Clopidogrel is one of the drugs that are given to the patients with high risk of heart attack or strokes. It is used to prevent such conditions for the patient with high risk of cardiovascular events. This drug helps in avoiding the blood clotting, and thus minimizing the risk of strokes and heart attacks. The CYP2C19 is one of the genes that come into action when the drug is affecting the blood clotting. It is responsible for the metabolic activity of the gene and more it is mutated more will be the different result of the drug. Thus to know the effects of the drug on the body and to know the impact of the drug during the treatment, Clopidogrel CYP2C19 Sensitivity Test is done.
There is no particular preparation required for the test. All you need is to consult with your doctor and tell him about your health conditions. Based on your health, medical history and different medication that you are taking, the doctor will give you various instructions that should be followed. These guidelines will help in having an accurate result. Moreover, one should wear loose clothes such or sleeveless shirt so that the doctor can take the blood sample easily and quickly.
Clopidogrel CYP2C19 Sensitivity Test result is based on the mutation in the CYP2C19 genes present in our DNA. However, the report may give the analysis of the other gene variants as well, but all we need to focus on how the CYP2C19 gene is being affected by the drug intake. The test will be positive if the gene is showing mutation after the drug intake. The test will be negative if there is no mutation in the gene and show that the body is not responding to the treatment or effects of the drugs.
Genotype method is used on the blood sample for the Clopidogrel Cyp2C19 Sensitivity Genotype Blood test. An alcohol pad is used to disinfect the skin and the needle. An elastic band is wrapped around the elbow to halt the blood flow and to increase the size of the vein. The needle is injected into the vein, visible on your skin, and blood is collected in the tube attached to the needle. Once enough blood is collected the needle is ejected, and the sample is sealed with your name. The sample is carried to the research laboratory for examination.
| Type | Gender | Age-Group | Value |
|---|---|---|---|
|
Clopidogrel Cyp2C19 Sensitivity Genotype Blood
|
Unisex
|
All age groups
|
Gene is mutated in Clopidogrel sensitive cases
|
Modern women want to have it all, in personal and professional life. They want to experience the joy of motherhood but not the pain associated with normal delivery. For such women, epidural analgesia during labour is a blessing. Epidural analgesia/anaesthesia is given to pregnant women during childbirth. Epidural painkillers stop the pain signals transmitted nerves from uterus. This stops the pain sensation of labour. For epidural analgesia, a catheter (small tube) is inserted into the epidural space in the spinal cord. It is through this tube that the drugs (painkillers) reach the desired nerves.
Types of Epidurals:
Epidurals can be
Merits and demerits of having an epidural--
Merits:
Demerits:
Though epidurals make childbirth easy, one cannot overlook its demerits.
Thus, they may take longer than usual to push the baby. If you wish to discuss about any specific problem, you can consult a Pain Management Specialist.
The Internet has glorified our lives in numerous ways, but at the same time, too much of information available online has also become very appalling in certain cases. One of the main scenarios that have borne the brunt of information overload is sexual health. Now-a-days, the adolescents or the teenagers have become very much vulnerable to increasing sexual risks owing to exposure to excessive online information.
Sexual Studies: The eternal curiosity about sexuality amongst the humans along with the unnecessary stigmas or taboos related to these have together led to a severe situation where people are resorting to a wrong form of information by misusing the internet.
How are the teenagers affected?
This has mounted up, especially amongst the teenagers because this is the transitional stage of a child to an adult where one goes through the maximum hormonal changes in the body. These hormones affect the metabolism and development of sexual maturity in those who are passing through this sensitive stage of puberty.
The superficial study of biological sciences and the changes felt by the adolescents have compelled them to dig more about sexuality by making use of the wonder weapon today, the internet. However, the social and other digital media contain sexual contents and information in a distorted manner and this has proved to be extremely pernicious in the following ways:
Studies have shown the present social media is flooded with illicit sexual content to the extent of almost 80% in the movies and 60% in the videos that are creating a severe psychological impact on everyone, irrespective of the gender. This is reaching to such an extent that sometimes they are getting addicted to watching these that is undermining their overall mental health.
Probable remedies: Now-a-days, various sexual awareness programmes are coming up and sexual orientation programme is becoming a part of the course curriculum in schools as well. Yet, unless and until the hush-hush mentality of the society regarding this particular aspect decreases, there will not be a significant change. There is always hope at the end of a dark tunnel and anybody who feels disturbed due to these issues can always consult and take help of the psychiatrists and sexologists who can handle such issues with the utmost consideration and under strict confidentiality.
However, one needs to open up completely before them or else, the treatment or counselling, whichever is applicable, will not be fulfilled in a proper manner. One has to break the boundaries, get enlightened, confront the facts and in turn, lead a healthier sexual life. If you wish to discuss about any specific problem, you can consult a Sexologist.
