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Dr. Pradeep Sharma

Dentist, Delhi

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Dr. Pradeep Sharma Dentist, Delhi
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To provide my patients with the highest quality healthcare, I'm dedicated to the newest advancements and keep up-to-date with the latest health care technologies....more
To provide my patients with the highest quality healthcare, I'm dedicated to the newest advancements and keep up-to-date with the latest health care technologies.
More about Dr. Pradeep Sharma
Dr. Pradeep Sharma is a renowned Dentist in Uttam Nagar, Delhi. You can visit him at Dr. Pradeep Dental Centre in Uttam Nagar, Delhi. Book an appointment online with Dr. Pradeep Sharma on Lybrate.com.

Lybrate.com has a number of highly qualified Dentists in India. You will find Dentists with more than 26 years of experience on Lybrate.com. You can find Dentists online in Delhi and from across India. View the profile of medical specialists and their reviews from other patients to make an informed decision.

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Dengue Vaxia

M.B.B.S,C.C.A,D.C.A,AASECT,FPA,AAD,M.I.M.S
General Physician, Gorakhpur
Dengue Vaxia

Dengvaxia - first vaccine against dengue

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Read more:

Dengue symptoms and what to do if you think you have denguedengue fever - remedies using papaya leaf juice

Full prescribing info - dengvaxia

Contents

Dengue tetravalent vaccine (live, attenuated).

Indications / uses

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Dosage / direction for use

The patient will receive 3 injections of 0.5 ml each at 6-month intervals.

The first injection will occur at the chosen or scheduled date; the second injection, 6 months after the first injection; and the third injection, 6 months after the second injection. Dengvaxia should be used according to the local vaccination schedule.

If the patient forgot an injection of dengvaxia: if the patient missed a scheduled injection, the physician will decide when to give the missed injection.

It is important that the patient follows the instructions of the physician, pharmacist or nurse regarding return visits for the follow-up injection. If the patient forgets or is not able to go back to the physician, pharmacist or nurse at the scheduled time, ask the physician, pharmacist or nurse for advice.

Administration: dengvaxia is given by the physician or nurse as an injection underneath the skin (subcutaneous route) in the upper arm.

Contraindications

Do not use dengvaxia if the patient is allergic (hypertensive) to the active substances or any of the other ingredients of dengvaxia listed in description (see description); has developed an allergic reaction after prior administration of dengvaxia. Signs of an allergic reaction may include an itchy rash, shortness of breath and swelling of the face and tongue; is suffering from a disease with mild to high fever or acute disease. In this case, the physician will postpone the administration of dengvaxia until the patient has recovered; has a weakened immune system, for example due to a genetic defect, hiv infection or therapies that affect the immune system (for example, high-dose corticosteroids or chemotherapy); is pregnant; is breastfeeding.

Use in pregnancy lactation: dengvaxia must not be given to pregnant or breastfeeding women.

If the patient is of child-bearing stage, the patient should take the necessary precautions to avoid pregnancy for 1 month following administration of dengvaxia; is pregnant or breastfeeding, the patient thinks may be pregnant or is planning to have a baby, ask the physician, pharmacist or nurse for advice before receiving dengvaxia.

Special precautions

Inform the physician, pharmacist or nurse before receiving dengvaxia if the patient is taking an immunosuppressive treatment (prednisone or equivalent to 20 mg or 2 mg/kg for 2 weeks or more). The physician will postpone administration of dengvaxia until 4 weeks after the treatment is discontinued; has experienced any health problems after prior administration of any vaccines. The physician will carefully consider the risks and benefits of vaccination.

As with all vaccines, dengvaxia may not protect 100% of persons who have been vaccinated. Vaccination with dengvaxia is not a substitute for protection against mosquito bites. The patient should take appropriate precautions to prevent mosquito bites, including the use of repellents, adequate clothing, and mosquito nets.

Fainting, sometimes accompanied by falling, can occur (mostly in adolescents) following, or even before, any injection with a needle. Therefore inform the physician, pharmacist or nurse if the patient fainted with a prior injection.

Adults above 45 years of age: adults above 45 years of age should not receive the vaccine.

Driving and using machines: no data are available on the effects of dengvaxia on the ability to drive or use machines.

Use in children: children less than 9 years of age should not receive the vaccine.

Side effects

Like all medicines, dengvaxia can cause side effects, although not all patients get them.

