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Molecules Roles They Play In Sleep!

Dr.Aravinda Jawali 91% (1523ratings)
Psychiatrist, Bangalore
Molecules Roles They Play In Sleep!

Benzodiazepines are a family of molecules, some of which are used as sleep-inducing medications, while others are used as tranquilizers. 
Benzodiazepines bind to a specific site on a neuron’s receptor for GABA, a neurotransmitter that counteracts the brain’s wakefulness mechanisms. Thus benzodiazepines promote sleep by augmenting this natural process.

The same gabaergic receptor also has binding sites that can be used both by barbiturates (a class of drugs once commonly used as sleep aids but now almost never used for that purpose) and by anesthetics, whose purpose is to put surgical patients to sleep.

Molecules that build up and make you sleep

As each day draws to a close, you feel the need to lie down and go to sleep. The onset of sleep, which seems like such a simple phenomenon from a behavioral perspective, is actually quite complex from a molecular one.
In the early 20th century, French psychologist Henri piéron hypothesized that prolonged wakefulness causes the build-up of a “sleep toxin" that is subsequently broken down during sleep. To test his hypothesis, piéron walked dogs through Paris at night to prevent them from sleeping. He then injected their cerebrospinal fluid into the brains of other dogs. He found that these other dogs then slept longer and more deeply than usual.

We now know that the “hypnogenic” (sleep-inducing) substances that piéron hypothesized do in fact exist. Some of them are small protein molecules that are produced by brain structures such as the hypothalamus and that inhibit the neurons of the wakefulness system.

But these proteins are not the only hypnogenic molecules. The build-up of serotonin in certain parts of the brain during periods of wakefulness also contributes to the onset of sleep. The serotonin level in certain areas of the brain also affects mood. That is why some problems such as depression and anxiety often lead to sleep disorders. People with low serotonin levels also tend to spend less time in restorative non-rem sleep over the course of the night.

Serotonin also plays an important role in sleep because the body uses it to synthesize melatonin. Melatonin is produced at night and plays a fundamental role in regulating the body’s biological clock. In fact, melatonin governs the entire sleep/wake cycle, whereas serotonin is involved more specifically in wakefulness, in triggering sleep, and in rem sleep.

Diagram of a melatonin molecule-
 (atoms: pale blue = carbon, dark blue = nitrogen, red = oxygen,
White = hydrogen)
Thus sleep is triggered by two inter-related processes: the production and build-up of hypnogenic substances in the body while we are awake, and cyclical fluctuations in substances such as melatonin that are associated with our body’s biological clock. 

Among the hypnogenic substances that build up while we are awake, adenosine has been the subject of much discussion since the mid-1990s. 

1 person found this helpful

Dominant, Submissive and Other Roles involved in BDSM

Dr.Vijay Abbot 92% (760ratings)
Graduate in Ayurvedic Medicine and Surgery ( GAMS )
Sexologist, Delhi
Dominant, Submissive and Other Roles involved in BDSM

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

  1. Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

  2. Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

  1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

  2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

  1. Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

  2. Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

  3. Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM. If you wish to discuss about any specific problem, you can consult a sexologist.

In case you have a concern or query regarding sexual health ask a doctor online, you can consult the best sexologist doctor online, & get the answers to your questions.

 

9267 people found this helpful

Dominants and Submissives Relationships: Different Roles in BDSM

Gautam Clinic Pvt Ltd 93% (8242ratings)
Sexologist Clinic
Sexologist, Faridabad
Dominants and Submissives Relationships: Different Roles in BDSM

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

  • Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

  • Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress  can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

  1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

  2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

  • Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

  • Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

  • Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM.

6684 people found this helpful

I am suffering from rheumatoid arthritis since last 15 years and also suffering from severe acidity problems since last 20 years. For rheumatoid arthritis I am taking medicine folitrax 15 one tablet in a week and lefnunomide 10 tablet daily one tablet and for acidity I am taking rab d (rabiprazole 20 with domperidon) it is controlled to some extent. Shall I change medicine?

Dr.Vaibhav Bhokare 88% (8262ratings)
MD-Ayurveda, Basic Life Support (B.L.S), Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurveda, Ahmednagar
How many days will you take rabeprazole? stop it as it has side effects like less absorption of vit b12 and calcium from gut. Causes anemia n calcium deficit in your body. We can provide you herbal medicines that will have no side effects. And both problems will be solved.
1 person found this helpful
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I have rashes on my skin and this cause black spot on body .if I rab this then water type liquid come out.

Dr.Prem Kishore Srivastava 93% (1677ratings)
MD - Dermatology , Venereology & Leprosy, Diploma In Dermatology And Venerology And Leprosy (DDVL), MBBS
Dermatologist, Bangalore
I have rashes on my skin and this cause black spot on body .if I rab this then water type liquid come out.
you apply Topinate cream twice daily for two weeks and Teczine 5mg 1 tablet daily at bedtime for 10 days.If you satisfied OK, otherwise consult privately with photos.
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HI, I have Acidity problem. From seven years .when I take rabitop d tablet .i feel bater. This tablet concerns from doctor bajrang pratap.

