Flagyl 400 MG Tablet
Flagyl 400 MG Tablet manufactured by abbot healthcare contains Metronidazole as an active ingredient. A prescription is required for this drug. The drug is an anti-protozoal used either on its own or in combination in the treatment of infections in the stomach and genital areas.
The medication is prescribed in the treatment of Amebiasis, Trichomoniasis, Bacterial Vaginosis, Bacterial infections and Surgical prophylaxis. This medication is not recommended with alcohol as it can cause severe discomfort and reactions.
This medication may have a lot of side effects and I should be taken under medical prescription some side effects include agitation, blurred vision, burning or tingling sensation of hands and feet, fevers and chills, skin rash, vaginal irritation, loss of appetite, constipation, yellow coloured eyes or skin and abdominal pain.
If the medication is taken while there is alcohol present in the system it can cause palpation, warmth, headache and breathing difficulty. This medication does not cause habit-forming tendencies. This drug is not recommended for women who just got pregnant but can be used in the later term of pregnancy.
Breastfeeding mothers should avoid this drug as it can be passed down through milk and cause severe indigestion or diarrhoea. This medication may lower blood count and convulsions.
Use Flagyl 400 MG Tablet with caution in patients with liver impairment due to potential accumulation, blood dyscrasias; a history of seizures, congestive heart failure, or other sodium retaining states; reduce dosage in patients with severe liver impairment, CNS disease, and severe renal failure (Clcr <10 mL/minute).
If H. pylori is not eradicated in patients being treated with Flagyl 400 MG Tablet in a regimen, it should be assumed that metronidazole-resistance has occurred and it should not again be used; seizures and neuropathies have been reported especially with increased doses and chronic treatment; if this occurs, discontinue therapy.
Take exactly as directed, with meals. Avoid alcohol during and for 24 hours after last dose. With alcohol your may experience severe flushing, headache, nausea, vomiting, or chest and abdominal pain.
Flagyl 400 MG Tablet may discolor urine (brown/black/dark) (normal). You may experience "metallic" taste disturbance or nausea or vomiting (small frequent meals, frequent mouth care, chewing gum, or sucking lozenges may help).
Refrain from intercourse or use a barrier contraceptive if being treated for trichomoniasis. Report lack of improvement or worsening of condition.
How long is the duration of effect?
The effect lasts for about 24 hours until discharged from the system.
What is the onset of action?
The medication’s effect can be felt within 1-2 hours of administration.
Are there any pregnancy warnings?
This drug is not recommended for women who are planning on getting pregnant and for women who are on the first few months of pregnancy as it can cause some complication to the foetus. Consult your doctor if you have any further queries.
Is it habit forming?
No habit forming tendencies have been reported and the drug is not addictive. Since it may cause many side effects hence the medication should be taken under medical supervision only.
Are there any breast-feeding warnings?
This medication is not recommended for lactating mothers as it can pass through breast milk to the child and cause complication. Consult your doctor for other alternatives.
Is It safe with alcohol?
No, this medication should not be taken while under the influence of alcohol as there can be an adverse side effect and major health complications.
Is it safe to drive while on this medicine?
This medication doesn’t cause drowsiness and you can drive or operate heavy machinery under the influence of this medication.
Does this affect liver function?
Unchanged in mild liver disease; reduce dosage in severe liver disease. The medication is known to cause liver injury and liver treatment of baseline liver enzymes if you are about to start this medication. Consult your doctor if you want to seek other alternatives or want to be on a safer side while under this medication. You should discontinue the treatment if you see the state of your liver deteriorating.
Does this affect kidney function?Dosing adjustment in renal impairment:
- Clcr <10 mL/minute: Administer every 12 hours
- Hemodialysis: Extensively removed by hemodialysis and peritoneal dialysis (50% to 100%); administer dose posthemodialysis.
- Peritoneal dialysis: Dose as for Clcr <10 mL/minute.
- Continuous arteriovenous or venovenous hemofiltration (CAVH/CAVHD): Administer usual dose.
Below is the list of medicines, which have the same composition, strength and form as Flagyl 400 MG Tablet , and hence can be used as its substitute.
Are there any missed dose instructions?
If you have missed a dose, take the missed dose as soon as you remember. Do not take more medication than you are prescribed for as you can do more harm than good.
Are there any overdose instructions?
If you have symptoms of overdose seek medical treatment immediately and rush to the nearest medical emergency. Consult a doctor and follow up as it may cause liver or other damages to your body.
Flagyl 400 MG Tablet belongs to the class anthelmintics. It enters into the organism and forms the free radical. A concentration gradient is created in the organism due to alteration in the molecule and promotes the influx of the molecule. Thus, the free radical and the altered molecule will interfere with the DNA synthesis and stops the growth of the organism.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Patients taking metronidazole, a disulfiram-like reaction characterized by flushing, headache, nausea, vomiting, sweating or tachycardia; patients should be warned to avoid alcohol during and 72 hours after therapy
Interaction with Lab Test
Interaction with Medicine
- CYP2C9 enzyme substrate; CYP2C9, 3A3/4, and 3A5-7 enzyme inhibitor.
- Increased toxicity: Flagyl 400 MG Tablet increases P-T prolongation with warfarin and increases lithium levels/toxicity; cimetidine may increase metronidazole levels.
Interaction with Disease
Use with caution in patients with liver impairment due to potential accumulation, blood dyscrasias; history of seizures, congestive heart failure, or other sodium retaining states; reduce dosage in patients with severe liver impairment, CNS disease, and severe renal failure (Clcr <10 mL/minute); if H. pylori is not eradicated in patients being treated with metronidazole in a regimen, it should be assumed that metronidazole-resistance has occurred and it should not again be used; seizures and neuropathies have been reported especially with increased doses and chronic treatment; if this occurs, discontinue therapy.
Interaction with Food
Ques: What is Flagyl 400 MG Tablet?
Ques: What are the uses of Flagyl 400 MG Tablet?
Ques: What are the Side Effects of Flagyl 400 MG Tablet?
Ques: What are the instructions for storage and disposal Flagyl 400 MG Tablet?
Ques: How long do I need to use Flagyl 400 MG Tablet before I see improvement of my conditions?
Ques: What are the contraindications to Flagyl 400 MG Tablet?
Ques: Is Flagyl 400 MG Tablet safe to use when pregnant?
Ques: Will Flagyl 400 MG Tablet be more effective if taken in more than the recommended dose?
Metronidazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 24 April 2019]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/metronidazole
Flagyl 400mg Tablets- EMC [Internet]. www.medicines.org.uk. 2018 [Cited 24 April 2019]. Available from:https://www.medicines.org.uk/emc/product/9238/smpc
Important information about Metronidazole- Drugs Bank [Internet]. drugsbanks.com. 2017 [Cited 24 April 2019]. Available from:https://www.drugsbanks.com/metronidazole/
METRONIDAZOLE- metronidazole tablet- Daily Med [Internet]. dailymed.nlm.nih.gov. 2006 [Cited 24 April 2019]. Available from:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9987047-9c99-45a5-829b-ae8b189cbfd4
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.