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Collectively grouped under the Ewing sarcoma family of tumors, Ewing's sarcoma is the second most common form of bone cancer, which is commonly seen in children and adolescents. Very rarely is it experienced in adults above the age of 30.
Typically forming in the bones of the chest, pelvis, head, back or trunk and in the long bones of the arms and legs, Ewing's sarcoma is believed to originate in certain kinds of primitive cells. When it begins to affect similar kind of cells found outside the bone, it is usually called an extraosseous Ewing's sarcoma.
1. Similar to all types of Ewing tumors, Ewing's sarcoma is generally caused by an alteration in a certain cell compelling a gene named EWS found on chromosome no. 22 to move over to a DNA section on any one of the surrounding chromosomes resulting in the activation of the EWS gene.
2. While it is not a hereditary condition, it usually occurs after childbirth, but no substantial evidence has been found as to why it happens so.
Symptoms of Ewing's sarcoma may include:
1. Swelling and pain especially in the arms, legs, back, chest or pelvis
2. Swelling accompanied by joint immobility
3. A bone breaks having no apparent cause
4. Swelling which may or may not be accompanied by a warm, tingling sensation
5. Fever resulting from unknown causes
6. Lumps or bumps which do not subside over time
7. Abnormal weight loss
8. High levels of fatigue
9. Tumors which have spread over to the lungs may cause shortness of breath
10.Tumors spread over to the spine may cause weakness or even paralysis.
Because the symptoms of Ewing's sarcoma can hardly be distinguished from symptoms caused by other infections or injuries, an early diagnosis is absolutely necessary for a successive treatment. If you wish to discuss about any specific problem, you can consult an oncologist and ask a free question.
The body produces a number of chemicals called hormones which are essential for the regulation of various functions including growth and metabolism. These hormones are produced by endocrine glands which are located in various parts of the body. One such important gland is the pituitary gland which produces the important growth hormone. This is essential for regulating optimal growth during the growing years and for maintaining proper amounts of body fat, muscles, and bones in the later years of life.
Causes: Deficiency of the growth hormones can occur due to a number of causes, some of which are listed below. It can be congenital (present at birth) or acquired later in life.
The congenital issue could be due to problem in the pituitary gland structure, leading to complete absence or reduced secretion of the hormone.
With age, there is a decrease in the amount of secretion. However, infections, injuries, brain tumors, surgery and radiation can also lead to altered amounts of secretion.
Symptoms: While growth hormone deficiency can occur at any age, symptoms differ depending on the age when the deficiency sets in.
In the early ages:
- Lower rate of growth for a given age
- Delayed developmental milestones
- Delayed onset of puberty
- Short stature/reduced height
- Younger looking compared to other children their age
- Fat deposition around the waist
- Delayed dental development
When the deficiency sets in during the later years, there is
- Low energy levels, constant tiredness
- Decreased strength
- Decreased exercise tolerance
- Decreased overall muscle mass
- Thin and dry skin
- Increased fat deposition and weight gain around the waist
- Changes in social behavior including alternate cycles of anxiety and depression
- Lack of motivation
- History of pituitary tumors
- High levels of fat and cholesterol
The diagnosis depends on the age of the person
- Blood tests are carried out to check the hormone levels in circulation
- In children, in addition to the hormone levels, x-rays to see the status of growth plates is very helpful.
- An insulin hypoglycemia test where insulin is given intravenously to see the levels of the growth hormone after 30 minutes.
- Total cholesterol levels, low-density lipoprotein (LDL) cholesterol, apolipoprotein B, and triglyceride levels can be used to supplement the above tests.
- CT scan and/or MRI of the brain may be needed if tumors are suspected.
Treatment: Once diagnosed, replacement therapy is given as shots a few times a week under the skin. This restores normal growth and helps in controlling the symptoms in adults too.
In cases of tumor, radiation or surgery may be required, but most cases are managed with hormone replacement.
Watch out for the symptoms if your child has delayed developmental milestones and early intervention can help restore growth and function to normal levels. If you wish to discuss about any specific problem, you can consult an endocrinologist.
I am a student and suffering from lumbar disc herniation since last two years or more treatments are being done but there have been no proper result but severe development in sciatic pain, numbness and feeling some effect on other leg also. And please suggest me some solution for this herniation.
Galactorrhea is not a disease per se, but more of an underlying medical condition or a symptom that involves discharge of a milky fluid from the nipples, which is not the breast milk. It becomes especially crucial owing to the similarity of the two, when breastfeeding the baby is concerned. It may happen even while you are not lactating or not even pregnant, mostly in menopausal women. Strangely, the syndrome has also shown to have occurred to men and children, irrespective of gender.
What are the contributing factors to the development of Galactorrhea?
- Galactorrhea is a major side effect of certain kinds of medication that leads to hormonal imbalance and ultimately leads to quasi-lactation.
- Increase in the levels of prolactin can result in Galactorrhea which may be due to a number of reasons ranging from excessive stimulation in the nipples and chest area (during sexual activities), or pituitary and thyroid problems. The former is not a major cause of worry. The latter can be fixed with proper medication.
- Kidney disease and spinal cord surgery may also result in this phenomenon.
- Substance abuse and birth control pills may also be responsible for breast discharge.
- At times, the causes for Galactorrhea may not be certifiably determined.
Various symptoms of Galactorrhea include:
- Milky discharge from one or both breasts simultaneously.
