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Dr. Mukul Gharote - Oncologist, Nashik

Dr. Mukul Gharote

85 (28 ratings)
MBBS, DM - Oncology, MD - General Medicine

Oncologist, Nashik

14 Years Experience  ·  800 at clinic  ·  ₹350 online
Dr. Mukul Gharote 85% (28 ratings) MBBS, DM - Oncology, MD - General Medicine Oncologist, Nashik
14 Years Experience  ·  800 at clinic  ·  ₹350 online
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My experience is coupled with genuine concern for my patients. All of my staff is dedicated to your comfort and prompt attention as well....more
My experience is coupled with genuine concern for my patients. All of my staff is dedicated to your comfort and prompt attention as well.
More about Dr. Mukul Gharote
Author of international paper on mutation analysis in chronic myeloid leukemia , type of blood cancer

Info

Education
MBBS - Maharashtra University of Health Sciences Nashik - 2004
DM - Oncology - BJ Medical College - 2015
MD - General Medicine - JNMC RAIPUR - 2010
Languages spoken
English
Hindi
Marathi
Awards and Recognitions
Speaker at international conference on blood cancer held at Dubai
Professional Memberships
EUROPEAN ASSOCIATION OF CANCER REASEARCH
American society of clinical oncology ( ASCO)
INDIAN COOPERATIVE ONCOLOGY NETWORK( ICON)

Location

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Mukta Cancer Clinic

Teerthroop Bunglow, Sunderban Colony, Near Deccan Petrol Pump, Bhujbhal, Farm Road, New NashikNashik Get Directions
  4.3  (28 ratings)
800 at clinic
...more
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"Very helpful" 6 reviews "Saved my life" 2 reviews "Caring" 3 reviews "Inspiring" 1 review "Thorough" 1 review "Sensible" 1 review "Practical" 1 review

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APML - Is Chemotherapy The Only Way Out?

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
APML - Is Chemotherapy The Only Way Out?

There are more than hundred varieties of blood cancer, but the most common ones are leukemia, lymphoma, and myeloma. Acute myeloid leukemia (AML), a type of leukemia, is when the white blood cells in the marrow begin to grow uncontrollably. This is an acute condition and both the onset and progress are very rapid. The cause is not known, and given the rapid progress, even treatment is often difficult. A more severe form of AML is the APML which is acute promyelocytic leukemia, which leads to reduced number of white and red blood cells and plasma.

This causes the following symptoms:

  • Anemia
  • Increased incidence of infections
  • Excessive bleeding from even minor cuts
  • Bleeding from nose and gums
  • Easy bruising
  • Blood in the urine
  • Extreme paleness and tiredness

What is different about APML?

There is one distinguishing factor with APML, which is that they contain a protein which when released into the bloodstream can cause severe bleeding, which may be very difficult to control. Chemotherapy kills these cells and so releases the proteins into the bloodstream. These cells need to be managed without chemotherapy, as the patient can even die of uncontrolled bleeding. With medical advances, two non-chemotherapy agents have been identified – all-trans retinoic acid (ATRA, vesanoid, or tretinoin) and arsenic trioxide (ATO or trisenox).

  1. ATRA: This is a type of vitamin A which is used either alone, in combination with chemo, in combination with arsenic trioxide, and also in combination with both chemo and arsenic trioxide. The effect is different in different people – helps control spread, helps prevent recurrence, and helps control symptoms. In many people, it has been successfully used instead of chemotherapy. ATRA is also used as a long-term maintenance agent. Side effects from ATRA include fever, dry skin, rashes, mouth sores, increased cholesterol, and swollen feet. These go away with stoppage of the drug.
  2. ATO: Arsenic is poisonous when given in large amounts. However, it was discovered that it could be used to treat APML with effects similar to ATRA. It is used alone, in combination with chemotherapy, with ATRA, or with both. It helps control the growth of cells and also helps in long-term maintenance therapy. ATO dosage needs to be monitored as it can cause heart rhythm issues.