Serious allergic reactions: if any of these symptoms occur after leaving the place where the patient received an injection, consult a physician immediately: difficulty in breathing, blueness of the tongue or lips, a rash, swelling of the face or throat, low blood pressure causing dizziness or collapse.

When these signs and symptoms occur they usually develop quickly after the injection is given and while the patient is still in clinic or physician's surgery.

Serious allergic reactions are very rare (may affect up to 1 in 10, 000 people), after receiving any vaccine.

Other side effects: the following side effects were reported during clinical studies in children, adolescents and adults (from 9 to and including 60 years of age). Most of the reported side effects occurred within 3 days after the injection of the vaccine: very common (may affect more than 1 user in 10): headache, muscle pain (myalgia), generally feeling unwell (malaise), feeling of weakness (asthenia), injection site pain, fever.

Common (may affect up to 1 user in 10): injection site reactions: redness (erythema), bruising (hematoma), swelling, and itching (pruritus).

Uncommon (may affect up to 1 user in 100): infections of the upper respiratory tract, dizziness, sore throat (oropharyngeal pain), cough, runny nose (rhinorrhea), nausea, skin eruption (rash), neck pain, hardening of skin at the injection site (injection site induration).

Additional side effects in adults (from 18 to and including 60 years of age): uncommon (may affect up to 1 user in 100): swollen glands (lymphadenopathy), migraine, joint pain (arthralgia), flu-like symptoms (influenza-like illness).

Additional side effects in children and adolescents (from 9 to and including 17 years of age: uncommon (may affect up to 1 user in 100): itchy rash (urticaria).

Reporting of side effects or any suspected adverse event: if the patient experiences any side effects after vaccination, advised to seek immediate medical attention.

By reporting side effects, it can help provide more information on the safety of the vaccine.

Click to view adr monitoring form

Interactions

Using other medicines and dengvaxia: dengvaxia may not have an optimal effect if it used at the same time as medicines that suppress the immune system such as corticosteroids or chemotherapy.

Inform the physician, pharmacist or nurse if the patient is taking or has recently taken any other vaccines or any other medicines, including medicines obtained without a prescription.

Caution for usage

Before administering any biological, the person responsible for administration must take all precautions to prevent allergic or other reactions. As with all injectable vaccines, appropriate medical treatment and supervision must always be readily available in the event of an anaphylactic reaction following the administration of dengvaxia.

Epinephrine (1: 1000) and other appropriate agents used to control immediate allergic reactions must be available to treat unexpected events such as anaphylaxis.

Dengvaxia must not be mixed with other medicinal products in the same syringe.

Dengvaxia must not be administered by intravascular injection under any circumstances.

Syncope (fainting) can occur following, or even before, any vaccination as a psychogenic response to injection with a needle. Procedures should be in place to prevent injury from falling and to manage syncopal reactions.

Separate syringes and needles, separate injection sites and preferably separate limbs must be used if any other vaccine (s) or medicinal product (s) is/are concomitantly administered.

Dengvaxia is reconstituted by transferring all the solvent (0.4% sodium chloride solution) provided in the blue-labeled pre-filled syringe into the vial of freeze dried powder with a yellowish green flip off cap. The pre-filled syringe is fitted with a sterile needle for this transfer. The vial is then gently swirled. After complete dissolution, a 0.5 ml dose of reconstituted suspension is withdrawn into the same syringe. For injection, the syringe should be fitted with the new sterile needle.

The suspension should be visually inspected prior to administration. After reconstitution, dengvaxia is clear, colorless liquid with the possible presence of white to translucent particles (of endogenous nature).

After reconstitution with the solvent provided, dengvaxia must be used immediately.

Any unused dengvaxia or waste material should be disposed of, preferably by heat inactivation or incineration, in accordance with local regulations.

Do not throw away any medicines via wastewater or household waste. Ask a pharmacist on how to throw away medicines that no longer use. These measures will help to protect the environment.

Storage

Store in a refrigerator. Do not freeze. Keep the vaccine in the outer carton in order to protect it from light.

Description

After reconstitution, one dose (0.5 ml) contains 4.5-6.0 log10 ccid50* of each serotype of the cyd dengue virus** (1, 2, 3 and 4).

* ccid50: 50% cell culture infectious dose.

