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Overview

Metronidazole 400 MG Tablet

Manufacturer: Cadila Pharmaceuticals Ltd
Medicine composition: Metronidazole
Prescription vs.OTC: Prescription by Doctor required

Metronidazole 400 MG Tablet is antibacterial and antifungal. It is used either on its own or in combination to cure inflammatory diseases, endocarditis, dracunculiasis, giardiasis, trichomoniasis and amebiasis. It can only treat certain parasitic and bacterial infections of the vagina, respiratory tract, skin and joints. Metronidazole 400 MG Tablet is sold under the trade name of Flagyl and Flagyl ER.

Like all medicines there are certain associated side effects with the usage of Metronidazole 400 MG Tablet which are dizziness, headache, upset stomach, abdominal pain, vomiting, nausea, reduced appetite, either diarrhea or constipation, blurred vision, clouded thoughts, fever, irritability, aggression, depression, difficulty speaking and breathing, skin rash or redness, a burning sensation, blisters, sore throat, darkening of the urine, rapid or irregular heartbeat and mouth ulcers to name a few. Should the side effects continue or worsen overtime, contact your health care provider right away.

Before starting Metronidazole 400 MG Tablet treatment you should consult with your doctor and tell him/her if you have any allergies, have liver, nerve disorders or blood cell disorders, stomach or intestinal infections such as Crohn’s disease, epilepsy or other kinds of seizures, if you’re pregnant or are planning to become pregnant. In case you are nursing a baby the use of Metronidazole 400 MG Tablet is not recommended as it may pass into breast milk and cause harm to the infant.

Metronidazole 400 MG Tablet comes in both capsule and tablet form. The dosage will be prescribed by your doctor determining your age, gender, overall health and the severity of your condition. The usual dosage in adults for a bacterial infection is about 7.5 mg orally every 6 hours over a period of 7-10 days. And if you are taking it by infusion then the advised dose is about 15 mg once for 1 hour daily over a period of 7-10 days as well. Dose for other treatments vary from one person to another. In case of drug overdose, seek medical attention immediately.

