sudden halt of normal functioning of the bones and joints too.

So how can you ensure bone and joint health in the long run?

Follow our tips!

  1. Eating Right: Pick calcium rich food like dairy products that have a low fat content, including milk and yogurt. Also, have a daily dose of green, leafy vegetables and plenty of citrus fruit and juices for your fill of calcium. Further, food like eggs and soya beans which have lots of vitamin D can also help in retaining good bone and joint health. Vitamin C rich fruit like watermelon, oranges, squash and tomatoes also help in natural tissue and cartilage repair. And finally, get plenty of Vitamin K to retain good bone density for a prolonged period with ingredients like leafy green vegetables, eggs and cheese.
  2. Exercise: This is the key to good bone and joint health. Much like machinery and tools, the bones and joints of your body can also wither with disuse and prolonged inactivity. Make sure that you indulge in exercises like long walks and muscle strengthening exercises which will give your joints and bones good amount of strength as well. Remember to speak with your doctor before you start a new exercise regime so that you avoid anything that may be harmful in case you have any other ailment. Low impact exercises will strengthen the spine, while fat burning and weight loss exercises will ensure that there is less pressure on the knees and lumbar area. Swimming and resistance building exercises can also be practised for these purposes.
  3. Abstinence: A major factor in promoting better bone and joint health is abstinence from all those things that can create problems in the long run, like smoking, drinking excessively and even too much consumption of caffeine and fatty food. All these things can create depletion of the natural bone mass. Also, switching to a lower heel for everyday wear footwear and changing your position during your time at your work station are a few things that will go a long way.

Take care of your bones and joints the right way today, for a healthier tomorrow.

Bone Cancer - Understanding The New Approaches For Treatment!

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Bone Cancer - Understanding The New Approaches For Treatment!

The human body has 206 bones and bone cancer can affect any of these bones. This condition starts when healthy bone marrow cells mutate and grow out of control to form a tumor. There are many different types of bone cancer. Treatment of bone cancer varies from case to case and depends on factors such as, type of cancer, stage at which it is diagnosed and the patient’s overall health amongst other factors.

Surgery, chemotherapy, and radiation are the three most common types of treatments favored for bone cancer. Surgery is usually used for low-grade tumors. This involves the removal of tumor and the surrounding healthy cells and tissues to ensure that that cancer does not recur. For high-grade tumors, surgery may be accompanied by chemotherapy, radiation or a combination of the two.

Chemotherapy involves the delivery of medication to destroy cancer cells orally or intravenously. Radiation involves the use of high energy X rays to kill cancer cells. This is often used to treat patients with a tumor that cannot be surgically removed.

Apart from these standard forms of treatment, bone cancer patients are often advised to take part in clinical trials for their treatment. This can be described as a research study to test the efficiency of new approaches to the treatment of bone cancer. A clinical trial can be used to treat the safety and efficacy of a new drug, the new dosage of standard drugs or a new combination of treatment types. As a member of a clinical trial, you may be one of the first few people to benefit from treatment even before it is available to the general public.

Some of the new options available through clinical trials are:

  1. Immunotherapy: This is also known as biologic therapy. It is designed to boost the patient’s immune system to fight cancer cells. Mifamurtidesi one of the types of immunotherapy being tested. Immune checkpoint inhibitors such as monoclonal antibodies are also being tested for their ability to block specific molecules.
  2. Targeted therapy: This type of therapy targets the genes and proteins that contribute towards the growth and survival of cancer cells. Targeted therapy limits the damage caused to healthy cells and tissues and only blocks the growth of cancer cells.
  3. Myeloablative therapy: This involves an intense regimen of chemotherapy. High doses of chemotherapy aim at destroying all the cancer cells. Unfortunately, in the process, healthy cells may also be killed. This may be followed by introducing stem cells through a bone marrow transplant to the patient’s body to renew blood cells.
  4. Intraoperative radiation therapy: These trials evaluate the use of radiation given inside the patient’s body during a surgery. In cases where tumor is in a distant location of the body, stereotactic body radiotherapy and radiofrequency ablation may be used.
     
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