** produced in serum-free vero cells by recombinant dna technology.

The powder is a white, homogenous, freeze-dried powder with possible retraction at the base, and may form a ring-shaped cake.

The solvent (0.4% sodium chloride solution) is a clear, colorless liquid.

After reconstitution with the solvent provided, dengvaxia is a clear, colorless liquid with the possible presence of white to translucent particles.

Excipients/inactive ingredients: essential amino acids including l-phenylalanine, non-essential amino acids, l-arginine hydrochloride, sucrose, d-trehalose dihydrate, d-sorbitol, trometamol, urea, sodium chloride, water for injections.

Mechanism of action

Dengvaxia contains dengue virus serotypes 1, 2, 3 and 4 that have been weakened. Dengvaxia works by stimulating the body's natural defenses (immune system), which produces its own protection (antibodies) against the viruses that cause dengue disease.

Dengue is a viral infection transmitted to humans through the bite of an infected aedes mosquito. Dengue is not transmitted directly from person-to-person. Nevertheless the virus which replicates in an infected individual can be transmitted to other humans through mosquito bites for 4-5 days (maximum 12 days) after the first symptoms appear.

Dengue disease results in a wide range of symptoms including fever, headache, pain behind the eyes, muscle and joint pain, nausea, vomiting, swollen glands or skin rash. Symptoms usually last for 2-7 days. Dengue disease can also be asymptomatic.

However, occasionally dengue can be severe and potentially lead to hospitalization and in rare cases to death. Severe dengue is characterized by high fever and any of the following symptoms: severe abdominal pain, persistent vomiting, rapid breathing, severe bleeding, bleeding in stomach, bleeding gums, fatigue, restlessness, coma, seizure and organ failure.

Source:- http://www.mims.com/philippines/drug/info/dengvaxia

More information about dengvaxia - first vaccine against dengue

Sanofi awaits govt approval to launch dengue vaccine in india

Sanofi pasteur - dengue vaccine frequently asked questions

14 people found this helpful

What should be done when having a tooth cavity. Can you suggest some medicines apart from injection.

BDS
Dentist, Kushi Nagar
What should be done when having a tooth cavity. Can you suggest some medicines apart from injection.
There is no injection for cure of tooth cavity, if you have cavity you need to restoration. Some anticaries past are available like xtar.
1 person found this helpful
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My gums are bleeding very nuch everyday without doing any thing because of that my mouth getting bad smell give me any description.

BDS
Dentist, Bangalore
My gums are bleeding very nuch everyday without doing any thing because of that my mouth getting bad smell give me an...
There are so many causes of bleeding gums - - brushing too hard - poor oral hygiene. - vitamin deficiency - taking blood thinners or other medications - bleeding or clotting disorders - mouth sores - other medical problems, including diabetes, heart disease, leukemia or scurvy few advice to stop bleeding gums-- - visit to a dentist for professional cleaning once in a year - use a soft toothbrush -- and brush properly! brush your teeth for at least two minutes twice a day and after meals. Hard brushing can further damage the soft tissues of your mouth. - floss at least once a day and be sure to floss beyond the gum line to remove more plaque. - control bleeding by applying pressure to the area with a cold compress. - rinse with salt water to keep the area clean. - avoid mouthwashes that contain alcohol, which can dry out your mouth. - stay away from smoking and other tobacco products, which can aggravate bleeding gums.
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Hello doctor , my self sudeep , I had made a teeth bridge just appro one month ago , today when I was having my lunch in afternoon I could not see the bridge , I have a doubt if I have swallowed it. It is a ceramic teeth, will there be any issue if its in stomach , I do not feel anything right now , I mean I do not feel any problem now, please let me know, I was having paratha and water also , do not know if I have swallowed it.

BDS, MDS Prosthodontics
Dentist, Greater Noida
Hello doctor , my self sudeep , I had made a teeth bridge just appro one month ago , today when I was having my lunch...
First of all make it clear that the bridge is in place or not. If you are in doubt get examined by dentist. You can also see if bridge is for missing teeth than you will have space left out if by any chance bridge swallowed. Anyhow if you doubt its swallowed it will get passed in stool. But if you fell any symptom like pain get radiographic examination done.
1 person found this helpful
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Had silver filling in my 3 teeth about 25 days ago. Their is metallic taste in my mouth every time. Is it because of that or any other problem? If yes then when will it go away?

