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Overview

Axentri 150Mg Tablet

Manufacturer: Emcure Pharmaceuticals Ltd
Medicine composition: Maraviroc
Prescription vs.OTC: Prescription by Doctor required

Axentri 150Mg Tablet is a medication used in the treatment of those infected with HIV. It is a type of antiretroviral drug that falls in the category of CCR5 receptor antagonist. It is an entry inhibitor that blocks HIV from entering and infecting the immune system cells. It works by attaching itself to the CCR5 coreceptor proteins on the surface of immune cells.

You should consult your doctor before taking Axentri 150Mg Tablet if you have any heart or kidney or liver problems, low blood pressure, allergy to any medicine or other substances, had Hepatitis B or Hepatitis C in the past, or if you are pregnant, breastfeeding, plan on becoming pregnant, are on any medication or supplements, taking hormone based birth control measures or if you have any other medical condition.

The possible side effects you may encounter after taking Axentri 150Mg Tablet includes postural hypotension, dizziness, fainting, myocardial infarction, heart problems, immune reconstitution inflammatory syndrome (IRIS), skin reactions, allergic problems like rashes, itching, swelling of tongue, mouth, lips, or throat. You should see a doctor immediately if any of these effects become bothersome or last for long duration of time.

Axentri 150Mg Tablet comes as 20mg, 25mg, 75mg, 150mg, 300mg oral tablets or 20mL oral solution. You should take it with some other HIV medicine and it should be swallowed whole, not chewed. It is advised that you should consult a doctor regarding the recommended dosage of Axentri 150Mg Tablet.

hiv infection
In addition to its intended effect, Axentri 150Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Rash
Insomnia (difficulty in sleeping)
Weakness
Increased liver enzymes
Flatulence
Loss of appetite
Is It safe with alcohol?
There is no data available. Please consult doctor before consuming the drug.
Are there any pregnancy warnings?
There is no data available. Please consult doctor before consuming the drug.
Are there any breast-feeding warnings?
There is no data available. Please consult doctor before consuming the drug.
Is it safe to drive while on this medicine?
There is no data available. Please consult doctor before consuming the drug.
Does this affect kidney function?
There is no data available. Please consult doctor before consuming the drug.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Are there any missed dose instructions?
If you miss a dose of Maraviroc, skip it and continue with your normal schedule. Do not double the dose.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

What is the life time of HIV person. Please explain stage of HIV infected person based on given report TC: 9900 cells/cumm DC polymorph: 60% lymphocytes: 30% eosinophills: 08% HB: 70%(0.2grams) ESR: 21 mm/ 1hr HIV test (TRIDOT): positive HIV 1: positive HIV 2: negative.

MD-PhD, FIPS, Fellow of Academy of General Education (FAGE), DPM, MBBS
Psychiatrist, Ludhiana
The aim of HIV treatment HIV is a virus that attacks the body?s defence against infection and illness ? the immune system. you can take drugs to reduce... Talk to your doctor Taking antiretroviral therapy is a long-term commitment. At present, once you start the drugs, you are likely to be on them for the rest of your life.... How anti-HIV drugs are dispensed You will get a prescription for your HIV treatment, when you attend your regular HIV clinic appointment, which you take to either the specialist HIV pharmacy (in... Generic medicines Pharmaceutical drugs are given several names: A research name based on its chemical make-up or manufacturer, e.g. DMP266. A generic name which is the chemical name of the... Types of antiretroviral drugs There are six main types (?classes?) of antiretroviral drugs: Nucleoside reverse transcriptase inhibitors (NRTIs), and nucleotide reverse transcriptase inhibitors (NtRTIs), which target an HIV protein called reverse transcriptase. These are often... Single-tablet regimens There are now fixed-dose pills that combine three anti-HIV drugs, from more than one class of drug. These allow many people to take their HIV treatment in... Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs) Most people now take these drugs in a fixed-dose pill that combines a number of drugs. These combination pills are listed first and there are also separate... Integrase inhibitors Names: Dolutegravir, Tivicay Dose: One yellow 50mg tablet once a day. Dolutegravir should be taken twice a day if taken with efavirenz, nevirapine or tipranavir, or for HIV... Non-nucleoside reverse transcriptase inhibitors (NNRTIs) Names: Efavirenz, Sustiva Approved dosage: Efavirenz is available as a generic drug, so its appearance will depend on which type your clinic buys. Efavirenz typically comes as 600mg... Protease inhibitors (PIs) Most protease inhibitors are prescribed with another drug (also a protease inhibitor) called ritonavir. Ritonavir is used to boost the effects of the other protease inhibitor in... CCR5 inhibitors Names: Maraviroc, Celsentri Approved dosage: The dose of maraviroc is dependent on the other anti-HIV drugs you take. Your HIV doctor or pharmacist will talk to you... Fusion inhibitors There is currently one drug in the fusion inhibitor class, called enfuvirtide (T-20, Fuzeon). This is now only prescribed in very rare and specific circumstances. Anyone on... Summary Combination HIV treatment prevents HIV from damaging your immune system, and so prevents ill health and prolongs...
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Popular Health Tips

