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My PSA level is 10.47 and USG report says that the size of my Prostrate is 73cc. On going through the report The doctor advised me to go for Prostrate biopsy. Though the biopsy report which was done on 09.01. 2016 reveals negative results but immediately after the test was done I suffered UTI infection with blockage of urine. Accordingly I had to be admitted in hospital during the period from 12.01. 2016 to 18.01. 2016. During my stay at hospital I was treated with i. V. Antibiotic (piperacillin and tazobactam) and has been discharged on 19.01. 2016 with Catheter in situ and advised to go for MRI –Prostate. Accordingly, On 30.01. 2016 I have been undergone with MRI and the report is as under I)Prostatomegaly with benign prostatic hyperplasia Ii)Ill-defined T2W hypointense mildly enhancing areas in peripheral zone of prostate right side towards base-PIRADS 3/5. Kindly explain me if there is any possibility of malignancy in the report.
The rising incidences of cancer have made it important for us to be vigilant about our health. It has been proven medically that if cancer is detected at an early stage -stage I & II , then the chances of cure and treatment along with full recovery are very high. For early cancer detection & for people at greater risk of cancer, PHC-Preventive Health Care plays a major role. Preventive Health Check is particularly important for the people who have a family history of cancer.
Almost all cancers are caused by damage or mutation in their genes, which, may be acquired from environmental exposure, dietary factors, hormones or through normal aging. In 90% of cases, these genes are not passed from parents to children. These are known as sporadic mutations and the cancers that they cause are called as sporadic cancers. But 5-10% of cancers are caused by gene mutations which are inherited from one or both parents & passed on to the children .These are hereditary or germline mutations & these cancers are known as hereditary or familial cancers.
People /children, who carry gene mutations have a higher risk of developing cancer at an earlier age or at some point in their life time.
Some of the common such cancers, which run in families, are:
- Breast cancer
- Ovarian cancer
- Colo-rectal cancer (cancer of large intestine )
- Prostate cancer
Breast, ovary & colo-rectal carcinoma have well established gene mutation studies.Mutation of BRCA 1 & BRCA2 Genes is responsible for 85% of hereditary breast cancers.
Estimated life time risk for developing breast cancer in woman with BRCA1 & BRCA2 mutation is 56-87% & risk for developing-bilateral /contralatral breast cancer is about 20-40%. These statistics make a preventive health check for women with breast cancer history in their family a necessity. Mutation in these genes confers about 20-40% increased life time risk for developing ovarian cancer. Hence the presence of gene mutation for breast cancer can trigger ovarian cancer.
However as stated above, other environmental and lifestyle factors can also cause breast cancer other than genetic BRCA1 & BRCA 2 gene mutations.
- Increasing age
- Early menarche
- Late menopause
- First birth after the age of 30
- Atypical lobular hyperplasia or Atypical ductal hyperplasia
- Prior breast biopsies
- Long term postmenopausal estiogen replacement
- Early exposure to ionizing radiation
Other Familial Cancers:
Familial cancer syndromes associated with colo-rectal cancers are familial adenomatous polyposis (FAP).It is an autosomal dominant inherited syndrome with more than 90% penetrance, manifested by hundreds of polyps developed by late adolescence .The risk of developing invasive cancer is almost 100% .So such patients should start getting colonoscopy at an earlier age- say by 20yr of age & should undergo Total Collectomy on development of significant polyps .
Other familial cancer syndromes are hereditary non -Polyposis Colo Rectal Cancer (HNPCC), Gardner's Syndrome, Turcot's Syndrome, Peutz-Jeghers Syndrome, Juvenile Polyposis.
Cancer Assessment & Conclusion:
For breast cancer risk assessment, we have the GAIL model & IBIS model, which take into consideration ,all the risk factors, apart from BRCA1 & BRCA 2 gene mutation. These models calculate the over all life time risk of development of breast cancer for any lady. For this, you have to consult a specialist experienced in area of hereditary cancers, cancer risk assessment, genetic counseling & testing.
To conclude, all people with cancers in their family should undergo genetic testing & counseling, to detect high risk individuals should take adequate measures & treatment.
I am 24 years old female and I have a lump in my left breast 'fibredenoma' of size 2.5*2.5*1.5 and it pains a lot even if I am not having my periods. According to some doctors, fibroadenoma are painless. Is this possible that fibroadenoma are painful? What should I do?
I am male, 81 years old, having prostate problem and taking one Urimax 0.4 mcg every night and have moderate difficulty in passing urine and I have to get up 4 times in the night for this purpose. And I have hyper tension (140/90) and taking Olways-AM one tablet every day. Kindly advise if I am on the right medication and can the enlargement of prostate is curable at my age? Thank you gentlemen.
Medical science constantly challenges the boundaries by finding not only the cures to the most dangerous diseases, but finds a way to prevent them even before they occur. With years of research, practice and data available for analysis, scientists are using advanced technology in combination with years of research to create a predicting mechanism for often fatal diseases like cancer.