BDS, MScD, PGDMLS - Orthodontist, Root Canal, Cosmetic & Aesthetic Dentist, MScD, PGDMLS
Dentist, Bhopal
Had silver filling in my 3 teeth about 25 days ago. Their is metallic taste in my mouth every time. Is it because of ...
Usually amalgam fillings do not cause Metallic taste it is quite possible that you are just preceding it because of psychological reasons there can be many other causes of Metallic taste suggest use of antibiotic gel or tablets so if you are under any medications you should consider their use as one of the cost.
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Hello sir I am 17 years old boy. My teeth are not in discipline manner & my some teeth are little big or yellow caused by flaurosis. So what can I do to improve dental health or how to get a cute smile. Which treatments are advisable for me (treatment for long time & minimum laxative effects). And please tell me their sequences.

BHMS
Homeopath, Faridabad
Hello sir I am 17 years old boy. My teeth are not in discipline manner & my some teeth are little big or yellow cause...
Hello Dental braces and orthodontics are ways of straightening crooked teeth, adjusting protruding teeth, closing up gaps in the teeth and adjusting over bites or under bites.You can consult a dentist if you are interested in dental braces. use Homeodent toothpaste, twice daily. These are few home tips to get rid of the paleness of teeth. Orange Peel: To diminish yellow tone on your teeth, rub orange peel onto them regularly. The vitamin C and calcium contained in the peel will tackle the microorganisms effectively. (i) Clean your teeth with orange peel before you sleep every night and notice the positive results in a few weeks. (ii) You can use orange peel powder, in case fresh orange peel is not available. (iii) Rinse your teeth after this application.
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I have a cavity in my teeth. How to cure this Cavity? But I know "It is initial stage" I do clean my teeth twice in everyday. Have a problem my brush or Paste? Please give me a proper advise.

PGDHHM, BDS
Dentist, Gurgaon
I have a cavity in my teeth. How to cure this Cavity? But I know "It is initial stage" I do clean my teeth twice in e...
Get the cavity filled as soon as possible. It is better to get a cavity in teeth filled in early stages, rather than waiting for decay to spread deeper. For prevention of cavities brush regularly twice daily morning and at night. Eat healthy balanced diet with plenty of fiber .fruits and vegetables.
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I feel unconscious when I want to the dental clinic for extraction of my maxillary third permanent molar?

MDS - Oral & Maxillofacial Surgery
Dentist, Chennai
I feel unconscious when I want to the dental clinic for extraction of my maxillary third permanent molar?
Dental anxiety is a common presentation that can be treated. A negative dental experience is a strong predictor of dental anxiety. Sedation can be an effective way to alleviate a patient’s stress and anxiety during dental treatment, enabling work to be undertaken more comfortably.
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When I brush my teeth, sometimes blood come out with the spittle. But it comes from a particular place every time. What should I do?

BDS, CDE Endo-Prostho, CDE - Cast Partial & Complete Dentures
Dentist, Pune
When I brush my teeth, sometimes blood come out with the spittle. But it comes from a particular place every time. Wh...
Hello, you need to visit a dentist and get it checked. Get an x-ray done. If there is a cavity get it filled. If there is infection to the root of tooth get it treated and then place a crown over it. Bleeding gums could be because of deposits on teeth surface or food lodged in between teeth. Visit a dentist and get your scaling and polishing done. Brush your teeth twice daily. Night brushing is very important. Floss regularly. Rinse after every meal. Visit dentist every 6 months.
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My sister often gets mouth ulcers (large in quantity) along with swelling of gums and lips. She has tried homeopathic medication. But this repeats very frequently. What should she do?

Certification in Full Mouth Rehabilitation, Post-Graduate Certificate in Oral Implantology (PGCOI), M.Sc - Master of Oral Implantology (MOI), Certified Implantologist, BDS
Dentist, Rajkot
Please check diet, it should be balanced and should include protein,vitamins ,fiber and carbohydrates. Chek gi disturbances if any ? cure constipation.
1 person found this helpful
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My son is 5+ all his teeth have cavity he is horrified of going to dentist these are milk teeth. Will the new teeth also get affected?