HIV - How It Affects Drug Resistance?

MBBS, MD - Dermatology
HIV Specialist, Mumbai
HIV - How It Affects Drug Resistance?

HIV infection is the causative factor of the acquired immune deficiency syndrome (AIDS). Worldwide research is being conducted and treatment strategies are being formulated to combat this fatal disease. Fighting HIV is not an easy task, since the disease cannot be completely reversed. However, worldwide use of anti-retroviral therapy has helped in controlling the spread and transmission of disease. Use of medications, regular screening and close contact with caregivers and physicians is necessary for proper management of the disease. Despite, available treatment options, a difficult obstacle that arises before or during the treatment is drug resistance.

Drugs are aimed at targeting the disease-causing pathogens like bacteria and viruses. These pathogens, over a period of time, develop the ability to acquire resistance against the targeted drugs. The pathogens continue multiplying despite the presence of the drug in the system. In today’s scenario, the potent drug combination of anti-retroviral therapy (ARV) has been successful in remarkably reducing HIV-related mortality. However, an increased emergence of resistance to the drug therapy is concerning.

Amongst the various drug classes available in the ARV, no drug is resistance-proof. The drugs belonging to the same class have a similar mechanism of action against the virus. So resistance developed against a particular class of drug inevitably leads to resistance against all the other drugs belonging to that class. An individual with HIV infection may have one or more drug-resistant mutations, which makes the person less sensitive to one or more anti-retroviral drugs. When the replication of virus in the system is not suppressed fully, a resistance towards it develops.

Non-compliance of the ARV results in resistance. Resistant viruses can spread the infection and affect ARV therapy. Drug resistance is usually attributed to inadequate adherence to the regimen. But in some cases, strict adherence to the drug is seen, yet there is a presence of resistance due to poor absorption. This implies that since the drug is not getting adequately absorbed in the body, it is unable to prevent the replication thus leading to drug resistance.

Anti-retroviral treatment is aimed at limiting the replication of HIV in the body. Various drug classes target different steps of replication, which stops further replicating and infecting of the cells. The nucleo-capsid contains viral genome and three enzymes vital to HIV life cycle:

  • Reverse transcriptase - Transcribes viral RNA genome into complementary deoxyribonucleic acid (DNA)
  • Integrase - Facilitates incorporation of pro-viral DNA into host cell genome
  • Protease - Cleaves viral polypeptide into individual functional enzymes

Drugs targeted on these steps are as follows

  • Nucleoside and non-nucleoside reverse transcriptase inhibitors like Nevirapine and Efavirenz act on the reverse transcriptase enzyme.
  • Integrase inhibitor Raltegravir acts on the Integrase enzyme.
  • Protease inhibitors like Ritonavir, Indinavir, Saquinavir act on the Protease enzyme.
  • Fusion inhibitor Enfuvirtide acts to prevent fusion of HIV with cell membranes.
  • CCR5 inhibitor Maraviroc block the CCR5 co-receptor.
  • A viral mutation occurring at any stage of this process can affect the efficacy of the drug therapy.

The emergence of drug resistance can be managed by evaluation of drug absorption and ensure strict adherence to the drug schedule. Genotype tests can be done to look for drug-resistant mutations in genes. Phenotype tests are done for measuring the ability of a virus in an individual to undergo replication in different drug concentrations. A successfully administered and effectively acted first-line drug treatment, preferably a 3-drug combination, reduces the chances of drug resistance in future.

In case you have a concern or query you can always consult an expert & get answers to your questions!

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