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Laser Hair Removal
Mole Removal Procedure
Skin Care Treatment
Skin Diseases Treatment
Cysts Removal Procedure
Wart Removal Technique
Chronic Skin Allergy Treatment
Stretch Marks Treatment
Tattoo Removal Procedure
Removal Of Stitches Procedure
Corn Removal Procedure
Liver Problems Treatment
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I have been suffering from acne from last 3 years they come n go my face is never clear, I have acne on my back and shoulder also, I have been eating a balanced diet but nothing is working I have taken antibiotics also (amoxilin, septran, doxycilin) for long time and even they hardly work I do not want to take medicine forever. please help me to get rid of my acne permanently.
I'm having dry skin nowadays. Also getting pimples which is becoming as black mark in face. Seems face becoming dull .Can you suggest what should be done for getting freshness back. Which cream and face Wash should be used to get rid of pimples.
Hi, My name is jitu and I am 32 years of old and I am having a problem related to hair my hair turning white day by day. Please suggest me a proper solution that I can use. It will a great help.
I am a 22 yr old male, I have a problem about my face. It looks dull, weak & does not match to my body tone. Not looking fair & bright. what should I do?
I have itch on my back seat. I am getting full itching with my nails so blood is coming out. And the area of skin color changed to black. Please suggest me an ointment to apply to reduce marks and itch.
My face skin is oily, On my face many black dot is there, when we press them some yellow color balls is get outside from my face skin. But due to that some holes type dots is generated permanently on face skin, please tell me what is solution for that.
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Skin whitening is the practice of using substances, mixtures, or physical treatments to lighten skin color. Skin whitening treatments work by reducing the content of melanin of the skin. Many agents have been shown to be effective in skin whitening.
Specific zones of abnormally high pigmentation such as lentigo spots, moles and birthmarks may be de-pigmented to match to the surrounding skin. In cases of vitiligo, unaffected skin may be lightened to achieve a more uniform appearance.
Discovery and design
Melanogenesis inhibitors have been discovered and developed through several methods, including: screening of synthetic chemical libraries (high-throughput screening is occasionally used), screening of plant extracts, computational (in silico) search, found as a side effect of previously known drugs and exploration of structural analogues of previously known tyrosinase inhibitors based on knowledge (in varying degrees) of their structure-activity relationship. Thus, the development and discovery of melanogenesis inhibitors illustrates many of the methods used in drug design. Some of the most potent competitive reversible tyrosinase inhibitors are synthetic compounds with a potency hundreds of times that of kojic acid.
Mechanisms of action
Melanin is the main substance responsible for the color of the skin. Melanin is class of dark polymers generated by the body through the process of melanogenesis. Among the melanin pigmenting the skin and hair, 2 types can be distinguished based on its chemical composition and biological route of synthesis: the black/brown eumelanin and the red/yellow pheomelanin. The variation of skin color among individuals is mostly because of variation of the content of melanin in the skin. Skin with little or no melanin is almost white. Other factors influence skin color in a lesser degree, including the amount of blood in blood vessels (because of the color of blood), skin thickness and content of carotenoids in skin.
Melanin in synthesized in melanosomes which are organelles produced in melanocytes. Melanocytes are cells dedicated to this function that are present in the skin, hair follicles, and other structures of the body. The synthesis of melanin (also called" melanogenesis" and" melanization") involves a chain of enzyme-catalyzed chemical reactions and non-enzyme-catalyzed reactions. The main precursor to melanin is l-tyrosine. The first step of melanogenesis is the conversion of l-tyrosine to l-dopa; this is the first and rate-limiting step and is catalized by the enzyme tyrosinase. Other enzymes involved in the synthesis include tyrosinase-related protein 1 (trp1) and tyrosinase-related protein 2 (trp2); trp2 is also known as" dopachorome tautomerase" (dct). L-tyrosine is taken by the melanocytes from the intercellular medium, then transported to the melanosomes. L-tyrosine is also synthesized within the melanocytes from l-phenylalanine by the enzyme phenylalanine-hydroxylas (pah)
Melanosomes are transferred to keratinocytes (the most abundant cell type in the skin). Most of the melanin of skin is found in keratinocytes. Additionally, melanocytes interact with keratinocytes through chemical signaling.