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Axentri 150Mg Tablet

Manufacturer: Emcure Pharmaceuticals Ltd
Medicine composition: Maraviroc
Prescription vs.OTC: Prescription by Doctor required

Axentri 150Mg Tablet is a medication used in the treatment of those infected with HIV. It is a type of antiretroviral drug that falls in the category of CCR5 receptor antagonist. It is an entry inhibitor that blocks HIV from entering and infecting the immune system cells. It works by attaching itself to the CCR5 coreceptor proteins on the surface of immune cells.

You should consult your doctor before taking Axentri 150Mg Tablet if you have any heart or kidney or liver problems, low blood pressure, allergy to any medicine or other substances, had Hepatitis B or Hepatitis C in the past, or if you are pregnant, breastfeeding, plan on becoming pregnant, are on any medication or supplements, taking hormone based birth control measures or if you have any other medical condition.

The possible side effects you may encounter after taking Axentri 150Mg Tablet includes postural hypotension, dizziness, fainting, myocardial infarction, heart problems, immune reconstitution inflammatory syndrome (IRIS), skin reactions, allergic problems like rashes, itching, swelling of tongue, mouth, lips, or throat. You should see a doctor immediately if any of these effects become bothersome or last for long duration of time.

Axentri 150Mg Tablet comes as 20mg, 25mg, 75mg, 150mg, 300mg oral tablets or 20mL oral solution. You should take it with some other HIV medicine and it should be swallowed whole, not chewed. It is advised that you should consult a doctor regarding the recommended dosage of Axentri 150Mg Tablet.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a HIV Specialist before using this medicine.

hiv infection
In addition to its intended effect, Axentri 150Mg Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Insomnia (difficulty in sleeping)
Increased liver enzymes
Loss of appetite
Is It safe with alcohol?
There is no data available. Please consult doctor before consuming the drug.
Are there any pregnancy warnings?
There is no data available. Please consult doctor before consuming the drug.
Are there any breast-feeding warnings?
There is no data available. Please consult doctor before consuming the drug.
Is it safe to drive while on this medicine?
There is no data available. Please consult doctor before consuming the drug.
Does this affect kidney function?
There is no data available. Please consult doctor before consuming the drug.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Are there any missed dose instructions?
If you miss a dose of Maraviroc, skip it and continue with your normal schedule. Do not double the dose.
Axentri 150Mg Tablet prevents HIV from attacking human cells. Maraviroc is a tiny molecule antagonist that inhibits communication between human CCRS and HIV-1 gp120. It does that by judiciously binds to the human chemokine receptor CCR5 on the membrane of CD4 cells.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

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MD-PhD, FIPS, Fellow of Academy of General Education (FAGE), DPM, MBBS
Psychiatrist, Bangalore
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Popular Health Tips

HIV - How It Affects Drug Resistance?

MBBS, MD - Dermatology
HIV Specialist, Mumbai
HIV - How It Affects Drug Resistance?

HIV infection is the causative factor of the acquired immune deficiency syndrome (AIDS). Worldwide research is being conducted and treatment strategies are being formulated to combat this fatal disease. Fighting HIV is not an easy task, since the disease cannot be completely reversed. However, worldwide use of anti-retroviral therapy has helped in controlling the spread and transmission of disease. Use of medications, regular screening and close contact with caregivers and physicians is necessary for proper management of the disease. Despite, available treatment options, a difficult obstacle that arises before or during the treatment is drug resistance.

Drugs are aimed at targeting the disease-causing pathogens like bacteria and viruses. These pathogens, over a period of time, develop the ability to acquire resistance against the targeted drugs. The pathogens continue multiplying despite the presence of the drug in the system. In today’s scenario, the potent drug combination of anti-retroviral therapy (ARV) has been successful in remarkably reducing HIV-related mortality. However, an increased emergence of resistance to the drug therapy is concerning.

Amongst the various drug classes available in the ARV, no drug is resistance-proof. The drugs belonging to the same class have a similar mechanism of action against the virus. So resistance developed against a particular class of drug inevitably leads to resistance against all the other drugs belonging to that class. An individual with HIV infection may have one or more drug-resistant mutations, which makes the person less sensitive to one or more anti-retroviral drugs. When the replication of virus in the system is not suppressed fully, a resistance towards it develops.

Non-compliance of the ARV results in resistance. Resistant viruses can spread the infection and affect ARV therapy. Drug resistance is usually attributed to inadequate adherence to the regimen. But in some cases, strict adherence to the drug is seen, yet there is a presence of resistance due to poor absorption. This implies that since the drug is not getting adequately absorbed in the body, it is unable to prevent the replication thus leading to drug resistance.

Anti-retroviral treatment is aimed at limiting the replication of HIV in the body. Various drug classes target different steps of replication, which stops further replicating and infecting of the cells. The nucleo-capsid contains viral genome and three enzymes vital to HIV life cycle:

  • Reverse transcriptase - Transcribes viral RNA genome into complementary deoxyribonucleic acid (DNA)
  • Integrase - Facilitates incorporation of pro-viral DNA into host cell genome
  • Protease - Cleaves viral polypeptide into individual functional enzymes

Drugs targeted on these steps are as follows

  • Nucleoside and non-nucleoside reverse transcriptase inhibitors like Nevirapine and Efavirenz act on the reverse transcriptase enzyme.
  • Integrase inhibitor Raltegravir acts on the Integrase enzyme.
  • Protease inhibitors like Ritonavir, Indinavir, Saquinavir act on the Protease enzyme.
  • Fusion inhibitor Enfuvirtide acts to prevent fusion of HIV with cell membranes.
  • CCR5 inhibitor Maraviroc block the CCR5 co-receptor.
  • A viral mutation occurring at any stage of this process can affect the efficacy of the drug therapy.

The emergence of drug resistance can be managed by evaluation of drug absorption and ensure strict adherence to the drug schedule. Genotype tests can be done to look for drug-resistant mutations in genes. Phenotype tests are done for measuring the ability of a virus in an individual to undergo replication in different drug concentrations. A successfully administered and effectively acted first-line drug treatment, preferably a 3-drug combination, reduces the chances of drug resistance in future.

In case you have a concern or query you can always consult an expert & get answers to your questions!

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