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Dr. Ashish

Dentist, Delhi

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Dr. Ashish Dentist, Delhi
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I'm a caring, skilled professional, dedicated to simplifying what is often a very complicated and confusing area of health care....more
I'm a caring, skilled professional, dedicated to simplifying what is often a very complicated and confusing area of health care.
More about Dr. Ashish
Dr. Ashish is a renowned Dentist in Sohna, Delhi. You can visit him/her at Me Panacea Dental Clinic in Sohna, Delhi. Book an appointment online with Dr. Ashish and consult privately on Lybrate.com.

Lybrate.com has an excellent community of Dentists in India. You will find Dentists with more than 35 years of experience on Lybrate.com. You can find Dentists online in Delhi and from across India. View the profile of medical specialists and their reviews from other patients to make an informed decision.

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Dengue Vaxia

M.B.B.S,C.C.A,D.C.A,AASECT,FPA,AAD,M.I.M.S
General Physician, Gorakhpur
Dengue Vaxia

Dengvaxia - first vaccine against dengue

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Read more:

Dengue symptoms and what to do if you think you have denguedengue fever - remedies using papaya leaf juice

Full prescribing info - dengvaxia

Contents

Dengue tetravalent vaccine (live, attenuated).

Indications / uses

Dengvaxia is a vaccine used to help protect adult or children against dengue disease caused by dengue virus serotypes 1, 2, 3 and 4. Dengvaxia is given to adults, adolescents and children 9 through 45 years of age living in endemic areas.

Dosage / direction for use

The patient will receive 3 injections of 0.5 ml each at 6-month intervals.

The first injection will occur at the chosen or scheduled date; the second injection, 6 months after the first injection; and the third injection, 6 months after the second injection. Dengvaxia should be used according to the local vaccination schedule.

If the patient forgot an injection of dengvaxia: if the patient missed a scheduled injection, the physician will decide when to give the missed injection.

It is important that the patient follows the instructions of the physician, pharmacist or nurse regarding return visits for the follow-up injection. If the patient forgets or is not able to go back to the physician, pharmacist or nurse at the scheduled time, ask the physician, pharmacist or nurse for advice.

Administration: dengvaxia is given by the physician or nurse as an injection underneath the skin (subcutaneous route) in the upper arm.

Contraindications

Do not use dengvaxia if the patient is allergic (hypertensive) to the active substances or any of the other ingredients of dengvaxia listed in description (see description); has developed an allergic reaction after prior administration of dengvaxia. Signs of an allergic reaction may include an itchy rash, shortness of breath and swelling of the face and tongue; is suffering from a disease with mild to high fever or acute disease. In this case, the physician will postpone the administration of dengvaxia until the patient has recovered; has a weakened immune system, for example due to a genetic defect, hiv infection or therapies that affect the immune system (for example, high-dose corticosteroids or chemotherapy); is pregnant; is breastfeeding.

Use in pregnancy lactation: dengvaxia must not be given to pregnant or breastfeeding women.

If the patient is of child-bearing stage, the patient should take the necessary precautions to avoid pregnancy for 1 month following administration of dengvaxia; is pregnant or breastfeeding, the patient thinks may be pregnant or is planning to have a baby, ask the physician, pharmacist or nurse for advice before receiving dengvaxia.

Special precautions

Inform the physician, pharmacist or nurse before receiving dengvaxia if the patient is taking an immunosuppressive treatment (prednisone or equivalent to 20 mg or 2 mg/kg for 2 weeks or more). The physician will postpone administration of dengvaxia until 4 weeks after the treatment is discontinued; has experienced any health problems after prior administration of any vaccines. The physician will carefully consider the risks and benefits of vaccination.

As with all vaccines, dengvaxia may not protect 100% of persons who have been vaccinated. Vaccination with dengvaxia is not a substitute for protection against mosquito bites. The patient should take appropriate precautions to prevent mosquito bites, including the use of repellents, adequate clothing, and mosquito nets.

Fainting, sometimes accompanied by falling, can occur (mostly in adolescents) following, or even before, any injection with a needle. Therefore inform the physician, pharmacist or nurse if the patient fainted with a prior injection.

Adults above 45 years of age: adults above 45 years of age should not receive the vaccine.

Driving and using machines: no data are available on the effects of dengvaxia on the ability to drive or use machines.

Use in children: children less than 9 years of age should not receive the vaccine.

Side effects

Like all medicines, dengvaxia can cause side effects, although not all patients get them.

Serious allergic reactions: if any of these symptoms occur after leaving the place where the patient received an injection, consult a physician immediately: difficulty in breathing, blueness of the tongue or lips, a rash, swelling of the face or throat, low blood pressure causing dizziness or collapse.

When these signs and symptoms occur they usually develop quickly after the injection is given and while the patient is still in clinic or physician's surgery.

Serious allergic reactions are very rare (may affect up to 1 in 10, 000 people), after receiving any vaccine.