When it comes to maintaining proper penis health, most men have a very good idea of what to do. They know all the basics of penis care, from taking care to wash properly to regularly inspecting the manhood to applying a high-quality penis health crème. But in the heat of the moment, when sexual fun is getting hot and heavy, a man might make a silly mistake. Those sexual mistakes can compromise penis health in a serious way.
Not sure what sexual mistakes might be a problem? Here's a list of the biggest issues a man might find himself doing when things are hot - and might regret when things cool off.
1. That lube isn't really lube. A man who is getting it on but suddenly realizes the need for lube might reach for whatever is handy, assuming a bottle of lube is not available - and sometimes that means he will try to use anything from shampoo or conditioner to lotion or cooking oils. Obviously these things are not meant for use as a sexual lubricant, and can lead to dry and cracked skin, irritation and more. Using lube designed specifically for the sexual purpose is always recommended.
2. The condom is too small. Though it is very important to always wrap it up before sexual activity, the wrapping itself might sometimes be the issue. Using a condom that is too small might lead to a little irritation in the heat of the moment, but a man can often ignore that for pursuit of pleasure. The aftermath is when things get rough, as the penis can develop small cuts, tears or even blisters from the use of a condom that is too tight. It pays to test out a variety of condoms to find the best fit.
3. There's been too much drinking. Sometimes a bit of inebriation can be a good thing, as it lowers inhibitions and can help both partners relax before the main event. But too much drinking can lead to serious problems, including trouble with getting it up or issues with stamina. But too much alcohol consumption can lead to even worse things, such as forgetting to use a condom or even suffering memory loss that leaves a man wondering just what happened the night before. Avoiding this is simple: don't drink too much before a bedtime romp.
4. Cleaning up is not a priority. There are plenty of bodily fluids sliding around during sexual activity, and much of that understandably winds up on a man's penis. From the natural lubrication that occurs during sex to the traces of spermicide in the condom, there can be several substances that linger. A man who doesn't clean off his penis after sex is asking for trouble, as those fluids can dry on the penis skin, leading to itching, irritation and redness, as well as a potential penis rash.
A man who pays attention to good penis care should always remember that caring for the penis extends to those moments when things are hot and heavy. Not only should a man be fully prepared for any sexual encounter, he should also be sure to take care to clean up well afterward. Maintaining good health should also include regular use of a high-quality penis health crème (health professionals recommend Man 1 Man Oil, which is clinically proven mild and safe for skin). Look for a crème that includes a multitude of vitamins and nutrients, such as vitamin A for odor-fighting properties, vitamin E to keep skin supple, and vitamin C to enhance sexual health. Amino acids such as L-arginine for blood vessel dilation and acetyl-L-carnitine for protection against peripheral nerve damage are also helpful. Combine it all in a Shea butter base and a man has the recipe for great penis health.
Adverse respiratory events (AREs) are leading causes of post-operative morbidity and mortality. Anesthesia is the use of medicine to prevent or reduce the feeling of pain or sensation during surgery or other painful procedures (such as getting stitches). Giving as an injection or through inhaled gases or vapours, different types of anesthesia affect the nervous system in various ways by blocking nerve impulses and, therefore, pain.
Anesthesia can help control your breathing, blood pressure, blood flow, and heart rate. It may be used to:
Adverse Respiratory Events (ARE)
Adverse outcomes of such events are fatal and lead to Death & Brain Damage. Three mechanisms of injury are reported to account for highest adverse respiratory events:
Inadequate Ventilation: Insufficient Gas Exchange can produce the adverse outcome. Esophageal Intubation: Incubation between the two sides of the esophagus inadvertently.
Difficult tracheal intubation: Tracheal Intubation is the placement of a flexible plastic tube into the trachea (windpipe) to maintain an open airway. It is performed facilitate ventilation of lungs in severely ill, anesthetized patients.
Other’s are as listed below:
Residual neuromuscular blockade is an important postoperative complication associated to the use of neuromuscular blocking drugs and is commonly observed in the post-anesthesia care unit (PACU) after non-depolarizing neuromuscular blocking agents (NMBAs) are administered intra-operatively. Incomplete neuromuscular recovery can be minimized with acceleromyography monitoring. The risk of adverse respiratory events during early recovery from anesthesia can be reduced by intra-operative acceleromyography use.
Reintubation is a serious adverse respiratory event and the consequences include increased cardiac and respiratory complications, prolonged length of stay at the PACU, intensive care unit (ICU) and hospital, prolonged mechanical ventilator support, higher costs, and increased mortality. Overweight and obesity have also been identified as risk factors for postoperative respiratory complications. Most adverse respiratory events are considered preventable with improved monitoring such as:
Closed observation of the clinical factors and appropriate monitoring by well trained people are factors necessary to prevent adverse outcome. If you wish to discuss about any specific problem, you can consult a General Surgeon.
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