Prorab 20 MG Tablet Health Feed

Benzodiazepines are a family of molecules, some of which are used as sleep-inducing medications, while others are used as tranquilizers. 
Benzodiazepines bind to a specific site on a neuron’s receptor for GABA, a neurotransmitter that counteracts the brain’s wakefulness mechanisms. Thus benzodiazepines promote sleep by augmenting this natural process.

The same gabaergic receptor also has binding sites that can be used both by barbiturates (a class of drugs once commonly used as sleep aids but now almost never used for that purpose) and by anesthetics, whose purpose is to put surgical patients to sleep.

Molecules that build up and make you sleep

As each day draws to a close, you feel the need to lie down and go to sleep. The onset of sleep, which seems like such a simple phenomenon from a behavioral perspective, is actually quite complex from a molecular one.
In the early 20th century, French psychologist Henri piéron hypothesized that prolonged wakefulness causes the build-up of a “sleep toxin" that is subsequently broken down during sleep. To test his hypothesis, piéron walked dogs through Paris at night to prevent them from sleeping. He then injected their cerebrospinal fluid into the brains of other dogs. He found that these other dogs then slept longer and more deeply than usual.

We now know that the “hypnogenic” (sleep-inducing) substances that piéron hypothesized do in fact exist. Some of them are small protein molecules that are produced by brain structures such as the hypothalamus and that inhibit the neurons of the wakefulness system.

But these proteins are not the only hypnogenic molecules. The build-up of serotonin in certain parts of the brain during periods of wakefulness also contributes to the onset of sleep. The serotonin level in certain areas of the brain also affects mood. That is why some problems such as depression and anxiety often lead to sleep disorders. People with low serotonin levels also tend to spend less time in restorative non-rem sleep over the course of the night.

Serotonin also plays an important role in sleep because the body uses it to synthesize melatonin. Melatonin is produced at night and plays a fundamental role in regulating the body’s biological clock. In fact, melatonin governs the entire sleep/wake cycle, whereas serotonin is involved more specifically in wakefulness, in triggering sleep, and in rem sleep.

Diagram of a melatonin molecule-
 (atoms: pale blue = carbon, dark blue = nitrogen, red = oxygen,
White = hydrogen)
Thus sleep is triggered by two inter-related processes: the production and build-up of hypnogenic substances in the body while we are awake, and cyclical fluctuations in substances such as melatonin that are associated with our body’s biological clock. 

Among the hypnogenic substances that build up while we are awake, adenosine has been the subject of much discussion since the mid-1990s. 

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

1. Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

2. Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

1. Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

2. Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

3. Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM. If you wish to discuss about any specific problem, you can consult a sexologist.

In case you have a concern or query regarding sexual health ask a doctor online, you can consult the best sexologist doctor online, & get the answers to your questions.

BDSM which stands for Bondage Domination Sadism and Masochism is a popular catch phrase to describe a certain type of behaviour in humans for gratification of pleasure by using means like bondage, pain, power and discipline. The concept of BDSM differs from person to person as one may consider power and humiliation as means of pleasure while another might consider it to be paraphilia (abnormal sexual desires).

Different roles in BDSM:

Dominance: This is a role assumed by a dom (male) or a domme (female) who controls the other person and the flow of events. Everything during the course of BDSM is regulated (from rules to positions) by the dominant partner.

• Daddy/Mummy: A term used to describe the dominant who usually chooses to assume a parental role to the sub.

• Master/Mistress: Widely used, this term is used to denote the dominant who demands different degrees of compliance from the submissive. The master/mistress  can choose to treat the sub in whatever way they want to.

The dominant can choose to use different forms such as:

1. Bondage: Using ropes or any device that limits the sub’s movement during the intercourse/foreplay.

2. Sadism: The dominant chooses to gratify pleasure by inflicting pain on the submissive.

Submission: The submissive one has to adhere to the set of rules laid down by the dominant partner and isn’t allowed to say “no” to any order given by the dominant.

• Slave: This term is used to denote a submissive who is entirely at the mercy of the dominant. Chained collars are common in this kind of role play.

• Brat: This term is used for a sub who has misbehaved by not complying with the dominant’s wishes and is punished (sexually or by inflicting pain otherwise) for the same.

• Pet: The sub is referred to as a “pet” (kitty/pony/puppy) and treated as one by the dominant. Collars, tails, leashes and cages are some of the equipment used in this kind of BDSM.