BDS (GOLD MEDALIST)
Dentist, Jamshedpur
Caries should be treated either filling or capping. Because it will take few years to shed all milk teeth. Caries may cause pain. So it need to be filled. Avoid too much chocolates and sweetened food. Take care of his oral hygiene. Consult a good pedodontist.
1 person found this helpful
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I am suffering a lot because of very bad smell from my mouth because of an artificial teeth I have to plant because of some damage. Could you please help me.

oral implantology, BDS
Dentist, Jaipur
I am suffering a lot because of very bad smell from my mouth because of an artificial teeth I have to plant because o...
consult a dentist near you for thorough clinical check up. if the artificial tooth is causing smell,get it removed and go for better quality replacement like implant or full ceramic bridge
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I am chewing tobacco frm 4 years now my mouth opening size is shorten what is remedy.

Certified Implantologist, BDS
Dentist, Hyderabad
I am chewing tobacco frm 4 years now my mouth opening size is shorten what is
remedy.
First to stop chewing tobacco then use muscle relaxants prescribed by dentist so consult the dentist near by you.
1 person found this helpful
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Hello, I suffering from. My tongue is going thicker to thicker and make me in problem like in talking, some time in breathing.

oral implantology, BDS
Dentist, Jaipur
consult a dentist for thorough check up. these problems can be diagnosed after clinical examination.
1 person found this helpful
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Hello sir, A bad smell comes from my mouth what can I do? I does not smoke & drink also. Please help me to get rid of this.

Advanced Aesthetics, BDS
Dentist, Mumbai
Hello sir, A bad smell comes from my mouth what can I do? I does not smoke & drink also. Please help me to get rid of...
Hi, there are various reasons of bad breath, like impurities in blood, inefficient digestive system, dry mouth (lack of saliva production), gum disease, cavities, plaque and tartar formation around teeth and gums, kind of diet, improper brushing / cleaning of mouth etc. I would advise you to get a thorough physical and dental examination to rule out the cause of bad breath and to solve it permanently.
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Dr. Constantly I am getting salty taste in my toungu and also it irritate to take food please Advise

BDS
Dentist, Pune
Smoking is usually associated with the salty tongue. If you are a nonsmoker then check on your water intake on daily basis.
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My teeth are yellow. In the corner of the teeth thre is white and bad smelling things which is not removed very well through brushing. I have a bad breath prblm too. Whenever I brush again it start to smell after 10 min. Remedy?

BHMS
Homeopath, Howrah
My teeth are yellow. In the corner of the teeth thre is white and bad smelling things which is not removed very well ...
To get stains removed from teeth take lemon juice in a spoon, dip brush or you can apply with fingertip also, apply over the stained teeth, keep for a minute and the rinse with water. It removes stain and as it contains citric acid/vit c which keeps teeth strong. This procedure should be done twice a week not more. Bad breath is due to digestive problems. Maintain proper bowel habits. Eat more fruits that are sour like tamrind, orange, mango, lemon etc. If still problem persists after 15 days consult for treatment.
2 people found this helpful
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I am 24 years old my front lower teeth is shaking and its gum is receding as well please suggest what should I do?

MDS - Oral & Maxillofacial Surgery
Dentist, Chennai
I am 24 years old my front lower teeth is shaking and its gum is receding as well please suggest what should I do?
Kindly consult a dentist in person for further suggestion. We need more investigations to decide upon treatment. You may need deep cleaning along with surgical, gum strengthening procedure. Rinse your mouth thoroughly with a mouth wash after every meals. Advance procedures can be done with laser. You may consult me in person. Dental tips: - visit a dentist every six months. Gargle your mouth thoroughly after every meal. Scrub gently to clean your tongue with a tongue cleaner. Floss all your teeth inter dentally & brush twice daily, morning & night, up & down short vertical strokes, with ultra-soft bristles, indicator brush.
1 person found this helpful
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Even when one brushes the teeth twice a day and rinses the mouth after every food, whats the reason for cavity?

BDS
Dentist, Patiala
Even when one brushes the teeth twice a day and rinses the mouth after every food, whats the reason for cavity?
Sir, its necessary that when you brush your teeth food debris get removed. There is no fun of brushing if debris are still there. So important is right techniques as wrong method to brush your may also lead to teeth damage.
2 people found this helpful
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Does by scaling polishing, the tooth get weaker. I heard from many peoples that it does. Is it true.

Dentist, Delhi
Does by scaling polishing, the tooth get weaker.
I heard from many peoples that it does. Is it true.
it is a myth.of it was so the instruments and materials should not be provided to the dentists.and the concept was not taught in colleges
1 person found this helpful
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