With both these drugs, there is a significant side effect, known as differentiation syndrome. Often seen during the first cycle of treatment, this happens when the leukemia cells release a protein into the blood. Symptoms include fever, breathing, kidney damage, and severe fluid buildup. With these two drugs being widely used effectively, chemotherapy is not the only treatment option for APML. In case you have a concern or query you can always consult an expert & get answers to your questions!

3301 people found this helpful

Vitamin C - Understanding Its Role As An Anti Cancer Drug!

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Vitamin C - Understanding Its Role As An Anti Cancer Drug!

When it comes to cold and the flu, Vitamin C or ascorbic acid is hailed as the best remedy and preventive agent. But did you know that this could also help fight against cancer? Vitamin C is a water-soluble vitamin that is not produced by our bodies and needs to be sourced through food. It is needed for the synthesis of collagen, norepinephrine, and carnitine. Collagen is required to develop bones, tendons, ligaments and blood vessels.

Norepinephrine is a neurotransmitter while carnitine is a protein required for transportation of fat to the mitochondria. Vitamin C is also a powerful antioxidant that protects the body against damage caused by free radicals. In addition, it boosts the immune system and increases the body’s ability to fight infections. Ideally, an adult man should have 90mg per day while an adult woman should consume 75mg vitamin C per day.

When it comes to cancer treatment, vitamin C can act as an immune-modulator. It enhances the body’s resistance to pathogens and suppresses production of IL-18. This is a key regulator in melanomas, carcinomas and other kinds of malignant skin tumours. In the case of gastric cancers, the production of IL-18 is boosted by the vascular endothelial growth factor. In the case of breast cancer, IL-18 induces the production of transferrin. Thus, by regulating and reducing the production of IL-18, vitamin C can help reduce the risk of skin cancers, stomach cancers, and breast cancer. Dosage is key to the efficacy of Vitamin C in preventing cancer as an immune modulator.

In its reduced form, vitamin C is known as ascorbate. This has the ability to act as a prooxidant. Ascorbate in high dosages induces apoptosis in some melanomas through mitochondrial dysfunction. Similarly, a low dose of ascorbate induces cell cycle arrest of some types of cancer cells. Thus, by acting as a prooxidant, vitamin C inhibits the growth of cancer cells. This includes growth by inducing endoplasmic reticulum stress, suppressing growth factors and inhibiting angiogenic factor production. It also produces hydrogen peroxide-dependent cytotoxicity in cancerous cells without affecting other healthy cells.

The efficacy of vitamin C in dealing with various types of cancer has been found to be most effective when administered intravenously. In addition, it may also be given orally. Since vitamin C is cytotoxic and does not affect other cells, the side effects of this type of cancer therapy are usually negligible.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3279 people found this helpful

Modern Day Targeted Chemotherapy & Cancer Care!

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Modern Day Targeted Chemotherapy & Cancer Care!

In the past, cancer was a disease that could not be cured. It was a threat to mankind. But as science has developed tremendously through all these years, today it is possible to fight cancer.
Cancer therapies have evolved with time. Until the late 90s, most of the drugs worked by killing the cancer cells. Some of the normal cells were also killed by them, but it was acceptable due to the huge effect on cancer cells.

In modern days, targeted therapies are being performed. Targeted therapy is a process of cancer treatment where instead of the cancer cells, the changes in the cells are targeted. Changes that help the cells grow, divide and thus spread cancer have been observed and so researchers can diagnose the right treatment that can block these affects and prevent cancer. This therapy uses drugs and it is different from traditional chemotherapy.

There are two types of Targeted therapy.

  • Small-molecule drugs: These drugs are small so that they can enter cells easily and target the changes inside the cells. They are taken as pills. They work by keeping the tissue around the tumor and starve it by stopping blood vessels that bring it nutrients.
  • Monoclonal antibodies: These are used to target the outer surface of cancer cells. They work like a plastic plug in an electric socket. They help chemotherapy and radiation therapy to cure cancer cells.