Breast cancer screening has always been done with mammography. The fact is that this method is only 75% accurate, laden with false positives and misses a whole set of women totally- and that too when cancer has already developed. Part of the problem comes from the dense breast tissue which one in three women have. This tissue masks the lumps, which makes it difficult for mammograms to accurately screen cancer.
Some breakthrough scientific methods are changing this by drawing on years of research to predict this deadly disease, years before it can manifest itself.
A genetic test to predict cancer 10-11 years ahead of time
This test was performed to see how environmental factors could influence cancer, along with habits like smoking, abusing alcohol or hormones, genetic changes that occur and are put a large percentage of the women at a high risk of developing this disease.
A simple blood test is used for the genetic analysis of hereditary cancer. Researchers found a biological marker, methylation of the ATM gene, which has a very high ability to predict the risk of developing cancer, several years before diagnosis. 'Methylation' concluded that when one biological indicator is exposed to carcinogenic substances, or other abusive substances like tobacco and alcohol, it may trigger the development of cancer. On the flip side, this test will take time to reach the commercial market and even then cannot give an exact timeline as to when someone may develop the disease.
A simple blood test to predict breast cancer 5 years before it develops
This is the kind of medical miracle the world is looking for. Last year in April, researches in Denmark identified a simple blood test that can predict breast cancer five years before it actually develops with an accuracy of a whopping 80%.
It works by "measuring all of the compounds in the blood to build a 'metabolic profile' of an individual, in order to detect changes in the way chemicals are processed, during a pre-cancerous stage," says Laura Donnelly, health editor at The Telegraph, which covered this development. Danish researchers observed 57,000 participants over 20 years, gathering blood samples along the way, specifically comparing a set of 800 women who remained healthy or developed breast cancer within 7 years of their first blood sample. The researchers found they were able to predict, with 80 percent accuracy, which patients would be affected by the disease, just by looking at the metabolic profiles they built from the participants' blood samples. The results have been published in Metabolomics.
Are you living with the uncertainty of a lump in your breast? It's time you take the first step and consult a specialist here.
I am 39 and weight 87ks I have a lump measuring almost 2 CMS in length on the right side of my stomach and it's there since almost more than 10 yrs, but now it pains sometimes when it is under pressure like a pin. My wife passed Away 2 years back cause of cancer and then multiple organ failure. I am having a daughter of 7 years ad hence I M afraid of getting myself checked. What could be the same. Please advice.
I'm 30 year old woman, my both breasts have pain for 1 year, and also those are differ in sizes. What should I do?
I am Aslam aged 60. My prostate is enlarged in size and measures 4.1*4.4*3.9cm vol 36.9cc Impression: prostatomegaly bilateral large simple renal cortical cyst what should I do?
Please can you tell me, what are the symptoms of blood cancer? And is there any treatment for blood cancer to cure?
Cholangiocarcinoma (Bile duct cancer), like any other cancer, leaves a person physically, mentally and emotionally drained. It has been mostly found to affect people above 60 years of age. The signs and symptoms associated are so common that very few people consult a physician. A delayed diagnosis implies delayed treatment. This goes on to aggravate and complicate the situation further. One needs to be a little alert. Any symptoms, no matter how common, should not be taken lightly. Look for the early signs and symptoms and bile duct cancer can be fully cured.
Signs and symptoms associated with Cholangiocarcinoma:
Bile duct cancer can be Extrahepatic (occurs in the duct outside the liver) or Intrahepatic (cancer develops within the smaller ducts inside the liver). It must be noted that Intrahepatic Bile duct cancer and Liver cancer are different.
- Bile duct cancer results in blocking the bile duct. This blockage severely effects the secretion of bilirubin and bile from the liver. Thus, the secretions (bile and bilirubin) which are supposed to flow into the intestine move back into the bloodstream. An elevated level of bilirubin in the blood gives rise to a condition, known as Jaundice (a condition resulting in yellowing of the eyes and the skin). The problem lies in the fact that many other factors can equally contribute to Jaundice. Consulting a physician at the earliest is the best resort.
- A sudden or drastic weight loss and loss of appetite is an alarming sign of Cholangiocarcinoma.
- Excessive itching can be an indication of something as big as bile duct cancer. Itching can be an outcome of the increased bilirubin (blood) reaching the skin.
- At an advanced stage of Cholangiocarcinoma, a patient may experience severe abdominal pain.
- At times, the tumour in the bile duct might exert immense pressure on the nearby organs. This can give rise to an enlarged abdominal mass. Bloated feeling is also very common amongst the patients.
- An unusual change in the colour of the stool and urine should not be neglected. The elevated bilirubin level from the intestine is usually eliminated out of the system through the urine. Thus the stool appears lighter and the urine a shade darker.
- A cholangiocarcinoma patient can, at times feel nauseated. Fever is also a common but an extremely important indication.
Bile duct cancer or cholangiocarcinoma can lead to many other complications. Click below to know every minute detail associated with Cholangiocarcinoma.