Axentri 150Mg Tablet is a medication used in the treatment of those infected with HIV. It is a type of antiretroviral drug that falls in the category of CCR5 receptor antagonist. It is an entry inhibitor that blocks HIV from entering and infecting the immune system cells. It works by attaching itself to the CCR5 coreceptor proteins on the surface of immune cells.
You should consult your doctor before taking Axentri 150Mg Tablet if you have any heart or kidney or liver problems, low blood pressure, allergy to any medicine or other substances, had Hepatitis B or Hepatitis C in the past, or if you are pregnant, breastfeeding, plan on becoming pregnant, are on any medication or supplements, taking hormone based birth control measures or if you have any other medical condition.
The possible side effects you may encounter after taking Axentri 150Mg Tablet includes postural hypotension, dizziness, fainting, myocardial infarction, heart problems, immune reconstitution inflammatory syndrome (IRIS), skin reactions, allergic problems like rashes, itching, swelling of tongue, mouth, lips, or throat. You should see a doctor immediately if any of these effects become bothersome or last for long duration of time.
Axentri 150Mg Tablet comes as 20mg, 25mg, 75mg, 150mg, 300mg oral tablets or 20mL oral solution. You should take it with some other HIV medicine and it should be swallowed whole, not chewed. It is advised that you should consult a doctor regarding the recommended dosage of Axentri 150Mg Tablet.
HIV infection is the causative factor of the acquired immune deficiency syndrome (AIDS). Worldwide research is being conducted and treatment strategies are being formulated to combat this fatal disease. Fighting HIV is not an easy task, since the disease cannot be completely reversed. However, worldwide use of anti-retroviral therapy has helped in controlling the spread and transmission of disease. Use of medications, regular screening and close contact with caregivers and physicians is necessary for proper management of the disease. Despite, available treatment options, a difficult obstacle that arises before or during the treatment is drug resistance.
Drugs are aimed at targeting the disease-causing pathogens like bacteria and viruses. These pathogens, over a period of time, develop the ability to acquire resistance against the targeted drugs. The pathogens continue multiplying despite the presence of the drug in the system. In today’s scenario, the potent drug combination of anti-retroviral therapy (ARV) has been successful in remarkably reducing HIV-related mortality. However, an increased emergence of resistance to the drug therapy is concerning.
Amongst the various drug classes available in the ARV, no drug is resistance-proof. The drugs belonging to the same class have a similar mechanism of action against the virus. So resistance developed against a particular class of drug inevitably leads to resistance against all the other drugs belonging to that class. An individual with HIV infection may have one or more drug-resistant mutations, which makes the person less sensitive to one or more anti-retroviral drugs. When the replication of virus in the system is not suppressed fully, a resistance towards it develops.
Non-compliance of the ARV results in resistance. Resistant viruses can spread the infection and affect ARV therapy. Drug resistance is usually attributed to inadequate adherence to the regimen. But in some cases, strict adherence to the drug is seen, yet there is a presence of resistance due to poor absorption. This implies that since the drug is not getting adequately absorbed in the body, it is unable to prevent the replication thus leading to drug resistance.
Anti-retroviral treatment is aimed at limiting the replication of HIV in the body. Various drug classes target different steps of replication, which stops further replicating and infecting of the cells. The nucleo-capsid contains viral genome and three enzymes vital to HIV life cycle:
Drugs targeted on these steps are as follows
The emergence of drug resistance can be managed by evaluation of drug absorption and ensure strict adherence to the drug schedule. Genotype tests can be done to look for drug-resistant mutations in genes. Phenotype tests are done for measuring the ability of a virus in an individual to undergo replication in different drug concentrations. A successfully administered and effectively acted first-line drug treatment, preferably a 3-drug combination, reduces the chances of drug resistance in future.
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