Lignox 2% Gel

Manufacturer: Indoco Remedies Ltd
Medicine composition: Lidocaine
Prescription vs OTC: Prescription by Doctor not required
Last Updated: March 23, 2022

Lignox 2% Gel can be used in dental and medical procedures. In dental, as an amide-type injectable local anaesthetic and topical local anaesthetic or as a patch: Production of mild topical anaesthesia of accessible mucous membranes of the mouth prior to superficial dental procedures.

Medically, it is a local anaesthetic and acute treatment of ventricular arrhythmias from myocardial infarction, cardiac manipulation, digitalis intoxication. It is also used as a topical local anaesthetic for providing relief od pain associated with postherpetic neuralgia.

Lignox 2% Gel is a drug of choice for ventricular ectopy, ventricular tachycardia, ventricular fibrillation. It is also used for pulseless VT or VF preferably administer after defibrillation and epinephrine and to control of premature ventricular contractions, wide-complex PSVT.

Being a local anesthetic. It is used topically on the skin to reduce itchiness and skin conditions such as insect bites, eczema and burns. It is also used to cure hemorrhoids and problems of the genital/anal regions. This medication functions by reducing pain, redness and swelling. The viscous variant is used for dental treatment.

On using Lignox 2% Gel you may experience certain side effects such as a burning or stinging sensation, dizziness, drowsiness, changing body temperatures, blurred vision or a pounding/ringing in your ears. Severe reactions include depression, numbness and vomiting. Should your reactions continue and become worse over time contact your doctor right away.

Before using Lignox 2% Gel inform your doctor if: you are allergic to any medicine, food, substances or ingredients contained within Lignox 2% Gel, you have diabetes, liver/ stomach problems and infections.

Take the dosage recommended by your doctor for your condition. This topical medication comes as a gel, spray, cream, lotion and skin patch. Apply on the affected area of the skin after cleaning and drying it well. It is usually recommended to use about 2-3 times a day.

Lignox 2% Gel has a narrow therapeutic index and severe toxicity may occur slightly above the therapeutic range, especially with other antiarrhythmic drugs; symptoms of overdose include sedation, confusion, coma, seizures, respiratory arrest and cardiac toxicity (sinus arrest, A-V block, asystole, and hypotension).

The QRS and Q-T intervals are usually normal, although they may be prolonged after massive overdose; other effects include dizziness, paresthesias, tremor, ataxia, and GI disturbance.

Treatment is supportive, using conventional therapies (fluids, positioning, vasopressors, antiarrhythmics, anticonvulsants); sodium bicarbonate may reverse QRS prolongation, bradyarrhythmias and hypotension; enhanced elimination with dialysis, hemoperfusion or repeat charcoal is not effective.

I.V.: You will be monitored during infusion. Do not get up without assistance. Report dizziness, numbness, double vision, nausea, pain or burning at infusion site, nightmares, hearing strange noises, seeing unusual visions, or difficulty breathing.

Oral: Lidocaine can cause numbness of tongue, cheeks, and throat. Do not eat or drink for 1 hour after use. Take small sips of water at first to ensure that you can swallow without difficulty. Your tongue and mouth may be numb; use caution avoid biting yourself. Immediately report swelling of face, lips, or tongue.

Patch: Patch may be cut to appropriate size. Apply patch to most painful area. Up to 3 patches may be applied in a single application. Patch may remain in place for up to 12 hours in any 24-hour period. Remove immediately if burning sensation occurs. Wash hands after application.

It is important to recognize that lidocaine has a narrow therapeutic index. Severe toxicity may occur at doses slightly above the therapeutic range, particularly when lidocaine is administered together with other antiarrhythmic drugs.

While lidocaine toxicity may elicit seizures, lidocaine may also cause respiratory arrest and cardiac toxicity (AV block, asystole, and hypotension).

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Anesthesiologist before using this medicine.

The primary use of this medicine are as follows:

  • Hypersensitivity

  • Heart Block

The common side effects of this medicine are as follows:

  • Abnormal Sensation

  • Application Site Swelling

  • Skin Redness

  • Thrombophlebitis

  • Dizziness

  • Blurred Vision

  • Vomiting

  • Urticaria

  • Edema (Swelling)

  • Severe Back Pain

  • Is It safe with alcohol?

    No interaction found
  • Are there any pregnancy warnings?

    Lignox 2% Gel is probably safe to use during pregnancy.
    Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
  • Are there any breast-feeding warnings?

    Lignox 2% Gel is probably safe to use during breastfeeding. Please consult your doctor.
  • Is it safe to drive while on this medicine?

    There is no interaction between driving and consuming this drug. So dose alteration is not needed.
  • Does this affect kidney function?

    There is no data available. Please consult doctor before consuming the drug.
  • Does this affect liver function?

    There is no data available. Please consult doctor before consuming the drug.
  • What is the onset of action?

    The effect of this medicine is initiated within 45-90 seconds.
  • How long is the duration of effect?

    The duration of the effect of this medicine will remain for 10-20 minutes.

Below is the list of medicines, which have the same composition, strength and form as Lignox 2% Gel , and hence can be used as its substitute.

  • Are there any missed dose instructions?

    The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.
  • Are there any overdose instructions?

    Seek emergency medical treatment or contact the doctor in case of overdose.

This medication acts as a local anaesthetic and antiarrhythmic that works by stabilising the neuronal membrane by blocking the voltage-gated sodium channels. This inhibits depolarization of the postsynaptic nerve that prevents the transmission of pain signals.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Medicine

    • CYP3A3/4 enzyme substrate.
    • Drugs which inhibit CYP3A3/4 may increase lidocaine blood levels.
    • Protease inhibitors like amprenavir and ritonavir may increase lidocaine blood levels.
    • Propranolol increases lidocaine blood levels.
  • Interaction with Disease

    Use cautiously in hepatic impairment, any degree of heart block, Wolff-Parkinson-White syndrome, CHF, marked hypoxia, severe respiratory depression, hypovolemia, history of malignant hyperthermia, or shock. Increased ventricular rate may be seen when administered to a patient with atrial fibrillation.

Ques: What is Lignox 2% Gel used for?

Ans: This medication is used to reduce the discomfort associated with the insertion of medical instruments such as needles or catheters. It also helps to reducing the pain and inflammation in conditions such as heamorrhoids (piles) and anal fissures.

Ques: Is Lignox 2% Gel toxic?

Ans: If this drug is used under the supervision of a medical practitioner, it is safe to use. However, if you use more than the recommended then it may lead to a number of serious health issues.

Ques: How long does it take for Lignox 2% Gel to work?

Ans: This medication is applied at the start of a medical procedure and takes 3-5 minutes for the numbing effect to occur.

Ques: Who should not be given Lignox 2% Gel?

Ans: Lignox 2% Gel should not be given to patients who are allergic to it, have decreased blood volume (hypovolemia), or complete heart block. If the solution contains adrenaline, then you must not inject it into a vein or used in areas such as fingers, toes, ears, nose or penis, as the blood supply to these areas may not be sufficient.

Ques: Is Lignox 2% Gel safe?

Ans: Yes, it is safe for usage when applied topically as instructed by your medical practitioner.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Lignox 2% Gel
What are the uses of Lignox 2% Gel
What are the contraindications of Lignox 2% Gel ?
What are the side effects of Lignox 2% Gel ?
Key highlights of Lignox 2% Gel
What are the substitutes for Lignox 2% Gel ?
What are the dosage instructions?
How does this medication work?
What are the interactions of Lignox 2% Gel ?
FAQs about Lignox 2% Gel