Amebiasis
Metronidazole 400 MG Tablet is used in the amebiasis which is a parasitic infection that affects the intestine and amebic liver abscess caused by Entamoeba histolytica.
Metronidazole 400 MG Tablet is used in the treatment of trichomoniasis which is a sexually transmitted disease caused by Trichomonas vaginalis.
Bacterial Vaginosis
Metronidazole 400 MG Tablet is used in the treatment of overgrowth of bacteria in the vagina caused by Lactobacillus species.
Bacterial infections
Metronidazole 400 MG Tablet is used to treat the infectins caused by bacteria in blood, lungs, genital areas caused by Bacteroides fragilis and Clostridium species.
Surgical prophylaxis
Metronidazole 400 MG Tablet is used to treat infections that may cause after surgery.
Not recommended in patients with known allergy to Metronidazole 400 MG Tablet or other nitroimidazoles.
In addition to its intended effect, Metronidazole 400 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Agitation Major Common
Blurred vision Major Common
Burning or tingling sensation of hands and feet Major Common
Convulsions Major Common
Fever and chills Major Less Common
Skin rash Major Less Common
Vaginal irritation Major Less Common
Loss of appetite Major Rare
Constipation Major Rare
Yellow colored eyes or skin Major Rare
Abdominal pain Minor Common
Dizziness Minor Common
Change in taste/ Metallic taste Minor Less Common
Dry mouth Minor Less Common
How long is the duration of effect?
The effect of this medicine lasts for an average duration of 24 hours.
What is the onset of action?
The peak effect of this medicine can be observed in 1 to 2 hours.
Are there any pregnancy warnings?
This medicine is not recommended in the first trimester of pregnancy to treat bacterial vaginosis and trichomoniasis. It can be used in the second and third trimesters of pregnancy only if clearly needed.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
This medicine is known to excreted through the breastmilk. It is used in breastfeeding women only if clearly needed. Breastfeeding should be avoided for 24 hours after single-dose maternal treatment. Monitoring of candidal infections and diarrhea is necessary.
Below is the list of medicines, which have the same composition, strength and form as Metronidazole 400 MG Tablet, and hence can be used as its substitute.
Aristo Pharmaceuticals Pvt.Ltd
Micro Labs Ltd
Emcure Pharmaceuticals Ltd
Abbott Healthcare Pvt. Ltd
Alkem Laboratories Ltd
Missed Dose instructions
If you miss a dose of Metronidazole 400 MG Tablet, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose instructions
Seek emergency medical treatment or contact the doctor in case of an overdose.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Disease
Information not available.
Interaction with Alcohol
Ethanol Moderate
Consumption of alcohol is not recommended in patients with Metronidazole 400 MG Tablet. Any symptoms of the fast heartbeat, warmth, headache, and breathing difficulty should be reported to the doctor.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Warfarin Major
Metronidazole 400 MG Tablet may increase the concentration of warfarin and increase the risk of bleeding. Inform the doctor if you have any bleeding disorder. Any symptoms of unusual bleeding, blood in stools, headache, and dizziness should be reported to the doctor. An alternate class of medicine should be considered based on the clinical condition.
Ethinyl Estradiol Moderate
The desired effect of contraceptive pills will not be achieved if these medicines are taken together. Appropriate dose adjustments or replacement of the medicine should be made under the doctor's supervision.
Atorvastatin Moderate
These medicines may increase the risk of nerve damage if given together. Any symptoms of numbness, tingling or burning sensation in feet, hands should be informed to the doctor. An alternate medicine should be considered based on the clinical condition.
Disulfiram Moderate
Metronidazole 400 MG Tablet is not recommended in patients receiving disulfiram due to the risk of confusion and psychotic symptoms. Inform the doctor if you are receiving these medications. Any symptoms of change in behavior, irritation, and altered coordination should be reported to the doctor.
What are you using Metronidazole 400 MG Tablet for?
Bacterial infections
Other
Amebiasis
Bacterial Vaginosis
Trichomoniasis
Surgical prophylaxis
How much was the improvement?
Average
Excellent
Poor
How long did it take before seeing improvement?
More than 2 days
Within a day
Within 2 days
Within 2 hours
Within 6 hours
How frequently did you take this medicine?
Thrice a day
Once a day
Twice a day
Not taking on daily level
Four times A Day
How did you take this medicine?
With Food
With or without food
Empty stomach
What were the side effects of this medicine?
Loss of appetite
Vaginal irritation
Fever and chills
Skin Rash
Agitation
Convulsions
Burning or tingling sensation of hands and feet
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I am having mouth ulcers from 1 years, it gets cured in few days and reoccur constantly in 15-20 days, I don't smoke either.

Bachelor of Dental Surgery
Dentist, Allahabad
I am having mouth ulcers from 1 years, it gets cured in few days and reoccur constantly in 15-20 days, I don't smoke ...
Dear Lybrate user, your ulcer problem is due to digestive system problem. Should treat your digestive system first. Then your ulcer problem will be easily treated with help of vitamins, renitidine, metronidazole, and mouth paint.

I am having recurrent giardia for the last 1.5 years and I have taken tinidazole (2 gram once), metronidazole (400 mg* 3 times for 7 days) once and metronidazole (14 days) another time, rifamaxin (10 days), albendazole (400 mg *5 days) during this these 18 months and still have symptoms. Can someone please help?

B.Sc (Bio), DMS (Cal), CMS , FWT, PET, DMLT (Cal), SBHM, Vacc,
Homeopath, Kolkata
Please you may take the given medicine for your suffering. 1) Cina -200. 2) Teucrium Marrumverum -200. In no 30 globules. To be taken four globules thrice daily before food no 1 and after food no 2 for one month. And report me the result for your suffering and consult with me over audio call. Notes:- do not take fatty, oily, spicy, fried food. Do not take water during meal, taken planty of water, water should be taken before one or two hour or after every meal.
1 person found this helpful

I am suffering form Leucorrhoea very badly, I feel exhausted, sleepy every time which effect my daily routine. Please suggest me a cure (ayurvedic / homeopathic) preferred! I'll be thankful to you!