Other side effects: the following side effects were reported during clinical studies in children, adolescents and adults (from 9 to and including 60 years of age). Most of the reported side effects occurred within 3 days after the injection of the vaccine: very common (may affect more than 1 user in 10): headache, muscle pain (myalgia), generally feeling unwell (malaise), feeling of weakness (asthenia), injection site pain, fever.

Common (may affect up to 1 user in 10): injection site reactions: redness (erythema), bruising (hematoma), swelling, and itching (pruritus).

Uncommon (may affect up to 1 user in 100): infections of the upper respiratory tract, dizziness, sore throat (oropharyngeal pain), cough, runny nose (rhinorrhea), nausea, skin eruption (rash), neck pain, hardening of skin at the injection site (injection site induration).

Additional side effects in adults (from 18 to and including 60 years of age): uncommon (may affect up to 1 user in 100): swollen glands (lymphadenopathy), migraine, joint pain (arthralgia), flu-like symptoms (influenza-like illness).

Additional side effects in children and adolescents (from 9 to and including 17 years of age: uncommon (may affect up to 1 user in 100): itchy rash (urticaria).

Reporting of side effects or any suspected adverse event: if the patient experiences any side effects after vaccination, advised to seek immediate medical attention.

By reporting side effects, it can help provide more information on the safety of the vaccine.

Click to view adr monitoring form

Interactions

Using other medicines and dengvaxia: dengvaxia may not have an optimal effect if it used at the same time as medicines that suppress the immune system such as corticosteroids or chemotherapy.

Inform the physician, pharmacist or nurse if the patient is taking or has recently taken any other vaccines or any other medicines, including medicines obtained without a prescription.

Caution for usage

Before administering any biological, the person responsible for administration must take all precautions to prevent allergic or other reactions. As with all injectable vaccines, appropriate medical treatment and supervision must always be readily available in the event of an anaphylactic reaction following the administration of dengvaxia.

Epinephrine (1: 1000) and other appropriate agents used to control immediate allergic reactions must be available to treat unexpected events such as anaphylaxis.

Dengvaxia must not be mixed with other medicinal products in the same syringe.

Dengvaxia must not be administered by intravascular injection under any circumstances.

Syncope (fainting) can occur following, or even before, any vaccination as a psychogenic response to injection with a needle. Procedures should be in place to prevent injury from falling and to manage syncopal reactions.

Separate syringes and needles, separate injection sites and preferably separate limbs must be used if any other vaccine (s) or medicinal product (s) is/are concomitantly administered.

Dengvaxia is reconstituted by transferring all the solvent (0.4% sodium chloride solution) provided in the blue-labeled pre-filled syringe into the vial of freeze dried powder with a yellowish green flip off cap. The pre-filled syringe is fitted with a sterile needle for this transfer. The vial is then gently swirled. After complete dissolution, a 0.5 ml dose of reconstituted suspension is withdrawn into the same syringe. For injection, the syringe should be fitted with the new sterile needle.

The suspension should be visually inspected prior to administration. After reconstitution, dengvaxia is clear, colorless liquid with the possible presence of white to translucent particles (of endogenous nature).

After reconstitution with the solvent provided, dengvaxia must be used immediately.

Any unused dengvaxia or waste material should be disposed of, preferably by heat inactivation or incineration, in accordance with local regulations.

Do not throw away any medicines via wastewater or household waste. Ask a pharmacist on how to throw away medicines that no longer use. These measures will help to protect the environment.

Storage

Store in a refrigerator. Do not freeze. Keep the vaccine in the outer carton in order to protect it from light.

Description

After reconstitution, one dose (0.5 ml) contains 4.5-6.0 log10 ccid50* of each serotype of the cyd dengue virus** (1, 2, 3 and 4).

* ccid50: 50% cell culture infectious dose.

** produced in serum-free vero cells by recombinant dna technology.

The powder is a white, homogenous, freeze-dried powder with possible retraction at the base, and may form a ring-shaped cake.

The solvent (0.4% sodium chloride solution) is a clear, colorless liquid.

After reconstitution with the solvent provided, dengvaxia is a clear, colorless liquid with the possible presence of white to translucent particles.

Excipients/inactive ingredients: essential amino acids including l-phenylalanine, non-essential amino acids, l-arginine hydrochloride, sucrose, d-trehalose dihydrate, d-sorbitol, trometamol, urea, sodium chloride, water for injections.

Mechanism of action

Dengvaxia contains dengue virus serotypes 1, 2, 3 and 4 that have been weakened. Dengvaxia works by stimulating the body's natural defenses (immune system), which produces its own protection (antibodies) against the viruses that cause dengue disease.

Dengue is a viral infection transmitted to humans through the bite of an infected aedes mosquito. Dengue is not transmitted directly from person-to-person. Nevertheless the virus which replicates in an infected individual can be transmitted to other humans through mosquito bites for 4-5 days (maximum 12 days) after the first symptoms appear.

Dengue disease results in a wide range of symptoms including fever, headache, pain behind the eyes, muscle and joint pain, nausea, vomiting, swollen glands or skin rash. Symptoms usually last for 2-7 days. Dengue disease can also be asymptomatic.

