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Prorab 20 MG Tablet Health Feed

Molecules Roles They Play In Sleep!

Dr.Aravinda Jawali 91% (1523ratings)
Psychiatrist, Bangalore
Molecules Roles They Play In Sleep!

Benzodiazepines are a family of molecules, some of which are used as sleep-inducing medications, while others are used as tranquilizers. 
Benzodiazepines bind to a specific site on a neuron’s receptor for GABA, a neurotransmitter that counteracts the brain’s wakefulness mechanisms. Thus benzodiazepines promote sleep by augmenting this natural process.

The same gabaergic receptor also has binding sites that can be used both by barbiturates (a class of drugs once commonly used as sleep aids but now almost never used for that purpose) and by anesthetics, whose purpose is to put surgical patients to sleep.

Molecules that build up and make you sleep

As each day draws to a close, you feel the need to lie down and go to sleep. The onset of sleep, which seems like such a simple phenomenon from a behavioral perspective, is actually quite complex from a molecular one.
In the early 20th century, French psychologist Henri piéron hypothesized that prolonged wakefulness causes the build-up of a “sleep toxin" that is subsequently broken down during sleep. To test his hypothesis, piéron walked dogs through Paris at night to prevent them from sleeping. He then injected their cerebrospinal fluid into the brains of other dogs. He found that these other dogs then slept longer and more deeply than usual.

We now know that the “hypnogenic” (sleep-inducing) substances that piéron hypothesized do in fact exist. Some of them are small protein molecules that are produced by brain structures such as the hypothalamus and that inhibit the neurons of the wakefulness system.

But these proteins are not the only hypnogenic molecules. The build-up of serotonin in certain parts of the brain during periods of wakefulness also contributes to the onset of sleep. The serotonin level in certain areas of the brain also affects mood. That is why some problems such as depression and anxiety often lead to sleep disorders. People with low serotonin levels also tend to spend less time in restorative non-rem sleep over the course of the night.

Serotonin also plays an important role in sleep because the body uses it to synthesize melatonin. Melatonin is produced at night and plays a fundamental role in regulating the body’s biological clock. In fact, melatonin governs the entire sleep/wake cycle, whereas serotonin is involved more specifically in wakefulness, in triggering sleep, and in rem sleep.

Diagram of a melatonin molecule-
 (atoms: pale blue = carbon, dark blue = nitrogen, red = oxygen,
White = hydrogen)
Thus sleep is triggered by two inter-related processes: the production and build-up of hypnogenic substances in the body while we are awake, and cyclical fluctuations in substances such as melatonin that are associated with our body’s biological clock. 

Among the hypnogenic substances that build up while we are awake, adenosine has been the subject of much discussion since the mid-1990s. 

1 person found this helpful

Dominant, Submissive and Other Roles involved in BDSM

Dr.Vijay Abbot 92% (760ratings)
Graduate in Ayurvedic Medicine and Surgery ( GAMS )
Sexologist, Delhi
Dominant, Submissive and Other Roles involved in BDSM

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

  1. Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

  2. Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

  1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

  2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

  1. Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

  2. Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

  3. Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM. If you wish to discuss about any specific problem, you can consult a sexologist.

In case you have a concern or query regarding sexual health ask a doctor online, you can consult the best sexologist doctor online, & get the answers to your questions.

 

9267 people found this helpful

Dominants and Submissives Relationships: Different Roles in BDSM

Gautam Clinic Pvt Ltd 93% (8242ratings)
Sexologist Clinic
Sexologist, Faridabad
Dominants and Submissives Relationships: Different Roles in BDSM

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

  • Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

  • Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress  can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

  1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

  2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

  • Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

  • Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

  • Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM.

6684 people found this helpful

I am post renal transplant patient, may I take this without any problems, veloz m?