BHMS
Homeopath, Gorakhpur
There are many causes of leukorrhea, the usual one being estrogen imbalance. The amount of discharge may increase due to vaginal infection or STDs, and it may disappear and reappear from time to time. This discharge can keep occurring for years, in which case it becomes more yellow and foul-smelling.  Leukorrhea may be caused by sexually transmitted diseases; therefore, treating the STD will help treat the leukorrhea. Treatment may include antibiotics, such as metronidazole. Other antibiotics common for the treatment of STDs include clindamycin or trinidazole. If you want Homeopathic treatment contact me privately. I will help you out from this problem.
2 people found this helpful

Hi all, I am 28 yrs I think I developed neuropathy 2 Months ago from taking 1000 mg of metronidazole. I started taking Neurobion (b- complex) tablet once a day 5 days ago prescribed by my doctor. Its been two months, is there any other treatment for this? And how long will it take my body to recover? Thanks.

MBBS, MD - Consultant Physician, DNB (General Medicine), DM - Neurology
Neurologist, Vijayawada
Yes it is secondary to metronidazole. Any drug related neuropathy takes 3-6 months for recovery usually.
1 person found this helpful

I am 30 week pregnant and from two days I feel pain in my stomach and I am also suffering from loose motion. Is there in any medicine that I can take to cope with it? Can I take metronidazole 400 mg, Is it safe during pregnancy?

MS - Obstetrics and Gynaecology
Gynaecologist, Delhi
I am 30 week pregnant and from two days I feel pain in my stomach and I am also suffering from loose motion. Is there...
Self medication during pregnancy is very risky, you are suffering from gastroenteritis, consult your gynaecologist take a soft bland diet ,drink lots of fluids like- nimbu paani ,coconut water, ors solution and butter milk.
3 people found this helpful

Popular Health Tips

Stomach Ulcer: 4 Best Ways To Treat It!

MBBS
Sexologist, Jammu
Stomach Ulcer: 4 Best Ways To Treat It!

Ulcer pain can be uneasy and unbearable at times. It is caused by a bacterium known as the H. Pylori. Pain medication, lifestyle changes, and healthy eating habits can ensure pain relief from this condition. Here is a list of 4 best ways to get instant pain relief from an ulcer:

  1. Medication - H. Pylori is often found in the digestive tract. Doctors suggest various combinations of antibiotics kill this bacterium. Some of those include tetracycline, levofloxacin, metronidazole, and tinidazole. These are prescribed as per the resistance rate of the bacteria. There are other sets of medication that blocks acid production in the body. These drugs which commonly go by the name of PPIs include esomeprazole, lansoprazole, and pantoprazole. The third set of medications reduces acidity in the stomach and gives instant relief. They are readily available over the counter and goes by the name antacid. The final line of medicines that are often prescribed by doctors includes Cytotec and Carafate. They protect the tissue lining of the intestine and the stomach.
  2. Consumption of cranberry - Cranberry has multiple health benefits. One of those includes the ability to fight against bacteria of the urinary tract. They also do not allow the bacteria to settle on the surface of the bladder. Cranberry in the form of juice, supplement and as a whole can be consumed daily to get relief from the stomach ulcer. It should be taken in specific quantity as too much of cranberry consumption can upset the stomach. Packaged cranberry juice from the market can be avoided as they contain high level of fructose which can unsettle the stomach.
  3. Flavonoids - A compound known as bioflavonoids are known to be extremely helpful for pain relief from an ulcer. These compounds naturally occur in many vegetables and fruits such as soybeans, berries, apples, legumes, green tea, broccoli and berries. Bioflavonoids available in red wine and citrus food should be strictly avoided as they can trigger ulcer pain. Bioflavonoids should be taken in measured quantities as too much consumption of it can cause harm in blood clotting. It can be consumed in the form of supplements if the body doesn’t receive the same from the daily diet.
  4. Deglycyrrhizinated licorice - This compound is nothing but licorice with the sweet flavour pulled out of it. A study showed that they are capable of completing curing the ulcer containing bacteria by inhibiting their growth. Deglycyrrhizinated Licorice is available in the form of candy and can be consumed once the pain starts. Supplements too are available in the market. Not more than 2 ounces of Deglycyrrhizinated Licorice should be consumed in a day as they can cause fluctuation in blood pressure and lead to heart diseases. In case you have a concern or query you can always consult an expert & get answers to your questions!
6255 people found this helpful

