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Kidney Stones Treatment
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Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Acne can present as noninflammatory lesions, inflammatory lesions, or a mixture of both, affecting mostly the face but also the back and chest.
Acne vulgaris has a multifactorial pathogenesis, of which the key factor is genetics. Acne develops as a result of an interplay of the following four factors: (1) follicular epidermal hyperproliferation with subsequent plugging of the follicle, (2) excess sebum production, (3) the presence and activity of the commensal bacteria Propionibacterium acnes, and (4) inflammation.
Acne occurs through the interplay of 4 major factors:
- Excess sebum production
- Follicular plugging with sebum and keratinocytes
- Colonization of follicles by Propionibacterium acnes (a normal human anaerobe)
- Release of multiple inflammatory mediators
The most common trigger is
During puberty, surges in androgen stimulate sebum production and hyperproliferation of keratinocytes.
Other triggers include
- Hormonal changes that occur with pregnancy or the menstrual cycle
- Occlusive cosmetics, cleansers, lotions, and clothing
- High humidity and sweating
- Associations between acne exacerbation and diet, inadequate face washing, masturbation, and sex are unfounded. Some studies suggest a possible association with milk products and high-glycemic diets. Acne may abate in summer months because of sunlight’s anti-inflammatory effects. Proposed associations between acne and hyperinsulinism require further investigation. Some drugs and chemicals (eg, corticosteroids, lithium, phenytoin, isoniazid) worsen acne or cause acneiform eruptions.
- Acne results in a variety of lesions. The most common acne locations include the face, neck, chest, and back, where the most sebaceous glands are located. Along the jaw line is a common location in adults. "Blackheads" (open comedones) and "whiteheads" (closed comedones) are follicular plugs that are either sitting below the skin surface (whitehead) or oxidized from being exposed to the air (blackhead). Papules are small pink to reddish-brown bumps, pustules are pus-filled lesions, and nodules or cysts are deeper pus-filled lesions.
- Mild acne consists of a few papules/pustules and/or comedones. Moderate acne has an increased number of lesions. Severe acne has numerous comedones, papules, pustules, and may have painful nodules.
- Acne can result in permanent scars, which can appear to be depressions in the skin or hyperpigmentation, which is dark red or brown flat marks where the acne lesions were.
I have dark circles and my eyes look tired. Is it because of smoking? I get a proper sleep. I need to get rid of these. What am I supposed to do?
Due to certain incident in may 2015 though it was protected sex, I had done my hiv test on 7th day, 135th day and 174th day from that incident. All report was negative. Do I need further test as I am scared and for last 6 month I am facing many health issues like hip pain, fissure, mouth sores, itching in lower part of legs or below knee.
Hi. I got suddenly black spots on my face . Last two months its become over. I use cosmetic s but no use.
Hi, I'm 22 year old. I am suffering for anal fissure since Jan 2018. It's does not heal yet, I have take medicines for 4 month. Its show not fully relaxed. Now I'm taking ayurvedic treatment the condition remain same. So kindly suggest me the good treatment please. and surgery is required or not? Please suggest me.
Doc I am suffering from really harsh acne problems I do not what to do I have tried many creams but still they r not gone. I am fed of this, they r leaving behind deep scars on face and skin has lost its fairness I do not know what I will do. N my skin in oily on spots too plzz doc help me out.
I had a surgery for fissure. Lateral internal sphincterotomy couple of days back. And I was told that I can return to work after 3 to 4 days from surgery. I asked my surgeon many times after surgery and got the same answer. Now m having little pain but manageable. Is it ok to resume work 4 days after surgery ?my work involves travelling 2 hrs and sitting for 7 hrs. Please suggest if it will have adverse effect on my wound.
I get rashes that looks like goosebumps and feels really rough to tough. Especially the parts of my thighs, the outer side of the thighs and upper arms outer part. What can be done? please help me out. It' s really iritating and very rough.
The skin is the largest organ of the body and for our overall health, it is important to ensure that it remains in good health. In the last few decades various cancers of the skin have been on the rise which has become a point of concern for medical professionals worldwide. A simple spot on your skin could be the very first sign of skin cancer and thus it is helpful to be armed with knowledge about this subject.
Types of skin cancer
Skin cancers are primarily categorized into one of three types:
Although the types of cancer are different, they have similar symptoms that you can look out for. Analyzing your skin spots or lesions for tell tale signs can tell you whether it needs to be checked out by a doctor or not. Let's look at some of them:
- The shades or colors of the patch: Cancerous skin cells will have various colors on them and may be pink or white in certain areas while being brown or black in other areas.
- The spot or lesion will always be changing: If the spot or growth on your skin is cancerous it will constantly change size shape or form as well as color.
- Almost always asymmetrical shape: Cancerous growth on your skin will tend to be irregular in shape and one side of it will not be similar to the other.
- The shape or borders of the spot: If the lesion or spot on your skin is jagged, quite irregular in shape or the sides are blurred then this may be a sign of a cancerous growth.
- Tenderness of the spots or the lesions: These spots can be painful, tender, itchy and also have redness in the area surrounding it. It could even be oozing or bleeding although this depends from patient to patient.
- Horn like growths: Certain form of skin spots or lesions will grow into small horn like growth on the skin and feel like nails. This is due to the excess presence of keratin which is found in nails and may be an indicator for skin cancer.
- Moles that change shape, size or color: If you have developed a mole and it keeps changing its color, size and edges it could be clear sign of melanoma. In such cases it is best to get it checked by your doctor.
Skin cancers are easily treatable if diagnosed early and have a high chance of being cured, but it is also important for you to self diagnose any spots or areas of concern so that you can take appropriate action in time. In case you have a concern or query you can always consult an expert & get answers to your questions!