- Discharge may be continuous or intermittent.
- Density and amount of discharge may also vary.
- In case of women, this may have a direct effect on periods, leading to irregular menstruation.
- The discharge may occur without pressure or when an external agency is involved.
- Headaches and worsening vision are also said to occur.
When you experience a nipular discharge, the most common tests you should undergo include a pregnancy test, prolactin level exam, mammography, ultrasounds, even an MRI for the pituitary gland evaluation. Based on the result, your physician prescribes the required medicines or advises you to stop taking a particular medicine that might be causing this discharge in the first place.
In case you have a concern or query you can always consult an expert & get answers to your questions!
I got. L4 and L5 disc prolapse. Doing physio therapy exercise. But could not walk or jogging exercise due to ankles and knee problem. And could not bend myself too. What to do?
I am 36 year old having problem of of disc slip in lumbar spine Dr. Asked for the surgery is only surgery is the option please suggest me other treatment.
When cells divide abnormally and uncontrollably, they can form a mass or lump of tissue. This lump is called a tumor. Bone tumors form in your bones. As the tumor grows, abnormal tissue can displace healthy tissue.
Some tumors are benign, meaning they aren’t cancerous. While benign bone tumors won’t spread to other parts of the body and are unlikely to be fatal, they can still be dangerous and may require treatment. Benign tumors can grow and could compress your healthy bone tissue. Other tumors are malignant, meaning they’re cancerous. Malignant bone tumors can cause cancer to spread throughout the body.
Causes of bone tumor:
The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include:
- Genetic defects passed down through families
- In most cases, no specific cause is found.
Symptoms of bone tumor:
Symptoms of bone tumor may include any of the following:
- Bone fracture, especially fracture from slight injury (trauma)
- Bone pain, may be worse at night
- Occasionally a mass and swelling can be felt at the tumor site
- Some benign tumors have no symptoms.
Diagnosing a bone tumor:
There are some common conditions like fractures, infections and other conditions that may resemble tumors. But, to be sure some physical examination to be performed which will check the tenderness in the bone and also the range of motion. Blood or Urine test may be performed to detect different proteins that may indicate the presence of tumor. Doctor may go with X-rays and depending on the X-ray results other imaging tests might be necessary i.e. CT scan, MRI PET scan. In some cases biopsy is also performed. In this test. a sample of the tissue that makes up the tumor is removed.
Treating bone tumor:
Bone cancer is generally treated with Surgery in which the entire tumor is removed. The surgeon carefully examines the margins of your tumor to make sure no cancer cells are left. Surgical techniques have improved greatly. Other ways to treat is radiation therapy which is used in conjunction with surgery. Still if the doctor feels that cancer cells are likely to spread or already spread then Chemotherapy is recommended.
I am having problem in my spinal cord disc L4 -L5. With some loss of fluid. Now my knee joint also getting pain. What you wil suggest.
Hi Sir/Madam. I Have Disc problem (L4 L5 S1. Is It Come Under Physically Handicapped). If I Apply Government Jobs. please help me. Thank you.
Fractures are simply a break in a bone. They can be caused due to injury, (traumatic fractures) or a pre-existing condition like osteoporosis that causes weakening of bones (pathologic fractures). There are many ways to classify fractures. All fractures fall into the major categories of simple and compound fractures. Simple fractures are fractures where bones remain inside the skin and don’t jut out. They are also called closed fractures.
Compound fractures, also called open fractures, are broken bones that penetrate through the skin. These types expose the bone and deep tissues to the environment. Compound fractures are more serious of the two. The healing here may be affected due to deep infections for which antibiotics need to be used. There are many different sub types of fractures and we’re only going to skim through them here.
- Comminuted fractures: Severe fractures in which a bone breaks into several smaller pieces.
- Avulsion fractures: A small piece of bone is completely torn off from the main bone due to fierce pulling off a part of the body.
Other types of fractures are characterised by the many different angles the bone breaks into like transverse, oblique and spiral fractures.
When a bone is broken there are symptoms like swelling that doesn’t subside on its own and pain. In such a case it’s imperative that one goes to a doctor for a diagnosis. Doctors can usually recognise most fractures by examining the injury and taking an X-ray. The X-ray also provides a clear idea about the type of fracture and the degree of displacement of the bone. And, it’s important that the patient doesn’t wait too long before approaching a doctor. This is because bones begin to heal very quickly after a fracture and the bone tissue will heal using any tissue available. This can lead to a misalignment of broken pieces of bone and cause disability and loss of function.
There are cases when X-ray may not show a fracture. This is especially common in fractures in the hip and wrist in older people. For diagnosing these, doctors will get some other tests done such as a computed tomography (CT) scan, magnetic resonance imaging (MRI), or a bone scan.
Fractures have to be treated by doctors. The doctors set the fractured bones in their proper place and hold them there so that they can heal. Setting a bone is called "reduction." Reduction without surgery is called "closed reduction." But if the fracture is serious, it’s going to require surgery with bone repositioning, called open reduction.
In extreme cases, pins, plates, screws, rods, or glue are used to hold the fractured bones in place, inside the body. Once the bone abutment has been treated, the bone is immobilised to allow the broken pieces to heal. In most cases, the fractured part is set in a rigid cast. The fractured ends of the bone can be fixed into place using metal pins connected to an external frame. This is removed after the bone has healed. If you wish to discuss about any specific problem, you can consult an orthopedist.