Dr.Jayvirsinh Chauhan 94% (33886ratings)
MD - Homeopathy, BHMS
Homeopath, Vadodara
HI, I have Acidity problem. From seven years .when I take rabitop d tablet .i feel bater. This tablet concerns from d...
It is a temporary solution And have many side effects. Better take homoeopathic treatment for permanent solution..
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I am having hyperacidity and for that I am taking rabeprazole 20 on empty stomach in the morning. I want to ask which one would be more effective for me. Rabeprazole 20, rabeprazole with levosulpiride or rabeprazole with domperidone and how long should I take this medicine to avoid side effects.

Dr.Tanmay Palsule 97% (6757ratings)
MD - Homeopathy, BHMS
Homeopath, Pune
I am having hyperacidity and for that I am taking rabeprazole 20 on empty stomach in the morning. I want to ask which...
It is important that you follow the following advice: Firstly, don’t miss breakfast, lunch or dinner. ... Secondly, avoid aerated drinks, tea, and coffee. ... Also, include milk and diary products in your diet. ... Don’t remain hungry for long periods of time. ... Raise the head of your bed if symptoms interfere with sleep. If your bed allows for it, raise the head of it by 6 to 8 inches. Gravity will keep the acid in your stomach. Don't just pile up pillows, though. These tend to bend your neck and body in such a way that increases the pressure. It will make the hyperacidity worse Consider losing weight. Losing weight may reduce some of the pressure on your lower esophageal sphincter, keeping stomach acid from leaking through Eat smaller meals. Decrease the amount of food you eat at any one time. This may reduce the amount of stress and pressure on your stomach Homoeopathy is free from side effects. For medication consult online in private.
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Gabapac-m tablet how to use. Rabeprazole 20 mg how to use aceclofenac and thiocolchicoside. How to use.

Dr.Abhaya Kant Tewari 93% (245ratings)
MD Medicine, DM Neurology
Neurologist,
Gabapac-m tablet how to use.
Rabeprazole 20 mg how to use
aceclofenac and thiocolchicoside. How to use.
Hello, each medicine though has a dose and is to be used accordingly, its not fair neither correct to discuss the use of medicines without knowing the disease and the aim of prescribing medicines it will be best for you if you consult the doctor who has prescribed the medication. Else the second best option will be to reconsult a doctor with complete details. Thats the best option for you.
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Hi, I have Hiatus Hernia and my doctor prescribed rab dsr and sucrose. Even after taking these medicines I do not see any relief. Any advice.

MCh(Minimally Invasive & Robotic Surgery), MS - Surgical, MBBS
General Surgeon, Guwahati
You can make one physiological modification by raising the legs at head end of you bed by 2 inches. Gravity will drain the gastric secretions downwards and give you relief. But if it also don't help, and you are taking medicines ,then probably you are left with only surgery option.
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How long should I take rabeprazole with levosulpiride to cure my acidity and avoid side effects?

Dr.Karuna Chawla 96% (112022ratings)
BHMS
Homeopathy Doctor, Noida
How long should I take rabeprazole with levosulpiride to cure my acidity and avoid side effects?
Razo 20 tablet is a proton pump inhibitor (ppi). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn. This medicine will not cure problem. It only works by reducing the amount of acid in the stomach. The day you do not take medicine normal acid production will be there n you will have symptoms. Do this 1. Don't take tea empty stomach. Eat something like a banana (if you are not diabetic) or any seasonal fruit or soaked almonds and a glass of water first thing in the morning (within 10 mins of waking up). No only biscuits or rusk will not do. 2. Don't overeat 3. Take your breakfast every day. Don't skip it. U can eat whatever your mother or grandparent eat in bfast. I mean to say whatever is your traditional food. If punjabi eat paratha, if belongs to south then take idli/ dosa etc. 4. Have light meals every 2 hours (in addition to your breakfast, lunch n dinner) e.g. Nariyal paani, chaach, a handful of dry fruits, a handful of peanuts, any fresh n seasonal fruit (eat whole fruit not juice), a cup of curd/milk etc 5. Finish your dinner at least 2 hours before going to sleep. Take simple food like rice n dal in dinner. 6. Maintain active life style7. Avoid fast foods, spicy n fried foods, carbonated beverages 8. Take a lot of green vegetables n fruit. It contains a lot of fiber which will help reduce tendency for constipation 9. Drink lot of water.10. Everyday preferably sleep on same time 11. Take half cup of cold milk when you feel acidity, it will help. Curd is good for u. 12. If its very severe then elevate your bed raising the head of your bed six to eight inches can help gravity keep gastric acid down in your stomach. This is for long term results but for now to bring your digestive system back on track you need to take medicines. For that I need more details, you can consult me.
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