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I have damaged the eponychium layer of skin of thumb finger, by biting the cuticle layer of thumb which was somewhat got removed, now skin near nails is not healing and looks somewhat dark, provide me some home techniques for healing skin and to make thumb skin normal.
I am 31yrs old these days I found some white spots in my both legs, please help me to prevent thanking you
I had developed fungal growth between my third and fourth fingers (from thumb side) of my right foot for a very long time. I have been applying rhus tox mixed with glycerine which gives some relief. Also, I have been taking rhus tox 30 orally as advised by a good homeopath. However, the problem has not disappeared. Please advise.
I am on dieting last year and I am suffering from very oily skin especially oily at nose area .now I start eating non veg for proper nutrition .is this is good or bad for my oily skin.
Hii sir I applied scrub on face but some allergy not high is happened on my face please suggest me solution.
I am a 27 year old women and recently married though i'm fair complexion but its very dull I keep drinking lots of water also but it doesn't work please suggest me how to get glowing complexion and also what type of diet should I follow and which cream or face wash should I use my skin is very loss and getting dull and wrinkle day by day please help me.
I have pigmentation on my face, I used a lot of medication but it is still there I am worry about it please tell me what should I do now?
I am feeling little pain around my anus while passing stool. Sometimes the pain goes and sometimes its dere. I can feel a small lump there. What is the prblm. How can I cure that?
I am 21 years old I have suffer from one scar in my hand it which has been came on before of 10 months I want to remove that one can you should suggest your advice.
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Skin whitening is the practice of using substances, mixtures, or physical treatments to lighten skin color. Skin whitening treatments work by reducing the content of melanin of the skin. Many agents have been shown to be effective in skin whitening.
Specific zones of abnormally high pigmentation such as lentigo spots, moles and birthmarks may be de-pigmented to match to the surrounding skin. In cases of vitiligo, unaffected skin may be lightened to achieve a more uniform appearance.
Discovery and design
Melanogenesis inhibitors have been discovered and developed through several methods, including: screening of synthetic chemical libraries (high-throughput screening is occasionally used), screening of plant extracts, computational (in silico) search, found as a side effect of previously known drugs and exploration of structural analogues of previously known tyrosinase inhibitors based on knowledge (in varying degrees) of their structure-activity relationship. Thus, the development and discovery of melanogenesis inhibitors illustrates many of the methods used in drug design. Some of the most potent competitive reversible tyrosinase inhibitors are synthetic compounds with a potency hundreds of times that of kojic acid.
Mechanisms of action
Melanin is the main substance responsible for the color of the skin. Melanin is class of dark polymers generated by the body through the process of melanogenesis. Among the melanin pigmenting the skin and hair, 2 types can be distinguished based on its chemical composition and biological route of synthesis: the black/brown eumelanin and the red/yellow pheomelanin. The variation of skin color among individuals is mostly because of variation of the content of melanin in the skin. Skin with little or no melanin is almost white. Other factors influence skin color in a lesser degree, including the amount of blood in blood vessels (because of the color of blood), skin thickness and content of carotenoids in skin.
Melanin in synthesized in melanosomes which are organelles produced in melanocytes. Melanocytes are cells dedicated to this function that are present in the skin, hair follicles, and other structures of the body. The synthesis of melanin (also called" melanogenesis" and" melanization") involves a chain of enzyme-catalyzed chemical reactions and non-enzyme-catalyzed reactions. The main precursor to melanin is l-tyrosine. The first step of melanogenesis is the conversion of l-tyrosine to l-dopa; this is the first and rate-limiting step and is catalized by the enzyme tyrosinase. Other enzymes involved in the synthesis include tyrosinase-related protein 1 (trp1) and tyrosinase-related protein 2 (trp2); trp2 is also known as" dopachorome tautomerase" (dct). L-tyrosine is taken by the melanocytes from the intercellular medium, then transported to the melanosomes. L-tyrosine is also synthesized within the melanocytes from l-phenylalanine by the enzyme phenylalanine-hydroxylas (pah)
Melanosomes are transferred to keratinocytes (the most abundant cell type in the skin). Most of the melanin of skin is found in keratinocytes. Additionally, melanocytes interact with keratinocytes through chemical signaling.
Had a SEBACEOUS CYST a month ago. . Now its gone all is left is a thin layer of skin wiy dark brown scar in the middle of my chest. . please can any1 tell me hw to get rid of SCAR.
Hi I am 24 old, I had sensitive skin, and I had rosacea on my face, I used the topmetrogel for one month, it reduces the redness little, but please tell me how long should I use this, and suggest the solution.
How can I improve my complexion. Due to sun exposure I lost my complexion and it is not even. And having black marks and black heads. Suggest me for better results. Thank yu.
Hi, My skin type is oily. I have a problem of Whitehead and open pores near my nose. So if I used home made therapy it is OK or not please suggest me. Solution is 1-2 tablets of aspirin, some water and teaspoon of honey. Please suggest me any side effect for this therapy. Thanks, Have a nice day.
Ageing is the only inevitable truth. However, it does not mean that it has to be reflected on your body. Skin loses collagen as you grow older and collagen is the element in your skin which keeps your skin tight and firm when you are young. Loss of collagen leads to skin sagging.
The causes behind ageing of skin can be both extrinsic as well as intrinsic. The main classifications of the causes are:
- Biological: This is an intrinsic factor which relies on the genes of the body and hence, it is out of our control. Naturally, with age, the regenerating capabilities of your body gradually lose pace due to the various hormonal changes that occur over time. A healthy lifestyle can go a long way in helping your skin look as young as possible.
- Environmental: Being an extrinsic factor, environmental factors that cause the skin to age can be controlled. Some of these factors, such as pollution, harmful rays of the sun, stress and unfavourable weather conditions are capable of damaging the skin. Sun exposure i.e. exposure to the UV rays of the sun, is deemed to be the primary reason behind skin ageing.
- Mechanical: Repeated behaviour over an extended period of time, such as frowning, squinting, smiling, etc., can cause grooves to be formed on the skin. These grooves may be permanent and hence, contribute to ageing skin.
How do you treat it?
A holistic approach is extremely vital for the treatment as well as control of ageing skin. The quality and features of skin differ among individuals and hence, the needs of the skin will vary too. Due to this reason, depending on the skin types and needs of the person, the skin care routine needs to be specialised and focussed.
To facilitate a specialised approach to ageing skin, a thorough analysis would be conducted by the dermatologists to understand what the skin needs and accordingly, diagnose the causes and symptoms of ageing skin. The diagnosis will allow the dermatologist to estimate the severity of the skin problem. This analysis will help the doctors to determine the adequate approach to address the ageing skin. A combination of services and technologies would be recommended based on the analysis. This combination would incorporate methods such as collagen building (with foods such as berries and dark green veggies), micro derma peels and skin tightening, as well as effective home skin care products which can be used to boost the skin’s beauty. The proposed approach would work to fill wrinkles, boost collagen and tighten sagging skin to make the skin look as natural as possible. If you wish to discuss about any specific skin problem, you can consult a specilized dermatologist and ask a free question.