Stomach Ulcers - 5 Ways It Can Be Treated!

DNB Gastroenterology, Consulatant Gastroenterologist, Chief gastroenterologist
Gastroenterologist, Nashik
Stomach Ulcers - 5 Ways It Can Be Treated!

A stomach ulcer or gastric ulcer refers to the defects or breakdown in the mucosal lining in the stomach. The stomach contains acid, which helps in digestion and any break in the tissue lining may result in severe pain or bleeding in some cases. The pain is usually felt in the abdomen.

Stomach ulcers cause great discomfort and should be treated effectively. Here are the primary ways for treating stomach ulcers:

  1. Antibiotics: In the case of H. pylori infection, you should take a course of more than two antibiotics, to be taken twice a day and must be continued for a week. Antibiotics such as amoxicillin, clarithromycin or metronidazole may be used in case of such stomach ulcers. However it is always recommended to consult a specialized doctor before consuming any of these medicines. After several weeks of using the antibiotics, you should get a test done for detection of H. pylori bacteria. If they are still present, you have to take different antibiotics.

  2. Proton Pump Inhibitors: Proton pump inhibitors or PPIs helps in the reduction of the amount of acid produced by the stomach. This prevents damage to the ulcer and lets it heal naturally. PPIs are generally taken for four to eight weeks. The most common PPIs which are used for treating stomach ulcers are omeprazole, pantoprazole and lansoprazole.

  3. H2 Receptor Antagonists: H2 receptor antagonists reduce the production of stomach acid and function the same as PPIs. The most common H2 receptor for treating stomach ulcers is ranitidine.

  4. Antacids/ Alginate: All measures to treat stomach ulcers take several hours to show results. Your doctor may prescribe antacid medications for neutralizing the stomach acid. This will provide relief for the moment, but the relief is quite temporary and for a short span of time. By this time, the strong medicines most likely start working. There is a certain antacid medicine known as alginate. This develops a protective coating on the stomach lining. Antacids are available at all over the counter medicine stores and you should consult your doctor to get the best antacid which would work effectively on your stomach ulcer symptoms. You should take antacids before going to sleep or after taking meals.

  5. Natural Remedies: Stomach ulcer can also be treated at home using natural remedies. Medicines may sometimes cause further digestive complications, so home remedies are much more easy to follow and do not have side effects. The best way is to follow a proper diet, which is comprised of certain food items that help in curing stomach ulcers. You should consume bananas, honey, garlic, green leafy vegetables like cabbage, licorice and capsaicin.

Stomach ulcers cause great pain and also bleeding in several cases. Proper treatment procedures should be taken in case of stomach ulcer. There are many medical remedies, as well as home remedies for treating stomach ulcers. If you wish to discuss about any specific problem, you can consult a Gastroenterologist.

1750 people found this helpful

Stomach Ulcers - Ways To Treat It!

FELLOWSHIP IN ADVANCED LIVER SURGERY AND LIVER TRANSPLANTATION, FELLOWSHIP IN HEPATOBILIARY AND LIVER TRANSPLANT SURGERY, MASTER OF SURGERY, MBBS
Gastroenterologist, Ahmedabad
Stomach Ulcers - Ways To Treat It!