Fields:

Targeted therapies are used in the fields below
Breast cancer
Lung cancer
Colorectal cancer
Melanoma
Kidney cancers

How It Works:
Targeted therapy can be used as a treatment option for cancer in the following ways:

  1. Destroy cancer cells: Cancer cells hide well from the immune system. This therapy points them out so that the immune system can destroy them. It also boosts the immune system to work better.
  2. Stop cancer cells growth: This therapy interferes with the proteins that divides the cancer cells and thus controls their growth.
  3. Kill the tumor: Blood vessels feed the cancer tumor. This therapy surrounds the tumor and stops the blood supply so that the tumor does not grow and remains small. And if the tumor already has blood supply, then it kills the blood vessels and causes the tumor to shrink.
  4. Deliver cell-killing substances: It delivers the cell-killing substances to the cancer cells. They are the monoclonal antibodies that are combined with chemotherapy drugs, toxins and radiation.
  5. Cause cancer cell death: Cancer cells avoid the dying process. These therapies cause them to go through the process.

Side Effects:
Targeted therapies are less toxic than standard chemotherapy. So it is a better option but it still has some side effects.

  1. Diarrhea
  2. Liver problems
  3. Skin problems
  4. Problems with wound healing
  5. Difficulty with blood clotting
  6. High blood pressure
  7. Gastrointestinal perforation

Even though it has some side effects, it is still way better and much more effective than traditional chemotherapy. So, cancer patients are advised to go through this modern-day therapy.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3062 people found this helpful

When I smoke I feel pressed on the right side of the neck, what may be the reason? Is it related to cancer?

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
When I smoke I feel pressed on the right side of the neck, what may be the reason? Is it related to cancer?
Hi Lybrate user, first of all smoking is injurious you might be knowing! kindly do usg neck to see for lymph node and x ray neck to rule out spondylosis. If you r a computer user, mobile user= continous stretch on certain neck muscles will cause such problem, increased by the sniffing action of cigarette smoking anyways pal do not smoke would be my friendly advice.
2 people found this helpful
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I am 17 years old and yesterday I received a CT scan it was normal but will it cause cancer to me in the future? Is there a way to prevent it from happening?

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Hi Lybrate user you are young and health conscious thats good! risk for cancer depends on family history and habits. It also depends upon any lump any where in the body. If not - no worry.
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Is Pleomorphic adenoma is a cancer? My mom have pleomorphic adenoma for past 5 years we taken biopsy it came noncancerous but doctor said it may transfer into cancer it is true what are chances it may transfer into cancer?

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Hi Lybrate user 1. Pleomorphic adenoma is benign salivary tumour. 2. Its chances of conversion to malignancy depends on age (more in 8 th/ 9 th decades of life). Common in females. 3. As such the conversion is low 0.17/ 1 million cases. Higher age higher incidence.
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My grandmother has gall bladder cancer. She is not able to digest the food. What should we do sir. Please advice me sir.

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
Hello Lybrate user, I hope she is fine. Kindly do the imaging tests and if operable kindly look forward. If not kindly try to give her more liquid and carbohydrate diet. And less oily food, if she is ready for treatment kindly go ahead.
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I see 2 round different skin colour change in my neck. Rest all side of my neck is is normal colour skin. 2 of my friends told me that, they had seen this in a tv. Doctor live program that this colour change should me taken seriously. It might be the start stage of cancer. Well now am afraid. What to do. Please help.

MBBS, DM - Oncology, MD - General Medicine
Oncologist, Nashik
I see 2 round different skin colour change in my neck. Rest all side of my neck is is normal colour skin. 2 of my fri...
Hello lybrate-user, colour change in moles or other matks on body can be changes of cancer. But you need to show it to skin specialist. Not all changes are of cancer. Relax. But do not ignore.
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