Dr.Pahun 91% (28993ratings)
Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Sexologist, Jaipur
I am post renal transplant patient, may I take this without any problems, veloz m?
You can take himcocid (himalaya) 2 tsf twice a day empty stomach. Since its ayurvedic and free of any side effects. Still, you want to take veloz m then yes you can take it before 30 minutes of taking breakfast.
1 person found this helpful
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I take full course of rabbies vaccination but I want to check rabbies vaccine effectiveness should I do igg test for measure rabbies specific antibodies.

Nitin Arora 92% (85ratings)
MD - Internal Medicine, MBBS
Internal Medicine Specialist, Jalandhar
I take full course of rabbies vaccination but I want to check rabbies vaccine effectiveness should I do igg test for ...
These tests are routinely available and indicated. Rabies vaccine usually has very high efficiency, so just relax if you have taken the full course.
1 person found this helpful
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Hi Sir, I am a 46 years old man and i use omeprazole instead of veloz d any problem?

Dr.Sajeev Kumar 92% (39992ratings)
C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Hi Sir, I am a 46 years old man and i use omeprazole instead of veloz d any problem?
Both Omeprazole and Velos D are almost same and the veloz d contains an additional ingredient domperidone which is useful nausea or vomiting . You can take veloz d in place of omeprazole
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Hello, Please tell me the validity of tetanus vaccine after administered and also rabbies vaccine. Please help.

Dr.Sajeev Kumar 92% (39992ratings)
C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Hello,
Please tell me the validity of tetanus vaccine after administered and also rabbies vaccine. Please help.
The effect of tetanus vaccine will be for one year and if you keep repeating every month for 3 months and thereafter, every year once the effect can last upto 5 years
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How to use "POTRATE -SF "syrup? Once I use it but forget how to use. I have urinal problem for a few days. Can I use it if so how to consume?

Dr.Sajeev Kumar 92% (39992ratings)
C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
How to use "POTRATE -SF "syrup? Once I use it but forget how to use. I have urinal problem for a few days. Can I use ...
YOu should not self medicate based on your previous treatment. This is taken 5 ML in a glass of water ofr urinary infection
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I have thyroid without having a fibril sf I dont have proper motion please help what to do.

Dt.Sumaiya Petiwala 90% (76955ratings)
Certified Diabetes Educator, Registered Dietitian (RD), PGDD, Bachelor of Unani Medicine and Surgery (B.U.M.S), General Physician
Dietitian/Nutritionist, Mumbai
Thyroid gland affects nearly every organ in the body. Many nutritional factors play a role in optimizing thyroid function. However, both nutrient deficiencies and excesses can trigger or exacerbate symptoms. Working in collaboration with a both a physician and a registered dietitian is essential to determine nutritional status for optimal thyroid health. Improper thyroid function causes undesired weight changes, significant cardiovascular risks, and symptoms such as fatigue, mood changes, and gastrointestinal upset, which can hinder the development of healthful behaviors. I focus on setting realistic goals for healthy changes and regular exercise when counseling clients. There many potential nutrient deficiencies and interactions with medications and supplements. Hence diligent care is to be taken while designing a holistic treatment plan. I being a both a registered dietitian and doctor have been successfully helping patients with their problems through a holistic approach using customized therapeutic diet and medications. Do reply back for private consultation.
1 person found this helpful
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Please suggest Can I take Thyronorm 50 mcg and Rabifast 20 mg in empty stomach at the same time or between a gap of 30 minutes? I would request for advice of endocrinologist for thyroid problem.

Dr.Prabhakar Laxman Jathar 95% (19644ratings)
MBBS, CCEBDM, Diploma in Diabetology, Diploma in Clinical Nutrition & Dietetics, Cetificate Course In Thyroid Disorders Management (CCMTD)
Endocrinologist, Hubli-Dharwad
Please suggest Can I take Thyronorm 50 mcg and Rabifast 20 mg in empty stomach at the same time or between a gap of 3...
Mr. lybrate-user, Thanks for the query. It is better to avoid any other drug intake after taking Levothyroxine tablet for at least 3 to 4 hours. The reason is that thyronorm is in very minute quantity, therefore, presence of any other molecule is likely to disturb its absorption. Thanks.
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