A stomach ulcer or gastric ulcer refers to the defects or breakdown in the mucosal lining in the stomach. The stomach contains acid, which helps in digestion and any break in the tissue lining may result in severe pain or bleeding in some cases. The pain is usually felt in the abdomen. Also, check out Stomach Aches and Pains in Kids.

Stomach ulcers cause great discomfort and should be treated effectively. Here are the primary ways for treating stomach ulcers:

  1. Antibiotics: In the case of H. pylori infection, you should take a course of more than two antibiotics, to be taken twice a day and must be continued for a week. Antibiotics such as amoxicillin, clarithromycin or metronidazole may be used in case of such stomach ulcers. However it is always recommended to consult a specialized doctor before consuming any of these medicines. After several weeks of using the antibiotics, you should get a test done for detection of H. pylori bacteria. If they are still present, you have to take different antibiotics.

  2. Proton Pump Inhibitors: Proton pump inhibitors or PPIs helps in the reduction of the amount of acid produced by the stomach. This prevents damage to the ulcer and lets it heal naturally. PPIs are generally taken for four to eight weeks. The most common PPIs which are used for treating stomach ulcers are omeprazole, pantoprazole and lansoprazole.

  3. H2 Receptor Antagonists: H2 receptor antagonists reduce the production of stomach acid and function the same as PPIs. The most common H2 receptor for treating stomach ulcers is ranitidineConsult a doctor for all stomach related problems.

  4. Antacids/ Alginate: All measures to treat stomach ulcers take several hours to show results. Your doctor may prescribe antacid medications for neutralizing the stomach acid. This will provide relief for the moment, but the relief is quite temporary and for a short span of time. By this time, the strong medicines most likely start working. There is a certain antacid medicine known as alginate. This develops a protective coating on the stomach lining. Antacids are available at all over the counter medicine stores and you should consult your doctor to get the best antacid which would work effectively on your stomach ulcer symptoms. You should take antacids before going to sleep or after taking meals.

  5. Natural Remedies: Stomach ulcer can also be treated at home using natural remedies. Medicines may sometimes cause further digestive complications, so home remedies are much more easy to follow and do not have side effects. The best way is to follow a proper diet, which is comprised of certain food items that help in curing stomach ulcers. You should consume bananas, honey, garlic, green leafy vegetables like cabbage, licorice and capsaicin.

Stomach ulcers cause great pain and also bleeding in several cases. Proper treatment procedures should be taken in case of stomach ulcer. There are many medical remedies, as well as home remedies for treating stomach ulcers. In case you have a concern or query you can always consult an expert & get answers to your questions!

2037 people found this helpful

Inflammation of The Vagina - Could it be Vaginitis?

MBBS, MD - Obstetrics & Gynaecology, Advanced Infertility
Gynaecologist, Mumbai
Inflammation of The Vagina - Could it be Vaginitis?

Vaginitis is the inflammation of one’s vagina accompanied by pain during intercourse, mild vaginal bleeding, painful urination, vaginal itching or a considerable change in the amount, odor and color of the vaginal discharge.
Causes:
1. A certain level of bacteria is normally found in one’s vagina (lactobacilli). Now if this count is outnumbered by the other bacteria (anaerobes), the balance in the vagina gets disrupted giving rise to bacterial vaginosis. Such kind of vaginitis usually stems from sexual intercourse with multiple sex partners.
2. Yeast infection occurs due to an overgrowth of fungal organisms in one’s vagina, especially Candida Albicans.
3. Trichomoniasis caused by the one celled microscopic parasite ‘Trichomonas Vaginalis’ generally spreads through sexual intercourse with an infected partner. The condition also makes one vulnerable to various sexually transmitted infections.
4. Spermicidal products, scented detergents, perfumed soaps, douches, vaginal sprays or foreign objects such as tampons that were not taken out or tissue paper might trigger allergic reactions or irritation in the vaginal tissues.

5. Surgical removal of the ovaries or reduced estrogen count after menopause might cause thinning of the vaginal lining, thereby resulting in vaginal burning, dryness or irritation.