However, occasionally dengue can be severe and potentially lead to hospitalization and in rare cases to death. Severe dengue is characterized by high fever and any of the following symptoms: severe abdominal pain, persistent vomiting, rapid breathing, severe bleeding, bleeding in stomach, bleeding gums, fatigue, restlessness, coma, seizure and organ failure.

Source:- http://www.mims.com/philippines/drug/info/dengvaxia

More information about dengvaxia - first vaccine against dengue

Sanofi awaits govt approval to launch dengue vaccine in india

Sanofi pasteur - dengue vaccine frequently asked questions

14 people found this helpful

Actually I took the treatment of teeth. I had braces on my teeth n take that treatment for 2 years n removed it after completion n the doctor gave some kind of cap after that n I just didn't use that cap n now gap between my teeth's are again there n they become so yellowish.

B.D.S
Dentist, Jaipur
Actually I took the treatment of teeth. I had braces on my teeth n take that treatment for 2 years n removed it after...
Hello. You might be facing relapse because you didn't use retainer. Get your check done with your dentist again. And get scaling and polishing done to maintain a good oral hygiene. Thank You
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Mouth ulcer in left cheek (near to upper molar) painful and difficult to eat or talk. Kindly suggest some medication. Thanks.

BDS, MDS
Dentist, Gorakhpur
Mouth ulcer in left cheek (near to upper molar) painful and difficult to eat or talk. Kindly suggest some medication....
If the ulcer appeared by it own, that is without any cheek biting or external truma, you can apply Amlexanox 3- 4 times daily until ulcer subsides. Drink plenty of water and maintain good oral hygiene without damaging the ulcer. THANK YOU.
2 people found this helpful
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I have a problem my teeth . Actually bleeding for my teeth & after brushing. & in night. Please advise.

BDS
Dentist, Jaunpur
The problem you are discussing is called as gingivitis Main reason is unclean tooth My recommendation is u need to take a professional oral prophylaxis In lay man term u need a professional cleaning
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How to teeth clean & white which toothpest best for this ? Available in medicine any

BDS
Dentist, Bangalore
How to teeth clean & white which toothpest best for this ? Available in medicine any
Gently brush the outside, inside and chewing surface of each tooth using short back-and-forth strokes. Gently brush your tongue to remove bacteria and freshen breath. Most dentists agree that a soft-bristled brush is best for removing plaque and debris from your teeth. Any toothpaste containing fluoride is good for teeth.
6 people found this helpful
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Hello I want to ask that after getting braces is there any side effects some people say that teeth get weak some say that it pains and feels sensitivity. So is it good to have braces or not.

BDS
Dentist, Akola
Hello I want to ask that after getting braces is there any side effects some people say that teeth get weak some say ...
There is no problem in going for braces it is a simple and a routine procedure There is movement of your teeth whilr the treatment is done so you feel mobile teeth and a slight pain after you change the wire for just 2 to 3 days
1 person found this helpful
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Is it advisable for a 21 year old with all teeth but not in perfect shape n size to get replaced by a new artificial set of teeths for a better dental care and smile?

BDS
Dentist, Mumbai
No.Always what is natural is the best.I suggest, if for cosmetic and aesthetic reasons you can't go for artificial teeth.However you can still go for orthodontic ( that's braces. We can now give you invisible braces too) or restorations like Laminates, Veneers, or composite restorations to give yourself a beautiful smile .We can give you beautiful smile designs these days. So don't get your natural teeth replaced.What's God given and natural is the best.Artificial will not be half as good.
1 person found this helpful
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I have tooth ache because of cavity to reduce the pain what should I do? I am 19 year old and now I went to the dentist and he filled up that teeth but sometimes it hurts very badly. Please suggest me something.

MDS, BDS
Dentist, Bangalore
I have tooth ache because of cavity to reduce the pain what should I do? I am 19 year old and now I went to the denti...
Your teeth if it hurts even after filling. Then it requires root canal treatment. Or there may be one more tooth which may be decayed and causing the pain. Get it checked near dentist again and get the proper treatment. For pain take painkiller. .Colgate pain out helps for temporary relief. You can do earn salt water rinsing for temporary relief.
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Hello Sir, My mouth is not open properly due to chewing habits. Kindly give us important tips for mouth open.

MDS - Oral & Maxillofacial Surgery
Dentist, Pune
Hello, Firstly you need to stop chewing tobacco and related stuff. You need to visit the dentist for mouth opening exercises and intralesional injections if required. In case mouth opening is not achieved, then minor surgery is required for the same.
1 person found this helpful
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I am 31 years old and my teeth very hard pain when I have cold drink & ice cream, what should I do.?

M.D.S.
Dentist, Mumbai
Hi if you get a sharp pain when you have cold drinks or ice, you would probably have hypersensitive teeth. I cannot give a definitive diagnosis without actually taking a look at your teeth, but I suggest you start using sensodyne medicated toothpaste. Brush with this and a soft toothpaste, and let the paste remain on the teeth for about a minute after brushing. Also, use lukewarm water for brushing and gargling. If this does not work you need to go to a dentist at once, as you may be having a cavity.
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