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Parkinson's disease is a disorder of the brain that leads to tremors and difficulty with walking, movement and coordination. It most often develops in people age 50 or older and is one of the most common nervous system disorders of the elderly, according to the National Institutes of Health. There is no known cure.
The major 12-year study in Taiwan found that while diabetes increases the risk of Parkinson's 2.2 fold, including metformin in the therapy negates that risk.
“An exciting aspect of the finding is that metformin seems to be working to protect the brain against neurodegeneration which contributes to Parkinsonism. This means it may also be considered a relevant therapy for the prevention of dementia as well,” said Mark Wahlqvist, professor at the National Health Research Institutes in Taiwan and lead author of the study.
Metformin is the first-line medication for patients with type 2 diabetes. This affordable and commonly prescribed oral drug lowers blood glucose levels by decreasing the amount of glucose produced by the liver and enhancing insulin action. It's a type of biguanide drug used since the 1950s with a relatively safe record.
Researchers also found that use of sulfonylurea drugs, a common treatment for diabetes, further increases the risk by about 57 percent.
Sylfonylureas are a category of oral medications that stimulate the beta cells of the pancreas to release more insulin, according to the American Diabetes Association. Sylfonylurea drugs have been in use since the 1950s and include glipizide, glyburide, glimepiride and chlorpropamide.
Researchers theorize that metformin may re-set the regulation of energy metabolism in the brain cells. They suspect that exercise and diet may have the same energy regulating effect.
The study does not examine the mechanism behind metformin's protective effect on the brain. Researchers say that additional research is needed in this area.
Past research has shown that metformin reduces cardiovascular mortality and several cancers, including those of the large bowel, liver and pancreas.
What happens if lopamax tablet to prevent and control seizures (epilepsy) is eaten with SB tablet to clean stomach.
I have a migraine problem. I am having a headache frequently about 2 times in a week. What is the solution for this?
I am 19 years old, female, and I had suffered from insomnia from the age of 12 or so. It went on for few years but I could manage sufficient sleep from the time I've been 17. Lately, I haven't been able to sleep at all again. Like sleepless nights and days for 4-5 days straight and then when I do happen to fall asleep after 4 days, it only lasts for 2-3 hours max. I've been having mood swings and frustration for no reason and well my surrounding and people are around me are getting affected by this behaviour. I even work out and exercise, go for an hour long run but I feel active for the rest of the day and night again. Is there possibility for this to reoccur? And I also get nightmares if I happen to fall asleep. It's getting difficult to manage with this kind of mood again. Kindly please advice how can I stop this from reoccurring.
Hi there Hope this week is treating you well Dear Dr. My mother is suffering from paralysis from last 4 years and due to paralysis her health suffers allots, she requires urgent medical intention because she not able to eat proper food which affects her health. Even she is totally on bed and also suffered from bed sore but at present she recovers from it. So kindly suggest me is she able to get denture so that it helps my mom to eat food and she can live longer. I am sending you few pics of her along with this mail. I will be thankful to you if you suggest me what to do further. As my mother is totally on bed so I am looking for a doctor who is kind hearted and take out time to visit our house in model town block -d by getting out time from his or her busy schedule. Till now we spend lakhs on my mother treatment and have very bad experience with doctors those who only bother about money rather than patient health but its doesn't mean that I though all doctors are same. As far home visit fee and treatment is concern I can afford but I only requires good treatment in return. Sumit.
There is a distinct relationship between sleeping disorders and your emotional health, both influence each other. Insomnia is a common sleeping disorder, which is generally caused due to stress and tension. Depression and anxiety also account for insomnia. It has been proven by research that people who experience sleeplessness or cases of insomnia are at a higher risk of depression and similar psychiatric disorders.
Insomnia is an important factor which causes depression and many people affected by it commit suicide. Researchers have found dysfunctional activity in the area of the brain where emotions are processed and regulated, among people with insomnia. Their study explains the mechanism by which insomnia affects and influences emotions in people, which leads to depression and other disorders.
The ways in which insomnia affects your emotions
- There is a clear difference in the brain activities of people with insomnia when compared with normal people who get good sleep. There is usually a great difference between the activities of the amygdala, which are neurons in the temporal lobe of the brain. The amygdala is very important in regulation and processing of emotions.
- Insomnia disrupts the ability of the brain to process negative emotions.
- Neural change and problems with regulating emotions are also caused because of insomnia.
- Insomnia disables the ability of judging or sensing any kind of emotion by looking at the face of a person. It is difficult to judge emotions such as anger and sadness in people suffering from insomnia. This impairment occurs more in women.
- Insomnia and similar sleeping disorders affect our inhibition and disrupt our impulse control mechanism. An insomniac person is likely to develop increased impulsiveness to negative stimulus.
- People suffering from insomnia develop a perception towards negative stuff and perceive most things in a negative way, rather than looking at the bright side which a normal person tends to do. People affected by insomnia are characterized by a negative mood and are pessimists in nature.
- A sleep deprived or insomniac patient shows greater activity around the limbic area of the brain. This is the area where major emotional regulation and processing are undertaken.
- A person suffering from insomnia develops a cranky personality. The patient is in an irritable mood and is triggered by the slightest and pettiest of circumstances. An insomniac patient is also characterized by swinging moods, high temper and general fatigue, which result due to lack of sleep.
Insomnia is a sleeping disorder which directly affects a person's emotions and the processing and regulation of emotions. There is a direct and important link between insomnia and emotional disorders. If you wish to discuss about any specific problem, you can consult a doctor and ask a free question.