Treatments:
1. For Bacterial vaginosis, your doctor might advise the application of clindamycin cream or metronidazole gel as well as metronidazole tablets which are to be taken orally.
2. Yeast infections might be treated with an anti-fungal suppository or cream, for instance, tioconazole, butoconazole, clotrimazole or miconazole. Oral medication, such as fluconazole is also administered to treat the same.
3. Metronidazole or tinidazole tablets are prescribed for Trichomoniasis.
4. Estrogen in the form of rings, tablets or vaginal creams is effective in treating low estrogen level after menopause.
5. For non-infectious vaginitis primarily caused by objects, such as tampons, sanitary napkins, laundry detergent or new soap, it is essential to pinpoint the source of the irritation and avoid them. If you wish to discuss about any specific problem, you can consult a Gynaecologist.

4800 people found this helpful

Stomach Ulcer - 4 Best Ways To Get Pain Relief!

MBBS
General Physician, Ahmedabad
Stomach Ulcer - 4 Best Ways To Get Pain Relief!

Ulcer pain can be uneasy and unbearable at times. It is caused by a bacterium known as the H. Pylori. Pain medication, lifestyle changes, and healthy eating habits can ensure pain relief from this condition. Here is a list of 4 best ways to get instant pain relief from an ulcer:

  1. Medication - H. Pylori is often found in the digestive tract. Doctors suggest various combinations of antibiotics kill this bacterium. Some of those include tetracycline, levofloxacin, metronidazole, and tinidazole. These are prescribed as per the resistance rate of the bacteria. There are other sets of medication that blocks acid production in the body. These drugs which commonly go by the name of PPIs include esomeprazole, lansoprazole, and pantoprazole. The third set of medications reduces acidity in the stomach and gives instant relief. They are readily available over the counter and goes by the name antacid. The final line of medicines that are often prescribed by doctors includes Cytotec and Carafate. They protect the tissue lining of the intestine and the stomach.
  2. Consumption of cranberry - Cranberry has multiple health benefits. One of those includes the ability to fight against bacteria of the urinary tract. They also do not allow the bacteria to settle on the surface of the bladder. Cranberry in the form of juice, supplement and as a whole can be consumed daily to get relief from the stomach ulcer. It should be taken in specific quantity as too much of cranberry consumption can upset the stomach. Packaged cranberry juice from the market can be avoided as they contain high level of fructose which can unsettle the stomach.
  3. Flavonoids - A compound known as bioflavonoids are known to be extremely helpful for pain relief from an ulcer. These compounds naturally occur in many vegetables and fruits such as soybeans, berries, apples, legumes, green tea, broccoli and berries. Bioflavonoids available in red wine and citrus food should be strictly avoided as they can trigger ulcer pain. Bioflavonoids should be taken in measured quantities as too much consumption of it can cause harm in blood clotting. It can be consumed in the form of supplements if the body doesn’t receive the same from the daily diet.
  4. Deglycyrrhizinated licorice - This compound is nothing but licorice with the sweet flavour pulled out of it. A study showed that they are capable of completing curing the ulcer containing bacteria by inhibiting their growth. Deglycyrrhizinated Licorice is available in the form of candy and can be consumed once the pain starts. Supplements too are available in the market. Not more than 2 ounces of Deglycyrrhizinated Licorice should be consumed in a day as they can cause fluctuation in blood pressure and lead to heart diseases. If you wish to discuss about any specific problem, you can consult a general physician.
3337 people found this helpful

Table of Content

About Metronidazole 400 MG Tablet
When is Metronidazole 400 MG Tablet prescribed?
What are the contraindications of Metronidazole 400 MG Tablet?
What are the side effects of Metronidazole 400 MG Tablet?
Key highlights of Metronidazole 400 MG Tablet
What are the substitutes for Metronidazole 400 MG Tablet?
What are the dosage instructions?
Where is the Metronidazole 400 MG Tablet approved?
What are the interactions for Metronidazole 400 MG Tablet?