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Kidney Stones Treatment
Removal Of Stitches Procedure
Corn Removal Procedure
Dressings Of Wounds Procedure
Varicose Vein Laser Treatment
Hernia Repair Surgery
Urinary Incontinence (Ui) Treatment
Stitching Of Wounds Procedure
Treatment Of Deep Vein Thrombosis - Dvt
Male Breast Reduction Treatment
Prostate Laser Surgery
Gastric Bypass Surgery
Treatment of Bone Marrow Transplantation
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Christmas & new year offers - skin whitening treatment
Visit our clinic & avail festive special offers with free consultation!
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Skin whitening is the practice of using substances, mixtures, or physical treatments to lighten skin color. Skin whitening treatments work by reducing the content of melanin of the skin. Many agents have been shown to be effective in skin whitening.
Specific zones of abnormally high pigmentation such as lentigo spots, moles and birthmarks may be de-pigmented to match to the surrounding skin. In cases of vitiligo, unaffected skin may be lightened to achieve a more uniform appearance.
Discovery and design
Melanogenesis inhibitors have been discovered and developed through several methods, including: screening of synthetic chemical libraries (high-throughput screening is occasionally used), screening of plant extracts, computational (in silico) search, found as a side effect of previously known drugs and exploration of structural analogues of previously known tyrosinase inhibitors based on knowledge (in varying degrees) of their structure-activity relationship. Thus, the development and discovery of melanogenesis inhibitors illustrates many of the methods used in drug design. Some of the most potent competitive reversible tyrosinase inhibitors are synthetic compounds with a potency hundreds of times that of kojic acid.
Mechanisms of action
Melanin is the main substance responsible for the color of the skin. Melanin is class of dark polymers generated by the body through the process of melanogenesis. Among the melanin pigmenting the skin and hair, 2 types can be distinguished based on its chemical composition and biological route of synthesis: the black/brown eumelanin and the red/yellow pheomelanin. The variation of skin color among individuals is mostly because of variation of the content of melanin in the skin. Skin with little or no melanin is almost white. Other factors influence skin color in a lesser degree, including the amount of blood in blood vessels (because of the color of blood), skin thickness and content of carotenoids in skin.
Melanin in synthesized in melanosomes which are organelles produced in melanocytes. Melanocytes are cells dedicated to this function that are present in the skin, hair follicles, and other structures of the body. The synthesis of melanin (also called" melanogenesis" and" melanization") involves a chain of enzyme-catalyzed chemical reactions and non-enzyme-catalyzed reactions. The main precursor to melanin is l-tyrosine. The first step of melanogenesis is the conversion of l-tyrosine to l-dopa; this is the first and rate-limiting step and is catalized by the enzyme tyrosinase. Other enzymes involved in the synthesis include tyrosinase-related protein 1 (trp1) and tyrosinase-related protein 2 (trp2); trp2 is also known as" dopachorome tautomerase" (dct). L-tyrosine is taken by the melanocytes from the intercellular medium, then transported to the melanosomes. L-tyrosine is also synthesized within the melanocytes from l-phenylalanine by the enzyme phenylalanine-hydroxylas (pah)
Melanosomes are transferred to keratinocytes (the most abundant cell type in the skin). Most of the melanin of skin is found in keratinocytes. Additionally, melanocytes interact with keratinocytes through chemical signaling.trp
I have very rashes on my private part and it is very painful in Summer when I apply cream and later on it again it get damage in some day.
MY SISTER DID A FACIAL FOR ME BUT AFTER FINISHING I FOUND OUT THAT MY FACE WAS SCRATCH BADLY I THOUGHT THAT IT'S JUST A WOUND AND WILL GO AWAY AFTER TWO TO THREE DAYS BUT NOW ITS HAS BECOME WORST IT HAS TURN BLACK WHEN I WASH MY FACE THE BLACK spot turns red ANY SUGGESTIONS WHICH LOTION SHOULD I USED.
I don't know, excess sweat comes from my face in just light work everytym. Is this make my face more black? I am so worried about it, How I cure this. please help me.
Hello sir/ madam, i'm white in color. I use to wear t-shirts and I recently have noticed that, the color of my arms become dull due to sun light. So please tell me what precautions I have to take?
I had a fungal infection on my face and read on Internet that to cure it I have to apply garlic paste on the infected region. I did so and my face started burning and I was feeling immense pain but I beard it and didn't remove the paste. The next day I saw my face and it was burnt. The region was black and small alsars immersed. The next day the dark alsars changed into black cloths. When I removed the cloths pink skin emerged from it. What should I do to prevent permanent spots on my face? Please tell me. Thank you.
I am 18 years old boy from South india. I want to know that how to cure hyperpigmentation and bowel movement? Is there any relation between these two disease?
I HAVE PIMPLE MARKS ON MY FACE It looks shiny like skin is covered over the marks Recommend me some good home remedies to reduce pimple marks. I had poped my pimples before with a sterilized needle. please help me how to remove pimple marks.
Hi doctor, I am 22 years and my problem is with my skin my hands, face and my neck looks more darker then my unexposed body ares. I use some face creams but no use. So please how can I get my natural glow back?
Dear Doctor, I am 35 years old man and I have black spot on my face not full face but only on particular area like nose. Cheek etc. I have used many cream for it but the result is always negative. So please help me and tell me good solution.
Suffering with anal pain from last one year. Whenever I had non-veg getting this problem. Please let me know the solution for this.
Sir cheeks was so lean and my face was not looking good. Pls suggest me some natural ways to get fleshy and chubby cheeks.
My face skin is very oily and always pimples comes on my face and also blood comes from pimples. What should I do?
Hi this is Tanu my problem is my skin. I am 28 years old I have sensitive skin n the big problem is pigmentation on my face pls help me this.
Prostate cancer is a very painful disease to go through. However, what some people do not realize is that prostate cancer is equally disturbing from a psychological view point, both for the patient and the family. Here are some psychological impacts of prostate cancer:
1. Shock, fear or anger
These are immediate reactions and you could feel any or all of these feelings when the disease is first reported to you. These feelings may continue for some time but if the patient is unable to come out of the state of the anger for a long time, then he may need psychological help.
Sometimes you may feel well and deny the fact that you have prostate cancer or not realize you really do. Accept it. This is the first step to curing it.
This is also a natural feeling and will haunt you till this disease is gone. However, there are many ways to help reduce it.
This is usually related to the side-effects in the early stages of prostate cancer. Trust your doctor. Finding a support group or talking to people in similar conditions may help.
6. Mood swings
This is one of the side effects of the hormone therapy used to treat prostate cancer. It may cause you to get angry and anxious and then tearful and depressed.
Some men are overly worried about their prostate-specific antigen or PSA test results. The anxiety may continue even after the PSA test is over.
8. Sense of loss
Hormone therapy causes many physical changes in your body, including weight gain, changes in your sex life as well as reduced physical strength. Few things will be the same after prostate cancer in all honesty. Talking to the people around you can help more than you know.
While prostate cancer can cause all sorts of negative emotions, it is crucial that you use your family to stay strong and do not slip into depression. There are also a few patients who accept this diagnosis well, if properly counselled. In the majority of cases, prostate cancer grows slowly. In those cases, new drugs are available which help the patient lead a near normal life.